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Apple | Spotify | Amazon Listen and follow ‘Hard Fork’Warning: this episode contains some explicit language. OpenAI has unveiled a new way to build custom chatbots. Kevin shows off a few that he has built — including a custom “Hard Fork” bot and a bot that gives investment advice inspired by his late grandfather. Then, we talk to Lina Khan, the chair of the Federal Trade Commission, about the agency’s approach to regulating A.I. That, and Sam Bankman-Fried’s recent fraud conviction, have us asking, How much damage hath the crypto world wrought?

Persons: OpenAI, Kevin, Lina Khan, Sam Bankman Organizations: Apple, Spotify, Federal Trade Commission

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicA critical gun case was argued before the Supreme Court this week. But instead of opening further freedoms for gun owners — as the court, with its conservative supermajority, did in a blockbuster decision last year — justices seemed ready to rule that the government may disarm people under restraining orders for domestic violence. Adam Liptak, who covers the Supreme Court for The Times, explains why.

Persons: Adam Liptak Organizations: Spotify, The Times

☆ ‘The Buccaneers’ Review: Edith Wharton’s Expats on Apple TV+
▼ + stars: | 2023-11-08 | by ( John Anderson | ) www.wsj.com time to read: +1 min

Kristine Frøseth, Alisha Boe, Josie Totah, Aubri Ibrag and Imogen Waterhouse Photo: Apple TV+If “The Buccaneers” is what it takes to keep Edith Wharton in circulation among a new generation of readers, it may be worth the price. On the downside, people will think “The Buccaneers” has something to do with Edith Wharton. The Buccaneers Wednesday, Apple TV+Wharton—chronicler of robber-baron America, genius of the social critique, stylist extraordinaire—had left four-fifths of “The Buccaneers” behind when she died in 1937. It was published in 1938, unfinished; Marion Mainwaring’s “completed” version appeared in 1993, to a predictable mix of bouquets and outrage. The version materializing on Apple TV+ is the interpretation of series creator Katherine Jakeways (the director is Susanna White ) and will have hardcore Wharton-ites squealing louder than the bevy of batty beauties exported from New York for the London Season in order to find themselves titled English husbands who need American money.

Persons: Kristine Frøseth, Alisha Boe, Josie Totah, Aubri Ibrag, Imogen Waterhouse, Edith Wharton, Wharton, America, extraordinaire —, Marion Mainwaring’s “, Katherine Jakeways, Susanna White Organizations: Apple, Buccaneers, Wharton, London Locations: batty, New York

Julia Botero , Christina Djossa and Jen Poyant and Dan Powell and‘I think what we did when we sent him away is we just delayed the inevitable. And the inevitable was very ugly.’Rick Reiss was scared for his teenage son, Gabriel. Gabe was struggling with depression and mood swings, and no amount of therapy or medication seemed to work. But when Gabe became violent, Rick wasn’t just scared for his son; he was scared of his son. So they made the decision to send Gabe to a wilderness therapy program.

Persons: Julia Botero, Christina Djossa, Jen Poyant, Dan Powell, ‘, Rick Reiss, Gabriel, Gabe, Rick wasn’t, Rick

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicIt’s been one month since the attack on Israel, but Washington has yet to deliver an aid package to its closest ally. The reason has to do with a different ally, in a different war: Speaker Mike Johnson has opposed continued funding for Ukraine, and wants the issue separated from aid to Israel, setting up a clash between the House and Senate. Catie Edmondson, who covers Congress for The Times, discusses the battle within the Republican Party over whether to keep funding Ukraine.

Persons: It’s, Mike Johnson, Catie Edmondson Organizations: Spotify, Ukraine, Senate, The Times, Republican Party Locations: Israel, Washington, Ukraine

☆ Opinion: Biden needs to call for a ceasefire and restore respect for international law
▼ + stars: | 2023-11-07 | by ( Mary Ellen O Connell | ) edition.cnn.com time to read: +45 min

Alexi J. Rosenfeld/Getty Images Europe/Getty Images Palestinians inspect a destroyed area following an Israeli airstrike in Gaza on October 21. Ronen Zvulun/Reuters A woman mourns over a dead man at the Al-Aqsa Martyrs Hospital in Gaza City on October 18. Yousef Masoud/The New York Times A morgue worker arranges body bags at al-Shifa hospital in Gaza City on October 12. Samar Abu Elouf/The New York Times/Redux Children run for cover as bombs fall near the Al-Shifa Hospital in Gaza City on October 9. Erik Marmor/AP Six-month-old Sama Alwadia is rescued from the rubble in Gaza City on October 9.

Persons: Mary Ellen O’Connell, Robert, Marion Short, “, ”, Mary Ellen, Khan, Ahmad Hasaballah, Ariel Schalit, Abed Rahim Khatib, Ronen Zvulun, Mahmud Hams, Leo Correa, Mohammed Abed, Amir Cohen, Mohammed Alaloul, Majdi, Fatima Shbair, Alexi J . Rosenfeld, Mustafa Hassona, Neil Hall, Saeed Jaras, Mohammad Abu Hattab, Mohammed Talatene, Ditza Heiman, Shir Torem, Salman Habaka, Ibraheem Abu Mustafa, Yuval Zilber, Hatem Ali, Jalaa Merey, Ahmad Salem, Ali Jadallah, Atef Safadi, Abed Zagout, Fadel Senna, Anas al, Yosef Vahav, Kiryat Shmona, Jalaa Marey, Albert Miles, Bernat, Ilan Rosenberg, Ashraf Amra, Manna, Tamar Chaya Torpiashvili, Abed Khaled, Tamir Kalifa, Khan Younis, Benjamin Netanyahu, Yoav Gallant, Ammar Awad, Jehad Al, Kafarnah, Teddy, Dan Kitwood, Dima Vazinovich, Jack Guez, Sagiv Ben Zvi, Evelyn Hockstein, Omar El, Mohammed Salem, Amir Levy, Yasser Qudih, Tsafrir, Francisco Seco, Mohammed Saber, Ali Mohmoud, Mai Yaghi, Yam Goldstein, Nadav, Khaled Joudeh, Samar Abu, Leon Neal, Hatem Moussa, Nir Oz, Wolfgang Schwan, Yousef Masoud, Shadi Tabatibi, Belal al Sabbagh, Rizek Abdeljawad, Ahmad Gharabli, Janis Laizans, Mohammed Dahman, Gallant, Ofir Libstein, Aza, Belal Khaled, Hod, Ayal Margolin, Antony Blinken, Joe Biden, Brendan Smialowski, Biden, Netanyahu, Kenny Holston, Kfar Aza, Ilia Yefimovich, Mahmoud Khaled, Dor Reder, Violeta Santos Moura, Mohammed Fayq Abu Mostafa, Antonio Macías, Macías, Eli Albag, Liri, Sergey Ponomarev, Dor Kedmi, Saher, Abraham Cohen, Valentin Ghnassia, Ghnassia, Yuri Cortez, Ibrahim Hams, Bashar Taleb, Baz Ratner, Yahya Hassouna, Mapal Adam, Agha, Reuters Itzik, Miriam Shafir, Dor Shafir, Savion Kiper, Maya Alleruzzo, CNN Sergey Ponomarev, Eden Guez, Ohad, Mohammed Soboh, Said, Noam Elimeleh Rothenberg, Ilai Bar Sade, Erik Marmor, Oren Ziv, Ramez Mahmoud, Roi Levy, Alleruzzo, Tali Touito, Oded, Ahmad Hasballah, Eyad Baba, Itai Ron, Hadas Parush, —, Ron Dermer, NPR’s Tom Bowman Organizations: Kroc, University of Notre Dame, Defense, CNN, Hamas, Mary Ellen O'Connell University of Notre Dame International, UN, UN Security Council, International Court of Justice, Nasser Medical, AP, Najjar, Reuters, Getty, Israel Defence Forces handout, Israel Defense Forces, Shutterstock, Reuters United Nations, Shifa, Palestine, Pictures, Bloomberg, Israeli Apache, United Nations Relief, Works Agency, Al Aqsa Martyrs Hospital, Palestinian, Al, IDF, EyePress, New York Times, Israeli, Getty Images, Nasser Medical Hospital, Deir Al, Tel Aviv University, Reuters Civil, AP Rockets, AP Israel's, Regional, Aqsa Martyrs Hospital, Israel's, Ahli Baptist Hospital, Ben Gurion International, Aris Messinis, Haim, Puma, Mount, Mount Herzl Military, Nova, Anadolu Agency, Nova Festival, Ben Gurion, West Bank, Rockets, United Nations, Reuters Police, Reuters Rockets, ISIS, United States, Gaza, US, Criminal, Pentagon Locations: Gaza, Israel, Khan Younis, Tel Aviv, Jerusalem, AFP, Jerusalem's, City, Rafah, Jerusalem's Old City, Deir Balah, Mahmud, Southern Israel, Anadolu, Ashkelon, Al, Gaza City, Haifa, Yanuh Jat, Netaim, Israeli, Golan Heights, Lebanon, Egypt, Sderot, Shareef, Beit Guvrin, Reuters Israeli, Kiryat, Al Aqsa, Deir Al, Balah, Kibbutz Be'eri, Ashdod, Holon, Najjar, Ichilov, Kibbutz Shefayim, Deir, Samar, Samar Abu Elouf, Deir al, Kibbutz Kissufim, Zahra City, Europe, Xinhua, East Jerusalem, Ras, Israel's, Yehuda, Aqsa, Hod HaSharon, Kiryat Shmona, Ahli, Gan, Kfar, North Sinai, Beit Kama, Cyprus, Kfar Saba, Be'eri, Rehovot, Mount Herzl, Modiin Maccabim, Kfar Aza, Mount Herzel, Yassin, Palestinian, Beitar Ilit, Ramat Gan, Itai, Beit Hanun, Rishon Lezion, United, Iraq, Syria, Geneva, Rome

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicIn a major new campaign poll from The New York Times and Siena College, former President Donald J. Trump leads President Biden in five of the six battleground states likeliest to decide the 2024 presidential race. Widespread discontent with the state of the country and growing doubts about Biden’s ability to perform his job as president threaten to unravel the diverse coalition that elected him in 2020. Nate Cohn, The Times’s chief political analyst, explains why the results are less a reflection of Trump’s growing strength than they are of Biden’s growing weaknesses.

Persons: Donald J, Trump, Biden, Nate Cohn Organizations: Spotify, The New York Times, Siena College

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicThe mass shooting in Maine last week, which killed 18 people, was the country’s deadliest of the year. It may have also been one of the most avoidable. More than five months earlier, the Army Reserve and a Maine sheriff’s department had been made aware of a reservist’s deteriorating mental health. Just six weeks before the killings, he had punched a friend and said he was going to carry out a shooting spree. Nicholas Bogel-Boroughs, a national reporter for The Times, explains why so many warnings failed to stop the shooting.

Persons: Nicholas Bogel Organizations: Spotify, Army Reserve, The Times Locations: Maine

LAS VEGAS (AP) — The former street gang leader charged with orchestrating the 1996 drive-by killing of Tupac Shakur in Las Vegas is expected to plead not guilty Thursday to murder, amid questions of whether he'll hire a defense lawyer or a judge appoints a public defender. Goodman spoke for Davis outside court two weeks ago, saying that prosecutors lack key evidence and witnesses to the killing committed 27 years ago. The attorney didn't give a reason Wednesday why Davis couldn’t hire him. He was arrested Sept. 29 outside a home in suburban Henderson where Las Vegas police served a search warrant July 17, drawing renewed attention to the unsolved murder of one of hip-hop music’s most enduring icons. His indictment alleges Davis provided a gun to someone in the Cadillac from which car-to-car gunfire mortally wounded Shakur and wounded rap music mogul Marion “Suge” Knight at an intersection just off the Las Vegas Strip.

Persons: Tupac Shakur, Duane Keith, Keffe, ” Davis, Shakur, Ross Goodman, Goodman, Davis, didn't, Marion “ Suge, Knight, Orlando, Lane ” Anderson Organizations: LAS VEGAS, Las, Prosecutors, West Coast Locations: Las Vegas, Nevada, Compton , California, Henderson, California, Compton, East Coast

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicIn late September, one of the world’s most intractable conflicts ended suddenly and brutally when Azerbaijan seized the enclave of Nagorno-Karabakh and tens of thousands of ethnic Armenians fled their homes. Andrew Higgins, the New York Times bureau chief for East and Central Europe, explains how the conflict started, why it lasted for more than 30 years, and what its end can tell us about the nature of seemingly unsolvable disputes.

Persons: Andrew Higgins Organizations: Spotify, Music, New York Times, East Locations: Azerbaijan, Nagorno, Karabakh, Central Europe

LAS VEGAS (AP) — The former Southern California street gang leader charged with killing Tupac Shakur in 1996 in Las Vegas has lost his bid to be represented at his arraignment by the lawyer who spoke publicly about his defense two weeks ago. The judge also could name a defense attorney in private practice to represent Davis at taxpayer expense, or assign a special public defender from the county, an alternate roster of possible court-appointed attorneys. Political Cartoons View All 1230 Images“We're just not sure at this point how this will play out and who will end up representing him,” said Jordan Savage, assistant special public defender. Edi Faal, Davis’ longtime personal lawyer in Los Angeles, said Wednesday he expected that a special public defender would be named to represent Davis. Davis is expected to plead not guilty to a murder charge that could put him in prison for the rest of his life.

Persons: Tupac Shakur, Ross Goodman, Duane Keith “ Keffe, ” Davis, Goodman, Davis, Tierra Jones, Scott Coffee, ”, Jordan Savage, Davis ’, Faal, Shakur, Marion “ Suge, Knight, he’s, Shakur’s, Orlando, Lane ” Anderson, Anderson, Marc DiGiacomo, Suge Knight Organizations: LAS VEGAS, Associated Press, Edi, AP, ” Prosecutors, West Coast, Davis Locations: Southern California, Las Vegas, Clark County, Clark, Los Angeles, Nevada, Compton , California, Compton, East Coast, Las

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicA wave of strikes that has paralyzed the auto industry came to an end on Monday, when the last of the three big car manufacturers, General Motors, reached a deal with the United Automobile Workers union. Neal E. Boudette, who covers the auto industry for The Times, discusses the historic deal and why it was such a big win for workers.

Persons: Neal E, Boudette Organizations: Spotify, General Motors, United Automobile Workers, The Times

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicOver the weekend, the Israeli military appears to have begun an invasion of the Gaza Strip, with tanks rolling into the enclave and Israeli soldiers fighting Hamas inside. But the operation remains shrouded in secrecy, and Israel is revealing little about its actions. Raja Abdulrahim, a Middle East correspondent for The Times, and Patrick Kingsley, the Jerusalem bureau chief, discuss the latest escalation in the war.

Persons: Raja Abdulrahim, Patrick Kingsley Organizations: Spotify, The Times Locations: Gaza, Israel, East, Jerusalem

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicHurricane Otis, which killed more than two dozen people in southern Mexico this week, exemplified a phenomenon that meteorologists fear will become more and more common: a severe hurricane that arrives with little warning or time to prepare. Judson Jones, who covers natural disasters for The Times, explains why Hurricane Otis packed such an unexpected punch.

Persons: Judson Jones, Hurricane Otis Organizations: Spotify, Music Hurricane Otis, The Times Locations: Mexico

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicWarning: this episode contains strong language. After 21 days without a leader, and after cycling through four nominees, House Republicans have finally elected a speaker. They chose Representative Mike Johnson of Louisiana, a hard-right conservative best known for leading congressional efforts to overturn the 2020 election. Luke Broadwater, a congressional reporter for The Times, was at the capitol when it happened.

Persons: Mike Johnson of, Luke Broadwater Organizations: Spotify, Republicans, The Times Locations: Mike Johnson of Louisiana

☆ Inflation is cooling, but the price hikes aren’t done
▼ + stars: | 2023-10-25 | by ( Lucy Bayly | Alicia Wallace | ) edition.cnn.com time to read: +8 min

Inflation in the United States has unquestionably cooled after hitting 40-year highs last year. Other key inflation gauges, the more comprehensive Personal Consumption Expenditures price index and the wholesale-focused Producer Price Index, have moderated as well. A spike in gas prices and other components such as persistently high shelter costs have kept inflation elevated. The locally owned Walnut Group restaurant company closed its venerable Mediterranean Restaurant (fondly called The Med), the French bistro Brasserie Ten Ten and the newer Italian entrant Via Perla. Courtesy Tim Romano PhotographyAlthough Brasserie Ten Ten had a nearly two-decade run before its closure, it was like starting a brand new restaurant, Hessel said.

Persons: Marlon Pando, White Lotus, Tony Hessel, he’s, Jerome Powell, Brandon Bell, —, ”, Lydia Boussour, United States —, Pando, “, Price, Frederic J . Brown, Mark Zandi, Chase Castor, hadn’t, Holly Wade, Peggy Romano, Romano, Brasserie, Tim Romano, Hessel, ” Hessel, you’ve, it’s Organizations: Minneapolis CNN —, Disney, Mexican Grill, White, Getty, Moody’s, National Federation of Independent, Washington Post, NFIB Research, shocker, Walnut Group, Via Perla Locations: Minneapolis, New Jersey, Boulder , Colorado, United States, Mexican, Austin , Texas, Alhambra , California, AFP, Marion , Kansas, —, Walnut

In Iowa, where evangelical Christians dominate the first-in-the-nation Republican presidential caucuses, Rowland and other pastors are delivering a message meant to resonate both biblically and politically. While curbing abortion has for decades energized Christian conservatives like no other issue, the attack by Hamas and Israel's response have put new pressure on Republican candidates to hew not just to traditional Republican support for Israel but to beliefs rooted in the Bible. Some Christians support Israel due to Old Testament writings that Jews are God’s chosen people and that Israel is their rightful homeland. Some evangelicals believe Israel is key to an end-times prophecy that will bring about the return of the Christian messiah. Daniel Hummel, author of “Covenant Brothers: Evangelicals, Jews, and U.S.-Israeli Relations," said that Republican support for Israel has become a proxy for other conservative priorities, particularly on immigration.

Persons: Steve Rowland peered, Rowland, “ Israel, Israel, Joe Biden, “ We’ve, ”, Nikki Haley, Donald Trump, Benjamin Netanyahu, Trump, Roe, Wade, Daniel Hummel, Haley, Ron DeSantis —, “, ” Hummel, Carolina Sen, Tim Scott, ” Scott, Scott, DeSantis, Joseph Brown, Netanyahu “, Brown, Marion, Vivek Ramaswamy, Ramaswamy, Brad Cranston, ” Ann Trimble Ray, ” Rowland, they've, Tiffany Stanley Organizations: Sun, of Christ, Republican, Iowa, GOP, South, United Nations, The Associated Press, “, Brothers, Trump, Florida Gov, Trump Republican Party, Baptist Church, Heritage Baptist Church, CNN, Associated Press Locations: NEWTON, Iowa, Des Moines, Altoona, Israel, Iran, South Carolina, Cedar Rapids, White, U.S, Tel Aviv, Jerusalem, It's, Carolina, Newton, Washington , Iowa, Burlington , Iowa, Gaza, Trump, , Iowa, Washington

☆ Double Alps portion on men's Tour menu, women to finish at L'Alpe d'Huez
▼ + stars: | 2023-10-25 | by ( Julien Pretot | ) www.reuters.com time to read: +3 min

It will be the first time since 1989 that the last stage of the race will be actually competed. "The last three four days will be very tough because we will be in the mountains," Tour director Christian Prudhomme told Reuters. "We were committed to avoid Paris because of the Olympics," Prudhomme told Reuters. "We went to the Tourmalet last year, we wanted to go to iconic places and L'Alpe d'Huez is part of cycling's history," women's Tour director Marion Rousse told reporters. "It's the toughest stage in Tour de France Femmes history with 4,000m of altitude gain.

Persons: Christian Prudhomme, Marion Rousse, Stephanie Lecocq, L'Alpe d'Huez, Florence, Marco Pantani's, la, Greg Lemond, pip France's Laurent Fignon, Jonas Vingegaard, Prudhomme, L'Alpe, du Glandon, Julien Pretot, Christian Radnedge Organizations: France, Femmes, Rights, Summer, Monaco, Reuters, de, Thomson Locations: Paris, France, Marion, Nice, Italy, Rimini, Massif, Netherlands, Belgium

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicOver the past few days, two of the lawyers who tried to help former President Donald J. Trump stay in power after losing the 2020 election pleaded guilty in a Georgia racketeering case and have agreed to cooperate with prosecutors against him. Richard Faussett, who writes about politics in the American South for The Times, explains why two of Mr. Trump’s former allies have now turned against him.

Persons: Donald J, Trump, Richard Faussett, Trump’s Organizations: Spotify, The Times Locations: Georgia, American

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicOver a year, the federal deficit — the gap between what the U.S. government spends and what it earns — has doubled, to nearly $2 trillion. That figure seems to validate the worries of congressional Republicans about government spending, which have been at the center of the messy fight over who should be House speaker. Jim Tankersley, who covers economic policy at the White House for The Times, explains the Republicans’ concerns — and why their plans would not come close to solving the problem.

Persons: —, Jim Tankersley Organizations: Spotify, White, The Times

☆ Hurricane Norma weakens but still 'dangerous' as it approaches Baja California peninsula
▼ + stars: | 2023-10-21 | by ( ) www.reuters.com time to read: +1 min

[1/5] People observe waves breaking on the beach as Hurricane Norma barrels towards the Baja California peninsula, in Cabo San Lucas, Mexico, October 20, 2023. REUTERS/Fernando Castillo Acquire Licensing RightsMEXICO CITY, Oct 21 (Reuters) - Hurricane Norma weakened to a Category 2 storm on Saturday as it approached the south of Mexico's Baja California peninsula where it was expected to make landfall later in the day, bringing with it a "dangerous storm surge." Mexican authorities called on residents of the state of Baja California Sur to take precautions and stay in their homes, while shelters were set up. "Norma is expected to remain a hurricane while it moves over the southern portion of Baja California Sur," the NHC said, noting nonetheless that further weakening was expected over the weekend. Local authorities maintained a "prevention zone" between the towns of Todos Santos and Los Barriles, in the state of Baja California Sur.

Persons: Fernando Castillo, Norma, Marion Giraldo, Isabel Woodford, Diane Craft Organizations: REUTERS, MEXICO CITY, U.S National Hurricane Center, NHC, Todos Santos, Mexican Pacific, Thomson Locations: Baja California, Cabo San Lucas, Mexico, MEXICO, Mexico's Baja California, Baja California Sur, Todos, Mexican

☆ Are vampires real? Scientists have linked diseases and decomposition to all the historical tropes of Nosferatu
▼ + stars: | 2023-10-21 | by ( Jenny Mcgrath | ) www.businessinsider.com time to read: +11 min

Vampires were very real to people in the past, but there are many ways science can explain their characteristics, whether they come from folklore or fiction. But many modern notions of vampires started with the 1700s media frenzy and continued with "Dracula" and other tales. "It's not like a vampire disease where people are wandering the earth for years and years getting to look more and more like vampires," he said. AdvertisementAdvertisementWhile sunlight sapped the count's powers, it was not until the 1922 film "Nosferatu" that the sun's rays killed vampires. As scientists began to learn and understand more about the body and death, stories about vampires started to evolve.

Persons: —, Varney, Michael Hefferon, They're, Hefferon, Michael Bell, Bram Stoker, Dracula, Stoker, Vlad the, Abraham Van Helsing, Vlad III, Vlad, Bram Stoker's, Emily Gerard, Marion McGarry, Charlotte, Charlotte Stoker's, McGarry, sickles, Mercy Bell, she'd, bloating, John Polidori, debonair Lord Ruthven, Lord Byron, Ruthven Organizations: Service, Getty, Dermatology Locations: Serbia, Vienna, Berlin, Paris, London, Romania, Serbian, Austria, Poland, Exeter , Rhode Island

☆ Risky biotech M&A therapy will heal more fractures
▼ + stars: | 2023-10-19 | by ( Jonathan Guilford | ) www.reuters.com time to read: +8 min

NEW YORK, Oct 19 (Reuters Breakingviews) - How can a suitor offering $1 billion see eye-to-eye with a seller asking for $2 billion? Such contingent value rights, or CVRs, are a way to get around the inherent uncertainty of an unproven drug. Its $74 billion takeover of Celgene in 2019 included a $6.4 billion payout dependent on a trio of drug approvals. There have been only 27 biotech market debuts this year, raising $2.2 billion, according to LSEG data. Given the nagging fissures in valuation perspectives, however, more dealmakers are apt to try this risky M&A therapy.

Persons: Schulman, Sidley, Bristol Myers, Myers, CVRs, Andrew Weisenfeld, IPOs, ”, Dan Lepanto, biopharma, Eli Lilly’s, Bristol Myers Squibb, Jeffrey Goldfarb, Sharon Lam, Streisand Neto Organizations: Reuters, Dow, Marion Laboratories, LyondellBasell Industries, Mirati Therapeutics, JPMorgan, Sanofi, Health Partners, Nasdaq Biotechnology, Reuters Graphics Reuters, Reuters Graphics, Leerink Partners, Therapeutics, Public, Bristol Myers, U.S . Food, Drug Administration, Thomson Locations: Celgene, Genzyme, U.S

LAS VEGAS (AP) — The Southern California street gang leader charged in the fatal shooting of Tupac Shakur in 1996 in Las Vegas will make a court appearance Thursday with a lawyer from one of the city's best-known political families, one that has represented mobsters, athletes and other famous clients. Attorney Ross Goodman told The Associated Press Wednesday he'll appear in Duane “Keffe D” Davis' defense against accusations that Davis orchestrated the drive-by killing of the rap music icon. Davis won't immediately enter a plea, Goodman said, he'll seek another two weeks to confirm that he'll be hired for Davis' case. Goodman is a son of former Las Vegas Mayor Oscar Goodman and current Mayor Carolyn Goodman. In July, a police raid at Davis' home drew renewed interest to Shakur's unsolved murder, one of hip-hop music’s enduring mysteries.

Persons: Tupac Shakur, Ross Goodman, Duane “ Keffe, ” Davis, Davis, Goodman, he'll, Davis ’, Oscar Goodman, Carolyn Goodman, Damon Arnette, Anthony “ Tony, Spilotro, Michael Spilotro, Chris Lammons, Alvin Kamara, Biggie Smalls, Christopher Wallace, Compton . Davis, Shakur, Marion “ Suge, Knight Organizations: LAS VEGAS, Associated Press, Edi, AP, Las Vegas, Las Vegas Raiders, Indianapolis Colts, New Orleans Saints, Las, Pro Locations: Southern California, Las Vegas, Compton , California, Henderson, Nevada, Los Angeles, Faal, ”, Indiana, Chicago, Compton ., Compton

Listen and follow The DailyApple Podcasts | Spotify | Amazon MusicThe House of Representatives still has no speaker, crippling a vital branch of the government. And the Republican who seems to be in the strongest position to take the role, Jim Jordan of Ohio, was once called a “legislative terrorist” by a former speaker of his own party. Catie Edmondson, who covers Congress for The Times, talks through the latest turns in the saga of the leaderless House.

Persons: Jim Jordan of, Catie Edmondson Organizations: Spotify, Republican, The Times Locations: Jim Jordan of Ohio

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