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☆ Why biotech CEOs are growing more cautious about going public — and what they're waiting for
▼ + stars: | 2023-01-30 | by ( Andrew Dunn | Yeji Jesse Lee | ) www.businessinsider.com time to read: +6 min

Biotech-startup CEOs are taking more nuanced approaches to going public amid a downturn. SAN FRANCISCO — After record years of initial public offerings in 2020 and 2021, biotech leaders told Insider that the "recipe" for going public no longer works. Most biotechs saw their valuations increase by between 20% and 50% after going public. Insider asked five startup CEOs about how they approach going public and their perspectives on the biotech-IPO market for 2023. But going public doesn't carry an importance of validation for herself or the field of biotech companies specializing in AI, she said.

☆ The recipe biotech startups use to go public is being thrown out. 5 startups CEOs reveal how they're changing their focus.
▼ + stars: | 2023-01-26 | by ( Andrew Dunn | Yeji Jesse Lee | ) www.businessinsider.com time to read: +6 min

☆ Private equity acquires a taste for drug development
▼ + stars: | 2023-01-09 | by ( David Carnevali | ) www.reuters.com time to read: +6 min

Jan 9 (Reuters) - Private equity firms that deemed drug development too risky for their liking in the past are increasingly investing in the sector, raising dedicated funds and coming up with deals that compensate them for the uncertainty involved. These deals are not structured as the leveraged buyouts that private equity firms are mostly known for. In most cases, the drug makers start paying the money back to the private equity firms when the drug is being developed, either by issuing equity, tapping cash on hand or borrowing. They also share a slice of the newly developed drug's revenue with the private equity firms once it's approved. Private equity firms also provide capital to spin out drugs into new companies.

☆ Eli Lilly has spent years and billions of dollars in search of an effective Alzheimer's drug. But success is not all or nothing for the stock
▼ + stars: | 2023-01-09 | by ( Kevin Stankiewicz | ) www.cnbc.com time to read: +22 min

Eli Lilly (LLY) has spent decades researching Alzheimer's disease without successfully bringing to market a treatment that slows the memory-destroying condition. For Eli Lilly as a company, an Alzheimer's drug is an important pursuit. Lilly's Alzheimer's history Eli Lilly's "first real foray" into Alzheimer's came in the 1990s, according to Dr. John Sims, Eli Lilly's head of medical development for donanemab. Financial implications for Lilly LLY mountain 2021-10-08 The Club started a new position in Eli Lilly (LLY) in October 2021. The Eli Lilly logo is shown on one of the company's offices in San Diego, California, September 17, 2020.

☆ Biogen's new CEO says Alzheimer's will become a major franchise for the company but that a different drug has the 'biggest undervalued potential'
▼ + stars: | 2023-01-09 | by ( Yeji Jesse Lee | ) www.businessinsider.com time to read: +4 min

But new CEO Christopher Viehbacher said that he sees Alzheimer's becoming a new franchise. He added that zuranolone, an antidepressant, is the "biggest undervalued potential" of the company. On the heels of the approval of a new Alzheimer's drug, Cambridge-based biotech company Biogen seems focused on expanding its focus to a wider range of illnesses. New Alzheimer's drug lecanemab could signal a new franchiseThe first is lecanemab, a drug for Alzheimer's disease that was granted an accelerated approval by the US Food and Drug Administration last week. "I think zuranolone is the biggest undervalued potential of Biogen," Viehbacher said.

☆ Biotech investor Brad Loncar shares 10 predictions for 2023, including a hot new cancer target, Nobel Prize winners, and a biotech founder running for president
▼ + stars: | 2023-01-04 | by ( Andrew Dunn | ) www.businessinsider.com time to read: +14 min

Loncar shared his 2023 forecast, including new drugs, Nobel Prize winners, and more globalization. Brad Loncar isn't expecting a miraculous rebound for the biotech industry in 2023. In an interview with Insider, Loncar shared 10 predictions for biotech in 2023, ranging from Nobel Prize winners and presidential runs to hot cancer targets and bankruptcy worries. 2022 was a rough year for the biotech industry, which once again underperformed the stock market. The industry runs to the next super-hot cancer target: Claudin 18.2In cancer research, drug companies are always on the hunt for the next promising target.

☆ How to Make Education an Investment After College
▼ + stars: | 2022-12-30 | by ( Veronica Dagher | ) www.wsj.com time to read: 1 min

Investing in learning as you age is a strategy to stay healthy and happy. To stay mentally sharp as you age, make sure to continue dedicated learning well beyond your college years. In one example of the importance of dedicated learning, more than six million Americans are currently living with Alzheimer’s disease and dementia. Researchers have found about 40% of Alzheimer’s is preventable. Strategies to ward off dementia include getting more sleep, exercising and eating a healthy diet to maintain brain health, said Rudolph Tanzi , a Harvard Medical School professor of neurology and co-author of “The Healing Self.”

A Michigan doctor who was reported missing on Christmas Eve was found dead Tuesday after a diving team searched a frozen pond near his home. Blackman-Leoni Public Safety via FacebookPayan was seen leaving his home on foot after detectives were able to access his password-protected surveillance system, authorities said Tuesday. The Jackson County Dive Team found Payan after cutting holes into the surface of a frozen pond on his property to search the water. Payan was a doctor of osteopathic medicine with a board certification from the American Board of Psychiatry and Neurology, according to his biography with Henry Ford Health. He studied at the Chicago College of Osteopathic Medicine and did his residency in psychiatry at Henry Ford Allegiance Health.

☆ Celine Dion has stiff-person syndrome, a one-in-a-million diagnosis. These are its symptoms.
▼ + stars: | 2022-12-08 | by ( Https | Media-Cldnry.S-Nbcnews.Com Image Upload Newscms Aria-Bendix-Byline-Jm.Jpg | Aria Bendix | ) www.nbcnews.com time to read: +4 min

Celine Dion's diagnosis with stiff-person syndrome has brought public attention to the rare neurological disorder, which affects roughly one or two out of every million people. People with stiff-person syndrome often experience rigidity in their torso and limbs, as well as severe muscle spasms that can cause them to fall down. Stiff-person syndrome overall disrupts the normal pathways of communication between the brain and the muscles. A small minority of cancer patients may also produce antibodies that attack the nervous system and trigger stiff-person syndrome, Helfgott added. Because many symptoms of stiff-person syndrome overlap with those of Parkinson’s disease, multiple sclerosis, fibromyalgia or anxiety, it often takes time to diagnose.

☆ Statins lower the risk of one of the deadliest kinds of strokes, study finds
▼ + stars: | 2022-12-07 | by ( Jen Christensen | ) edition.cnn.com time to read: +5 min

CNN —Doctors know that drugs called statins lower a person’s risk of a stroke due to a blood clot. But a new study shows that the inexpensive medications can also decrease the risk of a first stroke as a result of an intracerebral hemorrhage, the deadliest kind. People in the study who used statins for any period of time had a 17% lower risk of a stroke in the lobe areas of the brain and a 16% lower risk of a stroke in the non-lobe areas of the brain. When they used a statin for more than five years, they had a 33% lower risk of a bleeding stroke in the lobe areas and a 38% lower risk in the non-lobe areas. She said this study shows what biologically makes sense: Taking statins and keeping fatty deposits from building up in the arteries makes hemorrhagic strokes less likely.

☆ Hearing aids may lower your risk for cognitive decline and dementia, study finds
▼ + stars: | 2022-12-05 | by ( Madeline Holcombe | ) edition.cnn.com time to read: +4 min

CNN —Hearing aids might be an important tool in the effort to prevent cognitive decline and dementia, according to a new study. The new study published Monday in JAMA Neurology offers evidence that managing hearing loss may potentially help reduce or delay cognitive decline, Loh said. The use of hearing aids was associated with a 19% reduction in long-term cognitive decline, the study found. “Get screened for hearing loss, and if you do have hearing loss, speak with your audiologist or physician ENT to ensure appropriate and optimal correction to help stave off the potential dementia risk and cognitive decline,” Holland said. But in the meantime, people with hearing loss should talk with their doctor about whether it is appropriate to use hearing aids, Tan said.

☆ Ultraprocessed food may contribute to dementia, study says
▼ + stars: | 2022-12-05 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

CNN —We all eat them — ultraprocessed foods such as frozen pizza and ready-to-eat meals make our busy lives much easier. If more than 20% of your daily calorie intake is ultraprocessed foods, however, you may be raising your risk for cognitive decline, a new study found. While short of proof, this is robust enough that we should conclude ultraprocessed foods are probably bad for our brains.”There was an interesting twist, however. “Ultraprocessed foods drag diet quality down, and thus their concentration in the diet is an indicator of poor diet quality in most cases,” Katz said. One easy way to ensure diet quality is to cook and prepare your food from scratch, Suemoto said.

The authors noted that “social forces” may have played a part in the accelerated brain aging seen among their Black subjects. A lot of things contribute to dementia and Alzheimer’s, like high blood pressure and diabetes. Pete Comparoni“Elevated blood pressure is a very strong risk factor for worsening cerebrovascular disease,” King said. One option is through activities like restorative yoga, which Grant said can help address stress and regulate blood pressure and brain function. You have to go to your primary care doctor and check your blood pressure and blood sugar level.

☆ Teens’ brains aged faster during the first year of the pandemic, study says, and stress may be to blame
▼ + stars: | 2022-12-02 | by ( Jen Christensen | ) edition.cnn.com time to read: +5 min

CNN —The brains of US teens have physically changed during the Covid-19 pandemic, aging faster than normal, a new study says. Dozens of studies have found that teens’ and adolescents’ mental health has suffered during the pandemic. “The pandemic has not been kind to adolescent mental health,” said Gotlib, a psychology professor at Stanford University. There is a chance that their brain changes could have just been an immediate response to a stressor that will normalize over time, he said. Gotlib hopes parents and guardians keep in mind that although lockdowns and school closures may be over, the mental health consequences may be lingering.

☆ Poor sleep can make you prickly. Here’s what to do
▼ + stars: | 2022-12-01 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

Develop a sleep debt from those worries, and you’ll pay a price in your ability to think, plan and manage your emotions. “Sleep debt, also called a sleep deficit, is the difference between the amount of sleep someone needs and the amount they actually get,” said sleep specialist Dr. Raj Dasgupta, an associate professor of clinical medicine at the University of Southern California’s Keck School of Medicine. Research has found many people have little idea how much poor sleep has affected their mood and coping skills, said Dr. Bhanu Prakash Kolla, a sleep medicine specialist in the Center for Sleep Medicine at the Mayo Clinic in Rochester, Minnesota. Loss of sleep can directly affect your ability to control emotions and manage expectations, said Dr. Bhanu Prakash Kolla of the Mayo Clinic. “Sleep medications are seldom the solution for chronically poor sleep and impaired daytime functioning,” he said.

☆ Experimental drug appears to slow progression of Alzheimer’s disease in clinical trial but raises safety concerns
▼ + stars: | 2022-11-29 | by ( Jacqueline Howard | ) edition.cnn.com time to read: +11 min

It involved 1,795 adults, ages 50 to 90, with mild cognitive impairment due to early Alzheimer’s disease or mild Alzheimer’s disease-related dementia. Such a score is consistent with early Alzheimer’s disease, with a higher number associated with more cognitive impairment. By 18 months, the CDR-SB score went up 1.21 points in the lecanemab group, compared with 1.66 in the placebo group. Overall, there were serious adverse events in 14% of the lecanemab group and 11.3% of the placebo group. The researchers also wrote that about 0.7% of participants in the lecanemab group and 0.8% of those in the placebo group died, corresponding to six deaths documented in the lecanemab group and seven in the placebo group.

☆ Improve memory as you age by eating more flavonols, study says
▼ + stars: | 2022-11-28 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +7 min

CNN —Eating more flavonols, antioxidants found in many vegetables, fruits, tea and wine, may slow your rate of memory loss, a new study finds. The cognitive score of people in the study who ate the most flavonols declined 0.4 units per decade more slowly than those who ate the fewest flavonols. One of the most common flavonols, quercetin, has shown promise in reducing the onset of colorectal cancer and other cancers, according to studies. (For comparison, the average flavonol intake in US adults is about 16 to 20 milligrams per day, according to the study.) The study looked at the impact of the four major flavonols — kaempferol, quercetin, myricetin and isorhamnetin — on the rate of cognitive decline over the seven years.

☆ Secrets of ‘SuperAgers’ with superior memories into their 80s
▼ + stars: | 2022-11-26 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +7 min

Siegler is a cognitive “SuperAger,” possessing a brain as sharp as people 20 to 30 years younger. She is part of an elite group enrolled in the Northwestern SuperAging Research Program, which has been studying the elderly with superior memories for 14 years. Once accepted, colorful 3D scans are taken of the brain and cognitive testing and brain scans are repeated every year or so. A SuperAger’s brain, usually donated to the research program by participants after death, also has bigger, healthier cells in the entorhinal cortex. SuperAger brains had three times fewer tau tangles, or abnormal formations of protein within nerve cells, than the brains of cognitively healthy controls, the study also found.

☆ Daylight Saving Time debate sheds light on growing racial inequities in sleep health
▼ + stars: | 2022-11-25 | by ( Jacqueline Howard | ) edition.cnn.com time to read: +10 min

The American Academy of Sleep Medicine, the Sleep Research Society and other medical groups have advocated for ending the practice, calling for the adoption of a permanent standard time that would not involve shifting forward each spring and falling back each autumn. She authored a paper, published in September in the journal Sleep, detailing the potential health benefits of adopting a permanent standard time. Now, some sleep researchers worry about the potential effects that continuing to change standard time twice each year may have on sleep health inequities. “Fortunately, sleep health is largely modifiable.”As for the inequities seen in sleep health, it’s not that White adults don’t also experience a lack of sleep and its health consequences – but people of color appear to disproportionately experience them more, and that’s believed to be largely due to social systems in the United States. Improving sleep health has been a national objective in the federal government’s past two Healthy People programs, noted Caraballo-Cordovez, who is not involved in the programs.

☆ Turkey isn’t the reason you’re sleepy – really
▼ + stars: | 2022-11-24 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +3 min

The US Department of Agriculture recommends planning for one pound of turkey meat per person when preparing a holiday meal. “Tryptophan from turkey is unlikely to enter the brain and make enough serotonin to make us sleepy,” Malin said. “Turkey doesn’t really make us sleepy,” Knutson said. “Remember all the delicious side dishes surrounding the center piece of turkey, such as sweet potato pie, casseroles and yummy desserts,” he said. “Alcohol slows down your brain and relaxes your muscles so after a few drinks you’ll likely feel sleepy.”

☆ Does turkey make you sleepy? Here's what causes your food coma
▼ + stars: | 2022-11-24 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +3 min

Why we feel sleepy after a big Thanksgiving mealSerotonin is one of the “feel-good” hormones, which can calm and relax the body. The US Department of Agriculture recommends planning for 1 pound of turkey meat per person when preparing a holiday meal. “Tryptophan from turkey is unlikely to enter the brain and make enough serotonin to make us sleepy,” Malin said. “These tasty dishes contain a high amount of carbohydrates, which also contribute to post-meal sleepiness.”Another reason you feel sleepy after a meal is a change in blood flow from the head to the digestive system. “Alcohol slows down your brain and relaxes your muscles, so after a few drinks you’ll likely feel sleepy.”

Persons: ”, Raj Dasgupta, Steven Malin, ” Malin, Kristen Knutson, ” Knutson, ” Overeating, Dasgupta, ” Dasgupta Organizations: CNN, University of Southern California’s Keck School of Medicine, National Library of Medicine, Rutgers University, Adobe Stock, US Department of Agriculture, Northwestern University’s Feinberg School of Medicine Locations: New Jersey, Turkey

☆ How to save your sleep from the holidays
▼ + stars: | 2022-11-23 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +7 min

“You will enjoy the holidays more if you can protect your sleep time — and you may actually get more done if you aren’t tired and inefficient from sleep deprivation, she said. Watch your alcohol intakeWhile many of us believe that alcohol helps us fall asleep, it actually impairs sleep quality, Dasgupta said. “Remember, alcohol can make you fall asleep faster and sleep heavier during the first portion of the night. “Exercising improves sleep by reducing sleep onset, meaning it takes less time to fall asleep and decreases the amount of time you are lying in bed awake during the night,” Dasgupta said. “Studies have shown that exercise enables individuals with insomnia to fall asleep faster, sleep longer, and enjoy better sleep quality,” he said.

☆ Woman with a rare brain disease says doctors repeatedly dismissed her condition, blaming it on mental illness
▼ + stars: | 2022-11-17 | by ( Marianne Guenot | ) www.businessinsider.com time to read: +9 min

She has since been diagnosed with Moyamoya disease, a rare brain condition that affects fewer than 1 in 100,000 people. However, she said the earlier opinion caused a substantial delay in her Moyamoya diagnosis, adding: "everywhere I went, it followed me first. Moyamoya disease is caused by a narrowing of blood vessels in the brain. However, he noted that, in general, that a condition is rare is no excuse for dismissing a patient's symptoms. Still struggling to access careIn spite of her Moyamoya disease diagnosis, Simpson says she's still struggling to access support.

☆ BlackRock says it could be time to buy some growth and tech — Top ETFs to play the trade
▼ + stars: | 2022-11-14 | by ( Patti Domm | In | ) www.cnbc.com time to read: +4 min

BlackRock strategists recommend investors dip back into growth and tech for next year, but they say picking selective themes will be the best way to play them. BlackRock strategists say 2023 could be the year that changes the three-year pattern of growth and tech stocks moving in unison, both higher and lower. ETFs that fit these themes include BlackRock's iShares Self-Driving EV and Tech ETF , the iShares Global Clean Energy ETF , and iShares U.S. Infrastructure ETF. There is the iShares Cybersecurity and Tech ETF , IHAK and IRBO, the iShares Robotics and Artificial Intelligence Multisector ETF. BlackRock Future Health ETF, i Shares Genomics and Immunology and Healthcare ETF, and iShares Neuroscience and Healthcare ETF cover those themes.

☆ 5 tell-tale signs someone is manipulating you, according to a body-language expert
▼ + stars: | 2022-11-09 | by ( Don Weber | ) www.businessinsider.com time to read: +6 min

It's these types of manipulators I've spent a great deal of my career identifying. The hard and simple truth is that using body language to identify manipulation takes time and study. You're accustomed to the natural body language of your loved one and will have an easier time recognizing any deviations, whether conscious or subconscious. Signs of a manipulatorOnce you thoroughly understand a person's typical body language and gestures, you can start detecting deviations in their behavior. Eye contact and movementIt's commonly believed that if someone's looking you straight in the eyes, they're telling you the truth.

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