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Over the last three years, a new class of Alzheimer’s drug, the first to treat a root cause of the disease, has set off a roller coaster of hope and disappointment. Lecanemab (brand name Leqembi; pronounced le-KEM-bee) was given full approval by the Food and Drug Administration in July 2023 and is currently the only one of its class available to Alzheimer’s patients, outside clinical trials. The drug has been shown to slow the progression of the disease, but its benefits are fairly modest. With lecanemab having been approved for nearly a year — and with a similar drug, donanemab, being reviewed by an F.D.A. There are strict requirements for patients to be eligible for lecanemab; by one estimate, fewer than 20 percent met the qualifications for the medication.
Persons: Neurologists Organizations: Food and Drug Administration, New York Times, Mayo Clinic, Mayo Clinic , Massachusetts General Hospital, University of California Locations: Mayo Clinic , Massachusetts, San Francisco
Moviegoers sent Will Smith a clear message over the weekend: We forgive you. “Bad Boys: Ride or Die,” the fourth entry in the Sony Pictures franchise — and Mr. Smith’s first wide release since he slapped Chris Rock at the Academy Awards in 2022 — arrived to roughly $53 million in ticket sales in the United States and Canada, according to Sony. 1 result was a career milestone for Mr. Smith: He now has 15 first-place debuts as a leading man on his résumé. “Ride or Die,” which returned Mr. Smith to one of his signature roles, cost an estimated $100 million to make, not including marketing. The Rotten Tomatoes audience score stood at 97 percent positive on Saturday.
Persons: Will Smith, Smith’s, Chris Rock, , Smith, Martin Lawrence Organizations: Sony Pictures, Academy, Sony, Rotten Locations: United States, Canada, CinemaScore
The media is in meltdown over Caitlin Clark
  + stars: | 2024-06-04 | by ( Allison Morrow | ) edition.cnn.com   time to read: +4 min
New York CNN —The male-dominated sports media apparatus is stumbling over Caitlin Clark. He later apologized for using the slur, emphasizing that his broader thesis was that Clark’s star power created a halo around a league that’s been languishing in obscurity. “I was talking about how I hoped that the WNBA and sports media, ex-WNBA players, would show a little bit more respect to Caitlin Clark for what she has brought to the WNBA,” McAfee said on his show Tuesday. The league those women built has always been a physical one, a fact that Clark herself acknowledged in a postgame news conference. Much like Clark, the mainstream sports media is new to the WNBA.
Persons: Caitlin Clark, hasn’t, Chennedy, Clark, Pat McAfee, Clark —, ” —, , ” McAfee, it’s, McAfee, Charles Barkley, , Victoria Uwumarogie, Barkley, ” Clark isn’t, She’s “, who’ve, ” Uwumarogie, Monica McNutt, ” McNutt, Stephen A, Smith, huff, ’ ” McNutt Organizations: New, New York CNN, ESPN, Indiana, WNBA, TNT, CNN, Warner Bros . Locations: New York, Indiana, America, Iowa
I had a number in mind, but it wasn't my ageWhen I thought about retirement, I had a specific number in mind. Plus, I wanted to travel as long as I was physically able to and continue going to the theater regularly. Now, AI is changing the way everyone does business, and I'm not sure if I'm willing or able to climb the steep learning curve ahead. The final — and perhaps most compelling — reason for me to retire is so I can pursue my passions. I don't need to announce my retirement, throw myself a retirement party, or give myself a gold watch.
Persons: I'm, I've Organizations: Service, Social Security
Federal Documents CaseImage The federal indictment against Mr. Trump in the documents case. The charges were brought by Jack Smith, the special counsel appointed to oversee the federal investigations into Mr. Trump. Credit... Jacquelyn Martin/Associated PressLast summer, Mr. Smith charged Mr. Trump with conspiring to subvert democracy and stay in power against the will of voters following his loss in the 2020 election. Georgia Election CaseImage Fani Willis, the Fulton County district attorney, at a hearing on the Georgia election interference case in March in Atlanta. Dozens of pretrial motions have yet to be resolved, including recent sparring over the precedent in a legal case from the 1890s.
Persons: Donald J, Trump, Jon Elswick, Jack Smith, Smith, Aileen M, Cannon, Cannon’s, Jacquelyn Martin, Tanya S, Fani Willis, Alex Slitz Mr, Fani, Willis, Nathan Wade, Scott McAfee, Wade, McAfee’s, Sidney Powell, Kenneth Chesebro, Jenna Ellis, Donald Trump Organizations: Washington , D.C, Mr, Associated Press, Department, Justice Department, Associated, Capitol, of Appeals, Trump Locations: Manhattan, Florida, Washington ,, Georgia, , Washington, Fulton County, Atlanta ., Fulton County ,
Liaoning and ShandongAircraft carrier Liaoning set out for sea trials at Dalian shipyard with the help of tugboats. A J-15 fighter takes off from aircraft carrier Shandong during the combat readiness patrol and military exercises around Taiwan. Aircraft carrier USS Gerald R. Ford sails in the Adriatic Sea. China has no experience operating carrier catapults on its warships (though it did study carrier catapults when it purchased the decommissioned Australian carrier HMAS Melbourn from Canberra in 1985 under the guise of scrapping). AdvertisementChina's third aircraft carrier, the Fujian, docks in Shanghai with a Chinese flag seen in the foreground.
Persons: , Kuznetsov, Pu, Gerald R, Ford, George H.W, George H.W . Bush, Smith, Jackson Adkins, John F, Kennedy, Doris Miller, Dwight D, Eisenhower, Jacob Mattingly, Li Gang, Timothy Heath, Heath, China's, Benjamin Brimelow Organizations: Service, US Navy, Business, Shandong Aircraft, Getty, People's Liberation Army Navy, Getty Images Fujian, EA, Jiangnan Shipyard, Getty Images, PLAN, Xinhua News Agency, Nimitz, Ford, Aircraft, Greyhound, Navy, Carrier, USS Enterprise, Pacific Fleet, Shandong, RAND Corporation, US, Global Affairs, Fletcher School of Law, Diplomacy, Modern, Institute Locations: Shanghai, Fujian, China, China's, Liaoning, Dalian, Shandong, Soviet, Ukraine, Taiwan, Xinhua, Getty Images China, George H.W ., Adriatic, Melbourn, Canberra, Sanya, Hainan Province, West
political memoThe outcome of Donald Trump’s Manhattan trial on Thursday had seemed almost unthinkable to the Trump team as recently as last summer. Guilty.”When Mr. Trump got up to leave court, his face looked as if he’d been punched in the solar plexus. Mr. Trump and his allies on Capitol Hill and in conservative media assiduously prepared their audiences to be outraged, whatever the outcome. “There’s a sense of personal resentment,” added the senator, who is on a shortlist to be Mr. Trump’s running mate. He got MAGA’d yesterday,” Mr. Trump said in the hallway outside the courtroom.
Persons: Donald Trump’s Manhattan, Donald J, Trump’s, Trump, Mr, Eric, Eric Trump’s, Steve Witkoff, ” Mr, Witkoff, Adam Gray, Jack Smith, Washington, Tanya Chutkan, Manhattan, Mark Pomerantz, Alvin L, Bragg, Michael D, Cohen, , President Biden, Stephen K, Bannon, Alvin Bragg, Emil Salman, Biden, ” Neil Newhouse, Republican pollster, , Newhouse, , J.D, Vance, MAGA, Robert De Niro, De Niro, ” Ruth Igielnik Organizations: Trump, Republican National Convention, Credit, The New York Times, Democratic, Capitol, Republican, Senate, Republicans, Trump . Credit, Mr, New York Times, Quinnipiac University, “ Voters, Fox, stoke, Biden Locations: Manhattan, Florida, Georgia, New York, U.S, Trump ., Siena, Ohio, Lower Manhattan
What’s in Our Queue? & Mrs. Smith’ and MoreI just wrapped up a reporting fellowship at The Times, covering space, physics and the intersection of science and society. It’s a job that immerses me in all things science, so in my free time, I like to escape into other realms. Here are five things I’ve been indulging in lately →
Persons: Smith ’, It’s, I’ve, Organizations: The Times
The decision by the judge, Aileen M. Cannon, was made solely on the procedural grounds that prosecutors working for the special counsel, Jack Smith, had failed to properly inform Mr. Trump’s lawyers before making their request. It left open the possibility that the prosecution could try again to restrict Mr. Trump’s remarks about the agents if it follows the procedural rules. As part of her decision, Judge Cannon also temporarily denied an attempt by Mr. Trump’s legal team to push back against the government. Mr. Trump’s lawyers had filed a counter-motion seeking to have the prosecutors’ request stricken from the record and to have sanctions imposed on Mr. Smith and his deputies for failing to follow the proper procedure. Those remain largely where they stood when the dispute between the defense and prosecution began on Friday evening.
Persons: Donald J, Trump, Aileen M, Cannon, Jack Smith, Trump’s, Judge Cannon, Smith, Cannon’s, Mr Organizations: Mr
Former President Donald J. Trump’s lawyers on Monday assailed a request by federal prosecutors to limit what he could say about a new flare-up in a case accusing him of illegally retaining classified documents after leaving office. In an angry court filing, the lawyers pushed back hard against the request by the office of the special counsel, Jack Smith, to revise Mr. Trump’s conditions of release by forbidding him to make any public comments that might endanger federal agents working on the prosecution. On Friday evening, Mr. Smith’s team requested what amounted to a limited gag order on Mr. Trump, prompted by what it called “grossly misleading” social media posts the former president made last week falsely claiming that the F.B.I. had been authorized to kill him when agents searched Mar-a-Lago, his Florida club and residence, in August 2022. The former president’s statements were based on a recently unsealed operational order for the search that contained boilerplate language spelling out that the use of deadly force could be used only in case of emergency, a standard provision applied to all searches conducted by the bureau.
Persons: Donald J, Jack Smith, Smith’s, Trump Locations: Florida
Top NewsAn Israeli airstrike on a makeshift tent camp for displaced Palestinians in Rafah, Gaza, killed at least 35 people on Sunday night, the Gaza Health Ministry said. The Israeli military said the strike was aimed at a Hamas compound. In a statement, the Israeli military said it was looking into reports that “several civilians in the area were harmed” by the airstrike and a subsequent fire. “What kind of a tent will protect us from missiles and shrapnel?” he said. “There was darkness and no electricity.”Doctors Without Borders said more than 15 dead people and dozens of wounded in the Rafah strike were brought to a trauma stabilization center that it supports in Tal as Sultan.
Persons: Tal, Israel, , Benjamin Netanyahu, Bilal Al Sapti, Sapti, , Sultan, Dr, James Smith, Smith, I’ve, Patrick Kingsley, Johnatan Reiss, Iyad Abuheweila, Aaron Boxerman Organizations: Gaza Health Ministry, Palestine Red Crescent Society, The New York Times, International Court, Justice, Friday, United Nations Locations: Israeli, Rafah, Gaza, Palestine, Tal
Video Authorities in Rafah, Gaza Strip, said that an Israeli strike had killed and wounded displaced Palestinians seeking shelter in the area. The Israeli military said that it had targeted two senior Hamas leaders. Credit Credit... ReutersAn Israeli airstrike on a makeshift tent camp for displaced Palestinians killed at least 35 people in Rafah on Sunday night, the Gaza Health Ministry said. The Israeli military said its operation was aimed at a Hamas compound. Doctors Without Borders said more than 15 dead people and dozens of wounded in the Rafah strike were brought to a trauma stabilization center that it supports in Tal as Sultan.
Persons: Tal, Sultan, Dr, James Smith, Smith, , I’ve, Patrick Kingsley, Johnatan Reiss, Aaron Boxerman Organizations: Authorities, Credit, Reuters, Israeli, Gaza Health Ministry, Palestine Red Crescent Society, The New York Times, Hamas, United Nations Locations: Rafah, Gaza, Palestine, Israel, Tel Aviv, Tal
Here’s why we eat popcorn at the movies
  + stars: | 2024-05-25 | by ( Alicia Wallace | ) edition.cnn.com   time to read: +11 min
But the perfect (and very profitable) pairing of today wasn’t always the case: For many years, movie theaters wanted nothing to do with the snack. People watch movies in a newly reopened AMC River East theater on Aug. 20, 2020, in Chicago. Popular movies often bring collectible cups and popcorn buckets, or, in industry-speak, Collectible Concession Vehicles (CCVs). The cinema business will continue to evolve, but one thing will remain constant, said Gil of Queen’s University. “Theaters will stop playing movies before they will actually stop selling popcorn.”
Persons: , Fred Astaire, Ginger Rogers, ” Paul Dergarabedian, Andrew F, ” Smith, Cracker Jack, , Smith, ’ ” Smith, hawkers, Peter Stackpole, John Aitkin, John Sr, Aitkin, Alicia Wallace, CNN It’s, Loren Williams, Alicia Reese, Ricard Gil, Jason Wambsgans, Gil, Wedbush’s Reese, Red Robin, ” Nels Storm, Garfield ”, Cory Ryan, Heather Morgan, Alamo’s, ” Andrew Sherburne, Christian Meoli, Camilla Meoli, ” Gil Organizations: Minneapolis CNN, CNN, AMC, Exposition, Bettmann, Riverview, , Riverview Theater, Wedbush, Queen’s University, Chicago Tribune, Tribune, Service, Waffle, AMC Theatres ’, Walmart, Kroger, Alamo, University of Iowa’s, Cinemas Locations: Minneapolis, America, New England, South America, Philadelphia, Texas, South Minneapolis, Riverview, “ Kingdom, Canada, Chicago, Brooklyn , New York, Iowa City , Iowa, Seattle, Emerald, California
In photo at right, Rob Breakiron with his daughter, Isabelle, at a performance of Taylor Swift's Eras tour. He often wears Swift's merchandise or friendship bracelets from her ongoing Eras tour on team calls. He's seen updates on Swift's music and personal life as something employees from across generations jump in to discuss on a team messaging forum. Meta CEO Mark Zuckerberg posted photos of his face bejeweled and wrists covered in friendship bracelets, which have become a hallmark accessory of Swift's tour. Despite that, she said, Swift's music has been a "universal language" that's helped her connect with everyone from the fathers of fans to women who see themselves in the singer.
Persons: Megh McLaughlin, Rob Breakiron, Isabelle, Taylor, Isabelle Breakiron, Taylor Swift, Swift, he's, Angela Hall, Andrew Boyagi, Boyagi, He's, Johan Cruyff, Jeff Bezos, Ray Dalio, Mark Zuckerberg, Susan St, Ledger, that's, McLaughlin, Amani Albertsen, Wise, Albertsen, Sharif Karmally, Karmally, Beyoncé, Raeah Smith, Smith, hasn't, Matt Lindner, Lindner, Organizations: KPMG, Angela Hall of Michigan State University's School of Human Resources, Labor Relations, Society for Human Resource Management, Getty, Amazon, Disney, Michigan State's Hall, CNBC, Poets Department, Data Department Locations: Virginia, Australia, Cincinnati , Ohio, Amsterdam, Netherlands, St, HashiCorp, Florida, U.S, Atlanta, Texas, Minneapolis, Chicago
U.S. officials have said that AI systems could pose national security risks, for example by making it easier to engineer chemical, biological and nuclear weapons. The Biden administration in October required the makers of the largest AI systems to share details about them with the U.S. government. Microsoft executives said the agreement has safeguards to protect Microsoft's technology and prevent it from being used by Chinese entities to train AI systems. The Commerce Department already requires notifications and, in several regions, export licenses to send AI chips abroad. Microsoft executives said the company welcomes a debate on a new legal framework governing the transfer of AI technology and that the deal with G42 requires the UAE firm to comply with U.S. regulations as they evolve.
Persons: Brad Smith, Smith, Biden, Michael McCaul, we're Organizations: Microsoft, United Arab, Reuters, U.S ., U.S . Department of Commerce, U.S . House, Commerce Department Locations: Madrid, Spain, United Arab Emirates, U.S, UAE
download the appSign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. Read previewAs Donald Trump's criminal hush-money trial nears the end, the former president's defense team plans to call at least one witness — an ex-commissioner of the Federal Election Commission who's getting a whopping $1,200 an hour. Smith does not appear to be quoted in media coverage of Trump's hush-money case. Related storiesThe judges in both cases found that the defense improperly wanted Smith to interpret campaign finance law to the jury. AdvertisementIn putting Smith on the stand, Trump's defense team hopes to challenge the prosecution's argument that the hush-money payment breached those laws.
Persons: , Donald, Commission who's, Bradley Smith —, Smith, he'd, Trump, Juan Merchan, Bill Clinton, Bradley Smith, Douglas Graham, Sam Bankman, Suarez, Trump —, Eli Bartov, Arthur Engoron, Engoron, Stormy Daniels, Michael Cohen, Cohen, Daniels, Melania Trump Organizations: Service, Commission, Republican, Business, New, Save America PAC —, New York University, The Manhattan, Attorney's, Prosecutors, Trump Locations: Trump's, Manhattan, States
Mr. Keys and his wife, Charae Williams Keys, were getting into their car after a Father’s Day visit in 2021 with her grandparents in a leafy neighborhood near Walnut Hill Park in Columbus, Ohio. A 72-year-old neighbor carrying a rifle accosted them in the belief, he later told the police, that Mr. Keys had let the air out of his daughter’s tires and poisoned his lawn. It took a moment for everyone to realize that the shots had come from a fourth gun across the street. Elias Smith, a 24-year-old ex-Marine, had stepped to his front door with a so-called ghost gun, an AR-style rifle that Mr. Smith had assembled from parts ordered online. Within seconds, he opened fire, hitting Mr. Keys five times.
Persons: Jason Keys, Keys, Charae Williams, Elias Smith, Smith Locations: Walnut Hill, Columbus , Ohio
Read previewAfter one week of jury selection and four weeks of prosecution testimony, Donald Trump's New York hush-money trial is now in its home stretch. Then, the defense case will begin. "I'm doing everything possible to avoid big breaks between summations, jury charge, jury instructions, and deliberations," Merchan told the parties Thursday. AP/Christine CornellThursday: Deliberations could beginAgain, if the scheduling stars align, deliberations could begin Thursday, the last trial day before the four-day holiday. AdvertisementBefore deliberations can begin, jurors need to hear the entirety of the defense case — with or without Trump.
Persons: , Donald Trump's, Juan Merchan, Trump, Michael Cohen, Donald Trump, Julia Nikhinson, Cohen, Trump's, Todd Blanche, Susan Hoffinger, Blanche, — Bradley, Smith, Juan Merchan Jane Rosenberg, Christopher Conroy, Merchan's, Conroy, Merchan, Will Trump, Matt Gaetz, Mike Segar, Judge Cannon, Aileen Cannon, Christine Cornell Organizations: Service, Business, AP, Commission, Prosecutors, Reuters, Federal Election, Trump Locations: York, Florida, summations
RAG was the first," said Bob van Luijt, the CEO and cofounder of the AI data infrastructure company Weaviate. WeaviateThe innovation that's sweeping AI"Every industry that has a lot of unstructured data can benefit from RAG," van Luijt said. Courtesy of Kyle DeSanaHe said that a successful RAG chatbot could carry its own pitfalls. AI engineers are eager to find more proactive solutions that don't require constant meddling with the data RAG provides to the AI. Put simply, an AI chatbot would have an effectively infinite memory, letting it "remember" any data presented to it in the past.
Persons: , OpenAI's ChatGPT, RAG, Bob van Luijt, Bob, van Luijt, Nadaa, Taiyab, van Lujit, Van Lujit, that's, Kyle DeSana, DeSana, Weaviate, it's Organizations: Service, Nvidia, Companies, Google
Connected fitness company Hydrow, which Peloton once tried to buy, is growing sales and has acquired a majority stake in strength training company Speede Fitness as gymgoers move away from cardio exercises in favor of weights, the company told CNBC on Thursday. It said it acquired Speede Fitness so it can expand into strength training, one of the fastest-growing segments in fitness today. Hydrow's acquisition and sales growth come as Peloton, which is credited with creating the connected fitness market, struggles to turn around a slowing business. Hydrow's delivered unit sales for its connected rowing machine jumped 23% this year from the year-ago period. Peloton debuted its rowing machine, the Peloton Row, in September 2022, but has done little to advertise or highlight the $3,000 machine.
Persons: Hydrow, Bruce Smith, John Stellato, Smith, Travis Kelce, Justin Timberlake, Thomas Fitzgerald, Hydrow's Organizations: CNBC, Kansas City Chiefs
Investors shouldn't be spooked by Affirm 's post-earnings sell-off, according to JPMorgan. Analyst Reginald Smith upgraded the buy-now-pay-later stock to overweight from neutral on Thursday, a day after the stock dropped following its latest earnings report. As Smith put it in the headline of his upgrade to clients, we're "not letting a good sell off go to waste." Affirm reported $576 million in revenue for the fiscal third quarter, topping the consensus forecast of $550 million from analysts polled by FactSet. The company also issued strong current-quarter guidance for revenue and gross merchandise volume, which is the total dollar amount of all transactions made through Affirm.
Persons: Reginald Smith, Smith, that's, Shopify Organizations: JPMorgan, FactSet, Bloomberg
What Does a Lonely Brain Look Like?
  + stars: | 2024-05-09 | by ( Dana G. Smith | ) www.nytimes.com   time to read: +1 min
Everyone feels lonely from time to time — after, say, a move to a new school or city, when a child leaves for college, or following the loss of a spouse. It becomes “a personality trait, something that’s pretty sticky,” said Dr. Ellen Lee, an associate professor of psychiatry at the University of California, San Diego. Here’s what experts know about how chronic loneliness affects the brain, and some strategies to address it. How does loneliness change the brain? Experts think loneliness may have emerged as a unique type of stress signal to prompt us to seek companionship.
Persons: , Ellen Lee Organizations: University of California Locations: San Diego
But How Does the Worm Get in Your Brain?
  + stars: | 2024-05-08 | by ( Dana G. Smith | Dani Blum | ) www.nytimes.com   time to read: +1 min
Robert F. Kennedy Jr.’s disclosure that a doctor apparently found a dead worm in his brain has sparked questions about what brain parasites are, the damage they can cause and how, exactly, they get there. Brain parasites encompass far more than worms. There are “legions” of organisms that can affect the brain, said Scott Gardner, a professor of biological sciences at the University of Nebraska-Lincoln who specializes in parasites. In addition to worms, common brain parasites include single-celled organisms such as Toxoplasma gondii and some amoeba. The damage varies depending on the type of parasite and where it ends up in the brain.
Persons: Robert F, Kennedy Jr, Scott Gardner, , Daniel Pastula Organizations: University of Nebraska, Lincoln, University of Colorado Medicine
Judge Aileen Cannon on Tuesday delayed Donald Trump's classified documents case indefinitely. AdvertisementUS District Judge Aileen Cannon handed former President Donald Trump yet another legal win when she delayed his classified documents case indefinitely on Tuesday. It's just the latest legal win for Trump in the classified documents case handed to him by Cannon. Ty Cobb, a former Trump White House attorney, told CNN on Tuesday that Cannon's latest decision was "a combination of bias and incompetence." In light of Cannon's latest delay, Kalir said it was not surprising given her prior actions on the case.
Persons: Aileen Cannon, Donald Trump's, It's, , Donald Trump, Cannon, Trump, Jack Smith's, Canon, Katie Charleston, Justice Department —, Paula Reid, Judge Cannon, I'm, She's, aren't, Ty Cobb, galvanizes, Charlie Kolean, Kolean, Tre Lovell, it's, Doron Kalir, Fani Willis, Nathan Wade, Kalir Organizations: Trump, Service, Business, Justice Department, FBI, Mar, Appeals, Associated Press, Court, Trump White House, CNN, RED PAC, Cleveland State University College of Law Locations: Lago, Southern Florida, Trump's, South Florida, Georgia, New York
John Leguizamo revealed that he turned down Stanley Tucci's part in "The Devil Wears Prada." AdvertisementJohn Leguizamo said that he declined what turned out to be an iconic role for Stanley Tucci — lovable art director Nigel Kipling in "The Devil Wears Prada." 'The Devil Wears Prada,' the Stanley Tucci part," Leguizamo responded. 20th Century Studios"The Devil Wears Prada" wasn't the only role that Leguizamo said he regretted turning down. "I felt dissed, and they probably weren't dissing me, but I felt dissed," Leguizamo said.
Persons: John Leguizamo, Stanley, Wears, Leguizamo, Smith, , Stanley Tucci, Nigel Kipling, Tucci, Anne Hathaway's, Andy, Miranda Priestly, Meryl Streep, Anna Wintour, Vince Vaughn's, Brad Pitt, Angelina Jolie, Robin Williams, Williams, Sid Organizations: Service, Studios
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