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☆ Exclusive: China's clashing priorities behind rare money market distress
▼ + stars: | 2023-11-06 | by ( ) www.reuters.com time to read: +7 min

"Banks were grudging in lending, leaving non-banks asking each other for money in afternoon trade," he said. The reasons for the spike in interest rates and the ensuing market chaos are detailed here for the first time. They affect foreign exchange movements since the markets are the major avenue for the supply of money. The money market operator CFETS told traders to keep a 5% ceiling on repo transactions and said anyone involved in high-rate deals closed on Oct. 31 would need to explain themselves to regulators, according to sources who received the notice. "If the pattern of money supply and liquidity provision remains unchanged, the whole system remains fragile.

Persons: Xia Chun, Banks, outflows, CFETS, Tom Westbrook, Vidya Ranganathan, Raju Gopalakrishnan Organizations: People's Bank of China, China Foreign Exchange Trade, Yintech Investment Holdings, Reuters, China Everbright Bank, Co, China Central Depository, Shanghai Clearing House, Shanghai, Thomson Locations: SHANGHAI, SINGAPORE, Beijing, Shanghai, China

☆ Where does Speaker Mike Johnson sleep when he's in DC? Most likely in his Capitol Hill office
▼ + stars: | 2023-11-03 | by ( Bryan Metzger | Jack Newsham | ) www.businessinsider.com time to read: +7 min

Speaker Mike Johnson is less wealthy than most lawmakers and doesn't appear to have a DC residence. But where does the man who just recently ascended to the next spot in the line of succession sleep when he's in Washington, DC? Most likely in his small congressional office on the unglamorous, fluorescent-lit fifth floor of the Cannon House Office Building, according to several lawmakers and a long-time friend of Rep. Mike Johnson, the new speaker of the House. There are likely dozens of lawmakers sleeping in their offices each night, and some well-known former House members have been known to do it, including Florida Gov. Meanwhile, former House Speaker Nancy Pelosi — one of the richest members of Congress — has a residence in Washington, DC's Georgetown neighborhood.

Persons: Mike Johnson, —, Joe Biden, Kamala Harris, Johnson, it's, Ross Barrett —, Johnson's —, Barrett, Ron DeSantis, Kristi Noem, Kevin McCarthy, Paul Ryan, Ryan, NBC's, John Boehner, Tucker Carlson, Frank Luntz's, McCarthy, Nancy Pelosi —, Jackie Speier, Bennie Thompson, aren't, hasn't Organizations: Service, House, Naval, Cannon, Florida Gov, South Dakota Gov, CNN, Press, Fox News, GOP, Daily, Democratic, NPR, Mississippi, POLITICO, Republicans Locations: Washington, Louisiana, Longworth, Georgetown, California, Johnson's

☆ FDA panel says Vertex/CRISPR to assess safety risks of gene therapy in follow-up study
▼ + stars: | 2023-10-31 | by ( ) www.reuters.com time to read: +2 min

[1/2] A sign hangs in front of the world headquarters of Vertex Pharmaceuticals in Boston, Massachusetts, U.S., October 23, 2019. REUTERS/Brian Snyder/File Photo Acquire Licensing RightsOct 31 (Reuters) - A panel of advisers to the U.S. health regulator said on Tuesday Vertex Pharmaceuticals (VRTX.O) and CRISPR Therapeutics (CRSP.BN) could assess potential safety risks of their sickle cell disease gene therapy after approval. If the therapy is approved, Vertex has proposed a 15-year follow up of patients to evaluate the safety outcomes of the therapy. Patients who were treated with the therapy were free from severe vaso-occlusive crisis for 12 months from the infusion of exa-cel. "It was made pretty clear that any theoretical off-target editing concerns do not outweigh the benefits of drug approval," said Salim Syed, analyst at Mizuho.

Persons: Brian Snyder, Scot Wolfe, Salim Syed, Sriparna Roy, Krishna Chandra Organizations: Vertex Pharmaceuticals, REUTERS, CRISPR Therapeutics, Staff, U.S . Food, Drug Administration, UMass Chan Medical, Analysts, FDA, Mizuho, Thomson Locations: Boston , Massachusetts, U.S, Bengaluru

☆ Panera now displaying warning about its caffeinated lemonade in all stores after lawsuit over customer's death
▼ + stars: | 2023-10-29 | by ( Elizabeth Chuck | ) www.cnbc.com time to read: +5 min

A large Charged Lemonade contains 390 milligrams — nearly the 400-milligram daily maximum of caffeine that the Food and Drug Administration says healthy adults can safely consume. The legal complaint called Charged Lemonade a "dangerous energy drink" and argues that Panera failed to adequately warn consumers about its ingredients, which also include guarana extract, another stimulant. The caffeine content of Panera's Charged Lemonade has always been listed in-store, Panera said. Katz had gotten a large Charged Lemonade hours before she died, and had had at least one Charged Lemonade in the days prior, according to Victoria Rose Conroy, Katz's roommate and close friend. Crawford said if Charged Lemonade is going to remain on the menu, it should be less accessible to customers.

Persons: Sarah Katz, Panera, Red Bull, Elizabeth Crawford, Kline, Specter, Katz, Victoria Rose Conroy, Katz's, Conroy, Sarah, Crawford, shouldn't Organizations: NBC News, Ivy League, and Drug Administration, FDA, Katz's University of Pennsylvania, Panera, Sip Locations: North America, Philadelphia, Katz's

☆ Jamie Dimon's stock-moving trades show why investors should track CEOs' buying and selling
▼ + stars: | 2023-10-28 | by ( Kevin Stankiewicz | In Kevinstankiewicz | ) www.cnbc.com time to read: +24 min

While executive stock sales — such as Dimon's planned transactions next year — are not universally red flags, they can get complicated. Insider stock sales Executive stock trades are usually disclosed through SEC filings known as Form 4 documents and accessible through the regulator's EDGAR database — the electronic data gathering, analysis, and retrieval system. Rule 10b5-1 trading plans came into the fold just over two decades ago to reconcile these two discordant facts. Adopting Rule 10b5-1 trading plans gives public-company executives a way to protect against allegations of illegal insider trading in the future. Compared with a tiny stock sale executed through a predetermined plan, executive stock buys generally send a much stronger signal: The executive wants to make money, too.

Persons: Jamie Dimon, Dimon, Jim Cramer, Jim, Eliezer Fich, Dimon's, EDGAR, Chester Spatt, Spatt, —, Susan Li, Drexel's, Wharton, Drexel's Fich, Fich, I'm, Nancy Quan's, Quan, Marc Benioff, Carnegie Mellon's Spatt, Benioff, Howard Schultz, Schultz's, Schultz, Carnegie Mellon's, Nikesh Arora, Arora, Charles Scharf, Wells, Sehwa Kim, Kim, Foot, Mary Dillon, Locker, Dillon, Foot Locker, Jim Cramer's, Al Drago Organizations: JPMorgan Chase, JPMorgan, Dow Jones Industrial, Wall, Dimon, Pfizer, Capitol, Drexel University, Club, Securities, Exchange Commission, SEC, Carnegie Mellon's Tepper School of Business, CNBC, Stanford University, University of Pennsylvania's Wharton School, Stanford, Cola, Salesforce, Carnegie, Starbucks, Palo Alto Networks, Alto Networks, Broadcom, Federal Reserve, Washington Service, Columbia Business School, JPMorgan Chase &, Bloomberg, Getty Locations: U.S, Coke, Salesforce, FL

Seoul, South Korea CNN —South Korea’s Constitutional Court has upheld a law banning same-sex relations in the military, citing a threat to combat-readiness, in a judgment decried by the local LGBTQ community as a disappointing setback. “Even if sexual acts are consensual” they risk “causing serious harm to preserving the fighting power of the nation’s armed forces, if committed (while on duty),” it added. But the group said it was encouraged by the comments of the dissenting judges, who warned against deeming sexual acts between same-sex couples as abnormal. The dissenting judges said there is “no reason” to differentiate between consensual sexual acts by same-sex soldiers and heterosexual ones. With a mandatory military service imposed on almost all able-bodied men between the age of 18 and 28, South Korea has one of the world’s largest active armies.

Persons: ”, Boram Jang, scuffles, Hong Joon, pyo Organizations: South Korea CNN, Constitutional, Amnesty, National Health Insurance Service, South Korea’s, Seoul Queer Culture, Christian, Daegu Queer Culture Locations: Seoul, South Korea, Asia, South, Daegu

☆ Refusing to fly cost him his job. Here's why this 'slow traveler' says it was a price worth paying
▼ + stars: | 2023-10-26 | by ( Sam Meredith | ) www.cnbc.com time to read: +5 min

Gianluca Grimalda, a climate researcher and environmental campaigner, intends to "slow travel" back to Europe from Bougainville off the coast of Papua New Guinea. The ultimatum effectively required Grimalda, a climate researcher and self-styled "slow traveler," to promptly board a flight back to Europe. Gianluca Grimalda Climate researcherEmissions from air travel are a significant contributor to climate change and aviation is known to be one of the most challenging sectors to decarbonize. Grimalda spent several months conducting fieldwork into the social impact of climate change on the island of Bougainville. These are people that experience climate change on a daily basis," he added, noting that the coastal communities he'd interacted with had been forced to relocate inland in light of the rising sea level.

Persons: Gianluca Grimalda, Gianluca Grimalda Gianluca Grimalda, Grimalda, he'd Organizations: Kiel Institute, CNBC, Economy Locations: Europe, Bougainville, Papua New Guinea, Germany, Pacific, East New Britain, Singapore, Papua

☆ Off-duty Alaska Airlines pilot Joseph Emerson said he took 'magic mushrooms' 48 hours before allegedly trying to shut off plane's engines, court documents say
▼ + stars: | 2023-10-25 | by ( Elizabeth Wolfe Pete Muntean Cheri Mossburg Josh Campbell | Elizabeth Wolfe | Pete Muntean | ) edition.cnn.com time to read: +10 min

Emerson told investigators he “had consumed ‘magic mushrooms’ approximately 48 hours prior to the incident on the plane,” an affidavit filed by prosecutors states. Off-duty pilot Joseph D. Emerson was accused of trying to shut off a plane's engines mid-flight. “The officer and Emerson talked about the use of psychedelic mushrooms and Emerson said it was his first-time taking mushrooms,” the affidavit says. Authorities do not believe the incident was an act of terrorism or ideologically motivated violence, a law enforcement source familiar with the investigation told CNN. ‘It was very shocking,’ suspect’s neighbor saysEmerson’s neighbor, Ed Yee, told CNN it was “very shocking” to hear of the suspect’s alleged actions.

Persons: Joseph D, Emerson, “, “ Emerson, ” Emerson, It’s, Matt Johnson, Johns Hopkins, Johnson, Derealization, Joseph Emerson, “ I’m, ”, Jenna Plank, Emerson “, LiveATC.net, ‘, ’, Aubrey Gavello, ” Gavello, “ Laura Coates, Alex Wood, Wood, ” Wood, Ed Yee, ” Yee Organizations: CNN, Alaska Airlines, Sunday, US, Office, District of Oregon, Facebook, Portland police, Investigators, Everett , Washington , Alaska Airlines, Horizon, Embraer, Portland International Airport, FBI Locations: Washington, San Francisco, Oregon, Portland , Oregon, Port, Portland, Multnomah, Everett , Washington , Alaska

☆ Boeing cuts 737 Max delivery forecast as production issues dent third-quarter results
▼ + stars: | 2023-10-25 | by ( Leslie Josephs | ) www.cnbc.com time to read: +3 min

Boeing's new 737 MAX-9 is pictured under construction at their production facility in Renton, Washington, U.S., Feb. 13, 2017. Boeing said Wednesday it will deliver fewer 737 Max aircraft than it previously expected this year as it works through production flaws detected on some of the best-selling aircraft. Boeing maintained its expectations for 2023 free cash flow of $3 billion to $5 billion, despite the production problems. I view it as quite the opposite," CEO Dave Calhoun said in an employee note on Wednesday, as the company reported third-quarter results. ET when executives will face questions about its production pace, demand and how it expects to improve margins in its defense unit.

Persons: we've, Dave Calhoun Organizations: Boeing, Max, Budget, Ryanair, Sales, Air Force, Revenue Locations: Renton , Washington , U.S, LSEG

CNN —An off-duty pilot who was riding in the cockpit of an Alaska Airlines flight en route to San Francisco on Sunday is facing dozens of attempted murder charges after he tried to shut down the plane’s engines mid-flight, authorities say. “The fire suppression system consists of a T-handle for each engine; when pulled, a valve in the wing closes to shut off fuel to the engine,” Alaska Airlines said in a statement to CNN. The flight crew detained the suspect and the plane was diverted to Portland International Airport, the Port of Portland said in a statement. After Alaska Airlines acquired Virgin America in 2016, Emerson became a first officer with Alaska and worked about three more years to become a pilot for the airline, according to the airline statement. “Throughout his career, Emerson completed his mandated FAA medical certifications in accordance with regulatory requirements, and at no point were his certifications denied, suspended or revoked,” Alaska Airlines said in a statement.

Persons: Joseph D, Emerson, CNN’s Josh Campbell, Joseph Emerson, “, Mike Karn, LiveATC.net, ”, Aubrey Gavello, ” Gavello, Laura Coates, Alex Wood, Wood, ” Wood, Gavello, “ I’m, Ed Yee, ” Yee Organizations: CNN, Alaska Airlines, Sunday, Port, Portland police, Horizon, Airlines, Embraer, American Airlines, Portland International Airport, FBI, Detention, Federal Aviation Administration, FAA, Hamas, Passengers, Alaska, Alaskan Airlines, Alaska Air Group, Virgin America, Airbus, Boeing, Canadair Regional Jet, Havilland Locations: San Francisco, Portland , Oregon, Portland, Oregon, Everett , Washington, Sunday, Port, Multnomah, Israel, Alaska

☆ Insurance companies are betting on AI and mass data analytics in a battle against fraud that costs billions
▼ + stars: | 2023-10-24 | by ( Amanda Paule | ) www.businessinsider.com time to read: +9 min

AdvertisementAdvertisementLosses from insurance fraud are nearly double what they were 30 years ago. Scott Clayton, the head of claims fraud at Zurich Insurance Group. AdvertisementAdvertisementOn the other hand, around 40% of fraud is premeditated, and these cases can cost insurance companies upwards of €3,000, or around $3,170, according to the study. But the Insurance Fraud Detection Market is expected to grow from $5 billion in 2023 to $17 billion in 2028. AdvertisementAdvertisementIn the past 10 years, various third-party developers like Friss, IBM, and Shift Technology have started tailoring machine-learning systems to insurance companies.

Persons: —, they're, Alan Turing, It's, Scott Clayton, shallowfakes —, Clayton, I'm, we'll, Arnaud Grapinet, he's, Grapinet, it's, Rob Galbraith, Jennifer Lindberg, Rob Morton, Galbraith Organizations: Service, Coalition Against Insurance, Zurich Insurance, AXA Research Fund, Technology, IBM, Employees Locations: United States, Spain

☆ Family files lawsuit against Panera Bread after college student who drank ‘charged lemonade’ dies
▼ + stars: | 2023-10-23 | by ( Elizabeth Chuck | ) www.cnbc.com time to read: +8 min

On Sept. 10, 2022, Katz purchased a charged lemonade from a Panera Bread in Philadelphia, according to the suit. It's an energy drink that has lemon flavor," said Elizabeth Crawford, a partner at Philadelphia-based law firm Kline & Specter, PC. The lawsuit alleges the charged lemonade is "defective in design because it is a dangerous energy drink." Conroy said Katz had bought at least one other charged lemonade in the days prior to her cardiac arrest. Katz's parents, who declined to speak about the lawsuit, are desperate for people to understand exactly what is in Panera's charged lemonade before they buy it, Crawford said.

Persons: Panera, Sarah Katz, Katz, Victoria Rose Conroy, Conroy, Sarah, Red Bull, Elizabeth Crawford, Kline, Specter, I've, Crawford, Charles Berul, Berul Organizations: Ivy League, NBC News, of Pennsylvania, American Heart Association, National Hospital, Panera, Emergency, Food and Drug Administration Locations: Philadelphia, Washington

☆ China to bolster economic recovery and curb risks, central bank head says
▼ + stars: | 2023-10-21 | by ( Reuters Staff | ) www.reuters.com time to read: +2 min

SHANGHAI/BEIJING (Reuters) - China will promote a sustained economic recovery, focusing on expanding domestic demand, while fending off financial risks, People’s Bank of China Governor Pan Gongsheng said in a report published on Saturday. FILE PHOTO: A woman walks past the headquarters of the People's Bank of China (PBOC), the central bank, in Beijing, China September 28, 2018. The report is significant because it is the first time the governor has commented on policy after the publication of third-quarter economic data. It will also guide financial institutions to help resolve local government debt risks, including debt risks of local government financing vehicles, he said. Pan also said in the report China would resolve the default risk of bonds of big real estate enterprises, preventing risk contagion in stock, bond and foreign exchange markets, and ensuring the stable operation of financial markets.

Persons: Pan Gongsheng, Jason Lee, Pan Organizations: People’s Bank of China, People's Bank of China, REUTERS Locations: SHANGHAI, BEIJING, China, Beijing

☆ Caster Semenya: I Shouldn’t Have to Change My Body in Order to Race - The New York Times
▼ + stars: | 2023-10-21 | by ( Caster Semenya | ) www.nytimes.com time to read: +4 min

While my body was returning to its natural state, the World Anti-Doping Agency discovered that some of my peers were purposely altering theirs. officials to look the other way while they continued competing, even though they had taken illegal drugs. In 2018 the agency announced new regulations that would apply only to athletes with D.S.D. And I would have had to achieve and maintain that level for six months before I was eligible to compete. Follow The New York Times Opinion section on Facebook, Twitter (@NYTopinion) and Instagram.

Persons: I.A.A.F, Chand, Lamine, I’d, Semenya Organizations: Doping Agency, World Athletics, Times, Athletics, D.S.D, New York, Facebook, Twitter Locations: South Africa

☆ Doubts abound about a new Alzheimer’s blood test
▼ + stars: | 2023-10-18 | by ( Judith Graham | ) edition.cnn.com time to read: +10 min

The Quest Diagnostics blood test, AD-Detect, measures elevated levels of amyloid-beta proteins, a signature characteristic of Alzheimer’s. But Alzheimer’s researchers and clinicians aren’t convinced the Quest test is backed by sound scientific research. Though blood tests for Alzheimer’s are likely to become common in the years ahead, the Alzheimer’s Association said it’s premature to offer a test of this kind directly to consumers. Because the science behind blood tests for Alzheimer’s is still developing and because “patients may not really understand the uncertainty of test results,” Edelmayer said, the Alzheimer’s Association “does not endorse the use of the AD-Detect test by consumers.”Quest’s blood test is one of several developments altering the landscape of Alzheimer’s care in the United States. The bottom line: Before taking a test, “older adults need to ask themselves, ‘Why do I want to know this?

Persons: aren’t, Alzheimer’s, Michael Racke, ”, there’s, Suzanne Schindler, St . Louis, That’s, ” Schindler, Racke, Meera Sheffrin, —, Rebecca Edelmayer, ” Edelmayer, Eric Widera, Dr, Sanjay Gupta, Emily Largent, ’ ”, Munro Cullum Organizations: Health, Diagnostics, Alzheimer’s Association, Quest, University of Michigan, International Conference, Washington University School of Medicine, Senior, Stanford Healthcare, The University of Michigan, FDA, National Institute, Aging, University of California, Get CNN, CNN Health, University, Pennsylvania’s Perelman, of Medicine, HIPAA, University of Texas Southwestern Medical Center, Kaiser Health, KFF Locations: U.S, San Diego, St ., United States, San Francisco

Aaron Rodgers ditched the crutches and walking boot, strolled onto the field during pregame warmups Sunday and the New York Jets quarterback started throwing passes again. "It is unbelievable," said Zach Wilson, who has started the Jets' past five games in Rodgers' absence. And it has happened in the locker room among the teammates Rodgers felt as though he let down just four snaps into his debut with the Jets on Sept. 11. While Rodgers continues to work on his recovery in Southern California, he has twice joined the team for games. Against Kansas City two weeks ago, Rodgers was still on crutches and watched from a suite.

Persons: Aaron Rodgers, Zach Wilson, Rodgers, I'm, Pat McAfee, “, —, I've, Neal ElAttrache, Achilles, Robert Saleh, “ I'm, ” Rodgers, raved, ” Saleh, can’t, Saleh, “ It’s, “ He’s, he’s, Tyler Conklin Organizations: New York Jets, Jets, ” Jets, Kansas City, Fame Locations: Green Bay, Southern California

☆ A fund manager beating 90% of peers in 2023 after getting crushed last year shares the unconventional investing philosophy that sets him apart — and why Nvidia and these 5 other stocks will keep domin
▼ + stars: | 2023-10-13 | by ( James Faris | ) www.businessinsider.com time to read: +5 min

Six of the eight top holdings in his Virtus Silvant Large-Cap Growth Fund (STCIX) are among the top 20 performers in the S&P 500 this year. That performance is quite the departure from last year, where Sansoterra's fund fell more than 29%, yet still managed to finish in the top half of its category. "They're there, but they're just a little bit harder to find." "And a lot of money managers are quality growth, GARP-y growth, momentum growth, high beta growth, et cetera. Indeed, Sansoterra's fund has posted solid relative returns in almost every imaginable environment, data from Morningstar shows.

Persons: Michael Sansoterra's, Eli Lilly, Sansoterra, Sandeep Bhatia, haven't, it's, doesn't Organizations: Virtus Silvant, Growth, Nvidia, Meta, Morningstar, Silvant Capital Management

☆ Poland's toxic politics is splitting the country in two, one family at a time
▼ + stars: | 2023-10-11 | by ( Rob Picheta | ) edition.cnn.com time to read: +14 min

“We always end up talking about politics,” Karolina says with an exaggerated weariness. An increasingly toxic politics has polluted kitchens and dining rooms in every region of the country. But the negativity of the country’s politics – arguments echoed each hour on state TV, which is almost always turned on – has worn her down, she says. The efforts sparked years of legal challenges, protests and international confrontations – and hardened the Polish public. Asked whether Polish politics is more divided than they remember it, three generations of this family explode in agreement.

Persons: Karolina, “, – Stella, Patrycja, – Stella’s, Stanisława –, ” Karolina, ”, Stanisława, Stella Martynowska, Rob Picheta, PiS, –, ” Stella, Rob Picheta “, “ That’s, Stella, billows, Piotr Buras, ” Women’s, Donald Tusk, patsy, Tusk, Lech Walesa, Poland’s, Jarosław Kaczyński, ” “, ” Jacek Kucharczyk, Ewa Majewska, I’m, Igor Konior, Konior, Wanda, … I’m, ” Lucyna, Aleksandra Lukasiewicz, Lukasiewicz, “ It’s, “ We’re, ” Aleksandra Lukasiewicz, they’re, they’ve, Michal, I’ll, gesturing, ” Patrycja Organizations: Poland CNN, Soviet, Justice, CNN, European Council, Foreign Relations, Civic Coalition, Warsaw’s Institute of Public Affairs, Tusk’s Civic Coalition, PiS, Union Locations: Warsaw, Poland, Rob Picheta Poland, Polish, Hungary, Russia, Western Europe, Brussels, Berlin, Lublin, “, Rotterdam, Łódź, Bonita

☆ Blood tests needed for widespread Alzheimer's diagnosis on the way
▼ + stars: | 2023-10-11 | by ( Deena Beasley | ) www.reuters.com time to read: +6 min

Several Alzheimer's blood tests are in the works – and one is already being sold to consumers – but none have been established as accurate, formally approved by regulators or reimbursed by insurers. Researchers have been working for years on blood tests for Alzheimer's that can replicate these diagnostic tools. The need for blood tests has become more pressing since the FDA approved Leqembi in July. Accurate blood tests are expected to help identify which dementia patients actually have Alzheimer’s, the most common but not the only cause of dementia. "When there are widely available, scalable, sensitive and specific blood tests it will be an absolute game changer for Alzheimer's patients."

Persons: Denis Balibouse, Eli Lilly, Dr, Sarah Kremen, Eliezer Masliah, Eisai, Michael Irizarry, Roche, Bruce Jordan, Russ Paulsen, Deena Beasley, Caroline Humer, Bill Berkrot Organizations: Memory Centre, of Readaptation, University Hospital, REUTERS, FDA, Sinai Medical Center, Wednesday, Quest Diagnostics, National Institute, Aging, U.S . National Institutes of Health, C2N Diagnostics, Roche Diagnostics, Alzheimer's Association, RAND, Thomson Locations: Geneva, Switzerland, Leqembi, Eisai, Los Angeles, U.S

☆ Down syndrome families' fight for access to Alzheimer’s trials, treatments
▼ + stars: | 2023-10-10 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +9 min

In an extended portion of Eisai’s main Leqembi trial, CAA was associated with one death. 'THE DIGNITY OF RISK'Hillerstrom said the groups are "very strongly" lobbying Eisai and Lilly to conduct the safety trials in Down syndrome, and said he has been meeting with the companies to push them to design such trials. Lilly declined to comment on whether it is considering either a safety trial or taking part in that study. An Eisai spokeswoman said the company "has no immediate plans" to conduct clinical trials of Leqembi in people with Down syndrome. The company is collaborating with LuMind in a study gathering data on how Alzheimer's manifests in people with Down syndrome.

Persons: Oskar Hillerstrom, Lianor, Hampus, Brian Snyder, Lianor da Cunha, Oskar, de Oeiras, Teresa, Oskar’s, Hampus Hillerstrom, Eli Lilly's, LuMind, Hillerstrom, Lilly, Emily Largent, Beau Ances, Louis, I've, Ances, I'm, Michael Rafii, William Mobley, Mobley, Dawn Brooks, donanemab, Margot Rhondeau, Hannah, Julie Steenhuysen, Caroline Humer, Bill Berkrot Organizations: REUTERS, Rights, Reuters, CAA, University of Pennsylvania Perelman School of Medicine, Medicare, U.S . Food, Drug Administration, Washington University, National Institute, Aging, University of Southern, UC San Diego School of Medicine, LuMind, Syndrome, Thomson Locations: Lexington , Massachusetts, U.S, Santo, Portugal, United States, St, University of Southern California

☆ Alnylam gives up on expanded use of heart-disease drug in US after FDA declines approval
▼ + stars: | 2023-10-09 | by ( Mariam E Sunny | ) www.reuters.com time to read: +2 min

Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, U.S., August 29, 2020. The FDA, in 2019, approved Pfizer's (PFE.N) oral drug tafamidis, sold under the brand names Vyndaqel and Vyndamax, to treat transthyretin amyloid cardiomyopathy in the United States. Alnylam said it will focus on another drug candidate, vutrisiran, an under-the-skin injection in late-stage trials to treat ATTR amyloidosis-related cardiomyopathy. Branded as Amvuttra, vutrisiran is also approved in the U.S. to treat nerve damage in adult patients with hereditary ATTR amyloidosis. William Blair analyst Myles Minter estimates peak U.S. sales of $2.2 billion for vutrisiran as an ATTR cardiomyopathy treatment.

Persons: Andrew Kelly, patisiran, ATTR amyloidosis, Alnylam, Luca Issi, ATTR, William Blair, Myles Minter, Mariam Sunny, Pooja Desai Organizations: Food and Drug Administration, FDA, REUTERS, Alnylam Pharmaceuticals, RBC, Thomson Locations: White Oak , Maryland, U.S, Massachusetts, United States, Bengaluru

☆ Taiwan says China has 'very diverse' ways of interfering in election
▼ + stars: | 2023-10-04 | by ( ) www.reuters.com time to read: +3 min

REUTERS/Dado Ruvic/Illustration Acquire Licensing RightsTAIPEI, Oct 4 (Reuters) - China has "very diverse" ways of interfering in Taiwan's elections in January, from military pressure to spreading fake news, including manipulating opinion polls, a senior Taiwanese security official said on Wednesday. Ahead of elections, Taiwan routinely flags the risk of interference from Beijing, which claims the democratically governed island as its own, saying China seeks to sway the outcome to candidates who may be more favourable toward the country. "The way the Chinese Communists interfere in elections is very diversified," Taiwan National Security Bureau Director-General Tsai Ming-yen told lawmakers during a parliamentary committee session. China can use military pressure, economic coercion or fake news to create a false choice between "war or peace" in the election, seeking to frighten voters, Tsai said. China has increased military activities around Taiwan since the last election in 2020, and regularly sends warships and fighters into the seas and skies near the island.

Persons: Dado Ruvic, Tsai Ming, Tsai, William Lai, Lai, Xi Jinping, Ben Blanchard, Gerry Doyle Organizations: REUTERS, Rights, Taiwan National Security, Taiwan Affairs Office, Taiwan, Democratic Progressive Party, People's Liberation Army Rocket Force, Thomson Locations: Rights TAIPEI, China, Taiwan, Beijing

☆ 2023 on track to be the hottest year as September shatters heat records
▼ + stars: | 2023-10-04 | by ( Laura Paddison | ) edition.cnn.com time to read: +5 min

CNN —The Northern Hemisphere may be transitioning into fall, but there has been no let up from extreme heat. New data shows last month was the hottest September – the fourth consecutive month of such unprecedented heat – putting 2023 firmly on track to be the hottest year in recorded history. That’s well above the 1.5 degrees Celsius threshold to which countries aim to limit global warming under the Paris Climate Agreement. The extreme September “has pushed 2023 into the dubious honor of first place – on track to be the warmest year and around 1.4 degrees Celsius above pre-industrial average temperatures,” Burgess said. The significant margin by which heat records are being broken matters, she told CNN.

Persons: Copernicus, ”, Samantha Burgess, Paulo Amorim, Zeke Hausfather, Maximiliano Herrera, ” Herrera, Chris Ratcliffe, ” Burgess, El Niño, Friederike Otto, ” Otto Organizations: CNN, Bloomberg, Oceanic, Atmospheric Administration, Grantham Institute, Climate, “, United Locations: Paris, Libya, Greece, Bulgaria, Turkey, Canada, South America, York, Brazil, Spain, Poland, Austria, France, Europe, London, Dubai, United Nations, COP28

☆ Ray Dalio says the 10-year Treasury yield could rise to 5% — and there's risk it goes even higher
▼ + stars: | 2023-10-03 | by ( Yun Li | ) www.cnbc.com time to read: +2 min

Billionaire investor Ray Dalio believes the surging 10-year Treasury yield could rise even higher to the 5% threshold as he sees hotter inflation for longer. "It would seem that something like a 5% rate, and there's nothing precise about that, but in that neighborhood, you know, would be maybe about right ... with the risk higher," Dalio said Tuesday at the Greenwich Economic Forum in Greenwich CT. The 10-year Treasury yield, which serves as a benchmark for mortgage rates, jumped to 4.76% on Tuesday, i ts highest level since 2007. Deficit risk Then Dalio said the imbalance of government debt's supply and demand picture also caused yields to go higher. "When you look at the expected returns for this moment, cash is a relatively attractive asset class at this moment," Dalio said.

Persons: Ray Dalio, Dalio, That's Organizations: Greenwich Economic, Treasury, Federal Reserve, Bridgewater Locations: Greenwich, Greenwich CT

☆ Something is breaking in financial markets — Here's what's behind the sell-off
▼ + stars: | 2023-10-03 | by ( Jeff Cox | ) www.cnbc.com time to read: +7 min

Brendan McDermid | ReutersThat cracking sound in financial markets isn't the typical kind of break, where one asset class or another fractures and gives way. "The cost of capital is going up, companies are going to have to refinance at a higher rate." That sentiment was buttressed this week, when at least four central bank officials either endorsed hikes or indicated that higher rates would be staying in place for an extended period. Consumers, for one, are feeling the squeeze of higher rates on everything from mortgages to credit cards to personal loans. "Now, at some point, my guess is that markets will eventually get to cheap enough levels where you'll bring buyers in.

Persons: Brendan McDermid, Quincy Krosby, Krosby, Larry McDonald, Treasurys, McDonald, It's, Joseph LaVorgna, LaVorgna, Donald Trump, I've Organizations: New York Stock Exchange, Federal Reserve, Treasury, LPL, Labor Department, Wall, P Bank ETF, Congressional, Treasury Department, The, White House, National Economic Council, Nikko Securities Locations: New York City, Washington, U.S

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