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Gavin Newsom last year vetoed legislation that would have decriminalized the possession and personal use of several plant-based hallucinogens, including psychedelic mushrooms. Colorado and Oregon have already decriminalized psychedelic mushrooms and establish regulated systems for therapeutic use of the substances. In California, San Francisco, Oakland and Santa Cruz have effectively decriminalized possession of psychedelic mushrooms, meaning a person cannot be arrested or prosecuted for possessing limited amounts of plant-based hallucinogens. California already has “a massive network" of underground therapists who provide psychedelic therapy, Wiener said. Touted as a mind-bending drug in the 1960s, psychedelic mushrooms have been used in religious or spiritual practices in some cultures for centuries and possibly thousands of years.
Persons: Gavin Newsom, Democratic Sen, Scott Wiener, Newsom, Wiener, Republican Assemblymember Marie Waldron, ” Wiener, Waldron, Juliana Mercer, she's, we'll, ” Mercer, psychedelics, Susan Sagy Organizations: Democratic Gov, Democratic, Republican, Drug Administration, Heroic Hearts, Marine Corps, U.S ., California Coalition, Psychedelic Safety Locations: SACRAMENTO, Calif, California, Colorado, Oregon, San Francisco, Oakland, Santa Cruz, criminalization
AdvertisementThe Bay Area took the lion's share of capital raised on Carta in 2023, followed by Boston, then New York. AdvertisementAccording to Carta data, select metro areas saw the total early-stage funding raised decline by at least a third from 2022 to 2023. Yet early-stage funding was only down 24% in Boston, however, the smallest decrease of the metro areas that Carta tracks. According to Carta data, about $2.6 billion of capital raised in biotech flowed to Boston startups last year. Beyond biotechThe Carta data shows Boston also had strong showings across investment in software-as-a-service and hardware.
Persons: , Zach Weinberg, Roche, Carta, Founders, that's, Rudina Seseri, Seseri, Peter Walker, Michael Greeley, Greeley, Mark Castleman, Castleman, Clement Cazalot, Cazalot, Walker Organizations: Service, Massachusetts Turnpike, Partners, Business, Carta, Boston, East Coast, Companies, Area, Flare Capital Partners, pharma, Intel Ignite, Glasswing Ventures, Founders, Machinery, Pritzker Group, Armory Square Ventures, Way Ventures, Klaviyo's, New York Stock Exchange Locations: Boston, New York City, East, Boston , Cambridge, Newton , Massachusetts, Newark, Jersey City , New Jersey, New York, San Francisco, Bay, France, Copley
Therapists Trade the Couch for the Great Outdoors
  + stars: | 2024-02-05 | by ( Christina Caron | ) www.nytimes.com   time to read: +1 min
Sometimes a pine cone is just a pine cone. “Growing up, I had some challenges,” Ms. Oppenheimer said, referring to her prickly teenage past, “some struggles with managing my emotions.”But her grandmother, who died four years ago, was soft like the feather, and gave her unconditional love that reminded Ms. Oppenheimer how important it was to treat herself with “soothing tenderness,” especially when she became self-critical. Ms. Oppenheimer and her clinical supervisor, Heidi Schreiber-Pan, were visiting Talmar, a nonprofit farm that offers therapeutic programs and vocational training — a short drive from the busy road and nondescript strip malls near their office. At the farm, the only sounds were a burbling stream, trilling birds and several inches of snow crunching beneath their feet. It was the perfect location to teach Ms. Oppenheimer therapeutic techniques that make use of the natural world.
Persons: Rachel Oppenheimer, ” Ms, Oppenheimer, Ms, Heidi Schreiber Organizations: Chesapeake Mental Health, Locations: Towson, Md
Under-the-radar stock picks Morgan Stanley reckons the way to play the obesity theme in Asia is through names involved in GLP-1 drug development that "could find upside in burgeoning overseas markets." Calling it "top beneficiary as global demand for GLP-1 drugs significantly outpaces capacity," Morgan Stanley has an overweight rating on the stock. Morgan Stanley has an investment horizon of just over six months for WuXi AppTec and Innovent and over 12 months for Chugai and EBOS. Morgan Stanley's analysts estimate that worldwide sales of Orforglipron could hit $7 billion in 2023. Elsewhere, it sees opportunities for EBOS following the Australian government's approval for it to distribute obesity drugs.
Persons: Eli Lilly, Morgan, Sean Wu, Morgan Stanley's, Health Organization's, Morgan Stanley, Chugai, Goldman, EBOS, CNBC's Michael Bloom Organizations: Novo Nordisk, Health, WHO, BMI, WuXi AppTec, Australian, Hong Kong Stock Exchange, China Health Care, Goldman Sachs, Health Care Equity, Zealand ETF Locations: U.S, Asia, Asia Pacific, Australia, GLP, WuXi, China, Japan, New Zealand, Zealand
Novartis misses Q4 net income expectations, extends forecast
  + stars: | 2024-01-31 | by ( ) www.cnbc.com   time to read: 1 min
Novartis said in August that it plans to spin off its generics unit Sandoz to sharpen its focus on its patented prescription medicines. Swiss drugmaker Novartis reported a 6% gain in fourth-quarter adjusted net income on Wednesday, helped by cost cuts and strong growth of recently launched drugs. Core net income for the quarter came in at $3.13 billion, it said in a statement, missing analysts' estimate of about $3.3 billion, as per LSEG data. Novartis also extended its mid-term guidance, saying it expected sales to grow 5% per year until 2028, when adjusting for currency swings. CEO Vas Narasimhan previously led a push to cut jobs and focus on fewer therapeutic areas and geographic markets, before spinning off and listing generic drugs business Sandoz late last year.
Persons: Sandoz, Vas Narasimhan Organizations: Novartis
Instead of descending into her loss in the song, Rodrigo stands atop of her anger, reclaiming her agency in the process. The single “vampire” is up for record and song of the year, as well as best pop solo performance. “GUTS” could take home album of the year or maybe best pop vocal album, and finally, her track “ballad of a homeschooled girl” is up for best rock song. “I love the Grammys so much!” Rodrigo told The Associated Press at the film academy's Governors Awards in Los Angeles earlier this month. “I think I read a lot more this year, and that definitely informed the writing process of 'GUTS,'" she says.
Persons: Olivia Rodrigo, , Rodrigo, ” Rodrigo, , — Kennedy, Joan Didion, Leonard Cohen, Leonard Cohen’s Organizations: ANGELES, Associated Press, University of Southern Locations: Los Angeles, University of Southern California
All five adults had growth hormone deficiency as children and received pituitary growth hormones prepared in a specific way from cadavers. The treatment approach was discontinued after cases of a rare brain disorder called Creutzfeldt-Jakob disease were found to be associated with the administration of contaminated human growth hormone from cadavers. Although Alzheimer’s is not a prion disease, some separate research suggests that the two proteins that are hallmarks in Alzheimer’s disease — amyloid beta and tau — behave like prions. “This study suggests that in very rare circumstances Alzheimer’s disease may be transmitted between humans via human growth hormone from deceased donors. “I’m also intrigued by how these results may inform potential therapeutic targets and strategies in the future,” Isaacson said, regarding Alzheimer’s disease.
Persons: John Collinge, Jakob, Creutzfeldt – Jakob, Alzheimer’s, ” Collinge, , , ” Dr, Susan Kohlhaas, ” Kohlhaas, “ It’s, Dr, Richard Isaacson, , Isaacson, “ I’m, ” Isaacson, , Gargi Banerjee, ” Banerjee, James Galvin, Sanjay Gupta, ” Galvin, Lewy Organizations: CNN, Nature, University College London Institute, University College London, National Hospital for Neurology, Neurosurgery, Alzheimer’s Research, Science Media, Comprehensive, Brain Health, University of Miami Health, CNN Health Locations: United Kingdom, United States, United, Florida, UHealth, Creutzfeldt
JPMorgan thinks investors should flock to biotechnology company Beam Therapeutics , which the firm says stands to benefit from increased market share and a strong gene therapy pipeline. "We see BEAM outperforming our coverage over the mid-term, with current levels being an attractive entry point," the analyst said. The stock is down more than 4% so far this year, and has lost more than 42% over the past 12 months. BEAM 1Y mountain Beam stock. He added that BEAM-302 is "uniquely positioned" as a one-time genetic medicine for AATD, particularly given its success in preclinical trials.
Persons: Eric Joseph, Joseph Organizations: Beam Therapeutics, TAM Locations: U.S, 1H24
The first time I met my best friend Kesia's mom, Kate, she impressed me with her gentle disposition, as well as her amazing cooking. I hadn't really considered the possibility that I could become friends with my own parents, let alone the parents of my friends. When I was going through a hard time, Kate and I reconnectedBerlin was good, but challenging. When I told Kesia that I was struggling with bad depression, she suggested Kate and I connect, because we were going through the same thing. In the beginning, I was mostly worried about how my mental health struggles could affect my role as a mother.
Persons: Kate, Berlin, Kesia, reconnecting, bubbled Locations: Berlin, New Zealand
Read previewNicole Kidman says she was told she wouldn't have a career in Hollywood because she was too tall. Speaking on the "Radio Times Podcast" on Tuesday, Kidman said that her height was initially a challenge when she broke into acting. Related stories"I say I'm 5 foot 10 ½ inches, but I'm really 5 foot 11 inches. Having said that, I've had knee issues and all sorts of things — partly because of my height," Kidman added. In 2020, the star told Byrdie she trained to become a massage therapist to give her mom therapeutic treatment.
Persons: , Nicole Kidman, wouldn't, Virginia Woolf, Kidman, Annie, I'm, I've, Patrick Riviere, she's, Byrdie Organizations: Service, Virginia, Business Locations: Hollywood, Australian, Moulin Rouge, Sydney
Many of his medical achievements came at the cost of the health and well-being of enslaved Black women. He performed surgical experiments on enslaved Black women, often without the use of anesthesia. Black women were experimented on to improve health care for white womenSocietal, institutional, and systemic racism has endangered the lives of Black women for centuries. In a 2023 CDC study , Black women reported experiences of mistreatment during maternity care at the highest rate of women surveyed. As enslaved Black women were considered to be the property pf their owners, and therefore did not have their own rights of refusal, Sims' experimented on Black women in order to improve gynecological outcomes for white women.
Persons: Marion Sims, , J, Sims, Spencer Platt, fistulas, Lucy, Black, Julia Axelrod, Henrietta, Fannie Lou Hamer, sterilizing, vesicovaginal fistulas Organizations: Gynecology, Service, Design, Parks Department, Park, 103rd, Getty, Equity Locations: New York, Central, Mississippi, CDC, Montgomery
Her son was born at 25 weeks and spent 145 days in the NICU. When I was nearly 25 weeks pregnant, my colon ruptured. They warned that this would likely send me into early labor but said it would save my life. But our son would spend nearly five months — or 145 days — in the NICU. When Ryder was in the NICU, we still took monthly milestone pictures and dressed him up for holidays.
Persons: Lindsey Albarado, He's, , I'd, couldn't, Ryder, hadn't, — who's, Ryder's Organizations: Service, Children's Hospital New Locations: Children's Hospital New Orleans
Many biotech stocks struggled in 2023 despite a robust year for U.S. drug approvals. "We expect this environment to continue but look forward to the prospect of lower interest rates in 2024." When that happens, Canaccord Genuity said to expect a "strong rally across the biotech sector rewarding innovative, but riskier assets." Analysts have said the rich price reflects the opportunity for ImmunoGen's Elahere cancer treatment , which has quickly established itself as the standard of care for types of ovarian cancer. 'Oversold and cheap' In a research note Friday, Jefferies analyst Michael Yee said "a significant short squeeze" was helping biotech stocks in the fourth quarter.
Persons: Dan Lyons, Janus Henderson, John Newman, Canaccord Genuity, Janus, Lyons, Bristol Myers Squibb, Karuna, AstraZeneca, Eli Lilly, AbbVie, Jonathan Miller, Miller, bode, Jonathan Krinsky, Krinsky, BTIG's, Jefferies, Michael Yee, Yee, NASH, Madrigal, we're, David Risinger, — CNBC's Michael Bloom Organizations: Drug, Federal, Bristol Myers, Karuna Therapeutics, CART, Bristol Myers Squibb, Cerevel Therapeutics, Securities and Exchange Commission, pharma, P Biotech, Nasdaq Biotech, Apogee Therapeutics, Madrigal Pharmaceuticals, Madrigal, resmetirom, Vertex Pharmaceuticals, Leerink Partners Locations: ImmunoGen
"The aging population discussion in recent years has mostly revolved around future challenges to labor productivity and its economic growth implications," he said. AI, robotics and wearables The aging population stands to gain significantly from breakthroughs in robotics powered by artificial intelligence, according to Afzal. Arelis Agosto, research analyst at Global X ETFs, said wearables technology is one interesting area to invest in for the aging theme. "We view self-sustaining monitoring and therapeutic systems as the future of patient care, though it is particularly beneficial for elderly patients," Agosto said. Global X ETFs, a fund management company, offers a way to tap the aging theme through its Aging Population ETF.
Persons: Shams Afzal, There's, Afzal, Stryker, Dani Saurymper, Saurymper, Arelis Agosto, Agosto Organizations: Carnegie Investment, CNBC Pro, Stryker, EU, Longevity, Global, Carnegie, Abbott Laboratories, Agosto Locations: U.S, GLP, Agosto
The logo of Swiss drugmaker Roche is seen at its headquarters in Basel, Switzerland January 30, 2020. REUTERS/Arnd Wiegmann/File Photo Acquire Licensing RightsZURICH, Dec 4 (Reuters) - Roche (ROG.S) agreed to take over obesity drug developer Carmot Therapeutics (CRMO.O) for $2.7 billion, joining a list global contestants seeking to challenge the dominant makers of weight-loss drugs Novo Nordisk (NOVOb.CO) and Eli Lilly. After encouraging Phase I trial results, the drug is ready to be tested on humans in the second of three trial stages, Roche added. Among recent deals to acquire obesity drug development projects, AstraZeneca (AZN.L) last month agreed to pay up to $2 billion for the rights to an experimental pill from China's Eccogene. Roche will obtain access to Carmot's current R&D portfolio including all clinical and preclinical assets.
Persons: drugmaker Roche, Arnd, ROG.S, Eli Lilly, Swiss drugmaker, Roche, . New Roche, Thomas Schinecker, Ludwig Burger, Noel Illien, Rachel More, Louise Heavens Organizations: REUTERS, Rights, Carmot Therapeutics, Novo Nordisk, AstraZeneca, Pfizer, Thomson Locations: Basel, Switzerland, Swiss, ., Alzheimer's
[1/2] Vape pens stand in a display cabinet at a vape store, in Melbourne, Australia, May 2, 2023. REUTERS/Sandra Sanders/File Photo Acquire Licensing RightsSYDNEY, Nov 28 (Reuters) - Australia will ban imports of disposable vapes in January, the Health Minister said on Tuesday, the first step in a crackdown aimed at curbing the growing popularity of these nicotine-filled devices with young people. Despite one of the lowest rates of smoking in the OECD, a group of mostly rich countries, vaping in Australia is growing rapidly, especially among the young. First flagged in August, the reforms aim to curb the device's popularity in response to research showing the potential for long-term harm. To ensure the bans don't limit access for smokers looking to quit, doctors and nurses will be given expanded powers in January to prescribe therapeutic vapes where clinically appropriate.
Persons: Sandra Sanders, Mark Butler, Butler, Lewis Jackson, Miral Organizations: REUTERS, Rights, Health, Australian Border Force, Therapeutic Goods Administration, OECD, Thomson Locations: Melbourne, Australia
A year and a half ago, he started spending some of his weekends producing music in what he calls the passive listening space — and quickly found "lo-fi" music production to be a "very easy" side hustle. When he and Bono collaborate on lo-fi tracks, they set a timer — just two minutes for writing, producing and naming each song. The alleviation of expectations that comes with lo-fi music production is "kind of therapeutic," Turner says, and the extra cash doesn't hurt. Here's how he built and manages his lo-fi music side hustle. Turner says he uses TuneCore, an online service that places your tracks on platforms like Spotify, Apple Music, YouTube and TikTok.
Persons: you've, Michael Turner's, Turner, Mike Bono — he's, Bono, they've, Taylor Swift Organizations: CNBC, Spotify, Apple, Apple Music, YouTube
WORTHY, by Jada Pinkett Smith. Let’s get one thing out of the way: If you’re downloading Jada Pinkett Smith’s memoir just to hear about the Slap, you have 14 hours, 3 minutes and 6 seconds of listening to do before you reach your goal. Smith’s voice is calm and steady throughout this chapter; it quavers elsewhere, especially when she describes the 1996 death of Tupac Shakur, who had been her friend, protector and ardent supporter since her sophomore year of high school. The chapter “The Holy Joke, the Holy Slap and Holy Lessons” appears near the end of her book for a reason: It’s not the point. Smith also opens up, generously, about her depression, her therapeutic journey and her spirituality.
Persons: Jada Pinkett Smith, Read, Let’s, Jada Pinkett, Smith, “ Worthy ”, Will Smith, Chris Rock, Tupac Shakur, , Locations: Baltimore, Hollywood, Chile
Juaçaba’s work, by contrast, was plain yet potent in its attention to detail. “She leaves room for the imagination.”In one of their firm’s first projects, 2015’s Videiras Pavilion — an extension of a pre-existing country home in a valley 62 miles from Rio — a 386-square-foot structure seems to levitate over a gentle slope. Made largely from recycled timber left on-site by the previous owners, the external structure is rich in detail, featuring puzzlelike junctions of banisters and beams. Deep frames around unglazed windows double as outdoor seats. The black paint used in parts was inspired by the natural patina acquired by Indigenous palm-thatch dwellings, a resilient typology throughout Brazil that most architects, until recently, wouldn’t have considered architecture at all.
Persons: , Pedro Varella, Caio Calafate, Alziro Carvalho Neto, Felipe Rio, Gávea Organizations: Felipe Rio Branco Locations: Rio, Itanhangá, Gru.a, Rio —, Videiras, Brazil
Inside, I was met with a sea of patients, health care workers and the displaced. These children, Gaza’s youngest — as well as those in utero — are especially vulnerable to the burgeoning crisis of malnutrition and the prospect of starvation. These conditions, when combined with displacement and overcrowding in shelters, can quickly lead to disease outbreaks that threaten everyone, especially malnourished children. And without clean water, health care facilities cannot provide effective treatment to those in need, nor can they maintain basic infection prevention and control measures. Gaza’s children have endured far too much death and suffering already.
Persons: Wahida, Khan Younis, Balah Organizations: Nasser Hospital, United Nations, Hamas Locations: Afghanistan, Gaza, Khan, Deir al
Opinion | This Is Not the Way to Help Depressed Teenagers
  + stars: | 2023-11-18 | by ( ) www.nytimes.com   time to read: +3 min
Teenagers, who are still developing their identities, are especially prone to take psychological labels to heart. Plus, many of the skills taught in these programs were developed for people coping with severe mental illness, not everyday stresses. Such interventions work best with steady, consistent, hands-on support from a dedicated therapist. To be sure, psychologists have done some important and innovative work making mental health interventions more broadly accessible. But although such offerings fill gaps in our mental health infrastructure, they cannot take the place of more time- and resource-intensive forms of care.
Persons: , Foulkes, aren’t, they’d, Jessica Schleider Organizations: Northwestern University Locations:
In this crowded field, Vancouver-based Filament Health has a unique approach: extracting drugs like psilocybin and mescaline from natural sources, including mushrooms and cacti, rather than synthesizing the ingredients in a laboratory. Filament CEO Benjamin Lightburn spoke with The Associated Press about the ethical, therapeutic and medical case for using naturally derived psychedelics. Q: What do you mean by “natural psychedelics” and how are they produced? A: The iboga plant, which contains the psychedelic ibogaine, is probably the best example of that at Filament. There is a ton of interest from different researchers all around the world to use our psychedelic drugs.
Persons: Benjamin Lightburn, It’s Organizations: Associated Press, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Vancouver, West Africa, Gabon
The company's research and development (R&D) engine is intact and therefore it is unlikely to do transformative deals soon, Jorgensen said. It was the latest in a series of similarly-sized deals the company has done this year. Last week, when reporting quarterly earnings, it forecast another year of double-digit sales growth for its two most popular drugs: weight-loss drug Wegovy and diabetes Ozempic. To keep up with demand, Novo is racing to increase production of those drugs, which contain the same active pharmaceutical ingredient, semaglutide, and are delivered in self-injection pens. A healthcare banker, speaking on condition of anonymity, told Reuters after the interview there were many companies in the cardiometabolic space with early-stage drugs that Novo Nordisk may be able to buy.
Persons: Lars Fruergaard Jorgensen, Wegovy, Jorgensen, Novo, Novo's, Jacob Gronholt, Maggie Fick, Terje Solsvik, Emelia, Barbara Lewis Organizations: Novo, Novo Nordisk, Reuters, KBP Biosciences, Nordisk, Pedersen, Thomson Locations: Novo, COPENHAGEN, Singapore, Copenhagen, London
As the company's fortunes soar on demand for its popular weight-loss medicine Wegovy, Jorgensen said Novo sought to acquire companies working on medicines in the areas where it is already focused. The company's research and development (R&D) engine is intact and therefore it is unlikely to do transformative deals soon, Jorgensen said. It was the latest in a series of similarly-sized deals the company has done this year. Last week, when reporting quarterly earnings, it forecast another year of double-digit sales growth for its two most popular drugs: weight-loss drug Wegovy and diabetes Ozempic. To keep up with demand, Novo is racing to increase production of those drugs, which contain the same active pharmaceutical ingredient, semaglutide, and are delivered in self-injection pens.
Persons: Lars Fruergaard Jorgensen, Wegovy, Jorgensen, Novo, Novo's, Jacob Gronholt, Maggie Fick, Terje Solsvik, Emelia, Barbara Lewis Organizations: Novo, Novo Nordisk, Reuters, KBP Biosciences, Nordisk, Pedersen, Thomson Locations: Novo, COPENHAGEN, Singapore, Copenhagen, London
AstraZeneca is the latest player to enter the weight loss drug arena, a market which some analysts have forecasted could reach $100 billion by 2030 . The GLP-1 drug market is currently dominated by two players: Novo Nordisk , which sells Type 2 diabetes treatment Ozempic and weight loss medication Wegovy, and Eli Lilly , which sells Mounjaro as a treatment for Type 2 diabetes. Lilly just had the weight loss version of its drug, Zepbound , approved by the Food and Drug Administration. It's still early days for AstraZeneca's ECC5004 drug, which is being assessed in a U.S.-based phase 1 trial involving patients with Type 2 diabetes. He currently rates AstraZeneca stock as overweight.
Persons: Eccogene, Wegovy, Eli Lilly, Lilly, It's, Colin White, James Gordon, Morgan Stanley, Mark Purcell, AstraZeneca's Farxiga, Purcell, Michael Bloom, Christina Cheddar, Berk Organizations: AstraZeneca, Novo Nordisk, Food and Drug Administration, Centers for Disease Control, UBS, Wall Street, JPMorgan Locations: U.S
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