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The drug, donanemab, met all goals of the trial. "These are the strongest phase 3 data for an Alzheimer's treatment to date," said Maria Carrillo, chief science officer for the Alzheimer's Association. In the donanemab treatment group, Lilly said brain swelling, a known side effect of drugs of this type, occurred in 24% of the participants, with 6.1% experiencing symptoms. In the Leqembi Phase 3 trial, the drug was associated with brain swelling in nearly 13% of its study participants. It also said 47% of donanemab patients in the 18-month trial had no disease progression at 12 months, compared with 29% of the placebo group.

☆ Ex-Harvard Professor Charles Lieber Avoids Prison for Lying About China Funding
▼ + stars: | 2023-04-26 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

Charles Lieber, an expert in the field of nanoscience, was convicted in December 2021. Photo: katherine taylor/ReutersFormer Harvard Professor Charles Lieber was sentenced to six months of home confinement and two years of supervised release after being found guilty in 2021 of federal charges stemming from payments he received from a Chinese government talent program. Mr. Lieber, who long held joint appointments in Harvard University’s chemistry and engineering departments and is a renowned expert in the field of nanoscience, was convicted in December 2021 at trial in federal court in Boston.

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The people in the online spaces where Airman First Class Jack Teixeira spent his time and allegedly leaked highly classified documents had many things in common. In obscure game forums and private online chat rooms, his friends posted violent slurs against Black, gay and trans people, Jews, Ukrainians and pretty much everyone else. Everyone, that is, except Russians.

A Massachusetts Air National Guardsman arrested in connection with a leak of purported highly classified intelligence documents was charged Friday as federal prosecutors offered new details about how they think some of the government’s most closely guarded material ended up online. Prosecutors charged Jack Teixeira with unauthorized retention and transmission of national defense information and unauthorized removal and retention of classified documents or material, in a brief hearing in U.S. District Court for the District of Massachusetts.

WASHINGTON—The U.S. government is treating the apparent disclosure of classified material surrounding the war in Ukraine as an insider’s leak, people familiar with the matter say, and is working to identify and apprehend a key suspect in a massive intelligence breach that has exposed the challenges of safeguarding sensitive U.S. information and tested ties with some of America’s closest allies.

WASHINGTON—The U.S. government is treating the apparent disclosure of classified material surrounding the war in Ukraine as an insider’s leak, people familiar with the matter say, but hasn’t yet homed in on key suspects for a massive intelligence breach that has exposed the challenges of safeguarding sensitive U.S. information and tested ties with some of America’s closest allies.

☆ South Africa revokes 'state of disaster' declared over power crisis
▼ + stars: | 2023-04-05 | by ( Kopano Gumbi | ) www.reuters.com time to read: +3 min

The state of disaster gave the government additional powers to respond to the crisis, including by permitting emergency procurement procedures with fewer bureaucratic delays and less oversight. The newly appointed electricity minister Kgosientsho Ramokgopa said some crisis measures would remain in place. "The state is withdrawing the national state of disaster in response to OUTA's legal action challenging its rationality," said OUTA, a non-profit organisation that focuses on fighting government corruption and tax abuses. REUTERS/Esa AlexanderOUTA said the disaster regulations would have enabled corruption and that the crisis could be managed using existing laws. President Cyril Ramaphosa invoked disaster regulations on Feb. 9 to fight a paralysing power crisis that has included daily rolling power cuts by Eskom.

☆ Leonardo DiCaprio Testifies at Pras Michel’s 1MDB Trial
▼ + stars: | 2023-04-03 | by ( Byron Tau | Aruna Viswanatha | ) www.wsj.com time to read: 1 min

Actor Leonardo DiCaprio, who has been friends with rapper Pras Michel for years, hasn’t been accused of any crime. WASHINGTON—Actor Leonardo DiCaprio appeared in a Washington federal courthouse on Monday to testify in a closely watched criminal case featuring a potent mix of celebrity, money and geopolitical intrigue. The Academy Award-winning star of blockbusters such as “Titanic,” “The Revenant” and “Catch Me If You Can” appeared as a witness in a sprawling Hollywood-meets-Washington trial against the rapper Pras Michel , a founding member of the hip-hop trio the Fugees.

☆ U.S. State-Government Websites Use TikTok Trackers, Review Finds
▼ + stars: | 2023-03-21 | by ( Byron Tau | Dustin Volz | ) www.wsj.com time to read: 1 min

WASHINGTON—More than two dozen state governments have placed web-tracking code made by TikTok parent ByteDance Ltd. on official websites, according to a new report from a cybersecurity company, illustrating the difficulties U.S. regulators face in curtailing data-collection efforts by the popular Chinese-owned app. A review of the websites of more than 3,500 companies, organizations and government entities by the Toronto-based company Feroot Security found that so-called tracking pixels from the TikTok parent company were present in 30 U.S. state-government websites across 27 states, including some where the app has been banned from state networks and devices. Feroot collected the data in January and February of this year.

☆ FBI Once Bought Mobile-Phone Data for Warrantless Tracking. Other Agencies Still Do.
▼ + stars: | 2023-03-10 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

The FBI says it doesn’t currently buy commercial database information that includes location data derived from internet advertising. WASHINGTON—The Federal Bureau of Investigation this week acknowledged having bought precise geolocation data derived from mobile-phone advertising in the past before backing away from the practice in the face of thorny legal issues and public controversy. The precise location of millions of mobile devices and automobiles is increasingly available for sale by commercial vendors, sometimes offering a nearly real-time look at how a phone or vehicle moves around the world. Several government agencies, including the U.S. Department of Homeland Security, have bought access to this kind of commercial information such as the geolocation of phones without court authorization, something the FBI says it no longer does.

☆ Head of Israeli Cyber Firm NSO Group Reaffirms Company Commitment to Spyware
▼ + stars: | 2023-01-26 | by ( Byron Tau | Dustin Volz | ) www.wsj.com time to read: 1 min

WASHINGTON—Embattled Israeli technology firm NSO Group acknowledged that its clients had sometimes misused the company’s high-powered hacking tools but defended the need to give law-enforcement and intelligence agencies the ability to digitally break into and monitor smartphones. In his first media interview since taking over as chief executive in 2022, Yaron Shohat said NSO Group has lost customers since the Biden administration levied stiff measures against the company in late 2021, but has stabilized itself financially and recently attracted new deals. Mr. Shohat didn’t specify how many customers NSO Group currently has but said it was around a few dozen.

☆ California shooting victims: Who died in Monterey Park and Half Moon Bay attacks?
▼ + stars: | 2023-01-26 | by ( ) www.reuters.com time to read: +4 min

Jan 26 (Reuters) - Back-to-back mass shootings in California have claimed the lives of people who loved to dance at a studio in Monterey Park and farm workers in the coastal community of Half Moon Bay. HALF MOON BAY VICTIMSSeven people were killed and one person was in critical condition after a 66-year-old man on Monday attacked two mushroom farms near the resort town of Half Moon Bay, south of San Francisco, police said. "You look to improve your life and then you end up with this," said Juarez, quiet and sullen as he took a break from cooking at a Mexican restaurant in a Half Moon Bay strip mall. Perez was stunned when, upon arriving in Half Moon Bay in the late 1990s, he saw Martinez-Jimenez again at a party. The San Mateo County Coroner's Office declined to comment on the identities of the victims in the Half Moon Bay shooting.

Four people were arrested in connection with the alleged rape of Madison Brooks, a Louisiana State University student who was fatally hit by a car shortly after the suspects dropped her off in an East Baton Rouge subdivision. Lee is Washington's uncle, the East Baton Rouge Parish Sheriff's Office said. Carver told investigators that he, his friends and Lee did not know Brooks prior to meeting her at Reggie's, the report said. When they were about to leave, Brooks asked for a ride home, Carver told detectives. He told CBS affiliate WAFB of Baton Rouge that a rape did not occur.

☆ Trump Hit With $1 Million Fine for Lawsuit Deemed Frivolous
▼ + stars: | 2023-01-20 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

WASHINGTON—A federal judge in Florida levied a nearly $1 million fine this week on former President Donald Trump and his attorney, Alina Habba, over their filing of what he called a frivolous lawsuit alleging a political conspiracy during the 2016 election. “This case should never have been brought,” U.S. District Judge Donald M. Middlebrooks wrote in a scathing 46-page order imposing sanctions against the former president and his legal team. He called Mr. Trump “a prolific and sophisticated litigant who is repeatedly using the courts to seek revenge on political adversaries” and declared the former president jointly liable with his lawyer for paying the fine.

☆ Little-Known Surveillance Program Captures Money Transfers Between U.S. and More Than 20 Countries
▼ + stars: | 2023-01-18 | by ( Dustin Volz | Byron Tau | ) www.wsj.com time to read: +1 min

WASHINGTON—Hundreds of federal, state and local U.S. law-enforcement agencies have access without court oversight to a database of more than 150 million money transfers between people in the U.S. and in more than 20 countries, according to internal program documents and an investigation by Sen. Ron Wyden . The database, housed at a little-known nonprofit called the Transaction Record Analysis Center, or TRAC, was set up by the Arizona state attorney general’s office in 2014 as part of a settlement reached with Western Union to combat cross-border trafficking of drugs and people from Mexico. It has since expanded to allow officials of more than 600 law-enforcement entities—from federal agencies such as the Federal Bureau of Investigation, the Drug Enforcement Administration, and Immigration and Customs Enforcement to small-town police departments in nearly every state—to monitor the flow of funds through money services between the U.S. and countries around the world.

☆ Here's where to look for the next developments in the fight against Alzheimer's disease
▼ + stars: | 2023-01-17 | by ( Christina Cheddar Berk | ) www.cnbc.com time to read: +10 min

The Centers for Disease Control and Prevention estimates 5.8 million Americans were living with the disease in 2020 . BIIB 6M mountain Biogen's stock is trading well above its lows Leqembi treats Alzheimer's disease by targeting amyloid-beta plaques in the brain. Attention shifts to Eli Lilly Shares of other Alzheimer's drug developers have often mirrored Biogen's moves. Small drug developers Smaller Alzheimer's drug developers have also been boosted by research developments. Still in an early stage of its research, Prothena has traded as a proxy for developments in Alzheimer's treatment.

☆ George Santos Raised Money for Company the SEC Says Was a Ponzi Scheme
▼ + stars: | 2023-01-14 | by ( Byron Tau | ) www.wsj.com time to read: +1 min

George Santos was hired in 2020 by Harbor City Capital, where his job was to bring in investors for the company’s financial offering, according to people familiar with the matter. WASHINGTON—Embattled Rep. George Santos persuaded at least one person to make a six-figure investment in a Florida-based company that the U.S. Securities and Exchange Commission later said was a Ponzi scheme, according to people familiar with the matter and documents viewed by The Wall Street Journal. Mr. Santos was hired in 2020 to raise capital for the company, Harbor City Capital , and landed at least one significant investment from a wealthy investor, the people said. When the investment failed to deliver on the promised returns, according to one of the people, Mr. Santos sought to reassure the investor by saying he had personally raised nearly $100 million and had invested his own family’s money in Harbor City.

☆ Eli Lilly has spent years and billions of dollars in search of an effective Alzheimer's drug. But success is not all or nothing for the stock
▼ + stars: | 2023-01-09 | by ( Kevin Stankiewicz | ) www.cnbc.com time to read: +22 min

Eli Lilly (LLY) has spent decades researching Alzheimer's disease without successfully bringing to market a treatment that slows the memory-destroying condition. For Eli Lilly as a company, an Alzheimer's drug is an important pursuit. Lilly's Alzheimer's history Eli Lilly's "first real foray" into Alzheimer's came in the 1990s, according to Dr. John Sims, Eli Lilly's head of medical development for donanemab. Financial implications for Lilly LLY mountain 2021-10-08 The Club started a new position in Eli Lilly (LLY) in October 2021. The Eli Lilly logo is shown on one of the company's offices in San Diego, California, September 17, 2020.

Congressman-elect George Santos of New York, looking to the side, attended the opening session of the 118th Congress in the U.S. Capitol on Tuesday. Embattled Rep.-elect George Santos (R, N.Y.) spent his first day in Congress dodging reporters and voting in the contentious race for speaker, while Brazilian authorities said they intended to reopen a criminal investigation into allegations that he committed check fraud there in 2008. Mr. Santos, a 34-year-old who won a narrow victory for Republicans in a district of Long Island usually dominated by the Democrats, has faced scrutiny in recent weeks after admitting that he had lied to voters about his work and education history.

The Securities and Exchange Commission, based in Washington, told Arqit Quantum that its action was ‘a fact-finding inquiry,’ the U.K. company said. British cybersecurity company Arqit Quantum Inc. is facing an investigation from the U.S. Securities and Exchange Commission over its merger with a special-purpose acquisition company last year, the company disclosed Wednesday. Arqit saw its market value rise from $1.4 billion to over $4.5 billion soon after it completed the SPAC merger—a form of public listing—in September 2021 as investors embraced the company and its projections of surging revenue and profits in the emerging sectors of digital security and advanced cryptography. Its shares have since fallen significantly amid a broad investor retreat from SPACs and young high-growth companies.

☆ Justice Department Subpoenas State Officials on 2020 Election Communications With Trump
▼ + stars: | 2022-12-06 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

WASHINGTON—Local officials in three critical battleground states said they have received subpoenas from the Justice Department that appear to be part of an expanding investigation into efforts by former President Donald Trump and people representing him to reverse the outcome of the 2020 presidential election. Four counties in Michigan, Arizona and Wisconsin received federal grand jury subpoenas, officials there said. The counties—Maricopa in Arizona, Wayne in Michigan and Dane and Milwaukee in Wisconsin—are all in swing states targeted by Mr. Trump and his allies in the aftermath of his loss in the November 2020 election.

☆ What increasing confidence in Biogen's latest Alzheimer's drug means for Eli Lilly
▼ + stars: | 2022-11-30 | by ( ) www.cnbc.com time to read: +6 min

Donanemab is the name of Eli Lilly's Alzheimer's drug in its own late-stage trials. JPMorgan has a neutral (hold) rating on Biogen shares and an overweight (buy) rating on Eli Lilly shares. What it means for Eli Lilly Eli Lilly has a phase three trial underway for its donanemab Alzheimer's drug that is similar to lecanemab, which is why the Biogen-Eisai data has been interpreted as favorable for the Club holding. Clumps of the protein, known as amyloid plaques, are one of the key markers of Alzheimer's disease. Previous drugs developed around the a-beta hypothesis — including those from Eli Lilly — have failed to meaningfully delay the disease's progression.

☆ Oath Keepers Founder Stewart Rhodes Found Guilty of Seditious Conspiracy in Jan. 6 Case
▼ + stars: | 2022-11-29 | by ( Jan Wolfe | Byron Tau | ) www.wsj.com time to read: 1 min

WASHINGTON—A jury on Tuesday found two members of the Oath Keepers militia group guilty of seditious conspiracy by plotting to forcefully disrupt the peaceful transfer of power after the 2020 election, and convicted three others on lesser charges in the closely watched trial stemming from the Jan. 6, 2021, assault on the U.S. Capitol. After a seven-week trial in Washington and three days of deliberations, the jury said Oath Keepers founder Stewart Rhodes and one of his co-defendants, Kelly Meggs, plotted to use force to block Congress from formally certifying President Biden‘s election victory.

☆ Rare success for Alzheimer's research unlocks hope for future therapies
▼ + stars: | 2022-11-29 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +6 min

Eisai and Biogen are scheduled to present full data from their lecanemab study on Tuesday at the Clinical Trials on Alzheimer's Disease conference in San Francisco. Lecanemab’s success rests on years of research into the causes of Alzheimer’s as well as advances in measuring amyloid deposits through brain scans and spinal fluids. At least 16 treatments are being tested in clinical trials, with results expected over the next three years, according to a Reuters review of the clinicaltrials.gov registry. The drugmaker has been largely absent from the Alzheimer's space after the high-profile failure of its drug verubecestat five years ago. But several antibody therapies from Lilly, Biogen and AbbVie(ABBV.N) that were designed to slow the rate of tau accumulations failed outright last year.

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