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☆ Troubled health name bounces after strong quarter and guidance. Here's our view on the stock
▼ + stars: | 2023-08-03 | by ( Zev Fima | ) www.cnbc.com time to read: +6 min

Another possible catalyst is the monetization of BHC's Bausch + Lomb (BLCO) stake. Bausch + Lomb update On the earnings release, management highlighted a change in thinking about how to handle their stake in Bausch + Lomb. We'll be on the lookout for more information on the Bausch + Lomb situation in the coming days. Guidance BHC management raised their full-year revenue guidance for 2023 while reaffirming their adjusted EBITDA outlook. Excluding Bausch + Lomb, the team now expects full-year revenue to be in the range of $4.5 billion to $4.65 billion.

Persons: it's, Refinitiv, BHC's Bausch, Bausch, We'll, Generics, Jim Cramer's, Jim Cramer, Jim, Rafael Henrique Organizations: Health, Bausch Health, Management, Bausch Health Companies, BHC's, Dentistry, CNBC Locations: BHC, Bausch, East, Africa, Canada, Asia, China

☆ Quest Diagnostics launches Alzheimer's blood test for consumers
▼ + stars: | 2023-07-31 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +2 min

CHICAGO, July 31 (Reuters) - Quest Diagnostics (DGX.N) on Monday launched the first direct-to-consumer blood test to detect abnormal levels of beta amyloid, a key Alzheimer's protein which can appear years before dementia symptoms arise. The $399 test, called AD-Detect, uses the same technology as a blood test the company launched for use by doctors in early 2022. Users must first pay for the test on Quest's website. Quest will then arrange for an appointment with a telemedicine doctor to order it on their behalf. Quest's lab-developed test, created and performed in a single laboratory, has not undergone any FDA review.

Persons: Michael Racke, Biogen, Eli Lilly, Racke, Julie Steenhuysen, Richard Chang Organizations: Quest Diagnostics, Monday, U.S . Food, Drug Administration, Thomson Locations: Eisai, Alzheimer's

☆ Insight: Promising new Alzheimer's drugs may benefit whites more than Blacks
▼ + stars: | 2023-07-31 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +11 min

The company told Reuters that 49% of Black volunteers did not meet the trial's amyloid threshold requirements compared to 22% for whites and 55% for Hispanics. "Is it because MCI (mild cognitive impairment) or early dementia type-symptoms in Blacks are caused by other reasons more so than Alzheimer's?" In 96 dementia trials from 2000-2017, diverse populations only made up around 11% of enrollment, according to a 2018 study. Among Black people who died of Alzheimer's, their dementia was more likely to result from multiple causes, such as vascular disease. "Is it that it's not Alzheimer's disease?

Persons: Barrington, Vickie Riley, Charlie, Harriet Shaffer, Barrington Riley, –, Eli Lilly, Lilly, Crystal Glover, Eisai, Ivan Cheung, Cheung, Shobha, Biogen, Mark Mintun, Alzheimer's, Dr Lisa Barnes, Barnes, Joshua Grill, we're, Reisa Sperling, Brigham, Julie Steenhuysen, Caroline Humer, Suzanne Goldenberg, Daniel Flynn Organizations: Emory University Brain Health, Americans, Reuters, Prospective Black, Rush, Disease Research, and Drug Administration, FDA, Black, MCI, National Institutes of Health, Rush Center, University of California, Women's Hospital, Thomson Locations: Atlanta , Georgia, U.S, Chicago, Tokyo, Irvine, United States

☆ Adults with depression are at a greater risk of developing dementia, study shows
▼ + stars: | 2023-07-24 | by ( Madeline Holcombe | ) edition.cnn.com time to read: +4 min

A diagnosis of depression in adulthood could more than double your risk of developing dementia in older age, according to a new study. But the latest study shows a connection between dementia risk and depression diagnoses in early and mid-life as well. “Our results therefore provide strong evidence that depression is not only an early symptom of dementia, but also that depression increases dementia risk,” she said. “For example, there may be shared common risk factors for depression and dementia that occur earlier in the lifecourse, depression may increase dementia risk through alterations in levels of key neurotransmitters, or depression may lead to changes in health behaviors that in turn increase risk for dementia,” she added in an email. Regardless of dementia risk, treating depression should be a priority, Elser agreed.

Persons: Holly Elser, Natalie Marchant, Marchant, Elser, ”, ” Elser, ” Marchant Organizations: CNN, University of Pennsylvania, University College London

☆ New studies shed light on how genes might shape a person’s experience with Covid-19
▼ + stars: | 2023-07-19 | by ( Brenda Goodman | ) edition.cnn.com time to read: +7 min

New research is exploring another dimension to the puzzle of how people experience this infection: genes. Hollenbach says it’s the job of HLA molecules to present pieces of proteins to the immune system so they can be recognized if they’re ever encountered again. The researchers then took a closer look at this group to see if there were any similarities in the genes that coded for their HLA molecules, and there were. So folks with these HLA molecules likely already had some preexisting immunity against SARS-CoV2 and were able to clear the virus before it caused symptoms, Hollenbach said. Genes, Zeberg said, are likely only one part of reason why someone develops long Covid, and there are probably a slew of genes involved.

Persons: Covid, ”, Jill Hollenbach, Hollenbach, they’re, “, ” Hollenbach, they’d, it’s, Gene, Dr, Sanjay Gupta, Hugo Zeberg, Zeberg Organizations: CNN, University of California, San Francisco’s Weill, for Neurosciences, Karolinska Institute, Get CNN, CNN Health, Karolinska . Genes Locations: San, Stockholm, FOXP4

☆ Second Alzheimer’s drug to slow disease’s progression may be approved in the US this year
▼ + stars: | 2023-07-17 | by ( Meg Tirrell | ) edition.cnn.com time to read: +12 min

It was shown in May and in fuller Phase 3 clinical trial results released at the Alzheimer’s Association International Conference on Monday to delay the disease’s progression. More than 6 million Americans are estimated to have Alzheimer’s disease, with about 1 million estimated to be in the early symptomatic stages where these drugs have shown benefit. Both Leqembi and donanemab work by clearing buildups of a protein in the brain called amyloid, a hallmark of Alzheimer’s. It’s been a hypothesis that treating Alzheimer’s earlier with amyloid-clearing drugs would yield better results; Skovronsky said the donanemab trial bore that out. “We could look at people who had mild cognitive impairment, MCI, which is the earliest stage, versus mild Alzheimer’s versus moderate Alzheimer’s,” Skovronsky explained.

Persons: Leqembi, Eli Lilly’s donanemab, Lilly, “ Donanemab, Jennifer Manly, Kacie, ”, Dr, Gil Rabinovici, Renaud La Joie, Daniel Skovronsky, “, Skovronsky, ” Skovronsky, It’s, Eric Widera, Sharon Brangman, University of Wisconsin’s Dr, Nathaniel Chin, Donanemab, Lilly hasn’t, Lawrence Honig, Honig, White, Sanjay Gupta, Deters, ” Lilly, it’s “, it’s, there’s, Joe Montminy Organizations: CNN, Alzheimer’s Association, Food and Drug Administration, American Medical Association, Columbia University Irving Medical Center, University of California, MCI, SUNY, University of Wisconsin’s, Leqembi, FDA, donanemab, CNN Health, ” Manly Locations: Los Angeles, “

☆ Lilly drug slows Alzheimer's by 60% for mildly impaired patients in trial
▼ + stars: | 2023-07-17 | by ( Deena Beasley | ) www.reuters.com time to read: +5 min

Lilly expects the U.S. Food and Drug Administration to decide by the end of this year whether to approve donanemab. The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. The deaths of three trial patients were linked to the treatment, researchers reported. For high tau patients, donanemab was shown to slow disease progression by about 17%, while the benefit was 35% for those with low-to-intermediate tau levels. Both medications are also being studied in large trials to see if they have an impact on delaying onset of Alzheimer's disease symptoms.

Persons: Seth Gale, Brian Snyder, Eli Lilly, Anne White, Lilly, Susan Kohlhaas, Liana Apostolova, White, Liz Coulthard, donanemab, Deena Beasley, Ludwig Burger, Will Dunham, Bill Berkrot, Caroline Humer Organizations: Alzheimer Research, Brigham, Women’s, REUTERS, Alzheimer's Association International, U.S . Food, Drug Administration, Alzheimer’s Research, Indiana University School of Medicine, Doctors, University of Bristol, JAMA, FDA, Alzheimer's Association, Health Organization, New York Stock Exchange, Thomson Locations: Boston , Massachusetts, U.S, Amsterdam, Eisai

☆ Jury in Pittsburgh Synagogue Trial Finds Gunman’s Crimes Eligible for Death Penalty
▼ + stars: | 2023-07-13 | by ( Jon Moss | Campbell Robertson | ) www.nytimes.com time to read: +1 min

Mr. Bowers was found guilty on 63 counts, including hate crimes that carry a maximum sentence of death. The central question facing jurors over the last two and a half weeks was whether Mr. Bowers intended to kill his victims — one of the factors necessary for a death sentence. “The issue in this case is, what happens when your brain is broken?” said Michael Burt, a defense attorney, in his closing argument. “What happens when you don’t have the ability to know what is truth and what is not truth?”thanks. Defense witnesses who had examined Mr. Bowers said he had schizophrenia and other serious mental disorders.

Persons: Dor Hadash —, Joyce Fienberg, Richard Gottfried, Rose Mallinger, Daniel Stein, Melvin Wax, Irving Younger, Jerry Rabinowitz, Bernice, Sylvan Simon, Cecil, David Rosenthal, Bowers, ”, Michael Burt

CNN —The US Food and Drug Administration is expected to decide on Thursday whether to grant traditional approval to the Alzheimer’s drug Leqembi, the first medicine proven to slow the course of the memory-robbing disease. Leqembi, from drugmakers Eisai and Biogen, received accelerated approval in January based on evidence that it clears amyloid plaque buildups in the brain that are associated with Alzheimer’s disease. But because of an earlier coverage decision by CMS, which provides insurance coverage for many elderly patients with Alzheimer’s through Medicare, the drug hasn’t been widely used. People with more advanced forms of the disease may not benefit from the drug, he said, and may face increased safety risks. Broad Medicare coverage of Leqembi and similar types of medications to slow the progression of Alzheimer’s disease would probably have a big impact on the program’s spending.

Persons: drugmakers, hasn’t, “, ’ ”, Joe Montminy, Lawrence Honig, “ It’s, ”, Honig, it’s, Leqembi, ” Honig, Georges Naasan, Sue Rottura, ” Drugmaker Eisai, “ You’re, Ivan Cheung, Eisai, ” Montminy, Dr, Sanjay Gupta Organizations: CNN, Food and Drug Administration, Medicare, Services, CMS, Columbia University Irving Medical Center, Alzheimer’s, Behavioral, CNN Health, Kaiser Family Foundation Locations: Mount, Florida

☆ Fluctuating cholesterol linked with Alzheimer’s, study finds
▼ + stars: | 2023-07-05 | by ( Kristen Rogers | ) edition.cnn.com time to read: +6 min

In addition to total cholesterol, the study tracked triglycerides, a type of fat that comes from butter and oils; low-density lipoprotein cholesterol, also known as LDL or “bad” cholesterol; and high-density lipoprotein cholesterol, known as HDL or ‘good’ cholesterol. In the Neurology study, variations in LDL and HDL cholesterol weren’t associated with higher risk for Alzheimer’s disease or related dementias. Lipids and neurodegenerative diseaseThe authors found a link, but not a causal relationship, between fluctuating levels of cholesterol and triglycerides and risk of Alzheimer’s disease and related dementias. Exactly how varying lipid levels and risk for Alzheimer’s or related dementias are related remains unclear, Bielinski said. “Always consult your doctor or healthcare provider if you are concerned about your cardiovascular health, cholesterol levels, or cognitive decline,” Weber said via email.

Persons: ”, Christopher Weber, Suzette J, Bielinski, hadn’t, ” Bielinski, ” Weber, “, Weber Organizations: CNN, Alzheimer’s Association, Mayo Clinic, Neurology Locations: Minnesota

☆ Nike CEO John Donahoe on how he manages sleep health in a hectic life
▼ + stars: | 2023-06-30 | by ( Emily Grill | ) www.cnbc.com time to read: +6 min

Donahoe can't get seven hours of sleep every night, but he said that he tries to hit 70 hours of sleep every 10 days. Hitting this target, rather than exactly how much sleep he gets per night, is a sleep science workaround that the Nike CEO says has been working for him. Sleep science research has consistently shown that the average adult should aim for seven hours of a sleep each night. It's not necessarily always going to be the recommended seven hours of sleep that will ensure a good night's rest, according to sleep experts. In the long term, if you don't get enough sleep, there's health outcomes that can occur."

Persons: I've, Elon Musk, CNBC's David Faber, Bill Gates, John Donahoe, Donahoe, It's, Mark Wu, Wu, Gates, Jagdish Khubchandani, Khubchandani Organizations: Nike, CNBC, Summit, Apple Watch, Google, Johns Hopkins University, National Institute for Occupational Safety, Health, United, Blood Institute, Ball State University, New Mexico State University, Ball Locations: America, U.S, China, Santa Barbara , California, United States

☆ This fitness company wants to pay you $10,000 to walk 10,000 steps in a single day—here's how it works
▼ + stars: | 2023-06-22 | by ( Renée Onque | ) www.cnbc.com time to read: +3 min

For the new company's first hire, GymBird is choosing one lucky person to walk 10,000 steps in one day for $10,000, according to its site. Accepting the offer requires the CSO to train for a month until they feel comfortable walking 10,000 steps in a single day. "By the last day of the month, they must walk the full 10,000 steps within a 24-hour period," GymBird wrote in its job offering. Just under 10,000 steps each day (9,800) can lower risk of dementia by 50%, according to two studies published in JAMA Neurology and JAMA Internal Medicine last year. For every 2,000 steps you walk daily, you can reduce your risk of cancer, heart disease and premature death by 10%, peaking at 10,000 steps, the research shows.

Persons: GymBird, they're, Warren Buffett Organizations: CSO, Nutrition Solutions, Newsweek, CNBC Locations: U.S

☆ Night owls may die younger, but more than sleep is to blame
▼ + stars: | 2023-06-16 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

A 2022 study found night owls were more sedentary, had lower aerobic fitness levels, and burned less fat at rest and while active than early birds. Night owls were also more likely to be insulin-resistant, meaning their muscles required more insulin to be able to get the energy they need, the study showed. Studies have revealed night owls may take more risks and are more likely to skip breakfast and eat more later in the day. Night owls also have higher levels of visceral body fat in the abdominal region, a key risk factor for type 2 diabetes and heart disease. “The strongest reset for the circadian system is bright light,” Zee said.

Persons: ”, Christer Hublin, Bhanu Prakash Kolla, ” Kolla, Phyllis Zee, Zee, ” Zee Organizations: CNN —, Finnish Institute of Occupational Health, Center for Sleep Medicine, Mayo Clinic, Center, Northwestern University Feinberg School of Medicine, CNN, Northwestern Locations: Helsinki, Rochester , Minnesota, Chicago

☆ Food addiction: What it is and how to overcome it
▼ + stars: | 2023-06-15 | by ( Kristen Rogers | ) edition.cnn.com time to read: +11 min

Known as food addiction, the condition isn’t limited to older adults — previous food addiction data had primarily centered around young- to middle-age adults up to around 50, said Ashley Gearhardt, lead author of the latest research by Michigan Medicine and a pioneer in the field of food addiction studies. But the type of treatment that would be offered for food addiction would be very different, because not everyone who reports having food addiction is binging, and the underlying neurology of food addiction and binge eating disorder aren’t the same. Food hijacking the brainThe criteria defining food addiction revolve specifically around highly processed food, instead of all food, because of how the brain responds to its consumption, experts said. Living with food addictionNot everyone who eats highly processed food develops an addictive relationship to it. “So, I don’t have science to say, ‘Here is the best treatment for this addiction,’ which is unfortunate.”Undergoing therapy can help with food addiction.

Persons: Ashley Gearhardt, Gearhardt, Kristin Kirkpatrick, wasn’t, “, ’ ”, hasn’t, she’s, they’re, ” Kirkpatrick, “ It’s, ” Avena, It’s, ”, Nicole Avena, Kirkpatrick, we’ve, ” Gearhardt, they’ll, ‘, it’s, — you’re, we’re Organizations: CNN, Michigan Medicine, Cleveland Clinic, University of Michigan, Disorders Locations: New York, Michigan

☆ Why Do Women Have More Sleep Issues Than Men?
▼ + stars: | 2023-06-13 | by ( Lisa L. Lewis | ) www.nytimes.com time to read: +1 min

And they can be caused by a range of factors, including biological, psychological and social ones, experts say. What’s behind women’s sleep issues? Then, of course, there’s the sleep disruption that comes with caring for a newborn, Dr. Harris said — which can continue long after the baby is sleeping through the night. Up to 80 percent of women start getting hot flashes in perimenopause (the four or so years leading up to menopause) and may continue to get them for as many as seven years afterward, Dr. Baker said. For about 20 percent of women, though, these hot flashes are frequent and intense enough to disrupt sleep, she said.

Persons: Baker, Shelby Harris, Harris, ” Organizations: Albert Einstein College of Medicine Locations: Bronx

All six advisers on the panel voted in favor of Leqembi for treatment of the mind-wasting illness. That approval would also make Leqembi the first disease-modifying drug ever to achieve the regulatory milestone. Leqembi won accelerated approval by the FDA in January based on its ability to remove sticky amyloid plaques from the brain. Most U.S. Alzheimer's patients are Medicare-eligible. “We are in full agreement with the FDA Advisory Committee that Leqembi provides clinical benefit and that this benefit outweighs the risks."

Persons: Eisai, Leqembi, Tanya Simuni, Robert Alexander, Joanne Pike, Leroy Leo, Khushi, Julie Steenhuysen, Bill Berkrot Organizations: Food and Drug Administration, Alzheimer's Association, FDA, Northwestern University Feinberg School of Medicine, Banner Alzheimer's Institute, CAA, Medicare, Wall Street, Analysts, Alzheimer's, Thomson Locations: Leqembi, U.S, Bengaluru, Chicago

☆ Insomnia raises stroke risk in people under 50, study says
▼ + stars: | 2023-06-07 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +5 min

Stroke risk is typically higher in older adults with more health problems, the study noted. After controlling for other factors that contribute to stroke risk, researchers found people with five to eight symptoms of insomnia had a 51% increased risk of stroke compared with people who did not have insomnia, according to a statement on the study published Wednesday in the journal Neurology. In comparison, people who had one to four symptoms had a 16% increased risk of stroke compared with people with no symptoms of insomnia, the study found. Getting more than nine hours of sleep on average was linked with a twofold increase in stroke risk. However, taking a planned nap of less than an hour was not associated with an increased stroke risk, the study said.

Persons: ”, epidemiologist Wendemi, snored, Napping, Phyllis Zee, ” Zee, Andrew Freeman Organizations: CNN, Mayo Clinic, Virginia Commonwealth University, US Centers for Disease Control, Center, Northwestern University’s Feinberg School of Medicine, Jewish Health Locations: Richmond, Chicago, Denver

☆ Sleep apnea linked to smaller brain volume, study finds
▼ + stars: | 2023-05-31 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +7 min

However, people who snore heavily or who have sleep apnea can experience hundreds of mini-arousals per night — even though they don’t realize it. The study group underwent brain scans, memory tests that were repeated at about 21 months, and an overnight sleep study done at their homes. Severe sleep apnea was associated with worrisome changes in the brains of middle-aged and older adults, a July 2018 study found. “We surmise that hypoxia may also have a deleterious effect on the volume of the regions of the medial temporal lobe. Studies such as these reinforce the need to be assessed by a sleep specialist and treated for sleep apnea.

Persons: ”, Géraldine Rauchs, ” Rauchs, “, Rudy Tanzi, ” Tanzi, Tanzi, Rauchs Organizations: CNN, National Institute of Health, Medical Research, Harvard Medical School, Massachusetts General Hospital Locations: Caen, France, Boston, Massachusetts

☆ Cognitive decline accelerates after heart attack, study finds
▼ + stars: | 2023-05-30 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +4 min

However, age-related cognitive decline is quite different from Alzheimer’s disease and other dementias and should not be confused with those, experts say. During the course of the research, however, over 1,000 of the participants had an acute myocardial infarction, or heart attack. Past studies found linkThis isn’t the first study to find a connection between accelerated cognitive decline and heart attacks, Smith and Silbert noted. As in the new study, people with heart attacks or angina (chest pain) had annual rates of cognitive decline before the attack similar to those of people who never had a heart attack, but then experienced accelerated cognitive decline, they added. Possible explanations may include depression after having a heart attack, which has been linked to dementia, they said.

Persons: What’s, Eric Smith, Lisa Silbert, Smith, ” Smith, Silbert, ” Organizations: CNN, Cognitive Neurosciences, University of Calgary, Oregon Health & Science University School of Medicine, Aging Locations: United States, Alberta, Portland, White

☆ Older dogs who sleep badly may have dementia, study says
▼ + stars: | 2023-05-17 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +11 min

During his snooze, the study team will analyze Woofus’ brain waves to judge the quality of his sleep. John Joyner/NC State Veterinary MedicineTraining the dogs to accept EEGTo find out whether sleep problems in dogs indicate early signs of dementia as they do in people, Olby and her team turned to a group of senior dogs enrolled in an ongoing study testing antiaging supplements. John Joyner/NC State Veterinary MedicineFor the new study measuring a dog’s brain waves during sleep, researchers used a form of electroencephalogram called polysomnography, used in sleep clinics to diagnose sleep problems in people. Jake, a 13-year-old pointer, was one of 28 dogs trained to sleep with EEG electrodes. When sleeping brain waves were compared with a dog’s cognitive testing, researchers found that dogs with greater dementia spent less time in deep and REM sleep, just as people do.

☆ Oppenheimer says investors are missing opportunities in three biotech areas and the related stocks
▼ + stars: | 2023-05-16 | by ( Christina Cheddar Berk | ) www.cnbc.com time to read: +4 min

As biopharma investors follow the latest buzz around advancements in clinical research, they may be under-appreciating opportunities in neurology, psychiatry and genetic medicine, according to a report from Oppenheimer. "Valuation multiples across disease areas show CNS [ or central nervous system] and Genetic Medicine at relative low points." In July, the Food and Drug Administration could grant full approval to Leqembi , its Alzheimer's Disease treatment. As a very new area of medicine, gene therapy has greatest potential to accelerate sales growth as treatments come to market. He described immunology multiples as "generally stable" and genetic medicine multiples as highly volatile.

☆ How Parents Can Actually Help Teens Navigate Social Media
▼ + stars: | 2023-05-15 | by ( Catherine Pearson | ) www.nytimes.com time to read: +2 min

Dr. Gray added that teens might push back against these types of boundaries, particularly if parents were trying to enforce them retroactively. “Even though they may still have an emotional reaction.”Help teens understand how social media affects their brains. So teens “are really acting with a very highly active social brain, which is making them very vulnerable to peer pressure” as well as to novelty seeking, she said. Dr. Jensen urged parents to talk to their kids about these brain changes and how they make them particularly vulnerable to some of the more negative effects of social media. All of the content, feedback and stimulation available online “is highly accessible to kids right when their social brain is developing,” she said, describing it as a “perfect storm.”Ask: “Do you feel like you have control over social media, or do you feel like it’s controlling you?”That question is particularly effective at gauging whether a teen’s social media use has become problematic, said Jeff Hancock, the founding director of the Stanford Social Media Lab.

☆ Contaminated water in North Carolina has been linked to a higher risk of Parkinson's in a new study of over 300,000 veterans
▼ + stars: | 2023-05-15 | by ( Chris Panella | ) www.businessinsider.com time to read: +3 min

A new study found a connection between contaminated water at a military base and Parkinson's disease. The risk of Parkinson's was 70% higher for over 300,000 veterans from Marine Corps Base Camp Lejeune. Those stationed at Camp Lejeune were there for at least three months between 1975 and 1985. Even veterans who were not diagnosed with Parkinson's disease still had "significantly higher" risk for early signs and symptoms of the illness, the researchers reported in the study. Both Veterans Affairs and the Department of Defense have previously acknowledged the exposure of trichloroethylene at Camp Lejeune.

☆ Mutation Protected Man From Alzheimer’s Disease, Hinting at Treatment
▼ + stars: | 2023-05-15 | by ( Gina Kolata | ) www.nytimes.com time to read: +1 min

Dr. Arboleda-Rodriguez is a co-founder of a biotechnology company looking to produce drugs that could act on this research. The mutation results in a potent version of a protein, Reelin, in the entorhinal cortex. That super-potent Reelin ultimately prevents tangled strands of tau proteins from sticking together and forming the structures that are a characteristic of Alzheimer's. “We don’t know what sort of damage it might do, sticking needles in and dropping in chemicals,” he said. The man with what the researchers are calling “resilience” to Alzheimer’s was part of a decades-long study of 6,000 people living in Colombia who have a gene mutation that causes Alzheimer’s in middle age.

☆ Sleep apnea, lack of deep sleep linked to damage in brain, study says
▼ + stars: | 2023-05-10 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +8 min

If the sleep apnea is severe and untreated, people have three times the risk of dying from any cause. People with severe sleep apnea who spent less time in deep, also known as slow-wave sleep, had more damage to the white matter of the brain than people who had more slow-wave sleep, according to the study. “The association with sleep apnea was only unveiled when we isolated severe cases, suggesting that mild to moderate sleep apnea may not be significantly associated with white matter changes,” he said. About 34% of the participants had mild sleep apnea, 32% had moderate and 34% had severe sleep apnea. People with sleep apnea, however, can have dozens of micro-awakenings during the night as they snore, snort or gasp for breath.

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