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Dec 5 (Reuters) - Eli Lilly (LLY.N) on Tuesday said its recently approved obesity treatment Zepbound is now available in U.S. pharmacies and could cost $550 a month for customers whose health insurance does not cover the drug, or half the list price. Wall Street analysts expect sales of Zepbound to reach about $2 billion in 2024, and for sales of Novo Nordisk's (NOVOb.CO) rival obesity drug Wegovy to hit around $7.5 billion. An Eli Lilly and Company pharmaceutical manufacturing plant is pictured at 50 ImClone Drive in Branchburg, New Jersey, March 5, 2021. When the U.S. Food and Drug Administration approved Zepbound in November, Lilly said it would launch after the U.S. Thanksgiving holiday. Lilly's obesity drug has the same active ingredient, tirzepatide, as its previously approved diabetes drug Mounjaro, which has been used off-label for weight loss since its 2022 launch.
Persons: Eli Lilly, Wegovy, danuglipron, Zepbound, Lilly, Mike Segar, Eli Lilly's, Patrick Wingrove, Manas Mishra, Khushi, Arun Koyyur, Alexander Smith, Bill Berkrot Organizations: Wall Street, Novo, Pfizer, Company, REUTERS, CVS, U.S . Food, Drug Administration, U.S, Thomson Locations: U.S, Branchburg , New Jersey, Indianapolis, New York, Bengaluru
Indeed, studies show that drinking alcohol is less in vogue with younger millennials and Gen Z. Mounting concern around weight loss drugs GLP-1 drugs, which mimic the action of the glucagon-like peptide-1 hormone and stimulate insulin secretion after a meal, lower blood sugar and send feeling of fullness to the brain. What's more, GLP-1 drugs are an overwhelmingly American topic, with most Europeans unaware of them or unwilling to pay high prices. In total, GLP-1 users are only a very small slice of total alcohol consumers, said Spiros Malandrakis, lead alcohol industry researcher at Euromonitor International. The most vulnerable purveyors are those that are trailing the shift in consumption, notably domestic, non-premium beer brands.
Persons: Katie Pell, Pell, wasn't, millennials, Eli Lilly's Mounjaro, Goldman Sachs, Jason English, Nadine Sarwat, Bernstein, Sarwat, Spiros Malandrakis, , BUD YTD, who'd, Mickey Velado, Brian Sudano, Nell Healy, Healy, she's, Malandrakis, Ryan Brigden, Brigden, Sudano, Joseph Gabelli, Gabelli, Z, there's, it's, Garrett Nelson, They've, seltzer, Nelson, Molson Coors, Bud, he's Organizations: Gallup, Drugs, Nordisk's Ozempic, JPMorgan, CNBC, Euromonitor, Anheuser, Busch Inbev, Beverage Marketing, Constellation, Guinness, Corona, Heineken, Athletic Brewing Company, Heineken Holding, Carlsberg, Constellation Brands, Malandrakis, Beverage, Gabelli, Diageo, Molson Coors, Busch InBev, Molson, Anheuser Busch Locations: Brooklyn, U.S, GLP, imbibing, Angeles, Colorado, Washington, California, North Carolina, San Francisco Bay, Europe, British, Brazil, India
I spent Thanksgiving on a, eight-day Carnival Cruise with my husband and 12 of our friends. We booked an eight-day Carnival Cruise over the Thanksgiving holiday to celebrate our friends Tai and Darien's wedding anniversary. My husband and I spent about $3,800 to book the tripThe cruise cost $2,050 for the two of us. AdvertisementThe ship didn't satisfy our Thanksgiving cravings, but we still had nice mealsThe ship's Thanksgiving dinner, unfortunately, didn't tickle our fancy. But it felt good to lay in bed on the cruise and watch films I hadn't seen in years.
Persons: , Tai, fanny, Katrina Wilson, à, Stevie Wonder, we're, Lawrence, Whitney, I'd Organizations: Service, gratuities Locations: Florida, formalwear
Ozempic, Wegovy, Mounjaro: Diet drugs have taken over AmericaAlthough these types of drugs were originally meant to treat Type 2 diabetes, they are now widely used for weight loss. Thousands of Americans inject them weekly to cut pounds—and are seeing success. Researchers are finding that this class of drugs is changing the world’s understanding of obesity. Their popularity has led to shortages, leaving some patients unable to consistently take them, which has led to the return of cravings and pounds, doctors say. And some patients are relying too much on the drugs without eating the right foods and exercising.
Locations: America
These forms of deep brain stimulation require a surgical procedure during which electrodes — which generate electrical impulses to control any abnormal brain activity — are implanted into certain areas of the brain. With enough advancement in the field, doctors expect brain stimulation techniques for both severe disorders and health-and-wellness purposes will ultimately become noninvasive. Three major players There are only three companies with FDA-approved deep brain stimulation, or DBS, treatments: Medtronic , Abbott Laboratories and Boston Scientific . The spinal cord stimulation, or SCS, business is a hotbed of innovation right now, deep brain stimulation also is a key area." There is still plenty of doubt, however, about the efficacy of at-home brain stimulation devices, which offer a less direct approach to brain stimulation and don't always require FDA oversight.
Persons: , Bernstein, Lee Hambright, Hambright, Ali Rezai, Medtronic, Abbott, Rezai, Morningstar, Debbie Wang, Wang, Elon Musk, it's Elon Musk's, Casey Halpern, it's, Halpern, Taiwan's Organizations: Drug Administration, FDA, Abbott Laboratories, Boston, Rockefeller Neuroscience, West Virginia University, American Neuromodulation Society, Boston Scientific, DBS, FactSet, Neuroscience, BCI, University of Pennsylvania, TMS Locations: neuromodulation
Will gym stocks be hurt by an "Ozempic effect" similar to the blow that has rocked the medical device and food sector? Stock in Planet Fitness has slipped more than 16% from the start of the year, while Life Time has added roughly 20%. Planet Fitness sunk to a 52-week low in September after the company's board ousted Chris Rondeau as chief executive officer . PLNT YTD mountain Planet Fitness stock. At Life Time, anti-obesity medication is being incorporated into the weight loss programs it offers to members.
Persons: Simeon Siegel, it's, Jefferies, Chris Rondeau, Bahram Akradi, Warren Cheng, PLNT, Cheng, Jeff Zwiefel, Alexander Perry's, Perry, Curtis Harman, Harman, It's, Piper Sandler, Korinne Wolfmeyer, Wolfmeyer Organizations: BMO Capital Markets, ISI, Bank of America, GLP, Wellness, CNBC, Holdings, Nordisk's Ozempic
Kalamazoo, a small city in Western Michigan, is a way station along the drug trafficking corridor between Chicago and Detroit. In its parks, under railroad overpasses and here in the woods, people ensnared by drugs scramble to survive. Dr. Helmstetter, who makes weekly primary care rounds with a program called Street Medicine Kalamazoo, carried medications to reverse overdoses, blunt cravings and ease withdrawal-induced nausea. Rachel, 35, her hair dyed a silvery lavender, ran to greet Dr. Helmstetter. She takes the medicine buprenorphine, which acts to dull her body’s yearning for opioids, but she was not ready to let go of meth.
Persons: Nic Helmstetter, Helmstetter, Rachel Organizations: Medicine Locations: Kalamazoo, Western Michigan, Chicago, Detroit, Medicine Kalamazoo
CNN —Cutting 1 teaspoon of salt from your diet each day can lower your top blood pressure reading just as much as a typical hypertension medication, even if you don’t have high blood pressure, a new study found. Wirestock/iStockphoto/Getty ImagesNearly half of all Americans live with high blood pressure, according to the American Heart Association. Compared to the high-sodium diet, blood pressure on the extremely low-salt diet dropped 8 millimeters of mercury. “Compared to their normal diet, people reduced their blood pressure by about 6 millimeters of mercury, about the same effect you’d see for a first-line blood pressure medication,” Allen said. “Taste bud adjustment takes a little bit longer, but the blood pressure improvements are pretty quick,” she added.
Persons: , Norrina Allen, ” Allen, Andrew Freeman, Freeman, bouillon, , Allen, ” Freeman, Dietitians Organizations: CNN, American Heart Association, Northwestern University’s Feinberg School of Medicine, World Health Organization, Jewish Health, National Library of Medicine Locations: Denver
The author (R) and CNBC Make It senior editor Vanna Le making towers out of Diet Coke bottles and cans in 2018. For decades, drinking a Diet Coke every day gave me a burst of caffeine and satisfaction. I decided to make three changes at once: walk more, tweet less and, after 25 years, put down the Diet Coke. Don't miss: A Harvard nutritionist eats these 10 foods to 'fuel' her brain and 'stay sharp' A year later, I was three for three. I knew Diet Coke wasn't exactly barley tea or a turmeric latte.
Persons: Vanna Le, Coke, Wasn't, hadn't, Michiko Tomioka, Uma Naidoo, Harvard Medical School —, Naidoo, Uma Organizations: CNBC, Harvard Medical School, Cola Company, Harvard Medical Locations: Harvard
The Surprising Way to Eat Less Sugar This Holiday Season
  + stars: | 2023-11-07 | by ( Alina Dizik | ) www.wsj.com   time to read: 1 min
What if the best way to curb sugar cravings is just to eat as much as you want? That is the core of an idea gaining traction among dietitians, who say that letting ourselves graze unfettered on a cache of Halloween fun-size Snickers can reduce our sugar lust in the long run.
Trick Yourself Into Eating Less Sugar
  + stars: | 2023-11-07 | by ( Alina Dizik | ) www.wsj.com   time to read: 1 min
What if the best way to curb sugar cravings is just to eat as much as you want? That is the core of an idea gaining traction among dietitians, who say that letting ourselves graze unfettered on a cache of Halloween fun-size Snickers can reduce our sugar lust in the long run.
CNN —Older adults who don’t smoke tobacco but do use marijuana were at higher risk of both heart attack and stroke when hospitalized, while people who use marijuana daily were 34% more likely to develop heart failure, according to two new non-published studies presented Monday at the American Heart Association Scientific Sessions in Philadelphia. “You need to treat this just like you would any other risk factor (for heart disease and stroke), and honestly understand the risks that you were taking,” he said. Heart failure doesn’t mean the heart has stopped working, but that the heart isn’t pumping oxygenated blood as well as it should, according to the AHA. At the end of the study, researchers found people who reported daily marijuana use had a 34% increased risk of developing heart failure, compared to those who reported never using marijuana. Also called atherosclerosis, CAD is the most common type of heart disease, according to the US Centers for Disease Control and Prevention.
Persons: ” Robert Page II, , Westend61, Avilash, ” Page, it’s, Yakubu Bene, Alhasan Organizations: CNN, American Heart Association Scientific Sessions, Heart, Cannabis, Cardiovascular Health, University of Colorado Skaggs School of Pharmacy, Pharmaceutical Sciences, National Institute on Drug Abuse, Nazareth Hospital, AHA, US Centers for Disease Control, Health Locations: Philadelphia, Aurora , Colorado, Baltimore
Why it can be so hard to stay sober
  + stars: | 2023-11-02 | by ( Madeline Holcombe | ) edition.cnn.com   time to read: +8 min
To understand why the problem is so widespread, people must recognize the complexities around not just getting sober — but staying sober, Kelly said. Those predispositions can combine with a history of trauma or developmental experiences to make someone much more likely to develop an addiction, Kelly added. For some people, mental illnesses such as depression or anxiety occur alongside but independent of their addiction, Kelly said. “It does not mean that this individual is never going to be able to achieve recovery,” Dick said. “The devious nature of drugs means that when an individual has been using heavily, it also changes their brain and that makes it harder to maintain recovery,” Dick said.
Persons: Matthew Perry, , “ I’ve, ” Perry, ‘ Will, ’ ”, Danielle Dick, Dr, John F, Kelly, , , , ” Dick, Dick, ” Kelly, , they’ve, Dick said, you’ve, Don’t, Nancy Diazgranados, relapses, ” Diazgranados, Matt Organizations: CNN, Hollywood, Rutgers Addiction Research, Harvard Medical, Hospital Recovery Research, US Centers for Disease Control, Addiction, CDC, National Institute on Drug, National Institute, Alcohol Locations: Piscataway , New Jersey, Massachusetts, United States
[1/3] People are served in a Chipotle outlet in Manhattan, New York City, U.S., February 7, 2022. Chipotle said it has not seen any material impact from weight-loss drugs. While consumers taking weight-loss treatments consume fewer calories, "it's important the calories they do consume are coming from clean food. Chipotle forecast fourth-quarter comparable sales growth in the mid- to high-single-digit range, compared with estimates of a 5.38% rise. Reporting by Deborah Sophia in Bengaluru; Editing by Krishna Chandra Eluri and Devika SyamnathOur Standards: The Thomson Reuters Trust Principles.
Persons: Andrew Kelly, Brian Niccol, Chipotle, Sante Faustini III, we're, Niccol, Deborah Sophia, Krishna Chandra Eluri Organizations: REUTERS, Thomson Locations: Manhattan , New York City, U.S, California, Bengaluru
If this story were a TikTok video, the writer would be applying lip gloss right about … now. Unscrewing the cap on a tube of mauve goo and giving it a generous swipe across puckered lips. And once you see it, you won’t be able to unsee it. A clip of the “Laguna Beach” star Kristin Cavallari sitting in her car lip-syncing. A nutritionist offering tips on how to curb your cravings.
Persons: won’t, Kristin Cavallari Locations: Erewhon, Los Angeles
The use of Eli Lilly 's Mounjaro for weight loss can pull shoppers away from the snack aisle — though the transition will likely be gradual, according to Morgan Stanley. Kaufman noted a six-week study presented at ObesityWeek that showed users of Mounjaro cut calories and weight at a faster clip. The study also produced evidence that medication takers had a "significant reduction in food consumption," as well as fewer cravings for sweets and fast food fats. And while taking Mounjaro reduced food cravings overall, it had a particular impact on sweets, the study found. All four of the snack makers Kaufman said to watch have lost share value in 2023.
Persons: Eli Lilly, Morgan Stanley, Mounjaro, Pamela Kaufman, Kaufman, Hershey, Campbell, — CNBC's Michael Bloom Organizations: Drug Administration, Hershey, Brand Locations: Mondelez
One of the downsides of taking new anti-obesity medications is that patients tend to lose lean muscle mass along with body fat. "This is a major shortcoming in terms of not just quality of life for the patients who have to lose lean muscle mass, but there's actually room to improve on the weight loss and there [are] other metabolic benefits to improving your lean muscle mass ... [including] you might have better durability of weight loss." The drug is being tested in a phase 2b study alongside semaglutide to protect against loss of muscle mass. Until then, patients will need to watch what they eat and focus on exercise just as they would on any other weight loss regimen. When that occurs, muscle loss will be an even bigger issue than it is now.
Persons: Piper Sandler, Allison Bratzel, there's, Bratzel, Versanis, Eli Lilly, Eli Lilly's Mounjaro, they're, Lydia Alexander, Alexander, Sandler's Bratzel, incretins, Biohaven, Nestle, Ulf Mark Schneider, Jeff Jonas, Jonas, Stephens, Jim Salera, Atkins, Morgan Stanley, — CNBC's Michael Bloom Organizations: Wall, Nordisk's Ozempic, Obesity Medicine Association, Bristol Myers Squibb, Nestle, Gabelli, Quest, Foods Locations: Swiss
Minneapolis CNN —Ballpark attendance boomed this summer, Barbenheimer revived the box office and a Renaissance of live performances brought concerts into new Eras. However, it also could mean that holiday spending just might look a little different and skewed more toward experiences than it has done in past years. Respondents to KPMG’s 2023 holiday survey said they plan to spend 5% more this season, said Matt Kramer, KPMG’s consumer and retail national sector leader. “What stands out the most is this ‘leaning in’ to holiday travel and wanting to have those experiences with friends and family,” he said. A more comprehensive look at consumer spending will come at the tail end of the month when the Personal Consumption Expenditures data is released.
Persons: Barbenheimer, Everybody, , Keith Gentili, ” Taylor Swift, Allen J, , Ted Rossman, that’s, ’ ”, aren’t, Matt Kramer, Tamara Charm, Elijah Nouvelage, Patrick T, Fallon, Gus Faucher, Nathan Howard, Nancy Vanden Houten, , ” Rossman, Matt Schulz Organizations: Minneapolis CNN —, New Hampshire, Los Angeles Times, Getty, Bankrate, McKinsey, Travelers, Hartsfield, Jackson Atlanta International Airport, Bloomberg, Commerce, Apple, PNC Financial Services, Shoppers, canaries, LendingTree Locations: Minneapolis, New, Inglewood , California, splurge, , Los Angeles, AFP, Georgetown, Washington, what’s, Oxford
She started investing early, and increased her rate of investment after learning about FIRE. And these accounts are separate from Pham's husband — together their estimated net worth is just under $2 million. And when it feels easier to just spend freely, tracking her net worth has helped keep her focused. "That gives us another safety net," Pham says, noting the pension as an added benefit to working in public service. "By then, we should have at least $2 million in net worth.
Persons: Mia Pham, , Pham, haven't, they've, Roth, maxing, doesn't, it's, they're Organizations: Service, Roth IRA, Toyota Locations: San Diego —, San Diego
Food companies fear soaring Ozempic sales could hurt their bottom lines. AdvertisementAdvertisementExecutives at America's biggest food companies can't stop talking about Ozempic . And early data suggests that Ozempic sales will have some impact on the food industry. AdvertisementAdvertisementFor example, if consumers begin to prefer smaller portions, food companies have time to adjust their package sizes, and restaurants have time to modify their menus. "This is not an existential threat to the food industry," he said.
Persons: , Doug McMillon, Arun Sundaram, Morgan Stanley, Walmart's John Furner, Steve Cahillane, Rice Krispies, Jefferies, Sundaram, David M, Gordon, Ozempic Organizations: Service, America's, Nordisk, North, Walmart, Bloomberg, Wall, Cheesecake
In this photo illustration, a Krispy Kreme glazed doughnut is shown on May 12, 2022 in Daly City, California. Krispy Kreme is exploring strategic alternatives, including an all-cash sale, of its majority stake in Insomnia Cookies, the company said Tuesday. Krispy Kreme acquired control of Insomnia Cookies in 2018 in a deal backed by European investment firm JAB Holding, which had taken Krispy Kreme private in 2016. Krispy Kreme went public for the second time in 2021, at an implied valuation of $2.7 billion. Insomnia Cookies, which is known for serving cookies well into the early morning hours, has tripled its revenue since 2017, Krispy Kreme said Tuesday.
Persons: Krispy Kreme, Krispy, Mike Tattersfield, Seth Berkowitz, Berkowitz Organizations: CNBC, University of Pennsylvania Locations: Daly City , California
China’s Moutai Wants to Satisfy All Your Cravings
  + stars: | 2023-09-18 | by ( Jacky Wong | ) www.wsj.com   time to read: 1 min
This copy is for your personal, non-commercial use only. Distribution and use of this material are governed by our Subscriber Agreement and by copyright law. For non-personal use or to order multiple copies, please contact Dow Jones Reprints at 1-800-843-0008 or visit www.djreprints.com. https://www.wsj.com/business/retail/chinas-moutai-wants-to-satisfy-all-your-cravings-3abe2a9c
Persons: Dow Jones
You Won’t Lose Weight on Ozempic Forever
  + stars: | 2023-09-18 | by ( Dani Blum | More About Dani Blum | ) www.nytimes.com   time to read: +2 min
But doctors say some people seek out these drugs to lose as much weight as possible — and are dismayed and disillusioned when they stop. When they do, they tend to regain the weight they lost. Medications like Ozempic mimic a naturally occurring hormone and slow the emptying of the stomach, so that we feel fuller, faster and for longer. In clinical trials of semaglutide, the compound in Ozempic and Wegovy, people with diabetes have tended to lose less weight, less quickly, than people who did not have the condition, Dr. Hagan said. A small proportion of those who take these drugs won’t lose weight at all, he added.
Persons: ” Ms, Meinecke, Scott Hagan, Hagan, Andrew Kraftson Organizations: University of Washington, Michigan Medicine
Fernandez sees a total addressable market of $140 billion to support patients with obesity. He expects there is a potential for GLP-1 drugs to become as common and widely used, much like statins are used to lower cholesterol. Morgan Stanley's Flynn estimates a 30% share of the diabetes market would generate $109 billion on a worldwide basis for GLP-1 drugs. Layer in a 15% to 30% share of the obesity market and that equates to worldwide sales of $97.4 billion to $194.8 billion. Guggenheim's estimates also assume that oral GLP-1 drugs that are currently in development are able to come to market a few years from now.
Persons: Seamus Fernandez, Fernandez, Lilly, Eli Lilly, Morgan Stanley, Terence Flynn, Eli Lilly's Mounjaro, Insulet, Canaccord, William Plovanic, Plovanic, It's, Morgan Stanley's Flynn, Flynn, Novo, Michael Bloom Organizations: Wall, Novo, American Heart Association, Food and Drug Administration, Novo Nordisk, Iqvia, Disease Control Locations: GLP
Jaap Arriens | Nurphoto | Getty ImagesHeather Le Biller shed 9 pounds within the first week of taking Novo Nordisk 's blockbuster diabetes drug Ozempic – and then even more as she continued treatment. That means it could take years before the Food and Drug Administration and other regulators worldwide approve drugs like Ozempic and Wegovy as addiction treatments. Jerlhag and her colleagues at the University of Gothenburg in Sweden have studied the effect of GLP-1s on addictive behaviors for more than a decade. "The mechanism in the brain that regulates overeating is important in regulating addictive behaviors as well," Leggio told CNBC. Still, NIDA's Leggio advises against using GLP-1s off-label to reduce addictive behaviors, "simply because there's not enough evidence in humans that they work."
Persons: Jaap Arriens, Heather Le Biller, Ozempic –, Le Biller, they're, Angela Fitch, Brandon Bell, Dr, Lorenzo Leggio, semaglutide, , Eli Lilly, pharmacologist, Jerlhag, George Frey, NIDA's, Leggio, Steven Batash, Batash, NIDA's Leggio Organizations: Nurphoto, Novo Nordisk, CNBC, Wegovy, Obesity Medicine Association, and Drug Administration, Pharma, National Institute on Drug, University of Gothenburg, Company, Reuters, Brigade, Getty Locations: Riga, Latvia, France, Ozempic, Novo, U.S, Italian, Austin , Texas, Sweden, Provo , Utah, Queens , New York
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