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☆ California Privacy Agency Opens Probe Into Private Data Collected by Cars
▼ + stars: | 2023-07-31 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

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Persons: Dow Jones Locations: california

☆ California Opens Privacy Probe Into Who Controls, Shares the Data Your Car Is Collecting
▼ + stars: | 2023-07-31 | by ( Byron Tau | Catherine Stupp | ) www.wsj.com time to read: 1 min

Persons: Dow Jones Locations: california

Hunter Biden, President Biden’s son, pleaded not guilty to misdemeanor tax charges on Wednesday after a federal judge deferred a planned guilty plea deal. Photo: Anna Moneymaker/Getty ImagesWASHINGTON—A former business associate of Hunter Biden testified on Monday to Congress that President Biden and his son were in near daily communication and that the younger Biden would occasionally put his father on speakerphone at business dinners and in other situations, according to lawmakers present for the closed-door briefing.

Persons: Hunter Biden, Biden’s, Anna Moneymaker, Biden Organizations: Getty, WASHINGTON

Persons: Dow Jones, biden, 749b5187

☆ Michigan Charges 16 People With Acting as False Electors for Trump in 2020
▼ + stars: | 2023-07-19 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

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Persons: Dow Jones Locations: michigan

☆ Lilly drug slows Alzheimer's by 60% for mildly impaired patients in trial
▼ + stars: | 2023-07-17 | by ( Deena Beasley | ) www.reuters.com time to read: +5 min

Lilly expects the U.S. Food and Drug Administration to decide by the end of this year whether to approve donanemab. The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. The deaths of three trial patients were linked to the treatment, researchers reported. For high tau patients, donanemab was shown to slow disease progression by about 17%, while the benefit was 35% for those with low-to-intermediate tau levels. Both medications are also being studied in large trials to see if they have an impact on delaying onset of Alzheimer's disease symptoms.

Persons: Seth Gale, Brian Snyder, Eli Lilly, Anne White, Lilly, Susan Kohlhaas, Liana Apostolova, White, Liz Coulthard, donanemab, Deena Beasley, Ludwig Burger, Will Dunham, Bill Berkrot, Caroline Humer Organizations: Alzheimer Research, Brigham, Women’s, REUTERS, Alzheimer's Association International, U.S . Food, Drug Administration, Alzheimer’s Research, Indiana University School of Medicine, Doctors, University of Bristol, JAMA, FDA, Alzheimer's Association, Health Organization, New York Stock Exchange, Thomson Locations: Boston , Massachusetts, U.S, Amsterdam, Eisai

☆ Treating Alzheimer’s Very Early Offers Better Hope of Slowing Decline, Study Finds
▼ + stars: | 2023-07-17 | by ( Pam Belluck | More About Pam Belluck | ) www.nytimes.com time to read: +1 min

Treating Alzheimer’s patients as early as possible — when symptoms and brain pathology are mildest — provides a better chance of slowing cognitive decline, a large study of an experimental Alzheimer’s drug presented Monday suggests. The study of 1,736 patients reported that the drug, donanemab, made by Eli Lilly, can modestly slow the progression of memory and thinking problems in early stages of Alzheimer’s, and that the slowing was greatest for early-stage patients when they had less of a protein that creates tangles in the brain. For people at that earlier stage, donanemab appeared to slow decline in memory and thinking by about four and a half to seven and a half months over an 18-month period compared with those taking a placebo, according to the study, published in the journal JAMA. Among people with less of the protein, called tau, slowing was most pronounced in those younger than 75 and those who did not yet have Alzheimer’s but had a pre-Alzheimer’s condition called mild cognitive impairment, according to data presented Monday at the Alzheimer’s Association International Conference in Amsterdam. “The earlier you can get in there, the more you can impact it before they’ve already declined and they’re on this fast slope,” Dr. Daniel Skovronsky, Eli Lilly’s chief medical and scientific officer, said in an interview.

Persons: Eli Lilly, donanemab, “, they’ve, Dr, Daniel Skovronsky, Eli Lilly’s Organizations: Alzheimer’s Association International Locations: Amsterdam

☆ Second Alzheimer’s drug to slow disease’s progression may be approved in the US this year
▼ + stars: | 2023-07-17 | by ( Meg Tirrell | ) edition.cnn.com time to read: +12 min

It was shown in May and in fuller Phase 3 clinical trial results released at the Alzheimer’s Association International Conference on Monday to delay the disease’s progression. More than 6 million Americans are estimated to have Alzheimer’s disease, with about 1 million estimated to be in the early symptomatic stages where these drugs have shown benefit. Both Leqembi and donanemab work by clearing buildups of a protein in the brain called amyloid, a hallmark of Alzheimer’s. It’s been a hypothesis that treating Alzheimer’s earlier with amyloid-clearing drugs would yield better results; Skovronsky said the donanemab trial bore that out. “We could look at people who had mild cognitive impairment, MCI, which is the earliest stage, versus mild Alzheimer’s versus moderate Alzheimer’s,” Skovronsky explained.

Persons: Leqembi, Eli Lilly’s donanemab, Lilly, “ Donanemab, Jennifer Manly, Kacie, ”, Dr, Gil Rabinovici, Renaud La Joie, Daniel Skovronsky, “, Skovronsky, ” Skovronsky, It’s, Eric Widera, Sharon Brangman, University of Wisconsin’s Dr, Nathaniel Chin, Donanemab, Lilly hasn’t, Lawrence Honig, Honig, White, Sanjay Gupta, Deters, ” Lilly, it’s “, it’s, there’s, Joe Montminy Organizations: CNN, Alzheimer’s Association, Food and Drug Administration, American Medical Association, Columbia University Irving Medical Center, University of California, MCI, SUNY, University of Wisconsin’s, Leqembi, FDA, donanemab, CNN Health, ” Manly Locations: Los Angeles, “

☆ Alzheimer's diagnosis revamp embraces rating scale similar to cancer
▼ + stars: | 2023-07-16 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +4 min

July 16 (Reuters) - Alzheimer's disease experts are revamping the way doctors diagnose patients with the progressive brain disorder - the most common type of dementia - adopting a seven-point rating scale based on cognitive and biological changes in the patient. "Stage 1a is really the beginning of evidence that someone has the disease," Jack said. The new scale also includes a Stage 0 for people who carry genes that guarantee they will develop Alzheimer's. Noting the new system's similarity to cancer stages, Jack said, "There's no such thing as mild breast cancer. Jack also noted that many other conditions can cause dementia but not all dementia is Alzheimer's disease.

Persons: Clifford Jack, Eli Lilly's, Maria Carrillo, Jack, Julie Steenhuysen, Will Dunham Organizations: Alzheimer's Association, Mayo Clinic, National Institute of Aging, government's National Institutes of Health, Drug Administration, FDA, Down, Thomson Locations: Amsterdam, Rochester , Minnesota, Chicago

☆ Selling Your Cellphone Location Data Might Soon Be Banned in U.S. for First Time
▼ + stars: | 2023-07-11 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

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☆ First U.S. Ban on Sale of Cellphone Location Data Might Be Coming
▼ + stars: | 2023-07-10 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

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Persons: Dow Jones

☆ CTE: Heather Anderson, first professional female athlete to be diagnosed with degenerative brain disease
▼ + stars: | 2023-07-04 | by ( Hilary Whiteman | ) edition.cnn.com time to read: +7 min

CTE is a neurodegenerative disease that can occur after repeated traumatic brain injuries or hits to the head, with or without a concussion, and to date it has only been diagnosed in professional male athletes. In Australia, lawyers representing dozens of former professional AFL players have filed a class action suit against the Australian Football League (AFL), seeking compensation for injuries caused by alleged negligence. The AFL has acknowledged a link between head trauma and CTE and says it’s committed to mitigating the risks. The AFL Player’s Association, which represents the athletes, is pushing for greater support for current and former players, many of whom are living with the impact of successive brain injuries. Buckland said what’s most needed is a shift in attitudes, so that it’s no longer encouraged or even acceptable to expose children to activities where repeated head injuries are part of the game.

Persons: Heather Anderson, “, ”, neuropathologist Michael Buckland, …, Buckland, Anderson, CTE, James Elsby, It’s, it’s, what’s Organizations: Australia CNN — Scientists, Australian Football League, Sports Brain Bank, University of Sydney, AFL, league –, AFL Club, Adelaide Crows, Australian Defence Force, Australian Sports Brain Bank, US Centers for Disease Control, Boston, NFL, AFL Player’s Association, Boys ’ Locations: Brisbane, Australia, Darwin, United States

☆ 10 Things in Tech: Digital nomad regrets, a longevity researcher’s morning routine, and sun activity
▼ + stars: | 2023-06-28 | by ( Diamond Naga Siu | ) www.businessinsider.com time to read: +4 min

In case you missed it: This is the last week of 10 Things in Tech. The EV company only has six gigafactories across the world: Fremont, California; Sparks, Nevada; Berlin; Shanghai; Austin, Texas; and Buffalo, New York. Each location is outfitted with solar panels, and Musk claims 100 gigafactories could supply the world with all of its energy. My colleague Graham Rapier takes us into the world of Tesla's gigafactories and breaks down what their futures could look like. In a world of remote work, they're trying to pay people the least amount of money to get work done (think freelancers and contractors).

Persons: I'm, Siu, let's, Elon Musk, Graham Rapier, gigafactories, Tyler Le, Allbirds, M0.0nshot, Gigi Chow, Elon Musk's, Walter Isaacson, it's, David Sinclair, Lewis Joly, cardiologists, Eid Mubarak, Diamond Naga Siu, Alistair Barr, Hallam Bullock Organizations: it's, EV, Employers, Paris Air, Storm Shadow, Interactive Entertainment, Tencent Locations: Tech, Fremont , California, Sparks , Nevada, Berlin, Shanghai, Austin , Texas, Buffalo , New York, Silicon, San Francisco, Croatia, Dubrovnik, Harvard, Le Bourget, Paris, France, Ukraine, New York, Florida, Barcelona, Spain, San Diego, Silicon Valley, London

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Persons: Dow Jones, biden

President Biden’s son, Hunter Biden, has agreed to plead guilty to charges that he willfully failed to pay federal income taxes. Photo: Al Drago/Bloomberg NewsThe Justice Department said Tuesday that Hunter Biden would plead guilty to two misdemeanor tax offenses and enter a diversion program that would allow him to avoid a felony firearms conviction if he meets certain conditions. If he successfully completes the program, he would serve no jail time for the firearms charge. A judge will determine his sentence on the tax charges. Tax prosecutions for misdemeanor charges, without other charges, rarely lead to prison time.

Persons: Biden’s, Hunter Biden, Al Drago Organizations: Bloomberg, Justice Department

☆ ‘Lock Her Up’ Attacks on Clinton in 2016 Are Used in Case Against Trump
▼ + stars: | 2023-06-16 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

Persons: Dow Jones, donald, clinton, 3b266500

☆ U.S. Spy Agencies Buy Vast Quantities of Americans’ Personal Data, U.S. Says
▼ + stars: | 2023-06-12 | by ( Byron Tau | Dustin Volz | ) www.wsj.com time to read: 1 min

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Persons: Dow Jones

☆ The Federal Case Against Trump on the Mar-a-Lago Documents
▼ + stars: | 2023-06-10 | by ( Byron Tau | ) www.wsj.com time to read: 1 min

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☆ The story behind this playful rooftop portrait
▼ + stars: | 2023-06-09 | by ( Rebecca Cairns | ) edition.cnn.com time to read: +8 min

Hong Kong’s humidity – already oppressive – was intensified in the dark, maze-like alleyways of an unruly enclave known as Kowloon Walled City. Greg Girard, courtesy of Blue Lotus GalleryA ‘strange, vertical village’Girard first visited Kowloon Walled City in 1986 while on a shoot at the nearby airport. As such, the Walled City remained technically subject to Chinese rule, though this was never enforced. The site of the Walled City has since been transformed into a public park, which opened in 1995. Ongoing interest in the Walled City is, Girard suggests, because of the spirit it encapsulates: the aptitude for survival even in the harshest of circumstances.

Persons: –, Greg Girard, wasn’t, ” Girard, ”, Girard, Greg Girard ., ’ Girard, “, Ian Lambot, Lambot, Girard — Organizations: CNN, Kai Tek International, Lotus Locations: Hong, Kowloon Walled City, Walled City, Walled, Tung, Hong Kong, British, ”, “, City, Girard

☆ FBI Searched Jan. 6 Rioters and George Floyd Demonstrators in Spy Database
▼ + stars: | 2023-05-19 | by ( Dustin Volz | Byron Tau | ) www.wsj.com time to read: 1 min

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Total capacity of LNG-fired power plants will be 22.4 GW by 2030, accounting for 14.9% of the mix from zero now. The country will have a fleet of 13 LNG power plants by 2030, with the first one scheduled to go online from the fourth quarter next year. At the end of 2020, installed capacity of all coal-fired power plants was 21.38 GW, or 30.8% of the mix. Capacity of coal-fired power plants will increase to 30.13 GW by 2030, accounting for 20% of the mix. WIND By 2030, wind capacity will reach 27.88 GW, including 6 GW of offshore wind capacity.

☆ A man destined for Alzheimer's defied that fate. Now scientists want to know how
▼ + stars: | 2023-05-15 | by ( Brenda Goodman | ) edition.cnn.com time to read: +5 min

He seems to have been protected by a rare gene change that enhanced the function of a protein that helps nerve cells communicate. Scientists say that understanding how this gene change defended his brain may help prevent Alzheimer’s in other people. “Another big insight from this case is, it seems like maybe you don’t need this everywhere in the brain,” Arboleda-Velasquez said. This is the pathway that is important for extreme protection against Alzheimer’s,’ ” Arboleda-Velasquez said. The sister of the man in the new study also shared the rare protective gene change, and it helped her, but not as much.

☆ Mutation Protected Man From Alzheimer’s Disease, Hinting at Treatment
▼ + stars: | 2023-05-15 | by ( Gina Kolata | ) www.nytimes.com time to read: +1 min

Dr. Arboleda-Rodriguez is a co-founder of a biotechnology company looking to produce drugs that could act on this research. The mutation results in a potent version of a protein, Reelin, in the entorhinal cortex. That super-potent Reelin ultimately prevents tangled strands of tau proteins from sticking together and forming the structures that are a characteristic of Alzheimer's. “We don’t know what sort of damage it might do, sticking needles in and dropping in chemicals,” he said. The man with what the researchers are calling “resilience” to Alzheimer’s was part of a decades-long study of 6,000 people living in Colombia who have a gene mutation that causes Alzheimer’s in middle age.

☆ TikTok Tracked Users Who Watched Gay Content, Prompting Employee Complaints
▼ + stars: | 2023-05-05 | by ( Georgia Wells | Byron Tau | ) www.wsj.com time to read: 1 min

For at least a year, some employees at TikTok were able to find what they described internally as a list of users who watch gay content on the popular app, a collection of information that sparked worker complaints, according to former TikTok employees. TikTok doesn’t ask users to disclose their sexual orientation, but it cataloged videos users watched under topics such as LGBT, short for lesbian, gay, bisexual and transgender, the former employees said. The collection of information, which could be viewed by some employees through a dashboard, included a set of affiliated users who watched those videos, and their ID numbers, they said.

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