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The Food and Drug Administration has decided to delay action on a closely watched Alzheimer’s drug, donanemab, which the agency was widely expected to approve this month. will instead require donanemab to undergo the scrutiny of a panel of independent experts, the drug’s maker, Eli Lilly and Company, said Friday. The decision is likely to surprise many Alzheimer’s experts, doctors and patients who had expected the medication would soon be on the market. The F.D.A.’s move was startling to the company, which had been planning for the agency to greenlight the drug during the first quarter of this year. “We were not expecting this,” Anne White, an executive vice president of Lilly and president of its neuroscience division, said in an interview.
Persons: Eli Lilly, , Lilly, ” Anne White, Organizations: Drug Administration Locations: donanemab
Eli Lilly headquarters in Indianapolis, Indiana, US, on Wednesday, May 3, 2023. Eli Lilly said Friday that the Food and Drug Administration has pushed back its approval decision deadline for the drugmaker's experimental Alzheimer's treatment donanemab in a surprise move. The agency plans to call a last-minute meeting of its outside advisors to further review the treatment's safety and efficacy in a late-stage trial, Eli Lilly said. It's another setback for Eli Lilly, which is racing to compete with Biogen and Eisai. In 2021, the FDA approved an earlier, ill-fated Alzheimer's drug called Aduhelm from Biogen and Eisai, despite a negative recommendation from the agency's advisory panel.
Persons: Eli Lilly, Eli Lilly's, Leqembi, Anne White Organizations: and Drug Administration, FDA Locations: Indianapolis , Indiana, Biogen
As the prevalence of online betting grows, there's plenty of revenue to be had. The more people gamble — and the more culturally acceptable gambling becomes — the more possibility gambling addiction becomes a bigger issue. Of course, as fun as sports gambling is — as is gambling in general — it has some serious downsides for society. According to the National Council on Problem Gambling, 2 million Americans have a severe gambling problem, and another 4 million to 6 million a mild or moderate problem. The more people gamble — and the more culturally acceptable gambling becomes — the more possibility gambling addiction becomes a bigger issue.
Persons: Lia Nower, DraftKings, Jason Robins, iGaming, Robins, DraftKings isn't, , West Virginia —, Chad Beynon, Benyon, they're, Nower, Chris Grove, Grove, There's, let's, I've, legalizes iGaming, Emily Stewart Organizations: Knicks, Sports, Disney, American Gaming Association, NBA, NFL, Center for Gambling Studies, Rutgers University, Golden Nugget, Caesars, MGM, Macquarie, Companies, Atlantic City, Acies Investments, EKG Ventures, Vegas, National Council, Business Locations: Washington, Boston, Dublin, — New Jersey , Connecticut, Delaware , Michigan, Rhode Island , Pennsylvania, West Virginia, New York, Atlantic, New Jersey, Jackpocket, America
The Gaza aid convoy that ended in bloodshed this week was organized by Israel itself as part of a newly hatched partnership with local Palestinian businessmen, according to Israeli officials, Palestinian businessmen and Western diplomats. Israel has been involved in at least four such aid convoys to northern Gaza over the past week. It undertook the effort, Israeli officials told two Western diplomats, to fill a void in assistance to northern Gaza, where famine looms as international aid groups have suspended most operations, citing Israeli refusals to greenlight aid trucks and rising lawlessness. The diplomats spoke on condition of anonymity given the sensitivity of the matter. Israeli officials reached out to multiple Gazan businessmen and asked them to help organize private aid convoys to the north, two of the businessmen said, while Israel would provide security.
Organizations: United Nations Locations: Gaza, Israel
Mourning a person who was killed on Thursday when Gaza residents rushed toward aid trucks and Israeli forces guarding the convoy opened fire. Its bombing campaign and ground invasion have decimated Hamas’s control over northern Gaza, leaving both a gaping security vacuum and a humanitarian catastrophe. U.N. aid convoys carrying essential goods to northern Gaza have been suspended for days. Like Mr. Aqel, Mr. Khoudary said that he had organized some of the trucks that transported aid as part of the relief initiative involving Israel. Some were aid trucks he had dispatched, while others were organized by other contractors, he said.
Persons: Mourning, Izzat, Khoudary, Aqel, Peter Lerner, , Witnesses, Gazans, , Mr, Israel, ” Mr, Organizations: United Nations, The New York Times, British, Israel, Food Program, UNRWA, Food Locations: Gaza, Israel, Israeli
CNN —The Supreme Court will likely produce thousands of words when it decides this year whether former President Donald Trump may claim immunity from special counsel Jack Smith’s election subversion charges. Every time the Supreme Court grants an appeal it settles on a specific legal question to resolve. In the immunity matter, the court didn’t embrace Trump’s framing – nor the question Smith posed when he sought review on the same issue in December. “The question implicitly rejects Trump’s position of absolute immunity because of that language ‘whether…and to what extent,’” Eisen said. By taking the appeal, the Supreme Court has effectively pushed back the start of a trial in the federal election subversion case by weeks, at least.
Persons: Donald Trump, Jack Smith’s, , Norm Eisen, Obama, Trump, Smith, ” Eisen, , there’s, Andrew McCabe, , Ty Cobb, Trump’s, Mark Meadows, William Pryor, George W, Bush, ” Pryor, Meadows’s, Sri Srinivasan, Barack Obama Organizations: CNN, Trump, Court, Senate, Trump White, DC Locations: , Georgia
Now, we're tracking how well the analysts' picks have performed just three months into the new year. About 93% of analysts surveyed by LSEG hold a buy rating on Nvidia and have an average price target of $832.52. Warner Bros. Shares of Warner Bros. are down nearly 25% in the new year, and have lost about 45% over the past 12 months. Further, Warner Bros. did not give free cash flow guidance for 2024.
Persons: drugmaker Viatris, David Einhorn, Einhorn, Max Organizations: Dow Jones Industrial, CNBC, Nvidia, drugmaker, Pfizer, Warner Bros, APA Corp, Halliburton, Caesars Entertainment Locations: LSEG
CNN —Hungarian Prime Minister Viktor Orban said his country had opened a new phase with Sweden during a joint press conference with Swedish counterpart Ulf Kristersson on Friday as Budapest prepares to ratify Stockholm’s long-delayed NATO bid. Orban, who said last week that the Hungarian Parliament would vote on ratification on Monday, met with Kristersson on Friday and announced at the press conference that Hungary had bought four fighter jets from Sweden. “Being members together in NATO we [will be] able to reconstruct the full trust towards each other,” Orban added later. Sweden and Finland applied for NATO membership in 2022 and Finland joined NATO in April 2023 – doubling the alliance’s border with Russia. But Sweden’s bid was mired in challenges.
Persons: Viktor Orban, Ulf Kristersson, Orban, Kristersson, , ” Orban, Recep Tayyip Erdogan, Vladimir Putin, Katalin Organizations: CNN, Swedish, Budapest, NATO, Russia, Gripen, Kurdistan Workers ’ Party, European Union Locations: Hungarian, Sweden, Hungary, Ukraine, Finland, Russia, Turkey
CNN —President Joe Biden is embracing his bully pulpit as he calls out resistance from former President Donald Trump and Republicans on Ukraine and Russia. In repeatedly assailing Trump and his party from the White House, Biden also hopes to illustrate the stakes of the upcoming election and demonstrate his own efforts to unite the west against Russian aggression. House Republicans have scuttled efforts to pass a bipartisan border security bill and additional assistance for Ukraine – both at Trump’s urging. “Trump gave an invitation to Putin to invade some of our ally, NATO allies,” Biden said earlier this month. Why can’t Trump just say that?” Biden said in a White House video released Tuesday.
Persons: Joe Biden, Donald Trump, Donald Trump’s, Alexey Navalny, Vladimir Putin’s, Biden, Putin, Navalny, ” Biden, , ” Trump, assailing Trump, Strom Thurmond, “ I’ve, I’ve, Thurmond, segregationists, Strom, ” “ I’m, Mike Johnson, Trump, He’s, “ Trump, Abraham Lincoln, America, can’t Trump, he’s, they’re, Organizations: CNN, Republicans, House Republicans, Trump, San, Wednesday, White, Ukraine –, Democratic, United States Congress, , NATO, Super, Quinnipiac, Russia Locations: Ukraine, Russia, California, San Francisco, Israel, Palestinian, Los Angeles, Bay, White, Russian, United States, Avdiivka, Michigan , Wisconsin, Pennsylvania, Latvian, Lithuanian, Polish
CNN —President Joe Biden personally directed his senior campaign aides in recent days to focus more aggressively on former President Donald Trump’s inflammatory comments, according to two sources familiar with the president’s edict. For weeks, his campaign has said they are fully prepared for Trump to emerge as the GOP nominee. “Freedom and democracy itself are on the ballot in November.”That marked only the second time, according to a campaign official, that a Biden campaign statement was attributed directly to the president. It’s un-American.”The next day, the campaign went after Trump again after the former president repeated his threat to NATO members. He’s gone,” Trump taunted at a campaign rally), Biden quickly slammed those comments on X.
Persons: Joe Biden, Donald Trump’s, Trump, Biden, , ” Ammar Moussa, “ Donald Trump, , Robert Hur’s, Hur, “ Donald Trump’s, Putin, America’s, excoriated Trump, ” Biden, Nikki Haley’s, He’s, ” Trump, Major Haley Organizations: CNN, Republican, Trump, GOP, Biden, NATO, National Locations: Russia, Ukraine, Poland, Baltic States, Russian
In Gemini 1.5, improvements to the new tech are leaps and bounds above what the original Gemini can do. Gemini 1.5 Pro's context window capacity, however, can handle up to 1 million tokens. Gemini 1.5 is also getting better at generating good responses from super-long queries, without a user needing to spend much additional time fine-tuning their queries. Google says that in rolling out Gemini 1.5, it underwent extensive ethics and safety testing to greenlight it for wider release. The tech company has conducted research on AI safety risks and has developed techniques to mitigate potential harm.
Persons: , Sundar Pichai, Demis Hassabis, OpenAI's, Febrary, MoE Organizations: Service, Google, Gemini
“Make no mistake: Putin is responsible for Navalny’s death. A few moments earlier, Secretary of State Antony Blinken linked Navalny’s death directly to Russia’s president. Asked whether Navalny’s death might spur Congress to act in providing more Ukraine aid, Biden was hopeful. Even so, Johnson said in a statement Friday that Putin “is likely directly responsible” for Navalny’s death. “I made it clear to him that I believe the consequences of that would be devastating for Russia,” Biden said in Geneva, where the summit was held.
Persons: Alexey Navalny’s, Vladimir Putin, Joe Biden, Donald Trump, Putin, ” Biden, Roosevelt, “ Putin, ” Trump, Nikki Haley, Fani Willis ’, Trump, Putin’s, Biden, “ It’s, Kamala Harris, Antony Blinken, , , Mike Johnson, Johnson, Putin “, Tucker Carlson, Carlson, Trump’s, ” Haley, Truman, “ Trump, he’d, Navalny, we’re, ” Harris, Harris, Navalny’s, CNN’s Haley Britzky, Lauren Fox, Kate Sullivan Organizations: CNN, White, GOP, Fulton, NATO, Biden, Munich Security Conference, Republican, Republicans, Ukraine, Fox News, South Carolina Gov, South, Putin, Super, Ukraine wavers, , Trump Locations: Washington, Russia, Fulton County, Georgia, Europe, Moscow, Ukraine, Munich, United States, South Carolina, Michigan , Wisconsin, Pennsylvania, Latvian, Lithuanian, Polish, Geneva, Asia, transatlanticism
For investors, that suggests opportunity in certain dividend stocks, Kostin wrote. Since late 2022, Goldman Sachs' Dividend Yield and Growth basket (GSTHDIVG), a 50-stock, equal-weighted basket of stocks with high trailing dividend yield and high anticipated dividend growth, has outperformed the equal-weighted S & P 500 by 3 percentage points. As of October, here are some of the stocks in the firm's dividend yield and growth basket. Verizon Communications Communication services stock Verizon Communications is a constituent in the dividend growth basket. Other stocks in Goldman's dividend growth basket include Best Buy , Conagra Brands and Devon Energy .
Persons: Goldman Sachs, David J, Meta, Kostin, That's, Greenlight Capital's David Einhorn, Morgan Stanley, Simon Flannery, — CNBC's Michael Bloom Organizations: Facebook, Bank of America, Federal Reserve, Verizon Communications Communication, Verizon Communications, Verizon, Conagra Brands, Devon Energy Locations: Viatris
In a statement Sunday, Stoltenberg said such comments put European and American soldiers at an increased risk. He also criticized American defense pacts with Asian allies Japan and South Korea. The conflict has raised concerns Putin may have further expansionist ambitions, which the leader denies, or that a NATO country may become directly embroiled. European Council President Charles Michel also hit back against the comments and said they reemphasize the need to keep the alliance strong. You got to pay your bills.”Biden said Sunday that Trump “is making it clear that he will abandon our NATO allies” and outlined the potential consequences of Trump’s comments.
Persons: Jens Stoltenberg, Donald Trump, Trump, Stoltenberg, ” Stoltenberg, , NATO Ally, , Vladimir Putin, Putin, Trump’s, Joe Biden’s, Charles Michel, ” Michel, ” Trump, ” Biden Organizations: CNN, NATO, International Criminal, Washington, European, Atlantic Treaty Organization, Sunday, Trump, , Ukraine Locations: Russia, Europe, South, Taiwan, Asia, Japan, South Korea, Ukraine, Sweden, Finland, Turkey, China, Korea, North Korea, Philippines, United States, Pacific, Soviet Union, Canada, Poland, Baltic States, Israel
Trump is giving every impression that his second term would be even more aberrant than his first, as he vows to use presidential power to exact retribution against his enemies. While a Biden vs. Trump race would be a rematch of 2020, it would not necessarily be the same. In Trump, voters can pick an ex-president facing 91 criminal charges who has been found liable for fraud, sexual battery and defamation in court. It also offered a potential roadmap to the substance and character of his possible second term. Why the 2020 election lineup may be locked inThe renewed focus on Biden’s age is likely to open another round of speculation about whether he could be replaced on the Democratic ticket.
Persons: Joe Biden, Donald Trump, Biden, Trump, he’s, Vladimir Putin, Nikki Haley’s, crave, Robert F, Kennedy Jr, , “ Donald Trump’s, Putin, ” Biden, Trump’s, , Florida GOP Sen, Marco Rubio, “ Donald Trump, ” Rubio, Charles Michel, Russia, Tucker Carlson, Manuel Balce Ceneta, Michael, He’s, Michael Haley, Nikki Haley, Arizona Sen, John McCain, Robert Hur’s, parry, Mandel Ngan, gaffes —, , Ro Khanna, Jake Tapper, Biden’s missteps, Haley, Nancy Pelosi, he’d, Dean Phillips, Kamala Harris, Harris Organizations: CNN, Oval, Biden, Trump, NATO, White, Florida GOP, Foreign Relations, Union, European Council, GOP, ABC, Getty, ” Democratic, Democratic, Democratic Party Locations: South Carolina, Russia, NATO, Europe, miscalculations, Moscow, Ukraine, Poland, Baltic States, Florida, “ State, Russian, Conway , South Carolina, Africa, Arizona, Vietnam, Egypt, Mexico, AFP, California, reunifying
Investors expect the Securities and Exchange Commission to greenlight spot ether ETFs in May, but the price action for the crypto could be subdued compared to bitcoin's moves in the runup to its ETF approvals. That compares to the 55% surge bitcoin saw after BlackRock first filed its spot ETF application for the flagship crypto. Regardless, we see the spot ether ETF being less appreciated by the market." JPMorgan estimates a "no more than 50% chance" of spot ether ETF approval by May 23, the final deadline for the SEC to approve or deny the Ark/21Shares application . Schwenkler said any excitement leading up to potential ether ETF approvals will be "less speculative" and that a lot of it is priced in already.
Persons: Kenneth Worthington, Nico Cordeiro, there's, Owen Lau, Oppenheimer, Gustavo Schwenkler, Bitcoin, Solana, Schwenkler, — CNBC's Michael Bloom Organizations: Securities and Exchange Commission, JPMorgan, BlackRock, BTC, ETH, SEC, CNBC, Leavey School of Business, Santa Clara University, of Locations: Southern, of New York, bitcoin
LOS ANGELES (AP) — Denis Villeneuve doesn’t feel like he came back to Arrakis for “Dune: Part Two.” In his mind, he never left. Photos You Should See View All 21 Images“We all walked at the beginning into this project feeling confident,” Villeneuve said. “Dune: Part Two” cost a reported $122 million to produce and is arriving in theaters not a moment too soon. Christopher Nolan recently compared it to “The Empire Strikes Back.” Villeneuve demurred, but the internet went wild. “I think that’s the way movies will survive.”
Persons: — Denis Villeneuve doesn’t, , Frank Herbert’s, David Lean, Alejandro Jodorowsky, David Lynch, ” Villeneuve, Greig Fraser, they’d, Timothée Chalamet’s Paul Atreides, Paul, Jessica, Rebecca Ferguson, Villeneuve, Chalamet, “ Denis, ” Chalamet, “ It’s, Josh Brolin, Sicario, Gurney Halleck, Coen, I’ve, ” Brolin, it's, , he’s, Hans Zimmer, ’ ” Villeneuve, it’s, Christopher Nolan, ” Nolan, Herbert Organizations: ANGELES, Associated Press Locations: Arrakis, Budapest, Wadi Rum, Abu Dhabi, , Hollywood
GlaxoSmithKline on Wednesday lifted its long-term outlook following the smash-hit launch of its new RSV vaccine. GSK in November had forecast 2023 sales for the shot Arexvy between £900 million, or $1.1 billion, and £1 billion, or $1.26 billion, following its strong launch in the U.S. The company's RSV shot in part drove the higher forecast. The vaccine has about 70% market share for RSV, Walmsley added on Wednesday. Meanwhile, biotech company Moderna hopes to launch its own RSV vaccine this year.
Persons: Emma Walmsley, Walmsley, Arexvy, That's, Pfizer's, Albert Bourla, Bourla Organizations: GlaxoSmithKline, Stevenage, GSK, U.S, Pfizer, U.S . Food, Drug Administration, Moderna Locations: Britain, British, U.S, Canada, Japan
In her third-grade classroom in Charlotte, students earn fake money for performing various jobs, such as holding doors open, cleaning up, and assisting the teacher. In the videos, Lattimore reminds the kids to always keep $5 to cover the "rent" for their chairs and desks. One parent, Brittany Sales, shared that her daughter Marlii has gained valuable insights into money management through Lattimore's lessons, per NBC News. She told NBC News that she has earned six figures from monetizing her TikTok content and collaborating with brands. "My teacher salary is not even half of that," Lattimore told the news outlet.
Persons: , Shelby Lattimore, Lattimore, Brittany Sales, Marlii Organizations: Service, Business, NBC News, NBC Locations: Carolina, Charlotte, Brittany
Ocean Rebellions protest The Deep Sea Says No Why the deep sea? (Photo by Charles M. Vella/SOPA Images/LightRocket via Getty Images) Sopa Images | Lightrocket | Getty ImagesNorway says its controversial decision to approve deep-sea mining is a necessary step into the unknown that could help to break China and Russia's rare earths dominance. "We have been looking into the seabed minerals opportunity for a long time. Campaigners fear that exploration and exploitation activities in the deep sea could permanently alter a home that is unique to known — and many as yet unknown — species. "The argument put forward by the Norwegian government — and the deep-sea mining industry — that 'deep-sea mining can be done in a sustainable way' goes against the large consensus of scientific literature," Roux said.
Persons: Luciana, Charles M, Anne, Sophie Roux, Terje Aasland, Aasland, Arild Hermstad, Camille Etienne, Lucas Bravo, Javad Parsa, Norway's Aasland, Roux, Organizations: SOUTH, Getty, IEA, Energy, CNBC, Afp, European Commission, Ocean Alliance, Lightrocket Locations: ROTTERDAM, SOUTH HOLLAND, NETHERLANDS, Norway, China, Europe, Russia, Norwegian, Vietnam, Brazil, Svalbard, French, Oslo
Biden, in a rare statement on ongoing congressional negotiations, said the deal that Senate negotiators have worked toward is both tough and fair. “It would give me, as President, a new emergency authority to shut down the border when it becomes overwhelmed. Moreover, if crossings exceed 8,500 in a single day, DHS would be required to close the border to migrants illegally crossing the border. The source said if the new legislation were in effect, the border would be shut down now to illegal migrants. But a number of top Senate Republicans, including Mitch McConnell, say that the issue must be dealt with now since Democrats are willing to approve tougher restrictions.
Persons: Joe Biden, Donald Trump, , Trump, Biden, “ What’s, , GOP Sen, James Lankford of, Independent Sen, Kyrsten, Democratic Sen, Chris Murphy, , Mitch McConnell, Betsy Klein Organizations: Senate, GOP, , Department of Homeland Security, DHS, Independent, Democratic, Trump, Republicans Locations: Ukraine, Israel, Taiwan, James Lankford of Oklahoma, Arizona, Connecticut
This story is available exclusively to Business Insider subscribers. In a letter to investors seen by Business Insider, he said his short bets against companies he believed were overvalued went haywire. Einhorn did not name the four short positions in the letter that helped drag the entire short book down 25.6% last year but called the performance "disgusting." The short positions were not new ones. The firm declined to identify the four positions when asked by Business Insider or offer any additional comment on the letter.
Persons: David Einhorn's, Einhorn, ruing, overvalued, Elon Musk's Tesla, Tesla Organizations: Greenlight Capital, Business, Industry
Cohen already let the case proceed against Fox News — and on Wednesday, he rejected a request by Fox Corporation to throw out the claims against the parent company. The parent corporation had argued that it shouldn’t be involved in the defamation case because it only had general oversight of Fox News itself. The case is still in the discovery phase, with some major depositions taking place in the past month, including former Fox Corporation chairman Rupert Murdoch. The decision boosts Smartmatic’s case against the right-wing media behemoth. A similar 2020-related lawsuit by Dominion Voting Systems was also allowed to proceed against Fox and its parent company.
Persons: David Cohen, Murdoch, Cohen, Fox, Smartmatic, Donald Trump, Joe Biden, ” Smartmatic, ” Cohen, , defaming, , Erik Connolly, Rupert Murdoch, cravenly, Rudy Giuliani, Sidney Powell, couldn’t, ” Fox Organizations: CNN, Fox Corporation, Fox News, Manhattan, Fox ) Corp, Fox Corp, Fox, Dominion Voting Systems, Trump, Wednesday, Smartmatic, Locations: New York, York, Florida
"We ended our buyers' strike and found several promising new investments that we believe will help us in 2024," the hedge fund manager said in an investor letter dated Monday and obtained by CNBC. Einhorn had stopped building new stock positions at one point in the fourth quarter due to worries about intensifying geopolitical risks. Because of his conservative positioning, his hedge fund, particularly the short side, was hurt during 2023's strong year-end rally. Einhorn's hedge fund returned 22.1% in 2023, net of fees and expenses. His stellar track record made him one of the most followed hedge fund managers on Wall Street.
Persons: Capital's David Einhorn, Einhorn, he's, Greenlight, drugmaker, He's, CNBC's Leslie Picker Organizations: CNBC, Cornell grad, Greenlight Capital, Wall, Pfizer, Syensqo, U.S . Aerospace & Defense, Invesco Aerospace & Defense, P Aerospace & Defense Locations: Belgian, U.S
It has made over $80 million worldwide and proven big studio rom-coms can still find audiences. In December, he welcomed the audience at the New York City premiere to "the last romantic comedy to be made by a Hollywood studio." Its remarkable performance proves the studio rom-com is built for a comeback. SonyThe rom-com should make its move now in the wake of superhero burnout"Anyone but You" certainly isn't the first studio rom-com to find box-office glory in the last few years. So, for now, fans of the genre must wait and see if Hollywood will move forward with more romantic comedies.
Persons: , Will Gluck, Glen Powell, Sydney Sweeney, Singer, coms, Powell, Zoey Deutch, Scott Meslow, Sandra Bullock, Channing Tatum's, George Clooney, Julia Roberts, Jennifer Lawrence's, Marvel, John Fithian, Sweeney Organizations: Service, Sony, New, New York City, Hollywood, Marvel, Netflix, Sydney Opera House, Nielson, National Association of Theatre Owners, Audiences Locations: New York, Australia, Seattle, Sydney, Hollywood
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