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Read previewAt 93, John Starbrook competes in water polo games, hits the gym up to twice a day, and only stopped running marathons five years ago. As average life spans rise and an aging population becomes a global reality, interest in staying healthy for longer is growing. But a healthy lifestyle appeared to offset the effects of genes linked to a shorter lifespan by 62%. But he really amped things up at age 53 when he got into running marathons. Research suggests social bonds are an important part of a long, healthy life.
Persons: , John Starbrook, Starbrook, Judy Organizations: Service, UK, Guardian, Business, McKinsey, US News, University of Bergen, US Health Department, Department, London, Research Locations: Norway, London
Among people diagnosed with Alzheimer’s, researchers recognize familial forms of the disease and sporadic cases. This shifting appreciation of inherited risk, researchers say, is due to a better understanding of the role of a fourth gene that carries the blueprints to make a lipid-carrying protein called apolipoprotein E, known as APOE. One known as APOE2 is thought to be protective against the development of Alzheimer’s disease. They also compared people with two copies of APOE4 to people with other inherited forms of the disease — early-onset autosomal dominant Alzheimer’s disease (ADAD) and Down syndrome-associated Alzheimer’s disease (DSAD). Gene testing isn’t currently recommendedIt is also likely to change how people who carry the APOE4 gene are diagnosed and treated.
Persons: APOE4, , Dr, Juan Fortea, Sant, Fortea, Charles Bernick, Bernick, Alzheimer’s wasn’t, isn’t, they’re, ” Fortea, Sanjay Gupta, Reisa Sperling, , ” Sperling, ” Dr, Sterling Johnson, Johnson Organizations: CNN, Nature, National Alzheimer’s Coordinating, Neurology, Hospital de, Cleveland Clinic Lou, Brain Health, CNN Health, Alzheimer’s Research, Brigham, Women’s, Alzheimer’s, University of Wisconsin Locations: Alzheimer’s, Spain, United States, Santa, Barcelona, Wisconsin
“Now, post-surgery and post recovery, I am able to see in dimmer lighting with my left eye,” Cook said. A treatment that used CRISPR was found to be safe and efficacious in improving vision among a small sample of patients with inherited blindness in the Phase 1/2 clinical trial that Cook participated in. Months following the treatment, Cook was sitting with friends on a balcony that had Christmas lights wrapped around the railing. Courtesy Olivia CookBefore the treatment, Cook said that she sometimes could conceal the vision challenges she has had. Mass Eye and EarKalberer described the CRISPR treatment as “groundbreaking,” but warned it’s not a cure.
Persons: Olivia Cook, Cook, , ” Cook, , I’ve, “ I’d, you’d, CRISPR, Eric Pierce, Brigham, “ We’re, ” Pierce, Jason Comander, , Michael Kalberer, Kalberer, it’s, “ It’s, It’s, Pierce, Editas, We’re, Art Caplan, ” Caplan, , Vlad Diaconita, ” Diaconita, Dr, Sanjay Gupta, Aliaa Abdelhakim Organizations: CNN, Missouri State University, New England, of Medicine, Mass, Harvard Medical School, Editas Medicine, Perelman School of Medicine, University of Pennsylvania, University of Michigan, University of Miami, Oregon Health & Science University, US Food and Drug Administration, CEP290, pharma, NYU Grossman School, Medicine’s Department of Population Health, Columbia University Vagelos College of Physicians and Surgeons, CNN Health Locations: Springfield, United States, CEP290
CNN —The use of phrases such as “pregnant people” or “penis owners” in cultural or political discourse is sometimes met with confusion, or even anger. And it’s the most inclusive, streamlined way to refer to everyone who, regardless of their gender identity, has certain anatomy or biological abilities. Using gender-inclusive language can create an environment of acceptance, experts say. READ MORE: Gender identity: The difference between gender, sex and other need-to-knowsHere’s what experts have to say about these linguistic changes and concerns that have been raised. Gender-inclusive language may seem to be just words, but research has shown that acceptance can be lifesaving for transgender and nonbinary people, Miller said, both for medical and psychological reasons.
Persons: , Jack Drescher, Alberto Mier, they’re, , Keygan Miller, Miller, Dr, Dennis Baron, ” Miller, can’t, , hasn’t, “ it’s, ” Baron, Drescher, uteruses, ” Drescher, haven’t, ’ ” Baron, it’s, Organizations: CNN, Group, of Psychiatry, Columbia University, American Psychological Association, University of California, Los Angeles ’ Williams Institute, UCLA, University of Illinois, American Medical Association, American Psychiatric Association, National Institutes of Health Locations: New York City, United States, Los Angeles, Urbana, Champaign,
Roger Wonson reached his milestone 100th birthday in April 2024. AdvertisementWhen Roger Wonson celebrated his 100th birthday with friends at his care facility, he provided the entertainment. "I get a lot of kicks from music," Wonson told Business Insider. He played saxophone and drums in several bands in his home state of Massachusetts. "I don't eat a lot," Wonson said.
Persons: Roger Wonson, , Wonson, It's, Michelle Boudreau, Mary Sue, Wanson, it's, didn't, Ted Talks, I've, Declan Organizations: Business, Service, US Air Force, Beverly Locations: Massachusetts
A study found linked between healthy lifestyle habits and living longer. AdvertisementHealthy lifestyle choices could help us live up to five years longer, regardless of our genetic makeup, a study suggests. At the same time, a healthy lifestyle appeared to offset the effects of genes linked to a shorter lifespan by 62%. Making favorable lifestyle choices despite having genes linked to a shorter lifespan was linked to living 5.22 years longer than those who made unfavorable choices. However, she said that the effects of lifestyle factors in the study were notable because they suggest that while we can't change our genes, healthy habits may lessen their impact.
Persons: , Liz Williams, wasn't, Williams, It's Organizations: Service, University of Sheffield, Centers for Disease Control
Scientists identify ‘degrees of Kevin Bacon’ gene
  + stars: | 2024-05-02 | by ( Katie Hunt | ) edition.cnn.com   time to read: +6 min
Even humble fruit flies organize themselves into regularly spaced clusters, researchers have found. Within those social networks, certain individuals will often stand out as “gatekeepers,” playing an important role for cohesion and communication within that group. New research published Tuesday in the journal Nature Communications has identified a gene responsible for regulating the structure of social networks in fruit flies. The study opened up new opportunities for exploring the molecular evolution of social networks and collective behavior in other animals. FLPA/ShutterstockThe gene behind fruit fly social networksThe researchers investigated a number of gene candidates in fruit flies, a common lab organism used in the study of genetics.
Persons: , Kevin Bacon, Bacon, Joel Levine, Rebecca Rooke, ” Levine, Levine, , ” Allen J, Moore, wasn’t, ” Moore Organizations: CNN, Nature Communications, University of Toronto, University of Georgia’s Locations: Philadelphia, University of Toronto Mississauga
CNN —Even if your genetics put you at greater risk for early death, a healthy lifestyle could help you significantly combat it, according to a new study. Individuals with genetic risk could extend their lifespan by up to 5.5 years with a healthy lifestyle, the data showed. “Adherence to a healthy lifestyle could substantially attenuate the lifespan reduction for individuals with genetic susceptibility to a shorter lifespan,” Li said. But researchers were able to identify four factors that were associated with the biggest impact on risk of early death. Making lifestyle changesBuilding a healthier lifestyle may sound like a major undertaking, but manageable steps can help you get there.
Persons: Xue Li, Dr, Aladdin Shadyab, Shadyab, Li, ” Li, , Rosamund Dean, , you’ve Organizations: CNN, School of Public Health, Zhejian Univeristy, of Medicine, University of California, National Institute for Data Science, Health, Medicine, Zhejiang University, US Centers for Disease Control, CDC, of Locations: China, University of California San Diego, of Columbia, Guam, Puerto Rico
Opinion | Left and Right on the Happiness Scale
  + stars: | 2024-04-27 | by ( ) www.nytimes.com   time to read: +1 min
To the Editor:Re “Can Those on the Left Be Happy?,” by Ross Douthat (column, April 7):Mr. Douthat thinks, citing no evidence, that people on the left are “by nature” unhappier than moderates or conservatives, in part because he thinks we don’t believe in God anymore. The left is not “by nature” unhappy; we are often brutally honest with ourselves and unavoidably empathetic to the plights of those who suffer. If we feel more unhappy these days, it’s not because it’s in our genes. We see it all with clarity and are therefore motivated to change it. I’m a proud liberal who is determined and hopeful, and happy most of the time.
Persons: Ross Douthat, Douthat, , it’s, I’m, Jesus
Stayed up all night? Here’s how to feel better
  + stars: | 2024-04-19 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +5 min
CNN —It was a dream come true for millions of Taylor Swift fans, after the superstar released her latest album, “The Tortured Poets Department,” at midnight on Friday. “The strongest reset for the circadian system is bright light,” said Dr. Phyllis Zee, director of the Center for Circadian and Sleep Medicine at Northwestern University Feinberg School of Medicine in Chicago. “Research shows that movement can boost circulation and increase alertness, helping you shake off that sleepiness faster,” Daddy Dasgupta said. “It could limit your ability to sleep well that night,” said sleep specialist Kristen Knutson, an associate professor of neurology and preventive medicine at Northwestern University’s Feinberg School of Medicine. And of course, listening to Taylor Swift counts as long as you turn it off before bed!”CNN’s Madeline Holcombe, Kristen Rogers and Ashley Strickland contributed Taylor Swift lyrics to this article.
Persons: Taylor Swift, , Phyllis Zee, , Mina Dasgupta, Raj Dasgupta, Daddy Dasgupta, Taylor, ” Mina, ” Dasgupta, Cynthia Ackrill, Swift, it’s, Kristen Knutson, Dasgupta, Knutson, Madeline Holcombe, Kristen Rogers, Ashley Strickland Organizations: CNN, Poets Department, , Maserati, Center, Northwestern University Feinberg School of Medicine, “ Research, American Institute of, Northwestern University’s Feinberg School of Medicine Locations: Chicago, Huntington Heath, Pasadena , California
But by the time the marathon was over, Gruenfeld had decided she would run the 26.2 miles the next year. In October 1992, at 48 years of age, Gruenfeld crossed the finish line at Kona. And her Ironman career isn't over — Gruenfeld is training for her next triathlon, which she will compete in as an 80-year-old. The 80:20 rule — choosing healthy foods 80% of the time and being flexible the other 20% — is one way to make this easier, dietitian Nicole Ludlam-Raine previously told BI. Dr. Heidi Tissenbaum, a molecular, cell, and cancer biology professor at the University of Massachusetts Medical School, previously told BI that keeping the mind and body active is the most important factor in longevity.
Persons: , Cherie Gruenfeld, Gruenfeld, who'd, Donald Miralle, it's, Bryan Johnson, Nicole Ludlam, Raine, Meena Khan, You've, Dr, Heidi Tissenbaum, Ben Foster Organizations: Service, Boston Marathon, Business, Ohio State University, University of Massachusetts Medical School, Mobility, People's Athletic Club Locations: Boston, Kailua, Kona, Hawaii
Ramakrishnan shares his perspectives on the realities of aging, death and immortality. Nobel Prize-winning molecular biologist Venki Ramakrishnan offers his perspective on aging, death and immortality. But biologists don’t believe that aging and death are programmed in the sense that a fertilized egg is programmed to develop into a human being. Larger animals tend to live longer. CNN: What are the societal costs of the quest to cheat aging and death, particularly inequities?
Persons: Harper Collins, Nobel, Venki Ramakrishnan, Venki, they’ve, Jeanne Calment, Dolly, I’m, it’s, Don’t, Steven Johnson, we’re, we’d, It’s, Jessica DuLong, Organizations: CNN, Aging Locations: French, Brooklyn , New York
But there is no standard test to detect early cases of pancreatic cancer, before cancer cells have spread and when surgery is more likely to be helpful. But many studies investigating the potential of liquid biopsy tests for the early detection of pancreatic cancer are still in the early phases. The researchers found that their liquid biopsy approach detected 93% of pancreatic cancers among the US volunteers in their study, 91% of pancreatic cancers in the South Korean cohort and 88% of pancreatic cancers in the Chinese cohort. But there is no blood test that can detect early pancreatic cancer. “Smoking is the most important avoidable risk factor for pancreatic cancer,” according to the American Cancer Society.
Persons: , Brian Wolpin, ” Wolpin, “ There’s, Ajay Goel, ” Goel, , Goel, Al Neugut, Columbia University’s Herbert, Dr, Sanjay Gupta, ” Neugut, “ It’s, It’s, Wolpin Organizations: CNN, Dana, Farber Cancer Institute, US Preventive Services Task Force, American Association for Cancer Research, Hope Comprehensive Cancer Center, Molecular Diagnostics, Therapeutics, Surgeons, University of Pennsylvania, UC San Diego, Columbia, Columbia University’s Herbert Irving Comprehensive Cancer Center, Columbia University Mailman School of Public Health, CNN Health, American Cancer Society Locations: United States, City, Japan, South Korea, China, City of Hope, Hope
Intermittent fasting diet plans, meal kits, fitness trackers, and biological age tests can all offer something to busy people who want to feel in control. More than one in 10 Americans (12%) tried intermittent fasting in 2023, according to one food and beverage industry-backed survey. The business of intermittent fasting phone apps is blossoming and is on track for more growth in the next five to 10 years. There are many ways to do intermittent fasting — from skipping breakfast to whole days without foodPeople have been fasting for as long as people have been people. AdvertisementThe case against fasting to lose weight and live longerFirefighters in San Diego tried intermittent fasting out during the pandemic, with good results.
Persons: , Chris Hemsworth, Podcaster Andrew Huberman, Hugh Jackman, Dwayne, Johnson, Terry Crews, It's, Sam Altman, biohacking, Dave Asprey, Gary Vaynerchuk, Bryan Johnson, Jack Dorsey, it's, Hippocrates, Daniel Belsky, There's, Satchidananda Panda, I've, Krista Varady, Dr, Peter Attia, you've, Satchidananda, He's, Randy Shropshire, nix, Valter Longo, Longo, Belsky, Stephen Kritchevsky, Mark Cucuzzella, Nir Barzilai, Nir Barzilai Nir Barzilai, Barzilai, Panda, That's, Cucuzzella Organizations: Service, Business, Columbia University, 16ers, Salk Institute for Biological Studies, University of Illinois, Getty, Cancer, gerontology, USC, Firefighters, Wake Forest University, West Virginia University School of Medicine, Institute for Aging Research, Albert Einstein College of Medicine Locations: Greece, Chicago, San Diego, New York
But with Russian forces still inside the country and millions of Ukrainians displaced from their homes, fighting on the frontlines, or living overseas, there is no election in sight. Although Sunday is the day the constitution says Ukraine should be voting, it also does not allow it during wartime. He would have voted for Zelensky five years ago if he had had the chance and would vote for him now. Last August, President Zelensky was asked for his position in an interview on Ukrainian television and sounded sympathetic to holding a poll. As the United States Congress continues to dither over new military aid, elections in Ukraine became folded into the debate by some Republicans.
Persons: Volodymyr Zelensky, Zelensky, Viktor Yanukovych, Mykola Lyapin, Kateryna Bilokon, Yanukovych, , Jamie Oliver, , , Oleksiy Koshel, Zelensky’s, Vivek Ramaswamy, Lindsey Graham, , ” Zelenskiy, Valentyn Ogirenko, Graham, Ruslan Stefanchuk, ” Stefanchuk, disenfranchisement, Oleksandr Voitko, Valerii, Maria Kostenko, Victoria Butenko Organizations: CNN —, Republicans, Sunday, Putin, CNN, Zelensky, Kyiv International Institute of Sociology, Russia, United States Congress, Republican Party, South, 47th Brigade, Locations: Ukraine, Kyiv’s, Europe, United States, , South Carolina, Kyiv, Russian, Avdiivka, Italy, Russia
Poor irrigation practices, such as insufficient water application, using saline water, and not maintaining adequate drainage can also lead to salty soils. Irrigation can drive salinization, especially if farmers are watering their crops with salty water. In this case, that means watering crops with salt water in their lab. Globally, over 3,700 acres — just over four times the size of NYC's Central Park — of farmland grow SaliCrop seeds. Red Sea Farms, for example, is a Saudi Arabian company that uses selective breeding to grow crops that can be irrigated with salt water.
Persons: Ṛcā, SaliCrop, Guy Shery, Carmit Oron, Godbole, Sharon Devir, Devir, Karl Weatherly, they're, Andy Sacks Organizations: Service, Business, Getty, UN Locations: Israel, Spain, Oron, India, Europe, Africa, Kansas, Saudi Arabian, Sweden
As a medical oncologist, I am heartbroken — but hardly surprised. In fact, it is part of a rising global trend in which newly diagnosed cancer patients are getting younger. The global incidence of early-onset cancer increased by 79.1% and early-onset cancer deaths rose by 27.7% from 1990 to 2019, a 2023 study in the journal BMJ Oncology found. And because early-onset cancers are often diagnosed at advanced stages, they were once thought to be biologically different and more pernicious than their older counterparts. Younger patients may be pregnant at the start of therapy or worry about the effects on fertility.
Persons: Jalal Baig, Catherine , Princess of Wales, Kimmie Ng, , haven’t, oncologist Jalal Baig, Suneel Kamath, ” Kamath Organizations: Washington Post, NBC News, Foreign, CNN, BMJ Oncology, American Medical Association, Dana, Farber Cancer Institute, Boston Globe, Cleveland Clinic Taussig Cancer Institute, for Young, Cleveland Clinic, US Preventive Services Task Force Locations: Chicago, Washington, United States, Wales
Why don’t humans have tails?
  + stars: | 2024-03-23 | by ( Mindy Weisberger | ) edition.cnn.com   time to read: +10 min
One of those led to shorter tails; the more of that protein the genes produced, the shorter the tails. A tail as old as timeFor modern humans, tails are a distant genetic memory. While Alu’s role “seems to be a very important one,” other genetic factors likely contributed to the permanent disappearance of our primate ancestors’ tails,” Xia said. In their experiments, the researchers found that when mice were genetically engineered for tail loss, some developed neural tube deformities that resembled spina bifida in humans. “Maybe the reason why we have this condition in humans is because of this trade-off that our ancestors made 25 million years ago to lose their tails,” Yanai said.
Persons: , Alu, AluY, Bo Xia, ” Xia, , Xia, Itai Yanai, ” Yanai, , Bo, Yanai, TBXT’s, Liza Shapiro, ” Shapiro, africanus, Shapiro, spina, Mindy Weisberger Organizations: CNN, Gene, Broad Institute of MIT, Harvard University, Institute for Systems Genetics, New York University Grossman School of Medicine, University of Texas, Scientific Locations: Austin, Kenya
“They’re teenagers, at least in appearance, until they die.”Mexico's Lake Xochimilco is the only spot where axolotls are found in the wild. Daniel Cardenas/Anadolu/Getty ImagesWhile the wild axolotls of Lake Xochimilco have dwindled to near-extinction, countless axolotls have been bred for scientific laboratories and the pet trade. However, the axolotls you might find at a pet shop are different from their wild relatives in Lake Xochimilco. That means that the axolotl extinction crisis can’t simply be solved by dumping pet axolotls into Lake Xochimilco. (Plus, the pet axolotls likely wouldn’t fare well with the poor habitat conditions in the lake.)
Persons: Randal Voss, Voss, , ’ ”, Xolotl, “ ACK, uhl, ” Voss, Hector Vivas, they’re, Luis Zambrano, ” Zambrano, Daniel Cardenas, they’ve, Axolotls, Zambrano, axolotls, , ” Kate Golembiewski Organizations: CNN, University of Kentucky College of Medicine, , Aztecs, National Autonomous University of Mexico, Mexico City, International Union for Conservation of Nature, Axolotl, Amphibians Conservation, Anadolu, Getty Locations: Mexican, Xochimilco, Mexico City, It’s, Lake Xochimilco, Mexico, French, Europe, California , Maine , New Jersey, Washington, Minecraft, Chicago
The actress Olivia Munn said on Wednesday that she had been given a diagnosis of an aggressive form of breast cancer last year and soon after had a double mastectomy as part of her treatment. She said she tested negative for all of them, including BRCA, the most well-known breast cancer gene. “We called each other and high-fived over the phone,” Munn wrote. Two months later, Munn learned she had luminal B, a type of breast cancer. A month after that, she had the double mastectomy.
Persons: Olivia Munn, Munn, , ” Munn Organizations: HBO
Olivia Munn shared that she was diagnosed with breast cancer and underwent a double mastectomy in 2023. Munn said she had a normal mammogram and tested negative for known genes linked to cancer risk. Her doctor ordered more tests as a precaution because of a high risk according to a specific screening. AdvertisementOlivia Munn, the actress who starred in "X-Men: Apocalypse," said she was diagnosed with breast cancer and underwent a double mastectomy after routine testing failed to flag "an aggressive, fasting moving" type of cancer. Munn said she had undergone preventative testing in February 2023, which found she was negative for 90 different genes linked to cancer, including BRCA, the most well-known gene linked to breast cancer.
Persons: Olivia Munn, Munn, Organizations: Service, Business
The stem cells will also make it easier for conservation scientists to study the Asian elephant’s unique biology. An Asian elephant stem cell line stained in different colors to highlight different elements. Courtesy ColossalEngineering a woolly mammoth hybridThe elephant stem cells also hold the key to the mammoth’s rebirth. The research team at Colossal has already analyzed the genomes of 53 woolly mammoths from ancient DNA recovered from fossils. The number of modifications needed to make an Asian elephant resistant to the cold would be broadly similar, he said.
Persons: George Church, Ben Lamm, Eriona, Eriona Hysolli, John Davidson “, , Hysolli, Oliver Ryder, Ryder, ” Ryder, Christopher P, Michel “, Ben’s, Lamm, , That’s, We’ve, tramping, Colossal Organizations: CNN, Harvard University, Church, Dallas, Biosciences, Colossal, San Diego Zoo Wildlife Alliance, Colossal Biosciences, Christopher Locations: Dallas, , Siberia
A single genetic tweak that occurred among our ancestors 25 million years ago means humans today are unable to grow a tail, according to a new study. Scientists knew that a gene called TBXT was involved in the snipping of the tail. Asep Supriatna/Getty ImagesWandering DNA snipped off our tailsThe solution, they found, was in a type of "jumping gene" called an Alu element. Scientists found two Alu elements around a part of the TBXT gene, called Exon 6. Scientists tested their findings by inserting Alu sequences in mice.
Persons: , Himanshu Sharma, it's, we've, Asep Supriatna, Miriam Konkel, Emily Casanova, Konkel, Casanova Organizations: Service, Business, Anadolu Agency, Getty, NYU, Grossman School of Medicine, Nature, NYU Grossman School of Medicine, Science Locations: Pushkar, Rajasthan, India
Guilherme Gainett, then a biologist at the University of Wisconsin-Madison, was looking through a microscope at the embryo of a daddy longlegs when he saw it — or, rather, saw them. Daddy longlegs, the group of splendidly leggy arachnids also known as harvestmen, have been thought to have just two eyes. Arachnids include spiders, scorpions, harvestmen and other arthropods, and divining the relationships among this sprawling group of organisms is tricky. For the current study, Dr. Gainett used fluorescent tags to study the development of harvestman eyes. These findings suggest that the neural architecture that handles the daddy longlegs’ vision may be quite old.
Persons: Guilherme Gainett, Daddy longlegs, Gainett, Prashant Sharma Organizations: University of Wisconsin, Boston Children’s Hospital Locations: Madison
How to Spot Kawasaki Disease in Your Child
  + stars: | 2024-02-27 | by ( Emily Baumgaertner | ) www.nytimes.com   time to read: +1 min
Doctors across the United States are seeing a rise in Kawasaki disease, a mysterious condition that primarily affects children under 5. The illness is the most common cause of acquired heart disease in children worldwide but it is often unrecognized or misdiagnosed. Kawasaki disease is rare, but cases are climbing in the United States. Here are the important things to know about Kawasaki disease. Kawasaki disease, also known as K.D., is one of the leading pediatric mysteries.
Locations: United States
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