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☆ Giandomenico Picco, Diplomat Who Freed Hostages in Lebanon, Dies at 75
▼ + stars: | 2024-03-14 | by ( Clay Risen | ) www.nytimes.com time to read: +1 min

Giandomenico Picco, an Italian diplomat who as a lead negotiator for the United Nations helped resolve conflicts across the globe — most notably spending nearly a year in the early 1990s shuttling around the Middle East to secure the release of 11 hostages held by terrorist groups in Lebanon — died on Sunday in Wilton, Conn., north of Norwalk. His son Giacomo said the cause of his death, at an assisted living home, was complications of Alzheimer’s disease. Mr. Picco spent 20 years with the U.N., mostly in a series of loosely defined roles that placed him at the center of some of the world’s most dangerous hot spots. Early in his career he helped manage the conflict between Greece and Turkey over the island of Cyprus; in 1986 he mediated between New Zealand and France after French secret agents sank the Rainbow Warrior, a Greenpeace ship, in the Auckland harbor; and in 1988 he helped arrange the Soviet withdrawal from Afghanistan.

Persons: Giandomenico Picco, Lebanon —, Giacomo, Picco Organizations: United Nations, Greenpeace Locations: Italian, Lebanon, Wilton, Conn, Norwalk, Greece, Turkey, Cyprus, New Zealand, France, Auckland, Afghanistan

☆ F.D.A. Delays Action on Closely Watched Alzheimer’s Drug
▼ + stars: | 2024-03-08 | by ( Pam Belluck | ) www.nytimes.com time to read: +1 min

The Food and Drug Administration has decided to delay action on a closely watched Alzheimer’s drug, donanemab, which the agency was widely expected to approve this month. will instead require donanemab to undergo the scrutiny of a panel of independent experts, the drug’s maker, Eli Lilly and Company, said Friday. The decision is likely to surprise many Alzheimer’s experts, doctors and patients who had expected the medication would soon be on the market. The F.D.A.’s move was startling to the company, which had been planning for the agency to greenlight the drug during the first quarter of this year. “We were not expecting this,” Anne White, an executive vice president of Lilly and president of its neuroscience division, said in an interview.

Persons: Eli Lilly, “, Lilly, ” Anne White, ” Organizations: Drug Administration Locations: donanemab

☆ What Advice Would Nancy Reagan Give to Jill Biden? - The New York Times
▼ + stars: | 2024-03-05 | by ( Gahl Hodges Burt | ) www.nytimes.com time to read: +2 min

The choice she faces — promoting her husband’s political ambitions or protecting his legacy — can no longer be avoided. Having worked closely with Nancy Reagan during her husband’s first term, and seeing how she weighed choices like this one, I’ve found myself wondering if Mrs. Reagan were in Dr. Biden’s position, what advice would she have given to Ronald Reagan? Mr. Reagan and Mr. Biden’s legacies hung in the balance because of issues related to age. Mr. Biden’s age has clearly become a burden for his re-election prospects. Mrs. Reagan’s backing extended even to urging her husband to stand up to his powerful ideological advisers.

Persons: Lady Jill Biden, Nancy Reagan, I’ve, Reagan, Biden’s, Ronald Reagan, Nancy, Reagan’s, Walter Mondale, ”, Biden Organizations: ABC Locations: Soviet Union

The Dells contributed nearly $976 million to their charitable funds, which distribute gifts to a wide array of charities. Together, the 50 donors on the list contributed a total of $11.9 billion to charity in 2023. Only 23 of the richest Americans on the Forbes 400 list donated enough to appear on the Philanthropy rankings. 13 on the list, they contributed $210 million to the Institute for Protein Innovation, which shares its data with scientists for free. _____Maria Di Mento is a senior reporter and Jim Rendon is a senior writer at the Chronicle of Philanthropy, where you can read the full article.

Persons: Michael Bloomberg, Phil Knight, Penny, Michael Dell, Susan, Bill Gates, Melinda French Gates, Bernie Marcus, Ken Langone, Arthur Blank, “, ”, Renee Kaplan, — Franklin Antonio, Hugh Hoffman, —, Tim Springer, Chafen Lu, Diego’s Jay Kahn, Lauder, Sergey Brin’s, Michael J, Robert Kraft, Lucia Woods, David, Kathleen LaCross, Pierre Omidyar, Pam, They’re, John, Laura Arnold, Laura, ” Laura Arnold, Wendy Schmidt, Eric Schmidt, “ Younger, Kaplan, Jeff Sobrato, _____ Maria Di Mento, Jim Rendon, Kay Dervishi Organizations: New, New York City, Nike, Bloomberg, Knights, University of Oregon, Dells, Forbes, Forward, Qualcomm, Summer Science, SETI Institute, ALS Association , University of Cincinnati Foundation, Cincinnati Zoo, Botanical, Nature Center, Yale University, Institute for Protein Innovation, Price Club, Apple, San Diego Foundation, Discovery Foundation, Google, Fox Foundation, Parkinson’s Research, New England Patriots, Foundation, Combat, Ms, Foundation for Women, Chicago Foundation for Women, University of Virginia Darden School of Business, eBay, District of Columbia, Associated Press, Philanthropy Locations: New York, Portland , Oregon, Ohio, Moderna, California, Florida, Texas, Virginia, Washington, Hawaii, Massachusetts

☆ Apparently Healthy, but Diagnosed With Alzheimer’s?
▼ + stars: | 2024-03-04 | by ( Paula Span | ) www.nytimes.com time to read: 1 min

Determining whether someone has Alzheimer’s disease usually requires an extended diagnostic process. A doctor takes a patient’s medical history, discusses symptoms, administers verbal and visual cognitive tests. or a spinal tap — tests that detect the presence of two proteins in the brain, amyloid plaques and tau tangles, both associated with Alzheimer’s. All of that could change dramatically if new criteria proposed by an Alzheimer’s Association working group are widely adopted. Its final recommendations, expected later this year, will accelerate a shift that is already underway: from defining the disease by symptoms and behavior to defining it purely biologically — with biomarkers, substances in the body that indicate disease.

Organizations: Alzheimer’s Association

☆ Emma Heming Willis says husband Bruce’s life is still filled with joy
▼ + stars: | 2024-03-04 | by ( Lianne Kolirin | Jack Guy | ) edition.cnn.com time to read: +3 min

CNN —Bruce Willis’ wife has hit out at an online report that “there is no more joy” in her husband’s life. Emma Heming Willis said in a video posted to her Instagram profile on Sunday that she had been “clickbaited” by a headline “to do with my own family.”Appearing angry and frustrated, Heming Willis said she had been “triggered” by the story, which she came across on Sunday morning. Love is a beautiful thing ❤️ Wishing you all a Happy Valentine’s Day 🫶🏽 Emma Heming Willis/InstagramIn an interview last year, Heming Willis admitted that the diagnosis had been tough on her husband, herself and their two daughters. “What I’m learning is that dementia is hard,” Heming Willis told Hoda Kotb on the Today show on NBC. And that is no different for Bruce or myself or our girls.”That said, in a written message accompanying her video, Heming Willis explained that there was a lot more to the family’s situation than many headlines suggest.

Persons: Bruce Willis ’, Emma Heming Willis, ”, Heming Willis, Willis, “ Organizations: CNN, Alzheimer’s Research Locations: FTD

☆ UN agency accuses Israel of detaining, coercing staffers into false confessions about ties to Hamas
▼ + stars: | 2024-03-04 | by ( Jeremy Diamond | ) edition.cnn.com time to read: +5 min

Tel Aviv, Israel CNN —The UN agency for Palestinian refugees on Monday accused Israel of detaining and torturing some of its staffers, coercing them into making false confessions about the agency’s ties to Hamas. “Some of our staff have conveyed to UNRWA teams that they were forced to (make) confessions under torture and ill-treatment. These false confessions were in response to questioning about relations between UNRWA and Hamas and involvement in the 7 October attack against Israel,” UNRWA spokeswoman Juliette Touma said in a statement. UNRWA estimates that at least 4,000 Gazans have been detained by the Israeli military since the start of the war. According to the UNRWA report, some detainees reported being stripped, handcuffed and held in the cold with no access to toilets, food or water for over 24 hours.

Persons: Israel, Juliette Touma, Touma, ” Organizations: Israel CNN —, UN, UNRWA, UN Relief and Works Agency of, CNN, Agency, New York Times Locations: Tel Aviv, Israel, Gaza

ATLANTA (AP) — Since Jimmy Carter entered hospice care at his home in south Georgia one year ago, the former U.S. president has celebrated his 99th birthday, enjoyed tributes to his legacy and lost his wife of 77 years. Those advocates commend the Carter family for demonstrating the realities of aging, dementia and death. Almost half of Medicare patients who died that year did so under hospice care. JIMMY CARTER’S ENDURANCE IS NOT UNUSUALIn 2021, the average stay of hospice patients who died was 92 days, MedPAC calculated. About 10% of enrollees who die in hospice care stayed more than 264 days.

Persons: Jimmy Carter, Rosalynn Carter, Carter, “ It’s, ”, Angela Novas, it’s, “, Mollie Gurian, ” Gurian, Gurian, Chip Carter, Jimmy, Rosalynn, Novas, JIMMY CARTER’S, ’, Jimmy Carter’s, JIMMY CARTER, ” Novas Organizations: ATLANTA, Hospice Foundation of America, Medicare, Advisory, Novas, The Washington Post Locations: Georgia, Washington, Plains, U.S, “

☆ Japan’s Nikkei hits 34-year high
▼ + stars: | 2024-02-13 | by ( ) edition.cnn.com time to read: +2 min

Tokyo Reuters —Japan’s Nikkei share average closed at a fresh 34-year high on Tuesday as trading resumed after a long holiday weekend, with tech-related shares and strong corporate earnings supporting the benchmark stock index. The Nikkei climbed 2.89% to 37,963.97 to its highest since January 1990, after briefly breaching 38,000 points. The broader Topix rose 2.12%. Among other top gainers, Tokio Marine Holdings Inc and MS&AD Insurance Group Holdings Inc gained 11% and 10.82%, respectively. As the Nikkei climbs toward its all-time high, the US consumer price index (CPI) report out later on Tuesday will be in focus.

Persons: SoftBank, “, ” JP Morgan, ”, Charu Chanana Organizations: Tokyo Reuters, Japan’s Nikkei, Nikkei, Tokyo, SoftBank, ARM Holding, Tokio Marine Holdings Inc, Insurance, Holdings, CPI, Saxo Markets, Otsuka Holdings Locations: Tokyo

☆ How to fight dementia, according to neurologists
▼ + stars: | 2024-02-12 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +17 min

What about diabetes, cancer, thyroid disease, high blood pressure or heart disease? Some of the questions might seem unexpected to those who don’t write about brain health. However, my risk of developing vascular dementia, the second most common type after Alzheimer’s disease, is elevated. "Such spikes cause brain inflammation, disrupt brain metabolism and increase shrinkage of the thinking part of the brain," Isaacson said. The National Institute on Aging currently supports nearly 500 active clinical trials on Alzheimer’s disease and related dementias.

Persons: Louise Dittner, Krysta, Ryan LaMotte, It’s, ”, Natalia Rost, “, Rost, ” Rost, Richard Isaacson, ” Isaacson, mockingbird …, birthed, it’s, I’ve, Isaacson, Sandee LaMotte Organizations: CNN, Comprehensive, Massachusetts General Hospital, Harvard Medical School, American Academy of Neurology, Boca Raton, Weill Cornell Medicine, Presbyterian, Mayo Clinic, Volunteers, Alzheimer’s, National Institute on Aging, National Institutes of Health Locations: Massachusetts, Boston, neonatologists, Florida, United, New York, New York City, Nature

☆ Opinion | My Father, Ronald Reagan, Would Weep for America
▼ + stars: | 2024-02-11 | by ( Patti Davis | ) www.nytimes.com time to read: +1 min

The night before my father died, Ronald Reagan, I listened to his breathing — ragged, thin. Or of the man who lifted his voice to the overcast sky and said, “Mr. Long before my father ran for office, politics sat between us at the dinner table. The conversations were predictable: Big government was the problem, the demon, the thing America had to be wary of. I wanted to talk about the boy who bullied me on the school bus, not government overreach.

Persons: Ronald Reagan, “ Mr, Gorbachev, Long Organizations: America

☆ What is a typical degree of cognitive ability for a person in their 80s?
▼ + stars: | 2024-02-09 | by ( Mira Cheng | ) edition.cnn.com time to read: +10 min

How we change as we ageA decline in cognitive abilities is a normal part of healthy aging, said Dr. Emily Rogalski, Rosalind Franklin Professor of Neurology at the University of Chicago. A diagnosis of mild cognitive impairment is made clinically when cognitive difficulties become frequent and fall outside what is considered normal aging. “There’s not a whole lot of good evidence that there’s anything special about age 80 that leads to a drop-off” in cognitive abilities, Mather said. And they use cognitive tests, such as the Mini Mental Status Exam (MMSE) or Montreal Cognitive Assessment (MOCA), to assess performance in different cognitive areas. Although population-level data associates aging with cognitive decline, the actual manifestation of aging is very diverse on an individual level, Rogalski said.

Persons: Joe Biden, Donald Trump, Biden, Trump, Nikki Haley, Nancy Pelosi, Emily Rogalski, Rosalind Franklin, ”, Molly Mather, “, Angela Roberts, Roberts, “ There’s, Mather, MMSE, We’re, ” Mather, Nir Barzilai, Rogalski, “ We’ve, superagers, Barzilai, “ It’s, Dr, Sanjay Gupta, ” Roberts Organizations: CNN, House, Republican, NBC, Neurology, University of Chicago, UCSF, Aging, Northwestern University’s Feinberg School of Medicine, National Institute, Western University, Institute for Aging Research, Albert Einstein College of Medicine, American Federation for Aging Research, Trump, Biden, Get CNN, CNN Health, ” Locations: Mexico, Egypt, Montreal

☆ Message in a bottle from high school class found 32 years later unlocks memories of beloved teacher
▼ + stars: | 2024-02-07 | by ( Sarah Engel | Christina Zdanowicz | ) edition.cnn.com time to read: +2 min

CNN —The extraordinary discovery of a decades-old message in a bottle has inspired alumni of a Long Island, New York, high school to remember their beloved late science teacher. Merci, Gracias, Danke, Thank you, Shawn and Ben,” the letter read, addressed from Mattituck High School on Long Island in October 1992. Courtesy Adam TravisAmazement and wonder bubbled up in the Mattituck High School Alumni Facebook group about how the letter remained intact for 32 years – and how it was found just a few miles from the high school. “The message in a bottle project was one of his favorite and longest-standing projects over the years,” Brooks said. Earth science teacher Richard E. Brooks often assigned the "message in a bottle project," his son said.

Persons: Adam Travis, “, ” Travis, Travis didn’t, Shawn, Ben, Richard E, Brooks, “ Mr, ”, Benny Doroski, ” Brooks ’, John, John Brooks, ” Brooks, Brooks ’ Organizations: CNN, Mattituck High, Facebook, Mattituck High School Locations: , New York, Shinnecock Bay, Long, Alzheimer’s, Azores, Ireland, ”

Eli Lilly rode soaring demand for diabetes and weight-loss treatments to a better-than-expected finish in 2023, and the drugmaker expects momentum to carry into the new year. Lilly said on Tuesday that revenue could climb as much as 22% this year, as star sellers like the diabetes drug Mounjaro and its new weight-loss counterpart, Zepbound, gain market share. Mounjaro sales jumped 65% to $2.21 billion in the fourth quarter compared with the third quarter. Doctors also prescribe that drug off-label for weight loss, which is one of the hottest areas of pharmaceutical sales. The share price for Indianapolis-based Eli Lilly and Co. has climbed over 400% since the start of the decade.

Persons: Eli Lilly, Lilly, Doctors, David Ricks, “, ”, FactSet, donanemab Organizations: Company, Revenue, Drug Administration, Indianapolis Locations: Mounjaro, North Carolina

☆ Healthy living may battle cognitive decline even with signs of dementia in the brain, study suggests
▼ + stars: | 2024-02-05 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

CNN —Living a healthy lifestyle with a focus on a nutritious diet, regular exercise, minimum alcohol consumption and other healthy habits can help keep your brain sharp into old age, doctors say. But what if your brain already has signs of beta amyloid or tau — two of the hallmark signs of Alzheimer’s and other brain pathologies? Will a healthy lifestyle still protect you from cognitive decline? Not everyone who has signs of Alzheimer’s or vascular dementia goes on to develop cognitive issues, but many do. In fact, “a higher healthy lifestyle score was associated with better cognition even after accounting for the combined burden of brain pathologies,” according to Yaffe and Leng.

Persons: ”, Dr, Klodian, Richard Isaacson, “, Isaacson, wasn’t, —, Kobus, Lewy, Yue Leng, Kristine Yaffe, Yaffe, San Francisco Weill Institute for Neurosciences . Leng, Leng, it’s Organizations: CNN, Rush Institute, Healthy Aging, Rush University, “, University of California, San Francisco Weill Institute for Neurosciences . Locations: Chicago, Florida, San

☆ Exclusive-Eisai Expects 1,500 Alzheimer's Patients in China Launch, Sees ‘Huge’ Growth
▼ + stars: | 2024-02-04 | by ( Feb. | At P.M. | ) www.usnews.com time to read: +5 min

“China is one of the fastest-aging countries in the world and is one of the most important countries in the area of Alzheimer’s disease for Eisai,” a company spokesperson said. “The potential growth for Leqembi in China is huge.”Eli Lilly, which is developing a similar treatment called donanemab, told Reuters it has filed for approval in China. The Indianapolis-based company is now testing its drug in a 1,500-person trial with volunteers in China, Taiwan, South Korea and the EU, a spokesperson said. Leqembi, which works by removing a toxic protein called beta amyloid from the brain, is the first Alzheimer's treatment proven to alter the course of the fatal, brain-wasting disease. Once on treatment, suitable patients undergo a series of MRI scans to monitor for potentially fatal swelling and bleeding in the brain.

Persons: Julie Steenhuysen, Andrew Silver CHICAGO, ” Eli Lilly, Biogen, Liu Zhou, Eisai, ”, Hidemaru Yamaguchi, Soeren Mattke, Mattke, Andrew Silver, Caroline Humer, Bill Berkrot Organizations: Reuters, EU, Leqembi, Guangdong Medical University, ” Citi, Psychiatry, Siemens Healthineers, University of Southern, University of Southern California Brain Health Locations: SHANGHAI, China, ”, Leqembi, The Indianapolis, Taiwan, South Korea, Eisai, United States, Japan, Europe, U.S, University of Southern California, Chicago, Shanghai

☆ Unclaimed property day: More than 30 million people have unclaimed money or assets. Are you one of them?
▼ + stars: | 2024-02-01 | by ( Jeanne Sahadi | ) edition.cnn.com time to read: +4 min

Over 30 million people in the United States have unclaimed property that they have either forgotten about or never knew was theirs, according to the National Association of Unclaimed Property Administrators, which is a part of the National Association of State Treasurers. To get a complete picture of whether you have unclaimed money or assets, first check the unclaimed property sites of all the states where you have lived in your life (including the District of Columbia and Puerto Rico). Each state has its own laws and practices governing unclaimed or abandoned property, which you can find out about by visiting their unclaimed property sites that NAUPA links to here. Consider: More than $4 billion worth of unclaimed property was returned to people in fiscal year 2022, NAUPA said. Each state decides whether to reveal how much your unclaimed property is worth when you do your initial search.

Persons: ”, Michael W, you’ve, haven’t, it’s, Frerichs, state’s, NAUPA Organizations: New, New York CNN, National Association, National Association of State, Illinois, District of Columbia Locations: New York, United States, Puerto Rico, Illinois, Alabama

NEW YORK (AP) — Adele Zerilli Springsteen, the longtime legal secretary, musical muse and concert dance partner who captured countless hearts in her son Bruce Springsteen 's E Street Nation and beyond, has died at 98. Bruce Springsteen announced in an Instagram post that his mother died Wednesday. She was “real smart, real strong, real creative,” with a “refusal to be disheartened,” Bruce told biographer Dave Marsh. Her life had an incredible consistency, work, work, work every day, and I admired that greatly," he told "Uncut" magazine in 2002, praising her “noble” juggling of work and home. E Street Band member Steven Van Zandt tweeted Thursday that Adele Springsteen was the “Matriarch of our family and an unrelenting source of inspiring positive energy.

Persons: — Adele Zerilli Springsteen, Bruce Springsteen, Glenn Miller, Adele Springsteen —, ”, “, Springsteen, —, Bruce Springsteen’s, Zerillis, fathoming, Adele Springsteen's, Adele, Bruce, ” Bruce, Dave Marsh, Ellis, Steven Van Zandt, Adele Springsteen, Bruce's, Douglas, Pamela Springsteen, Virginia, Rhonda Shafner, Dalton Organizations: Smiths, New, Stone, MetLife Locations: American, New York City, Freehold, New Jersey, America, Europe, New, Ellis, Los Angeles

☆ Adele Springsteen, Rock Star’s Mother, Dies at 98
▼ + stars: | 2024-02-01 | by ( Orlando Mayorquin | More About Orlando Mayorquin | ) www.nytimes.com time to read: +1 min

Adele Springsteen, who nurtured the budding musical talent of her son, the pioneering rock star Bruce Springsteen, died on Wednesday. No cause was given, but Ms. Springsteen had struggled for more than a decade with Alzheimer’s disease. Her son has been outspoken about his relationship with his mother and her influence on him. Ms. Springsteen rented him his first guitar when he was 7, he said in 2021 during his Broadway show, “Bruce on Broadway,” which ran for more than two months as the city began to emerge from pandemic-related closures. The show had wide-ranging reflections, including thoughts about his mother.

Persons: Adele Springsteen, Bruce Springsteen, Springsteen, “ Bruce, James, ” Organizations: Broadway, St, James Theater, NBC

☆ Biogen Abandons Its Controversial Alzheimer’s Drug Aduhelm
▼ + stars: | 2024-01-31 | by ( Rebecca Robbins | More About Rebecca Robbins | ) www.nytimes.com time to read: +1 min

The drug maker Biogen said on Wednesday it would abandon its ownership rights to Aduhelm, an Alzheimer’s drug that had provoked fierce criticism of the company and regulators after it was approved based on weak evidence that it would help patients. The company will also stop a clinical trial that the Food and Drug Administration had ordered to confirm whether the drug is effective in slowing the progression of Alzheimer’s disease. Biogen’s decision closes out a yearslong saga that generated outrage and eroded trust in the regulatory process for bringing new medicines to market. adviser called the approval of the drug perhaps “the worst approval decision that the F.D.A. has made that I can remember.” A congressional inquiry later found that the F.D.A.’s process for approving Aduhelm was “rife with irregularities” and involved “lapses in protocol,” including unusually close collaboration with Biogen.

Persons: Biogen, Aduhelm Organizations: and Drug Administration

☆ Polycystic ovary syndrome, or PCOS, linked with cognitive decline, study finds
▼ + stars: | 2024-01-31 | by ( Kristen Rogers | ) edition.cnn.com time to read: +7 min

CNN —Polycystic ovary syndrome, known as PCOS, has long been known for symptoms such as missed periods or excess body hair. Polycystic ovary syndrome refers to symptoms related to a hormonal imbalance in people assigned female at birth. “Our results suggest that people with this condition have lower memory and thinking skills and subtle brain changes at midlife. The findings highlight “potential cognitive vulnerabilities in women with PCOS, though it’s important to know that these are cognitive weaknesses, not impairments,” Maki said. For one, the study showed an association between PCOS and cognitive decline, but didn’t prove that the condition causes cognitive decline, the authors said.

Persons: ”, Pauline Maki, Maki wasn’t, Eunice Kennedy, PCOS, Heather G, Huddleston, “, ” Maki, Mateja Perović, Wiebke Arlt, wasn’t, Arlt, Katherine Sherif, Ricardo Azziz, ” Sherif Organizations: CNN, Mental Health Research, University of Illinois, National, of Child Health, Human, World Health Organization, University of California, PCOS, University of Toronto, Imperial College London’s Institute, Clinical Sciences, Thomas Jefferson University, University of Alabama Locations: midlife, University of Illinois Chicago, Philadelphia, Birmingham

Biogen will stop developing its Alzheimer’s treatment Aduhelm, a drug once seen as a potential blockbuster before stumbling soon after its launch a couple years ago. The company also is helping Japanese drugmaker Eisai sell another Alzheimer’s treatment, Leqembi, which already has full FDA approval. Leqembi is the first medicine that’s been convincingly shown to slow the cognitive decline caused by Alzheimer’s disease, though only modestly. Political Cartoons View All 253 ImagesAduhelm was the first new Alzheimer’s disease drug introduced in nearly two decades. But doctors were hesitant to prescribe the intravenous drug, given weak evidence that the drug slows Alzheimer’s.

Persons: drugmaker, Biogen, that’s, Aduhelm Organizations: Food and Drug Administration, Regulators, FDA, Cambridge, Inc Locations: Japanese, Cambridge , Massachusetts

☆ Rare cases of possible Alzheimer’s transmission uncovered in recipients of discontinued medical treatment
▼ + stars: | 2024-01-29 | by ( Jacqueline Howard | ) edition.cnn.com time to read: +9 min

All five adults had growth hormone deficiency as children and received pituitary growth hormones prepared in a specific way from cadavers. The treatment approach was discontinued after cases of a rare brain disorder called Creutzfeldt-Jakob disease were found to be associated with the administration of contaminated human growth hormone from cadavers. Although Alzheimer’s is not a prion disease, some separate research suggests that the two proteins that are hallmarks in Alzheimer’s disease — amyloid beta and tau — behave like prions. “This study suggests that in very rare circumstances Alzheimer’s disease may be transmitted between humans via human growth hormone from deceased donors. “I’m also intrigued by how these results may inform potential therapeutic targets and strategies in the future,” Isaacson said, regarding Alzheimer’s disease.

Persons: John Collinge, Jakob, Creutzfeldt – Jakob, Alzheimer’s, ” Collinge, ’, –, ” Dr, Susan Kohlhaas, ” Kohlhaas, “ It’s, Dr, Richard Isaacson, ”, Isaacson, “ I’m, ” Isaacson, “, Gargi Banerjee, ” Banerjee, James Galvin, Sanjay Gupta, ” Galvin, Lewy Organizations: CNN, Nature, University College London Institute, University College London, National Hospital for Neurology, Neurosurgery, Alzheimer’s Research, Science Media, Comprehensive, Brain Health, University of Miami Health, CNN Health Locations: United Kingdom, United States, United, Florida, UHealth, Creutzfeldt

☆ Mental Acuity Questions Catch Up With Trump
▼ + stars: | 2024-01-26 | by ( Susan Milligan | ) www.usnews.com time to read: +9 min

"Some people at Biden's and Trump's age are in a nursing home. Still, questions about the mental capacities of both Biden and Trump have been an issue in the campaign. How could they go after Trump's mental state without drawing attention to Biden's age – a factor polls show is one of his greatest vulnerabilities? Her youth and GOP membership make her a good person to challenge Trump on his mental acuity, but it's "too little, too late," he says. "The reason Trump's age has generally not been an issue is [because of] the energy around his supporters and the energy directed at him from his supporters.

Persons: Donald Trump, –, Joe Biden, Trump, Biden, It's, Steven Austad, Biden's, …, Joe, missteps, He's, Viktor Orban, Orban, Barack Obama, Obama, you'd, John Gartner, Trump's, Gartner, Trump –, Goldwater, Barry Goldwater, Donald Jurivich, Jurivich, Ronald Reagan, Reagan, Nikki Haley, Nancy Pelosi, Haley, I’ve, ” Haley, let’s, Donald, Basil Smikle, Smikle, Melody Crowder, Meyer, " Crowder Organizations: United Nations, Capitol, ABC, Washington Post, Biden, University of Alabama, Conservative, Fox News, New York Post, New Hampshire, Johns Hopkins University, Gartner, American Psychiatric Association, Donald Trump View, University of North Dakota School of Medicine & Health Sciences, GOP, Democratic, Columbia University, Davidson College, Trump Locations: Biden's, Hungarian, Turkey, Baltimore, United States, South Carolina

☆ New blood test that screens for Alzheimer’s may be a step closer to reality, study suggests
▼ + stars: | 2024-01-22 | by ( Jacqueline Howard | ) edition.cnn.com time to read: +11 min

Alzheimer’s disease, a brain disorder that affects memory and thinking skills, is the most common type of dementia, according to the National Institutes of Health. “A blood test being negative speeds up the investigation for other causes of the symptoms and this is just as important,” Ashton said. Isaacson, who has researched blood biomarkers in people with no or minimal cognitive complaints, likened testing blood samples for signs of Alzheimer’s disease to how people undergo routine blood tests for high cholesterol. It is possible that currently available treatments for Alzheimer’s disease would work better in those diagnosed early in this way,” he said. The combination of a simple screening test with an effective treatment for Alzheimer’s disease would have a dramatic impact for individuals and for society.”

Persons: ” Nicholas Ashton, Ashton, ”, Kaj Blennow, Henrik Zetterberg, antiamyloid, immunoassay, ” Ashton, Richard Isaacson, ” Isaacson, Isaacson, ‘, “, Dr, Sanjay Gupta, David Curtis, ” Curtis Organizations: CNN, University of Gothenburg, National Institutes of Health, Quest Diagnostics, Alzheimer’s, Alzheimer’s Association, Get CNN, CNN Health, University College London, Science Media Locations: Sweden, United States, Wisconsin, Pau, Florida

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