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☆ NIH to test Pfizer’s Paxlovid, other treatments as potential long Covid therapies
▼ + stars: | 2023-07-31 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +1 min

The National Institutes of Health said Monday it launched mid-stage clinical trials to test at least four treatments, including Pfizer 's antiviral Covid-19 pill Paxlovid, as potential therapies for long Covid. But the lack of a specific long Covid treatment pushes some patients to seek unproven – and potentially dangerous – remedies for the condition. "NIH is committed to a highly coordinated and scientifically rigorous approach to find treatments that will provide relief for the millions of people living with long COVID." The NIH will test the safety and effectiveness of the treatments – which include both drugs and medical devices – in groups of 100 to 300 patients with long Covid symptoms. The first part of the phase two trial will test a longer dosing regimen of Paxlovid to see if it improves long Covid symptoms.

Persons: Lawrence Tabak Organizations: National Institutes of Health, Pfizer, Health, NIH

☆ Netanyahu warns against overturning controversial new law in CNN interview
▼ + stars: | 2023-07-27 | by ( Tara John | ) edition.cnn.com time to read: +5 min

“What you’re talking about is a situation, or potential situation, where in American terms, the United States’ Supreme Court would take a constitutional amendment and say that it’s unconstitutional. The law, which would limit the power of Israel’s Supreme Court, is an amendment to one of Israel’s Basic Laws, which exist in place of a formal constitution. The Supreme Court has said that it will hear appeals against the law in September. Israel’s new law strips the Supreme Court of the ability to reject some government decisions on the basis of the “reasonableness” standard. Amir Cohen/ReutersThe country has no upper chamber of the parliament, but it has a relatively strong Supreme Court.

Persons: Wolf, Benjamin Netanyahu, CNN —, ” Netanyahu, CNN’s Wolf, Ariel Schalit, Joe Biden, Netanyahu, we’re, We’re, ”, Amir Cohen, Blitzer, they’re, unfazed Organizations: CNN, CNN — Israel’s, United States ’, Biden White House, AP Locations: United, Tel Aviv, Israel, United States, Iran, American

☆ Fact Check-No evidence tornado-hit Pfizer plant produced COVID vaccines
▼ + stars: | 2023-07-26 | by ( Reuters Fact Check | ) www.reuters.com time to read: +2 min

A Facebook post included the same video clip and the text: “Pfizer plant in North Carolina hit by a tornado. The Rocky Mount plant did not produce or store COVID vaccines, a Pfizer spokesperson told Reuters in an email. The plant also made vials and syringes, according to the Pfizer website (here). The Rocky Mount Pfizer plant damaged by a tornado produced sterile injectables among other products. There is no evidence that it produced or stored COVID vaccines.

Persons: ”, Read Organizations: Pfizer, Vaccines, North Carolina ”, Reuters, Mount, UPS, Biotech, Fierce, Rocky Locations: North Carolina, U.S, Kalamazoo , Michigan, Michigan, Wisconsin, Pleasant Prairie , Wisconsin, Louisville , Kentucky, Columbus , Ohio, Wisconsin and Massachusetts

☆ Tornado Tears Through Pfizer’s N.C. Site, Threatening Crucial Drug Supplies
▼ + stars: | 2023-07-20 | by ( Christina Jewett | More About Christina Jewett | ) www.nytimes.com time to read: +2 min

It was also unclear how deeply the destruction would exacerbate existing national drug shortages, which have reached a 10-year high in recent months. Hospitals are on high alert because low-cost generic products manufactured at the site, such as the sedative propofol, are already among the most shortage-prone on the market. The tornado ripped through a 16-mile strip of the Rocky Mount area, about 50 miles east of Raleigh, at about 12:30 p.m. on Wednesday. She said Pfizer and the Food and Drug Administration had teams on-site to assess the damage. It also makes vancomycin, an antibiotic administered to fight severe infections, and muscle blockers including succinylcholine, also used in surgery.

Persons: I’m, ”, Michael Ganio, Mittal Sutaria, Sutaria, Vizient Organizations: American Society of Health, Pharmacists, National Weather Service, Pfizer, Food and Drug Administration Locations: Rocky, Raleigh, Vizient

☆ Water, Water, Everywhere, and Now Her Husband Is Gone
▼ + stars: | 2023-07-16 | by ( Cj Hauser | ) www.nytimes.com time to read: +2 min

Bishop skillfully invokes and revises the “forbidden passion” trope of a relationship between an older teacher and a young ingénue. The meta-conversation in the book is smart — What does it mean to tell a true story? As J.B. becomes a suspect in Patrick’s death, she returns to Australia for the first time since she got married. They have an uncanny, dreamlike quality, unfolding without J.B. quite being able to participate in them fully. J.B. is a very good narrator, but I suspect she is not recounting her saga for the reader — she’s telling it for herself.

Persons: Bishop, Patrick, “, Meg Wolitzer’s “, Liane Moriarty’s “ Locations: Australia

☆ Janitor heard ‘annoying alarms’ and turned off freezer, ruining 20 years of school research worth $1 million, lawsuit says
▼ + stars: | 2023-06-27 | by ( Jessica Xing | ) edition.cnn.com time to read: +3 min

CNN —A university janitor who turned off a freezer after hearing multiple “annoying alarms,” ruined more than 20 years of research, according to a lawsuit filed against his employer by Rensselaer Polytechnic Institute in upstate New York. The school is seeking more than $1 million in damages and legal fees from Daigle Cleaning Systems as a result of the incident. The college does not believe the janitor is at fault but instead blames Daigle Cleaning Systems for failing to properly train and supervise him, according to the suit. CNN reached out to attorneys for Daigle Cleaning Systems and the Rensselaer Polytechnic Institute for comment. A warning was posted on the freezer, according to the court filing.

Persons: Lakshmi, Baruch ’ Organizations: CNN, Rensselaer Polytechnic Institute, Daigle, Systems Inc, Systems, Supreme, Biochemical Solar Energy Research, AS IT Locations: New York, Troy , New York, Rensselaer, “

☆ Eli Lilly gorges on obesity options
▼ + stars: | 2023-06-27 | by ( ) www.reuters.com time to read: +2 min

NEW YORK, June 27 (Reuters Breakingviews) - Eli Lilly (LLY.N) has filled its plate with potential obesity treatments, unveiling data from two more on Monday. With so many options under development at Lilly, Novo Nordisk (NOVOb.CO) and others, it raises reasonable questions about capital allocation. Obesity drugs have investors salivating, but is this just more pharmaceutical R&D overkill? Pfizer’s cholesterol-lowering Lipitor, for one, reached consumers after rivals, and a decade after Merck’s version. Lilly’s research budget, projected at 24% of revenue this year, exceeds that of many peers, including Pfizer’s (PFE.N) 19%.

Persons: Eli Lilly, Robert Cyran, Aston Martin, Jeffrey Goldfarb, Sharon Lam Organizations: YORK, Reuters, Novo Nordisk, Twitter, Vodafone, Thomson Locations: Lilly, China, Canada

☆ Pfizer to end development of experimental obesity pill due to elevated liver enzymes
▼ + stars: | 2023-06-26 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +3 min

Pfizer on Monday said it would stop developing its experimental obesity and diabetes pill, lotiglipron, due to elevated liver enzymes in patients who took the drug once a day in mid-stage clinical studies. New York-based Pfizer said it will instead focus on its other oral obesity drug, danuglipron, which is in a fully enrolled phase two clinical trial. Pfizer CEO Albert Bourla has said that an obesity pill could eventually generate $10 billion each year for the company. The new class of obesity drugs is piquing public interest and causing a weight loss industry gold rush. Analysts believe Eli Lilly’s pill has an edge over Pfizer’s danuglipron.

Persons: William Sessa, Albert Bourla, Eli Lilly, Eli Lilly’s, danuglipron, Wells, Mohit Bansal, orforglipron, Bansal Organizations: Pfizer, Novo Nordisk, National Institutes of Health Locations: New York, danuglipron

☆ Remembering Sally Ride: 40th anniversary of her historic spaceflight
▼ + stars: | 2023-06-18 | by ( Jackie Wattles | ) edition.cnn.com time to read: +9 min

CNN —It has been 40 years since Sally Ride became the first woman from the United States to travel into outer space. She was not open about her personal life, according to former NASA astronaut Steve Hawley, who was married to Ride from 1982 to 1987. However, the educational company she cofounded, Sally Ride Science, revealed more of her personal life in her 2012 obituary, recognizing her longtime partner, Tam O’Shaughnessy, after Ride died of pancreatic cancer. NASASherr’s book “Sally Ride: America’s First Woman in Space” was first published in 2014. A trailblazer’s legacyRide’s ambition and love of knowledge extended far beyond her role as an astronaut, Sherr noted.

Persons: Sally Ride, Steve Hawley, Sally, Tam O’Shaughnessy, Ride, NASA hasn’t, General, Christina Koch, Victor Glover, Artemis, NASA's, Lynn Sherr, “, Sherr, ” Sherr, Dale Moore, ”, Billie Jean King, Martin Luther King Jr, ’, King Charles III, Prince of Wales, ‘, Valentina Tereshkova, Svetlana Savitskaya, Ride’s, Lyndon B, Johnson, Gloria Steinem, Richard Drew, Tam O'Shaughnessy, Barack Obama, Kevin Dietsch, O’Shaughnessy, Charles Tasnadi, Eileen Collins, NASA’s Koch, Jessica Meir, —, Rob Navias Organizations: CNN, NASA, Sally Ride, NASA’s, Space Center, CAPCOM, Johnson Space Center, ABC News, Ride, Edwards Air Force Base, Stanford University, Stanford Daily, Soviet Union, Girls Club of America, Magazine, White, UPI, Sally Ride Science, University of California, UC San Diego, Poets, State Department, United Nations Locations: United States, Houston, California, Soviet, New York, Washington ,, San Diego, Columbia

☆ Chris Christie Is Running for the Nomination of a Party That Doesn’t Exist - The New York Times
▼ + stars: | 2023-06-08 | by ( Michelle Goldberg | ) www.nytimes.com time to read: +3 min

But my enjoyment of his newfound Resistance shtick doesn’t bode well for Christie. The people he needs to win over are not liberal New York Times columnists, but voters who hate liberal New York Times columnists. The trick, for a Republican, is going to be painting Trump as a weak loser who will sabotage right-wing priorities. At times Christie tried to do this, as when he criticized Trump for his failure to build the border wall and repeal the Affordable Care Act. presidential nomination, would he be willing to accept the role of the presidential candidate of a 2024 center-right independent party?” Steinberg wrote in April.

Persons: Christie, ”, Trump, Alec Baldwin, Ivanka Trump, Jared Kushner —, you’ll, —, Kushner, Prince Mohammed bin Salman, doesn’t bode, “ idolizing ” Vladimir Putin, Volodymyr Zelensky, Biden, John McCain, pander, filleting, Marco Rubio, he’s, Alan Steinberg, Bush, ” Steinberg Organizations: Trump, State, New York Times, Republican, “ Locations: State of New Jersey, Saudi Arabia, Ukraine, Europe

☆ A Writer Recognizes Herself in Another Writer’s Story
▼ + stars: | 2023-06-08 | by ( Jean Hanff Korelitz | ) www.nytimes.com time to read: +1 min

THE MYTHMAKERS, by Keziah WeirWhat navel-gazers we writers of fiction are! It’s an attribute few of us would deny, but while it most often evokes autobiography, even those of us who tend not to mine our “lived experience” are still drawn back ceaselessly into the great and fascinating murk that is … writing about writing fiction. Some of us — myself included (see: “The Plot”) — have an insatiable appetite for stories that grapple with these issues. I am happy to report that Keziah Weir’s assured first novel, “The Mythmakers,” is a laudable addition to a reading list that already includes such standouts as Meg Wolitzer’s “The Wife,” Karen Dukess’s “The Last Book Party,” Andrew Lipstein’s “Last Resort” and R.F. Kuang’s new novel, “Yellowface.” In “The Mythmakers,” most of the relevant offenses surround a recently deceased novelist named Martin Keller as a young journalist sets out to investigate a simple act of appropriation and finds something far more complex and — for any writer — infinitely more shameful.

Persons: Keziah Weir, Weir’s, Meg Wolitzer’s “, ” Karen Dukess’s “, ” Andrew Lipstein’s, Martin Keller

☆ F.D.A. Approves Pfizer’s R.S.V. Vaccine for Older Adults
▼ + stars: | 2023-05-31 | by ( Christina Jewett | ) www.nytimes.com time to read: +3 min

Each year, about 60,000 adults 65 and older are hospitalized with R.S.V. The Centers for Disease Control and Prevention estimated that in one year, more than 21,000 people in that age group would need to take the GSK vaccine to prevent one R.S.V. Several treatments, including a maternal vaccine and a monoclonal antibody for infants against R.S.V., are under agency review. The GSK vaccine, called Arexvy, was nearly 83 percent effective against severe R.S.V. The final vote of the F.D.A.’s advisory panel in favor of the Pfizer vaccine’s safety and efficacy was 7 to 4.

Persons: Miller Fisher, Jerica Pitts Organizations: Disease Control, GSK, Pfizer, Infants, R.S.V

☆ Wine at Wegmans? Not in New York, if Liquor Stores Can Help It.
▼ + stars: | 2023-05-31 | by ( Luis Ferré-Sadurní | ) www.nytimes.com time to read: +2 min

The two main alcohol distributors in the state, Southern Glazer’s Wine & Spirits and Empire Merchants, have collectively spent at least $120,000 since the year began on lobbying state officials, disclosure records show. The families that own Southern Glazer’s, which is the largest liquor distributor in the United States and based in Florida, also contributed at least $25,000 to Ms. Hochul’s campaign last year. The commission failed to reach consensus on some of the most contentious issues, such as allowing grocery stores to sell wine. It is now up to lawmakers to decide whether to turn the proposed changes into legislation. law, introduced a bill that incorporated the commission’s recommendations.

Persons: Hochul’s, ”, Harry Bronson, “, James Skoufis Organizations: Empire Merchants, Rochester Democrat, Anheuser, Busch, State Senate, Hudson Valley Democrat Locations: Southern, United States, Florida, logjam, Albany, State, Hudson Valley

☆ Justine Triet: French film director attacks Macron during Palme d'Or acceptance speech
▼ + stars: | 2023-05-28 | by ( Niamh Kennedy | ) edition.cnn.com time to read: +3 min

CNN —French film director Justine Triet condemned what she called French President Emmanuel Macron’s “shocking” repression of the pension reform protests during her Palme d’Or acceptance speech at the Cannes Film Festival on Saturday. “The commodification of culture that the neoliberal government defends is in the process of breaking the French cultural exception,” Triet continued. Triet is just the third woman to win the Palme d’Or, one of cinema’s tpp prizes, after New Zealand’s Jane Campion and France’s Julia Ducournau. “Happy to see the Palme d’Or awarded to Justine Triet, the 10th for France! France’s social unrest has cast a shadow over this year’s instalment of the film festival.

☆ FDA advisors recommend Pfizer’s RSV vaccine for infants but raise safety concerns
▼ + stars: | 2023-05-18 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +3 min

The Food and Drug Administration's independent panel of advisors on Thursday recommended full approval of Pfizer's vaccine that protects infants from RSV, but raised safety concerns over premature births that may be tied to the shot. Ten of the advisors said the safety data on Pfizer's shot was adequate, while four said it was not. The FDA earlier this month approved the first RSV shot for adults ages 60 and older from GlaxoSmithKline. The agency is expected to make a decision within weeks on Pfizer's other RSV shot for that same age group. Pfizer's shot for infants is administered to expectant mothers in the late second or third trimester of their pregnancy.

☆ Earth-size exoplanet may be covered in volcanoes
▼ + stars: | 2023-05-17 | by ( Ashley Strickland | ) edition.cnn.com time to read: +6 min

Instead, the exoplanet, called LP 791-18 d, is likely covered in volcanoes and may experience eruptions with the same frequency as Jupiter’s moon Io, the most volcanically active place in our solar system, according to researchers. LP 791-18 d is located about 90 light-years from Earth in the Crater constellation, where it orbits a small red dwarf star. And astronomers believe the massive planet LP 971-18 c might be contributing to the newly detected exoplanet’s possible volcanism. As the two objects orbit their star, LP 971-18 c and the newfound exoplanet LP 791-18 d closely pass each other, allowing the gravitational pull of the larger planet LP 971-18 c to tug on planet d and reshape its orbit. The discovery of LP 971-18 d points to the importance of data collected by space telescopes.

☆ R.S.V. Vaccine Approved for Older Adults
▼ + stars: | 2023-05-03 | by ( Christina Jewett | ) www.nytimes.com time to read: +3 min

advisory panel reviewed data from trials for two vaccines aimed at older adults, one from GSK and one from Pfizer. The virus can lead to pneumonia, which is far more worrisome for older adults and especially for those with underlying medical conditions like heart and lung disease or diabetes. vaccine for older adults is also expected to receive F.D.A. in older adults and said it expected authorization in the first half of this year. Last week, the European Medicines Agency did recommend approval of GSK’s vaccine for adults 60 and older.

☆ Pfizer’s Earnings Fall With Cooling Demand for Covid Products
▼ + stars: | 2023-05-02 | by ( Dean Seal | ) www.wsj.com time to read: 1 min

Pfizer reaffirmed its outlook to see revenue decline by as much as a third this year from its record high $100 billion in 2022. Photo: Gabby Jones for The Wall Street JournalPfizer ’s first-quarter revenue and earnings were down by nearly a third from a year ago, when the spread of the Omicron variant of Covid-19 buoyed demand for pandemic products. The drugmaker for the first three months of the year logged revenue of $18.28 billion, down 29% from a year ago but still well above Wall Street analyst estimates for $16.61 billion, according to analysts polled by FactSet.

☆ CDC eases certain Covid-19 vaccine requirements for international travelers to US
▼ + stars: | 2023-04-28 | by ( Brenda Goodman | ) edition.cnn.com time to read: +2 min

CNN —The US Centers for Disease Control and Prevention is still requiring international visitors boarding flights to the United States to be vaccinated against Covid-19, but it’s easing vaccine requirements for those travelers. International travelers boarding flights to the United States will now be considered fully vaccinated two weeks after getting a single dose of either the Pfizer or Moderna mRNA vaccine any time after August 16, 2022, when bivalent formulations first became available. Previously, foreign travelers entering the United States were considered fully vaccinated two weeks after the second dose of a vaccine that required two primary doses, or two weeks after a vaccine that only required a single shot, such as the Johnson & Johnson vaccine. A number of older, monovalent vaccine regimens also qualify a foreign visitor as fully vaccinated. As part of the update, the older monovalent mRNA Covid-19 vaccines are no longer recommended in the United States, and updated vaccines are recommended for everyone age 6 months and older.

☆ Ball Doctoring: A History of Excuses, Denials and Knowing Winks
▼ + stars: | 2023-04-21 | by ( Benjamin Hoffman | ) www.nytimes.com time to read: +1 min

For nearly as long as baseball has existed, pitchers have been using various methods, legal and otherwise, to doctor the ball. Some want the ball to spin more, some want it to spin less. Some are looking for more movement, and others are looking for more control. In this case, Scherzer, who was ejected from Wednesday’s win over the Los Angeles Dodgers, insists he was using rosin — which is legal — and nothing more. Scherzer made little in the way of excuses or denials about the stickiness of his hands when asked about his decision to drop his appeal and serve a 10-game suspension.

☆ Fact Check-Experts say Pfizer COVID vaccine trials did not cause more miscarriages and there is no evidence of COVID-19 vaccine impact on fertility
▼ + stars: | 2023-03-31 | by ( Reuters Fact Check | ) www.reuters.com time to read: +4 min

Women who got pregnant during Pfizer’s COVID vaccine trials did not have an unusual rate of miscarriage, experts said as they responded to an online video. This is a miscarriage rate of 14%, which is within the “normal” or expected rate of miscarriage per pregnancy, Male said. They also said there is no evidence of impact from COVID-19 vaccines on fertility. Pfizer started a global trial of pregnant women in February 2021. There is no evidence that COVID-19 vaccines affect fertility and pregnancies during Pfizer’s COVID vaccine trials did not have an unusual rate of miscarriage.

☆ Gig workers still pose roadblock for Uber and Lyft
▼ + stars: | 2023-03-14 | by ( ) www.reuters.com time to read: +2 min

NEW YORK, March 14 (Reuters Breakingviews) - Uber Technologies (UBER.N) and Lyft (LYFT.O) dodged a pothole, but bigger roadblocks may be on the horizon. Jefferies estimates Uber, Lyft and food delivery service DoorDash (DASH.N) will avoid a $20 million to $170 million knock on next year’s earnings thanks to the ruling. A group of Uber and Lyft drivers in New York City staged a strike in February over demands for higher wages. And with a tight job market, competition for workers from employers in other sectors – like retailers, which are hiking minimum wages – is stiff. The Biden administration could still step in, too, having proposed new guidelines for classifying independent workers as employees.

☆ Ritchie founder perfects disappointed dad routine
▼ + stars: | 2023-03-13 | by ( ) www.reuters.com time to read: +2 min

The company stretching for its acquisition has done something worse: It disappointed dad. Ritchie investors are expected to approve the fiercely contested deal on Tuesday, a surprising outcome, especially to company co-founder David Ritchie. The pair didn’t speak out before because they assumed, given the weight of opposition to the deal, it was dead. If she succeeds, shareholders better hope her optimistic deal math holds up. They do not reflect the views of Reuters News, which, under the Trust Principles, is committed to integrity, independence, and freedom from bias.

☆ Mark Zuckerberg takes on Elon Musk
▼ + stars: | 2023-03-13 | by ( ) www.reuters.com time to read: +2 min

NEW YORK, March 13 (Reuters Breakingviews) - Mark Zuckerberg is eyeing Elon Musk’s turf. Meta Platforms (META.O) is exploring a stand-alone social network for sharing text updates, according to a statement from the social media network to Breakingviews on Monday. The move makes sense since Facebook and Instagram have done a better job wringing money from their users than Twitter has. Since Musk bought Twitter in October 2022, the network has been plagued by technical difficulties and fleeing advertisers. Zuckerberg has a business model that knows how to monetize users, whereas Twitter is still figuring that out.

☆ Pfizer’s $43 bln deal is a pricey pipeline fix
▼ + stars: | 2023-03-13 | by ( ) www.reuters.com time to read: +2 min

NEW YORK, March 13 (Reuters Breakingviews) - Pfizer (PFE.N) has found a partial, costly replacement for waning sales of Covid-19 vaccines. The $225 billion pharmaceutical giant said Monday it had agreed to shell out $43 billion for oncology specialist Seagen (SGEN.O), inclusive of net debt. Snag is, Pfizer’s return will probably be low, and the deal may not even receive antitrust approval. Add estimated savings of $1 billion and the result is $1.2 billion of operating profit after tax, assuming the statutory corporate rate. That’s about a 3% return on the purchase price, similar to what Breakingviews estimated when news of talks leaked in February.

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