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The transplant surgery took 21 hours. Initially, doctors were just planning to include the eyeball as part of the face transplant for cosmetic reasons, Rodriguez said during a Zoom interview. Presently, the transplanted eye is not communicating with the brain through the optic nerve. James, who had retained vision in his right eye, knew he might not regain vision in the transplanted eye. "Hopefully this opens up a new path.”James might still regain sight in the transplanted eye, Rodriguez said.
Persons: Aaron James, Eduardo D, Rodriguez, James, it's, , Eduardo Rodriguez, Rodriquez, ” Rodriguez, , ” James, Nancy Lapid, Bill Berkrot Organizations: Hot, NYU Langone, Surgeons, NYU Langone Health, Thomson Locations: Hot Springs , Arkansas, New York, Arkansas
Prescriptions for ketamine have soared in recent years, driven by for-profit clinics and telehealth services offering the medication as a treatment for pain, depression, anxiety and other conditions. With its recent adoption for pain, patients are increasingly encountering those same effects. Ketamine targets a brain chemical messenger called glutamate, which is thought to play a role in both pain and depression. “We want patients to disassociate or feel separate from their pain, depression or anxiety,” said Dr. David Mahjoubi, owner of Ketamine Healing Clinic in Los Angeles. But the experts found “weak or no evidence” for ketamine in many more conditions, including back pain, migraines, fibromyalgia and cancer pain.
Persons: , , Padma Gulur, Gulur, Daniel Bass, Bass, ” Bass, David Mahjoubi, they’re, Eric Schwenk, Thomas, “ There’s, Johnson, Samuel Wilkinson, Caleb Alexander, Matthew Perrone Organizations: WASHINGTON, Duke University, Duke, Food and Drug Administration, FDA, Thomas Jefferson University, Epic Research, Johnson, Drug Enforcement, Yale University, Johns Hopkins University, Twitter, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: As, U.S, Southgate , Kentucky, Los Angeles, anesthesiology, Massachusetts
And though comprehensive sickle cell care — at dedicated centers with expert hematologists, social workers and pain management specialists — reduces hospitalizations, and is the standard for diseases like cystic fibrosis and hemophilia, which do not disproportionately affect Black people, these centers are few and far between for sickle cell. Into this complicated landscape enters the possibility of gene therapy. It’s important to note that this isn’t the first cure for sickle cell. is expected to review another gene therapy from the company Bluebird Bio that targets sickle cell disease but does not use CRISPR; this was the therapy Mr. Holmes received as part of the N.I.H. When she was 17 and hospitalized, facing the reality of her chronic illness, she told her mother that she was ready to pursue gene therapy.
Persons: Holmes, Elizabeth Ford, Ford Organizations: Vertex Pharmaceuticals, CRISPR Therapeutics, Bluebird
An estimated 100,000 people in the United States have sickle cell disease, most of whom have African ancestry. will decide on another application for sickle cell gene therapy made by Bluebird Bio. Two other companies and an academic center, Boston Children’s Hospital, are testing their own sickle cell gene therapies. While these therapies could reduce the suffering of sickle cell patients in the United States and other wealthy countries, there is an even greater need for them in some developing countries like Nigeria. One company, Beam, is testing a way to provide gene editing that requires nothing more than a single infusion in a doctor’s office.
Persons: , Mariah Jacqueline Scott, Scott, , Stephan Grupp, What’s Organizations: Institute for Clinical, CRISPR Therapeutics, Children’s Hospital of Philadelphia, Bluebird, Boston Children’s Hospital Locations: United States, Highland Park, N.J, Boston, Nigeria
The moon’s gravitational pull is also the force behind ocean tides and partly why our planet has a 24-hour day. Geologist and astronaut Harrison Schmitt used an adjustable sampling scoop to retrieve lunar samples during the Apollo 17 mission in 1972. Zircon crystals formed as the moon cooled 4.46 billion years ago, and a new analysis traced them in the Apollo 17 samples. NASAAn ancient landscape has been discovered beneath the East Antarctic ice sheet, thanks to ice-penetrating radar. Understanding the hidden, well-preserved landscape could help scientists predict the evolution of the ice sheet and how it may fare as temperatures warm in the climate crisis.
Persons: Harrison Schmitt, Eugene Cernan, , Jennika Greer, Nick Gray, James Webb, Stewart Jamieson, Ashley Strickland, Katie Hunt Organizations: CNN, NASA, Apollo, University of Glasgow, JBA Consulting, Environment Agency Engineers, Environment, Durham University, CNN Space, Science Locations: Europe, Africa, Asia, Australia, England's Isle of Wight, Isle of Wight, Orkney Islands, Denman, East Antarctica, Belgium, North Wales, Iraq, Syria
It can stimulate stem cell production. It can help repair DNA. It can lower blood pressure. Taurine has demonstrated the potential to lower blood pressure through several mechanisms. Taurine has also been shown to inhibit the release of stress hormones like cortisol, which can raise blood pressure.
Persons: I've, Taurine Locations: Taurine
Lab models of human embryos raise hopes and concerns
  + stars: | 2023-10-26 | by ( Katie Hunt | ) edition.cnn.com   time to read: +14 min
From the moment sperm fuses with an egg, human embryo development involves a string of complex and little understood processes. What happens during human embryo development, particularly in the crucial first month, remains largely unknown. However, 14 days is an important milestone because it is when permitted lab research on cultured human embryos routinely ends. He said, in the future, it might be possible to go as far as 40 days with human embryo models. Some in the field envision a “tipping point” wherein human embryo models might be afforded some protection like those surrounding human embryos, as scientific advances diminish the differences between the embryo models and their real-life counterparts.
Persons: CNN — It’s, , Jacob Hanna, demystify, they’ve, Hanna, “ It’s, ” Hanna, , Peter Rugg, Gunn, it’s, , Robin Lovell, Francis Crick, Naomi Moris, Francis Crick Institute’s, Moris, we’ve, ” Moris, It’s, Bobbie Farsides, ” Farsides Organizations: CNN, Weizmann Institute of Science, Weizmann Institute, Israel, Weizmann, Babraham Institute, International Society for Stem Cell Research, Stem Cell, Francis, Francis Crick Institute, Genetics, Development, , Sussex Medical School Locations: Israel, London, Brighton
Del Pistoia had been travelling a lot between France and the US for work and began feeling more fatigued than usual. However, to decrease the likelihood of the cancer returning, Del Pistoia underwent a bone marrow transplant. Then, after being able to stand up, I was able to walk.”Recovery was slow but, bit by bit, Del Pistoia started to rebuild his life. Exciting futureNow, with a IRONMAN World Championship race in the bag, Del Pistoia is on the hunt for more challenges. Away from sport, Del Pistoia has recently qualified as a seaplane pilot and wants to use his platform to raise awareness and improve accessibility for those living with disabilities.
Persons: Cyril Del Pistoia, Frenchman, Del, , ” Del, Del Pistoia, “ You’re, Donald Miralle, , I’ve, couldn’t, hasn’t, they’re Organizations: CNN, CNN Sport, Frenchman, Del, Nice Locations: Del Pistoia, Nice, France, ” Del Pistoia, Canada, Australia
Those advocates still face one giant hurdle: FDA regulators say the treatment hasn't been shown to work. But with the backing of thousands of ALS patients, Brainstorm took the rare step of “filing over protest,” essentially forcing the agency to render a decision. Still, ALS patients see reasons for optimism. At Wednesday’s meeting, people with such reservations are certain to be outnumbered by appeals from ALS patients and their families. That compromise would be similar to FDA's approach to Relyvrio last year, another ALS drug with questionable data.
Persons: Lou Gehrig’s, drugmaker, they’re, , Marc Scheineson, Brian Wallach, Wallach, , Brainstorm’s, NurOwn, Patricia Manhardt, Anthony Windebank, reanalyzing, weren’t, Terry Heiman, Patterson, it’s, Holly Fernandez Lynch, Matthew Perrone Organizations: WASHINGTON, Drug Administration, FDA, drugmakers, Congress, Obama White House, ALS Association, Mayo Clinic, Physicians, Temple University, University of Pennsylvania, Twitter, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP
LONDON (AP) — Ian Wilmut, the cloning pioneer whose work was critical to the creation of Dolly the Sheep in 1996, has died at age 79. While Dolly's creation was heralded as a revolution by some scientists, it unnerved many, with critics calling such experiments unethical. Wilmut, a trained embryologist, later focused on using cloning techniques to make stem cells that could be used in regenerative medicine. Whitelaw described Wilmut as a “titan” of science and said his work in Dolly's creation transformed scientific thinking at the time. He said the legacy of Wilmut's work in cloning Dolly continues to be seen.
Persons: Ian Wilmut, Dolly, Wilmut, Dolly Parton, Bill Clinton, Sir Ian Wilmut, Bruce Whitelaw, Whitelaw, Organizations: University of Edinburgh, biosciences, Roslin Locations: Scotland
REHOVOT, Israel (Reuters) - Scientists in Israel have created a model of a human embryo from stem cells in the laboratory, without using sperm, eggs or a womb, offering a unique glimpse into the early stages of embryonic development. "The question is, when does an embryo model become considered an embryo? At the moment we are really, really far off from that point," said team leader Jacob Hanna. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. The study raises some ethical questions over the possibility of potential future manipulation in human embryo development, Hanna and others noted.
Persons: Jacob Hanna, Hanna, Magdalena Żernicka, Goetz, Rami Amichay, Ari Rabinovitch, Mark Heinrich Organizations: Israel's Weizmann Institute of Science, International Society for Stem Cell Research, University of Cambridge Locations: REHOVOT, Israel, Boston
The Israeli team emphasised that they were a long way from being able to create an embryo from scratch. "The question is, when does an embryo model become considered an embryo? At the moment we are really, really far off from that point," said team leader Jacob Hanna. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. The study raises some ethical questions over the possibility of potential future manipulation in human embryo development, Hanna and others noted.
Persons: Mehmet Yunus Comar, Jacob Hanna, Hanna, Magdalena Żernicka, Goetz, Rami Amichay, Ari Rabinovitch, Mark Heinrich Our Organizations: Weizmann Institute of Science, Israel's Weizmann Institute of Science, International Society for Stem Cell Research, University of Cambridge, Thomson Locations: Rehovot, Israel, Boston
Scientists used stem cells to create a model of an embryo in the lab without sperm or egg. Researchers brought us one step closer to understanding those early days by making a model of a human embryo in the lab, without using sperm or eggs. How scientists grew a model human embryo without a sperm or eggAn illustration of embryonic stem cells. Stem cells are cells that form other, more complex cell types depending on what messages the body sends them. Starting with stem cells, the researchers turned them into types of cells that make up a human embryo, from placenta to fetus.
Persons: Jacob Hanna, Hanna, aren't Organizations: Service, Weizmann Institute of Science, Mayo Clinic, BBC Locations: Wall, Silicon
CNN —Scientists have grown kidneys containing mostly human cells inside pig embryos, an important step toward growing kidneys and potentially other human organs that could be used for transplants in people. “The paper describes pioneering steps in a new approach to organ bioengineering using pigs as incubators for growing and cultivating human organs,” said Dusko Ilic, a professor of stem cell sciences at King’s College London, in a statement. “It is remarkable to see about 60% of the primordial pig kidney contained human cells,” Wu said. What the researchers didTo generate kidneys mostly composed of human cells in pigs, the scientists used cutting-edge techniques harnessing advances in stem cells, gene editing and embryology. “This (new) work is different from existing xenotransplantation approach and aims to generate organs mostly composed of human cells in pigs,” Wu said.
Persons: , Miguel Esteban, ” Esteban, , Dusko Ilic, Jun Wu, Wu, ” Mary Garry, ” Wu, Esteban, ” Joseph A, Vassalotti, ” Vassalotti Organizations: CNN —, Guangzhou Institute of Biomedicine, Chinese Academy of Sciences, Procurement, Transplantation Network, King’s College London, University of Texas Southwestern Medical Center, University of Minnesota’s, Heart Institute, National Kidney Foundation, Icahn School of Medicine Locations: Health, United States, Mount Sinai
House Majority Leader Steve Scalise said he has multiple myeloma. It's a rare blood cancer that can be treated for years but currently is not curable. The results uncovered some irregularities and after undergoing additional tests, I was diagnosed with Multiple Myeloma, a very treatable blood cancer," Scalise said in the statement. The results uncovered some irregularities and after undergoing additional tests, I was diagnosed with Multiple Myeloma, a very treatable blood cancer. "Unfortunately, if left untreated, myeloma cells can multiply and continue to grow in a person's bone marrow," he added.
Persons: Steve Scalise, Scalise, Sarah McBride, Trump, Anders Kolb, Kolb, MSKCC, " Kolb, James T, Hodgkinson Organizations: Service, Twitter, Louisiana Republican, Memorial Sloan Kettering Cancer Center, Leukemia, Lymphoma Society, Congressional Locations: Wall, Silicon, Washington, Louisiana, M.D
CNN —A novel trial that has been described as “the last roll of the dice” for a generation of HIV vaccines has entered its latter stages. Nearly 40 years since HIV was identified as the cause of AIDS, and 36 years since the first HIV vaccine trial, the medical community still does not have a working vaccine. But that is not necessarily why they were chosen to participate, said Eugene Ruzagira, PrEPVacc trial director. Evaluating the combination of a trial HIV vaccine and PrEP is a first, say organizers. “I did my very first HIV vaccine trial in 1991,” recalled Weber.
Persons: PrEPVacc, , Jonathan Weber, Frank, Helena Herholdt, Eugene Ruzagira, Ruzagira, , Weber, ” Ruzagira, “ We’ve, Mark Runnacles, Edward Jenner, Louis Pasteur, Galileo, Win McNamee, Humphry Davy, JEAN, SEBASTIEN EVRARD, Haydn West, Joe Raedle, ANNE, CHRISTINE POUJOULAT, Alexander Fleming, Fleming, wasn't, Louise Joy Brown, Sandy Huffaker, Daniel Acker, James Watson, Francis Crick, Rosalind Franklin, Watson, Crick, Raphael GAILLARDE, Sean Gallup, Wilhelm Conrad Röntgen, Thomas Edison's, INDRANIL MUKHERJEE, Descovy, Luwano Geofrey, Dr, Luke Dray, Geofrey, Nishanta Singh, Sharon Lewin, Lewin, “ it’s, it’s, ” Lewin, ” Geofrey Organizations: CNN, Imperial College Academic Health Science Centre, PrEPVacc, Medical Research, Uganda Virus Research Institute, European Union, Smithsonian National Museum of, Cleveland Clinic, Volvo, Bayer, U.S . Food, Drug Administration, Getty, Keystone, — Farmers, Food and Drug Administration, FDA, Bloomberg, PANTHAKY, PrEP, US Centers for Disease Control, Independent, The University of Melbourne, International AIDS Society, Muhimbili University of Health, Allied Sciences, Dar Locations: Entebbe, Uganda, Thailand, London, Mbeya, Tanzania, South Africa, Ugandan, Durban, Masaka, Salam, African, Africa, China, FPG, AFP, United States, America, U.S, Peoria , Illinois, Europe, , Dar es Salaam, Rwanda
FRANKFURT, Aug 28 (Reuters) - Bayer (BAYGn.DE) said an experimental stem cell therapy developed by its U.S. subsidiary BlueRock had shown signs of easing Parkinson’s disease symptoms in an early 12-patient trial. The German drugmaker announced the trial had succeeded in a brief summary in June, saying it was a first for a stem-cell Parkinson's therapy, but held back details for a medical conference. The five participants on a lower dose experienced 0.72 hours longer per day with well-controlled symptoms on average and the time of worsening symptoms was 0.75 hours shorter per day for them. For BlueRock's experimental therapy, the researchers took human pluripotent embryonic stem cells and transformed them into dopamine-producing nerve cells. Parkinson's, for which there is no cure and which affects more than 10 million people worldwide, causes progressive brain damage.
Persons: BlueRock, Christian Rommel, Bayer's, Britain's, Ludwig Burger, Susan Fenton Organizations: FRANKFURT, Bayer, U.S, drugmaker, International Congress, Cambridge University, South Korea's, CHA Hospital, Cyto Therapeutics, Chinese Academy of Sciences, Harvard University, Japan's Kyoto University Hospital, Thomson Locations: Copenhagen, Denmark, Australia, United States
Big-ticket items included $150,000 red-light therapy beds and $70,000 hyperbaric chambers. It's not just tech bros who seem to be obsessed with health, wellness, and longevity trends. AdvertisementAdvertisementThe Information, a subscription tech industry news site, recently conducted an anonymous poll of 500 subscribers' health and wellness habits. At Next Level Therapeutics, a wellness center in New York City, a 15-minute NovoThor full body red light therapy session costs about $55, according to its booking page. Among the general population, wellness trends like cold plunges and red light therapy are gaining popularity as the quest to live longer increasingly goes mainstream.
Persons: It's, Jeff Bezos, Mark Zuckerberg, Elon Musk, Bryan Johnson, Dustin Giallanza, they'd, James Carroll, Thor Photomedicine, Carroll, Keith Rabois, Miami Rabois Organizations: MLB, MLS, Mayo Clinic, Venture, Founders Fund, FDA, Miami Locations: Braintree, NovoThor, New York City, Mayo
“And since the masks that are most effective are N95 that are now readily available, that’s the kind of mask you should wear,” he added. But the agency doesn’t make a broad recommendation for everyone to adopt masks. Morris Brown College in Atlanta announced a return to mandated physical distancing and masks just one week after classes started in August. And pediatricians are poised for the typical return-to-school surge in all kinds of respiratory illness, whether colds, flu or Covid. “The virus is always lurking, waiting for openings, so I think Covid is just going to be a bit of a roller coaster, probably forever,” Wachter said.
Persons: Joe Biden, Jonathan Reiner, , ” Reiner, Biden, , Reiner, Eric Topol, ” Topol, ” What’s, Robert Wachter, ” Wachter, haven’t, Peter Chin, Topol, Dr, Sara Bode, Bode, It’s, , ” Chin, Hong, You’ve, you’ve, Amanda Musa, Brenda Goodman, Deidre McPhillips, Meg Tirrell Organizations: CNN, George Washington University School of Medicine & Health Sciences, US Centers for Disease Control, CDC, Scripps, Research, Covid, Department of Medicine, University of California San, University of California, Morris Brown College, Nationwide Children’s Hospital, American Academy of Pediatrics ’, School Health, Internal Locations: Covid, Florida, University of California San Francisco, San Francisco, Atlanta, Columbus , Ohio, Washington
BERLIN, Aug 23 (Reuters) - Roche (ROG.S) inadvertently published positive lung cancer drug trial data from an interim analysis, boosting the Swiss drug maker's shares even though more data will be needed to confirm the treatment's efficacy. Roche said on Wednesday that market participants had made it aware of the inadvertent disclosure of an interim data analysis on new immunotherapy tiragolumab, part of an experimental class of drugs known as anti-TIGIT. The data lifted Roche shares by 5% and sent shares of other companies testing anti-TIGIT drugs higher. J.P. Morgan analysts said the interim data suggested a survival benefit was within reach in the final analysis, but the clinical relevance remained uncertain. The unintended disclosure regards the second interim analysis of a Phase III trial known as Skyscraper 1.
Persons: Roche, tiragolumab, Morgan, Roche's, TIGIT, Paul Arnold, Christy Santhosh, Jason Neely, Friederike Heine, Mark Potter Organizations: Merck & Co, Gilead Sciences, iTeos Therapeutics, Arcus Biosciences, Thomson Locations: U.S, Zurich, Bengaluru
But I don’t think we’re all aware of the age beliefs. To do that, researchers like him are targeting the essential biology of aging – the underlying reasons why we get old. When those biological processes fail or break down, we get sick – and aging is the biggest risk factor for that deterioration. In the meantime, though, remember this: Aging is probably not nearly as bad as you might imagine. And as my mom told me, we should all truly embrace getting older, because it sure as heck beats the alternative.
Persons: , , Diana Nyad, , Diana, I’m, Don’t, she’s, Dan Buettner, Dan, , Becca Levy, Levy, It’s, Ellsworth, Wareham, Nir Barzilai, Barzilai, ” Barzilai, ’ ”, Dr, Sanjay Gupta, CNN’s Andrea Kane Organizations: CNN, Yale, Albert Einstein College of Medicine, Einstein Institute for Aging Research, FDA, CNN Health Locations: Cuba, Florida, United States, Japan, Ellsworth Wareham, Loma Linda , California
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Persons: you'll, Charlotte Tilbury, we've, Kiehl's Creme, Bobbi Brown, it’s, Charlotte, Jo Malone, Jo Malone London’s, Suede, Wood, Kate Somerville, Dyson, Augustinus Bader, Mascara Organizations: Nordstrom, skincare, nab, Triple, Oil
Health care is just one area to consider, according to Saurymper, who manages Pacific Asset Management's Longevity & Social Change Fund. As well as health care and pharmaceutical stocks, its holdings span fitness and nutrition, personal care, aesthetics and financials. "Now I think about health care along the lines of units of health care, rather than a drug. Investing in companies that leverage technology to deliver efficient health care is also crucial in cutting costs, he added. Education Looking beyond more obvious aging themes, the fund manager said education and well-being also offer investors a major opportunity.
Persons: Dani Saurymper, Saurymper, Eli Lilly, They're, it's, There's, CNBC's Ganesh Rao Organizations: CNBC, Alzheimer's, Tech, Apple, Apple Watch, CVS Locations: U.S
Some of this work is done by Britain's' Cambridge University, South Korea's Bundang CHA Hospital, International Stem Cell Corp's (ISCO.PK) Cyto Therapeutics in Australia, the Chinese Academy of Sciences, Harvard University and Japan's Kyoto University Hospital. For BlueRock's experimental therapy, researchers took induced pluripotent stem cells, which are modified to regain the ability to form any type of specialised tissue, and transformed them into dopamine-producing nerve cells. When surgically implanted into the brain of a person with Parkinson's disease, the therapeutic cells are designed to restore neural networks destroyed by the disease. Initial trial results showed the cells multiplied and started making dopamine, an important brain signalling molecule which is lacking in Parkinson's patients. Parkinson's, for which there is no cure and which affects more than 10 million people worldwide, causes progressive brain damage.
Persons: Wolfgang Rattay, Bayer, BlueRock, Britain's, Jennifer Doudna, Ludwig Burger, Miranda Murray, Mark Potter Organizations: Bayer AG, REUTERS, Bayer, Cambridge University, South Korea's, CHA Hospital, Cyto Therapeutics, Chinese Academy of Sciences, Harvard University, Japan's Kyoto University Hospital, BlueRock Therapeutics, Mammoth Biosciences, Thomson Locations: Leverkusen, Germany, FRANKFURT, Australia, San Francisco Bay
There's one stock that resonates the most for fund manager Dani Saurymper as social trends shift amid an aging population. As such, it's well placed to plug the "massive skills gap" in the health care industry, according to Saurymper. As well as health care and pharmaceutical stocks, its holdings span fitness and nutrition, personal care, aesthetics and financials. "Now I think about health care along the lines of units of health care, rather than a drug. However, key industries exposed to the aging population go beyond the challenges of aging, he added.
Persons: Dani Saurymper, Adtalem, Saurymper, There's Organizations: CNBC Locations: It's, U.S
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