The CDC report showed that the rate of drug overdose deaths involving fentanyl increased from 5.7 per 100,000 people in 2016 to 21.6 per 100,000 in 2021.
Fentanyl-related deaths rose by about 55% in 2019-2020, and 24.1% in 2020-2021, said Merianne Rose Spencer, one of the report's authors.
Between 2016 and 2021, the rate of drug overdose deaths involving methamphetamine increased more than fourfold, and cocaine-related overdose deaths more than doubled, the CDC said.
Heroin related deaths decreased from 4.9 per 100,000 in 2016 to 2.9 in 2021, the report found.
The Biden administration has been pushing for action as U.S. drug-related overdose deaths surpassed 100,000 in 2021, according to government estimates.