George had 35 points, nine rebounds, eight assists and six steals for the Clippers, who scored the game's final seven points to break a four-game losing streak.
Ivica Zubac recorded 16 points, 12 rebounds and four blocked shots while Marcus Morris Sr. added 11 points for Los Angeles.
The star forward also contributed nine rebounds and seven assists.
Cade Cunningham's 27 points, seven assists and six rebounds led the Pistons, who were playing the tail end of a back-to-back.
Scottie Barnes added 21 points, seven rebounds and eight assists and Gary Trent Jr. scored 21 points for the Raptors, who were playing without Fred VanVleet (back).