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The links between the children's deaths and contaminated medicines first came to light in October, when the World Health Organization sent out an alert saying four cough syrups made by India's Maiden Pharmaceuticals Ltd contained toxic levels of diethylene and ethylene glycol and should be withdrawn. The new investigation "strongly suggests" that medicines contaminated with the toxins, imported into Gambia, led to the cluster of acute kidney injury among 78 children. Maiden has denied its drugs were at fault for the deaths in Gambia, and the Indian government has said the syrups showed no contamination when it tested them. "This likely poisoning event highlights the potential public health risks posed by the inadequate quality management of pharmaceutical exports," the report said. Since the deaths in Gambia, 201 children have also died in Indonesia, and 19 in Uzbekistan, linked to different manufacturers' contaminated cough syrups.
Viruses in Cambodian bird flu cases identified as endemic clade
  + stars: | 2023-02-26 | by ( ) www.reuters.com   time to read: +2 min
Feb 26 (Reuters) - The viruses that infected two people in Cambodia with H5N1 avian influenza have been identified as an endemic clade of bird flu circulating in the country, the U.S. Centers for Disease Control and Prevention (CDC) said. The cases reported last week had raised concerns they were caused by a new strain of H5N1, clade 2.3.4.4b, which emerged in 2020 and has caused record numbers of deaths among wild birds and domestic poultry in recent months. An investigation into the source and to detect any additional cases is ongoing, the CDC said, adding that so far there had been no indication of person-to-person spread. The World Health Organization said it is working with Cambodian authorities following the cases, describing the situation as worrying due to the recent rise in cases in birds and mammals. Reporting by Juby Babu in Bengaluru; additional reporting by Jennifer Rigby in London; editing by Barbara LewisOur Standards: The Thomson Reuters Trust Principles.
LONDON, Feb 24 (Reuters) - The World Health Organization is working with Cambodian authorities after two confirmed human cases of H5N1 bird flu were found among one family in the country. The U.N. health agency last assessed the risk to humans from avian flu as low earlier this month. "The global H5N1 situation is worrying given the wide spread of the virus in birds around the world and the increasing reports of cases in mammals including humans," Briand said. WHO-affiliated labs already hold two flu virus strains that are closely related to the circulating H5N1 virus that manufacturers can use to develop new shots if needed. A global meeting of flu experts this week suggested developing another strain that more closely matches H5N1 clade 2.3.4.4b, Webby said in the briefing.
Flu experts gather with H5N1 risk on the agenda
  + stars: | 2023-02-24 | by ( Jennifer Rigby | ) www.reuters.com   time to read: +3 min
But it is also a chance to discuss the risk of animal viruses spilling over to humans and causing a pandemic. At this week's meeting, H5N1 clade 2.3.4.4b was a key topic, the World Health Organization (WHO) and global flu experts told Reuters. They will brief reporters on both the seasonal flu vaccine composition and spillover risks later on Friday. "We need to really continue the efforts for a flu pandemic." A number of companies that produce seasonal flu vaccines can also make pandemic flu vaccines.
[1/2] People wait to cross the border into Equatorial Guinea by car and by foot in Kye-Ossi, Cameroon, May 23, 2015. Authorities have restricted movement around the two villages that are directly linked, he said, and contact tracing was ongoing. Equatorial Guinea's neighbour Cameroon on Friday restricted movement along its border after the "unexplained deaths", its Health Minister Malachie Manaouda said in a statement. Equatorial Guinea said on Wednesday that it had registered the "unusual epidemiological situation" over the past weeks in Kie-Ntem province's Nsok Nsomo district that caused nine deaths in two adjacent communities over a short period. A Cameroon district health official near the border area said around 20 deaths had been recorded on Wednesday in villages in Kie-Ntem province, which borders Cameroon's Olamze district.
HONG KONG, Feb 8 (Reuters) - The world should "calm down" about the possibility of new COVID-19 variants circulating in China, leading Chinese scientist George Gao said. "The world should completely calm down from the fear that there are new variants or special variants circulating (in China)," Gao, professor at the Institute of Microbiology at the Chinese Academy of Sciences and former head of the Chinese Center for Disease Control and Prevention (CDC), told Reuters. The variants causing infections in China were the same Omicron sub-variants - BA.5.2 and BF.7 - seen elsewhere in the world, he said by email. Gao said China was continuing widespread viral genomic sequencing, and would identify any new variants if they emerged. A total of 13 cases of variants were found, including 1 case of XBB.1, 5 cases of BQ.1.1, 1 case of BQ.1.1.17, 4 cases of BQ.1.2 and 2 cases of BQ.1.8.
LONDON, Feb 8 (Reuters) - The recent spread to mammals of H5N1 influenza - commonly known as bird flu - needs to be monitored, but the risk to humans remains low, the World Health Organization said on Wednesday. He said the risk to humans remained low, noting that human cases have been rare since the flu strain emerged in 1996. "But we cannot assume that will remain the case and we must prepare for any change in the status quo," Tedros said. He said people were advised not to touch dead or sick wild animals and to instead report them to local and national authorities, who were monitoring the situation. The WHO also recommended strengthening surveillance in settings where humans and animals interact, he said.
HONG KONG, Feb 8 (Reuters) - The world should "calm down" about the possibility of new COVID-19 variants circulating in China, leading Chinese scientist George Gao said. "The world should completely calm down from the fear that there are new variants or special variants circulating [in China]," Gao, professor at the Institute of Microbiology at the Chinese Academy of Sciences and former head of the Chinese Center for Disease Control and Prevention (CDC), told Reuters. The variants causing infections in China were the same Omicron sub-variants - BA.5.2 and BF.7 - seen elsewhere in the world, he said by email. Gao said China was continuing widespread viral genomic sequencing, and would identify any new variants if they emerged. The authors said there were some limitations to the study, including China's decision to end large-scale mandatory testing.
LONDON/GENEVA, Feb 1 (Reuters) - Governments may have to reserve drugs and vaccines for the World Health Organization to distribute in poorer countries to avoid a repeat of the "catastrophic failure" during the COVID-19 pandemic, according to an early draft of a global pandemic agreement. The agreement, which is commonly known as the pandemic treaty, has been drawn up by WHO member states and will now go through a lengthy negotiating process before being finalised. Talks on the draft treaty will begin on Feb. 27 and are set to continue to 2024. However, there will be "heat and opposition" in the negotiations ahead, particularly around the intellectual property provisions, said James Love, director of the NGO Knowledge Ecology International. The draft also calls for a new WHO Global Pandemic Supply Chain and Logistics Network to ensure better and fairer distribution of counter-measures, as well as a global compensation scheme for vaccine injuries.
REUTERS/Athit Perawongmetha/Summary WHO's executive board meets from Jan. 30-Feb. 7WHO seeking $6.86 bln for 2024-2025 budgetBody seen pushing for bigger role in global health crisesGENEVA, Jan 30 (Reuters) - The World Health Organization will push at its board meeting this week for an expanded role in tackling the next global health emergency after COVID-19, but is still seeking answers on how to fund it, according to health policy experts. Also on his list was "the position of the World Health Organization, recognizing there is a need for a reinforced central role for WHO" in the global health emergency system. "It's a huge knot," said Nicoletta Dentico, the co-chair of the civil society platform the Geneval Global Health Hub. PANDEMIC PREPARATIONThe WHO, which celebrates its 75-year anniversary having been set up in 1948, will also use the meeting to advocate for a boosted role in pandemic preparedness, documents showed. Tedros will call for a Global Health Emergency Council to be set up linked to WHO governance.
WHO maintains highest alert over COVID, but sees hope ahead
  + stars: | 2023-01-30 | by ( ) www.reuters.com   time to read: +1 min
Jan 30 (Reuters) - The World Health Organization (WHO) said on Monday that COVID-19 continues to constitute a public health emergency of international concern, its highest form of alert. The pandemic was likely in a "transition point" that continues to need careful management to "mitigate the potential negative consequences", the agency added in a statement. It is three years since the WHO first declared that COVID represented a global health emergency. More than 6.8 million people have died during the outbreak, which has touched every country on Earth, ravaging communities and economies. Reporting by Abinaya Vijayaraghavan in Bengaluru and Jennifer Rigby in London; Editing by Toby Chopra and Nick MacfieOur Standards: The Thomson Reuters Trust Principles.
The deaths of children from acute kidney injury began in July 2022 in Gambia, followed by cases in Indonesia and Uzbekistan. The WHO has said the deaths are linked to over-the-counter cough syrups the children took for common illnesses and which contained a known toxin, either diethylene glycol or ethylene glycol. The WHO, working with Indonesia’s drugs regulator, also issued an alert in October about cough syrups made by four Indonesian manufacturers and sold domestically. The manufacturers are: PT Yarindo Farmatama, PT Universal Pharmaceutical, PT Konimex, PT AFI Farma. PT Universal Pharmaceutical Industries’ lawyer, Hermansyah Hutagalung, said it had pulled from the market all cough syrups deemed dangerous.
WHO urges 'immediate action' after cough syrup deaths
  + stars: | 2023-01-23 | by ( Jennifer Rigby | ) www.reuters.com   time to read: +3 min
REUTERS/Anushree FadnavisLONDON, Jan 23 (Reuters) - The World Health Organization has called for "immediate and concerted action" to protect children from contaminated medicines after a spate of child deaths linked to cough syrups last year. The medicines, over-the-counter cough syrups, had high levels of diethylene glycol and ethylene glycol. It called for action across its 194 member states to prevent more deaths. It also issued a warning last year for cough syrups made by four Indonesian manufacturers, PT Yarindo Farmatama, PT Universal Pharmaceutical, PT Konimex and PT AFI Pharma, that were sold domestically. It also asked governments and regulators to assign resources to inspect manufacturers, increase market surveillance and take action where required.
While many analysts say a return to economic normality will be gradual as the impact of COVID weakens, some see the Lunar New Year as a welcome early consumption boost. But with so many people on the move, health experts fear a deepening of the COVID outbreak, leaving the elderly in rural villages particularly vulnerable. Reuters reported on Tuesday that doctors in both public and private hospitals were being actively discouraged from attributing deaths to COVID. State media reported that some 390,000 passengers were expected to travel from Shanghai train stations on Tuesday alone for what is known as the Spring Festival holiday - seen as the world's largest annual mass migration before COVID. As travellers moved through stations in Shanghai, China's largest city, some expressed optimism despite the risks.
While many analysts say a return to economic normality will be gradual as the impact of COVID weakens, some see the Lunar New Year as a welcome early consumption boost. But even as workers move out, health experts fear a broadening and deepening of its COVID outbreak, leaving the elderly in rural villages particularly vulnerable. The WHO earlier welcomed Saturday's announcement after last week warning that China was heavily under-reporting deaths from the virus. "This is especially important during periods of surges when the health system is severely constrained," the statement said on Monday. As travellers moved through stations in Shanghai, China's largest city, some expressed optimism despite the risks.
[1/3] Mark Suzman, Chief Executive Officer (CEO) of the Bill & Melinda Gates Foundation, speaks during an interview with Reuters at the COP27 climate summit in Egypt's Red Sea resort of Sharm el-Sheikh, Egypt, November 7, 2022. REUTERS/Emilie MadiCompanies Bill & Melinda Gates Foundation Trust FollowLONDON, Jan 17 (Reuters) - It is not right for the Bill & Melinda Gates Foundation to play such a big role in global health funding, but the group will not back away until others step up, its chief executive said. The Gates Foundation has faced criticism that it has too much power and influence in the global health realm, including within the World Health Organization, without the requisite accountability. "It's not right for a private philanthropy to be one of the largest funders of multinational global health efforts," he said, adding that countries ought to be leading the charge. Suzman said the aim of the fund was not to set the agenda for the WHO or other global health groups, but to provide them with better options and data as they make key decisions.
WHO recommends that China monitor excess COVID-19 mortality
  + stars: | 2023-01-16 | by ( ) www.reuters.com   time to read: +2 min
LONDON/GENEVA, Jan 16 (Reuters) - The World Health Organization (WHO) said on Monday it recommended that China monitor excess mortality from COVID-19 to gain a fuller picture of the impact of the surge in cases there. China said on Saturday that nearly 60,000 people with COVID-19 had died in hospital since it abandoned its zero-COVID policy last month, a big jump from the figures it reported prior to facing international criticism over its COVID-19 data. "WHO recommends the monitoring of excess mortality, which provides us with a more comprehensive understanding of the impact of COVID-19," the U.N. agency told Reuters in a statement when asked about China. "This is especially important during periods of surges when the health system is severely constrained." "But it would be even more important to get full GSD (genetic sequence data) of circulating virus in China.
GENEVA, Jan 11 (Reuters) - The World Health Organization said it is working with China to manage the risks of COVID-19 surging again as people travel for Lunar New Year celebrations but the country's response continues to be challenged by a lack of data. COVID-19 is spreading unchecked in China after the country lifted its zero-COVID policy in December, but the WHO said it still does not have enough information from China to make a full assessment of the dangers of the surge. That is also an issue in working with China on how to mitigate the risks of travel ahead of the Lunar New Year public holiday, which officially runs from Jan. 21, the WHO said. The WHO also said China is still heavily underreporting deaths from COVID-19, although it is now providing more information on its outbreak. "There are some very important information gaps that we are working with China to fill," said COVID-19 technical lead, Maria Van Kerkhove.
The holiday, known before the pandemic as the world's largest annual migration of people, comes amid an escalating diplomatic spat over COVID curbs that saw Beijing introduce transit curbs for South Korean and Japanese nationals on Wednesday. The virus is spreading unchecked in China after Beijing abruptly began dismantling its previously tight curbs in early December following historic protests. Among them, South Korea and Japan have also limited flights and require tests on arrival, with passengers showing up as positive being sent to quarantine. COUNTING DEATHSSome of the governments that announced curbs on travellers from China cited concerns over Beijing's data transparency. Annual spending by Chinese tourists abroad reached $250 billion before the pandemic, with South Korea and Japan among the top shopping destinations.
LONDON, Jan 11 (Reuters) - An international meeting this week will discuss setting up a global system of wastewater monitoring for COVID-19, including at airports, after several countries said they would start tests on flights coming from China. Countries including the United States and Australia have moved to set up wastewater testing on flights and in airports amid a surge of cases in China. It is also becoming more important as routine testing has waned - the World Health Organization says testing for COVID-19 has declined by 90% in recent months. There are hopes that establishing a more formal wastewater surveillance network worldwide could provide information not only on COVID-19, but also on other emerging disease threats. However, there are technical and logistical challenges ahead, Gawlik said, including how to handle samples and how to interpret and use the information gathered.
NEXU Science Communication/via REUTERSLONDON, Jan 10 (Reuters) - Genomic sequencing allowed the world to track new coronavirus variants throughout the pandemic. Now British researchers plan to use it to better understand a host of other respiratory pathogens, from influenza to respiratory syncytial virus (RSV). The work will begin later this year by using leftover material from swabs taken for COVID-19 diagnostic purposes, sequencing SARS-CoV-2, influenza, RSV and other common respiratory viruses in a combined process. While some of the viruses targeted typically cause mild, cold-like symptoms, others can cause serious illness, particularly in vulnerable populations. The five-year initiative aims to begin work from spring this year and is funded by Wellcome.
The study by researchers from healthcare provider Clalit, Ben-Gurion University of the Negev and Sapir College has not yet been peer reviewed. The study was carried out from the end of September until mid-December and looked at 622,701 people aged 65 and over who were eligible for the bivalent booster. "Hospitalization due to Covid-19 occurred in 6 bivalent recipients and 297 participants who did not" receive it, the study said. "Participants who received the bivalent vaccine had lower hospitalization and mortality rates due to Covid-19 than non-recipients up to 70 days after vaccination." While the bivalent vaccine targets the original strain and its BA.4/BA.5 Omicron subvariant, scientists have been closely watching another Omicron subvariant, XBB.1.5, which has been rapidly spreading in the United States.
That might ease some concerns about the outbreak since Beijing abruptly reversed its "zero COVID" policy last month. But many Chinese funeral homes and hospitals say they are overwhelmed, and international health experts predict at least 1 million COVID-related deaths in China this year without urgent action. But the WHO said there is "no inevitability" in terms of predictions of large numbers of deaths. "It really does depend on the measures that are in place," said the WHO's COVID-19 technical lead Maria van Kerkhove. She said the WHO was working with China to improve access to life-saving tools and cope with health workforce issues in badly-hit areas.
[1/2] The World Health Organization logo is pictured at the entrance of the WHO building, in Geneva, Switzerland, December 20, 2021. REUTERS/Denis BalibouseLONDON, Jan 3 (Reuters) - Leading scientists advising the World Health Organization said they wanted a "more realistic picture" about the COVID-19 situation from China's top experts at a key meeting on Tuesday as worries grow about the rapid spread of the virus. The WHO has invited Chinese scientists to a virtual closed meeting with its technical advisory group on viral evolution on Tuesday, to present data on which variants are circulating in the country. Speaking to Reuters ahead of the meeting, she said some of the data from China, such as hospitalisation numbers, is "not very credible". A WHO spokesperson said that a "detailed discussion" was expected about circulating variants in China, and globally, with Chinese scientists expected to make a presentation.
"It's clear that we are in a very different phase [of the pandemic], but in my mind, that pending wave in China is a wild card." Last week, he told reporters in Geneva that he was "hopeful" of an end to the emergency some time next year. Tedros's earlier comments spurred hopes that the United Nations agency could soon remove the Public Health Emergency of International Concern (PHEIC) designation for COVID, which has been in place since January 2020. Some global health experts had expected China to wait for the WHO to lift the emergency status before easing its own pandemic response measures. WHO member states are currently working on re-designing the rules that govern global health emergencies to potentially address issues like this.
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