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In this videoShare Share Article via Facebook Share Article via Twitter Share Article via LinkedIn Share Article via EmailDr. Fillit on Eli Lilly's Alzheimer's drug: Really having breakthroughs & success for the first timeDr. Howard Fillit, Alzheimer’s Drug Discovery Foundation co-founder and chief science officer, joins 'Squawk Box' to discuss news of FDA panel's approval of Eli Lilly's Alzheimer's drug Donanemab, the future of Alzheimer's treatments, and more.
Persons: Fillit, Eli Lilly's Alzheimer's, Howard Fillit, Eli Lilly's Organizations: Discovery Foundation, FDA
Over the last three years, a new class of Alzheimer’s drug, the first to treat a root cause of the disease, has set off a roller coaster of hope and disappointment. Lecanemab (brand name Leqembi; pronounced le-KEM-bee) was given full approval by the Food and Drug Administration in July 2023 and is currently the only one of its class available to Alzheimer’s patients, outside clinical trials. The drug has been shown to slow the progression of the disease, but its benefits are fairly modest. With lecanemab having been approved for nearly a year — and with a similar drug, donanemab, being reviewed by an F.D.A. There are strict requirements for patients to be eligible for lecanemab; by one estimate, fewer than 20 percent met the qualifications for the medication.
Persons: Neurologists Organizations: Food and Drug Administration, New York Times, Mayo Clinic, Mayo Clinic , Massachusetts General Hospital, University of California Locations: Mayo Clinic , Massachusetts, San Francisco
The criminal trial and conviction of (mostly former) national leaders has happened in stable, mature democracies, just as it has in former dictatorships. The track record of convicted leaders shows just how risky it is to try to predict what will happen. In 2017, South Korea impeached and later criminally convicted now-former President Park Geun-hye in a bizarre corruption scandal involving the influence of a friend and confidante. After a scandal emerged involving the state oil company Petrobras, Lula was convicted in 2017 of corruption and money laundering. “Political leaders can choose how they will speak about these institutions.”
Persons: Chris Good, Donald Trump, , Trump, Stormy Daniels, Cristina Fernández de Kirchner, Sebastian Kurz, ” Kurz, Park, , Nicole Bibbins Sedaca, Nicolas Sarkozy, Bertrand Guay, Bibbins Sedaca, Jacques Chirac, ” Bibbins Sedaca, Sarkozy, Moammar Gaddhafi illicitly, Silvio Berlusconi, Yara Nardi, Berlusconi “, , Berlusconi, Matteo Salvini, Giorgia Meloni, Luiz Inacio Lula da Silva, Nelson Almeida, Luiz Inácio Lula da Silva, Lula, Jair Bolsonaro, Oliver Stuenkel, Fundação Getulio Vargas, ” Stuenkel, Politicization, Stuenkel, didn’t, Lula “, Mark Peterson, Ariel Edwards, Levy, Lula —, Chirac, Trump’s Organizations: CNN, ABC News, Economist Intelligence Unit, Freedom House, Getty, Freedom, Reuters, Forza Italia, Five Star, AFP, Brazil, Petrobras, Bolsonaro, School of International Relations, Fundação, NEW, Manhattan Criminal, Trump, Twitter, Facebook Locations: The, Manhattan, Argentina, Austrian, South Korea, Washington, DC, France, Italy, Brazil, Paris, AFP, Moroccan, Milan, Trump, America, São Paulo
Long before people develop dementia, they often begin falling behind on mortgage payments, credit card bills and other financial obligations, new research shows. What they found was striking: Credit scores among people who later develop dementia begin falling sharply long before their disease is formally identified. The issues start even earlier: The study finds evidence of people falling behind on their debts five years before diagnosis. “The results are striking in both their clarity and their consistency,” said Carole Roan Gresenz, a Georgetown University economist who was one of the study’s authors. Credit scores and delinquencies, she said, “consistently worsen over time as diagnosis approaches, and so it literally mirrors the changes in cognitive decline that we’re observing.”
Persons: Long, , Carole Roan Gresenz, Organizations: Federal Reserve Bank of New, Georgetown University Locations: Federal Reserve Bank of New York, Equifax
“It’s often helpful to think about episodic memory as remembering, whereas semantic memory is just knowing,” he said. To find out whether Eurasian jays are capable of "mental time travel," researchers worked with birds trained to find food hidden under cups. “The idea is that with human episodic memory, we remember details of events that, at the time, weren’t necessarily relevant to anything. This aspect of episodic memory is sometimes referred to as “mental time travel.”To find out whether Eurasian jays are capable of mental time travel, the researchers worked with birds that had been trained to find food hidden under cups. “The big disease of memory is Alzheimer’s disease, and of course, the most debilitating aspect of Alzheimer’s disease is a profound loss of episodic memory,” Crystal said.
Persons: CNN —, , James Davies, Davies, , “ There’s, James Davies Corvids, Nicola Clayton, , advisee, ” Davies, weren’t, didn’t, , I’ll, ’ ” Davies, Jonathon Crystal, ” Crystal, “ It’s, Kate Golembiewski Organizations: CNN, University of Cambridge’s, University of Indiana Bloomington Locations: Chicago
However, a new study finds regular use of fish oil supplements may increase, not reduce, the risk of first-time stroke and atrial fibrillation among people in good cardiovascular health. Nearly one-third of those people, who were followed for an average of 12 years, said they regularly used fish oil supplements. Over-the-counter fish oil suffers from a lack of purity and consistency, as well as the potential contaminants and heavy metals such as mercury that come with fish, Freeman said. “In addition, studies over the last 10 years have not been very positive for over-the-counter fish oil,” he added. “Fish oil was either having no benefit or in some cases it may harm, such as with stroke and AFib.
Persons: ’ ”, Andrew Freeman, , , Freeman, that’s, ” Freeman, sasirin, Richard Isaacson, Isaacson, Chia, ” Isaacson Organizations: CNN, Jewish Health, Costco, Food and Drug Administration, US, NSF International Locations: United States, Denver, United Kingdom, Boca Raton , Florida, Lake
Blood biomarkers of telltale signs of early Alzheimer’s disease in the brain of his patient, 55-year-old entrepreneur Simon Nicholls, had all but disappeared in a mere 14 months. “I don’t use the term ‘reverse.’ I don’t know what reverse means when it comes to the field of Alzheimer’s,” Isaacson said. ‘It was time to turn to my brain’Slowly, Nicholls’ heart condition began to improve, but the bad news didn’t end there. A brain scan found telltale signs of vascular damage in Nicholls’ brain, which occurs when the tiniest blood vessels are starved of oxygen. Not only was Nicholls blood negative for amyloid and tau, the test suggested that his brain amyloid might be normal, with no distinguishable signs of the disease.
Persons: Sanjay Gupta, Anderson Cooper ”, Richard Isaacson, Simon Nicholls, , , Isaacson, “ Simon, ” Isaacson, Nicholls, ” Nicholls, Anderson Cooper, It’s, APOE4, Simon, ” Simon Nicholls, Sylver, Lewy, Richard Isaacson ‘, APOE ε4, “ I’ve, Isaacson doesn’t, “ I’m, Shocked, Dr, we’d, “ It’s, Salvadore, Richard Isaacson “, ‘ It’s, I’m Organizations: CNN, telltale, ” CNN, Boca Raton Locations: Boca Raton , Florida, New York City, Florida, Nature, Miami, Isaacson’s Florida, tirzepatide
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CNN —Ask Jane Seymour about her longevity as an actress and she can point to several things, including her willingness to take on a variety of roles. The show, which Seymour also executive produces, has humor as well as mystery and it’s a natural fit for the “Dr. There’s no too small a role.”And there’s no role too emotional for Seymour either. These days Seymour has found love with her boyfriend John Zambetti, who is a doctor and a musician. Now he says ‘Can we watch Dr. Quinn?’”Season 3 of “Harry Wild” premieres Monday on AcornTV.
Persons: Jane Seymour, “ I’m, Harry Wild ”, Harriet “ Harry ” Wild, Fergus, Rohan Nedd, Seymour, Quinn, , , Harry, Glen Campbell, Alzheimer’s, “ Glen Campbell, James Keach, John Zambetti, She, Dr, James Bond, , “ He’d, Quinn ’ Organizations: CNN, Medicine Locations: Covid, AcornTV
CNN —Has your doctor quizzed you about your level of physical activity? If so, you can thank Exercise is Medicine, a global health initiative managed by the American College of Sports Medicine. Created in 2007, the initiative encourages health care providers to assess patients’ physical activity during visits, plus include regular exercise when designing care plans. Health care providers can impact patient health by routinely assessing physical activity at every interaction. EIM now includes Exercise is Medicine on Campus, for example, a program that helps colleges and universities promote and assess physical activity among students, faculty and staff.
Persons: CNN —, Jacob Wackerhausen, Elizabeth Joy, EIM, Joy, it’s, ” Joy, , Amy Campbell, GVSU, Campbell, ” Campbell, There’s, you’ve, “ Rather, Gerren Liles, “ It’s, , Melanie Radzicki McManus Organizations: CNN’s, CNN, American College of Sports Medicine, American, of Lifestyle Medicine, Intermountain, Lore Health, Health, Grand Valley State University, EIM, CARE, Cancer, New Locations: Salt Lake City, Grand, Grand Rapids , Michigan, they’ll, EIM, New York, New York City, Liles
People have wanted to reconnect with deceased loved ones for centuries, whether they’ve visited mediums and spiritualists or leaned on services that preserve their memory. In September 2023, it introduced ChatGPT voice, where users can ask the chatbot prompts without typing. HereAfter AI, founded in 2019, allows users to create avatars of deceased loved ones. “Remembering is very important; it reflects the human condition and importance of deceased loved ones.”But she noted the relationship we have with our closest loved ones is built on authenticity. Creating an AI version of that person could for many “feel like a violation of that.”Bill Abney said he feels uneasy about communicating with his late fiancée through AI platforms.
Persons: Ana Schultz, Kyle, , Schultz, , Schutz, they’ve, ” Ana Schultz, ElevenLabs, Joe Biden, Biden, ChatGPT, OpenAI, Danielle Jacobson, she’s, Phil, Cole, ” Jacobson, “ Cole, Replika, Rohit Prasad, Val Kilmer, It’s, Mary, Frances O’Connor, , ’ ”, Bill Abney, Kari, ” Abney, “ I’m, Jodi Spiegel, Sims Organizations: CNN, Davidson College, Tech, Alexa, MARS, Amazon, University of Arizona Locations: Rock Falls , Illinois, Alabama, Johannesburg, South Africa, , San Francisco, Newfoundland, Canada
Among people diagnosed with Alzheimer’s, researchers recognize familial forms of the disease and sporadic cases. This shifting appreciation of inherited risk, researchers say, is due to a better understanding of the role of a fourth gene that carries the blueprints to make a lipid-carrying protein called apolipoprotein E, known as APOE. One known as APOE2 is thought to be protective against the development of Alzheimer’s disease. They also compared people with two copies of APOE4 to people with other inherited forms of the disease — early-onset autosomal dominant Alzheimer’s disease (ADAD) and Down syndrome-associated Alzheimer’s disease (DSAD). Gene testing isn’t currently recommendedIt is also likely to change how people who carry the APOE4 gene are diagnosed and treated.
Persons: APOE4, , Dr, Juan Fortea, Sant, Fortea, Charles Bernick, Bernick, Alzheimer’s wasn’t, isn’t, they’re, ” Fortea, Sanjay Gupta, Reisa Sperling, , ” Sperling, ” Dr, Sterling Johnson, Johnson Organizations: CNN, Nature, National Alzheimer’s Coordinating, Neurology, Hospital de, Cleveland Clinic Lou, Brain Health, CNN Health, Alzheimer’s Research, Brigham, Women’s, Alzheimer’s, University of Wisconsin Locations: Alzheimer’s, Spain, United States, Santa, Barcelona, Wisconsin
Olive oil may lower risk of dementia-related death
  + stars: | 2024-05-06 | by ( Kristen Rogers | ) edition.cnn.com   time to read: +5 min
CNN —A daily spoonful of olive oil could lower your risk of dying from dementia, according to a new study by Harvard scientists. Olive oil can be a healthy, tasty addition to foods such as sandwiches and salads. Replacing 5 grams — around 1.2 teaspoons — of margarine or mayonnaise consumed daily with olive oil was associated with an 8% to 14% lower risk of death from dementia. “It is also possible that olive oil has an indirect effect on brain health by benefiting cardiovascular health,” she added. Besides cooking with olive oil, you can also use it to make salad dressings or vinaigrettes, mayonnaise, pesto or bread dip.
Persons: Anne, Julie Tessier, Harvard University’s T.H, , Duane Mellor, ” Mellor, Tessier, , David Curtis, Mellor, Curtis, Olive, it’s Organizations: CNN, Harvard, JAMA, American Society, Harvard University’s, of Public Health, Nurses, Health, Aston Medical School, Aston University, University College London Locations: Chan, North America, United Kingdom
Scientists are proposing a new way of understanding the genetics of Alzheimer’s that would mean that up to a fifth of patients would be considered to have a genetically caused form of the disease. Currently, the vast majority of Alzheimer’s cases do not have a clearly identified cause. The new designation, proposed in a study published Monday, could broaden the scope of efforts to develop treatments, including gene therapy, and affect the design of clinical trials. It could also mean that hundreds of thousands of people in the United States alone could, if they chose, receive a diagnosis of Alzheimer’s before developing any symptoms of cognitive decline, although there currently are no treatments for people at that stage. The new classification would make this type of Alzheimer’s one of the most common genetic disorders in the world, medical experts said.
Locations: United States
Peter Oosterhuis, a British golfer who won 20 tournaments around the world, played in the Ryder Cup six times and later distinguished himself as a commentator for CBS and Golf Channel, died on Thursday in Charlotte, N.C. His wife, Ruth Ann (DuClos) Oosterhuis, said that his death, at a memory care facility, was caused by complications of Alzheimer’s disease. That year, Oosterhuis (pronounced OH-ster-house) spoke to Golf Digest about his life and career. One detailed memory he still had: “In the 1973 Ryder Cup, I played Lee Trevino in one of my singles matches. Lee told his teammates, ‘If I don’t beat Oosterhuis, I’ll come in here and kiss your butts.’ Lee didn’t beat me.”
Persons: Peter Oosterhuis, Ruth Ann, Oosterhuis, , , Lee Trevino, Lee, I’ll, ’ Lee didn’t Organizations: Ryder, CBS, Golf, Digest Locations: British, Charlotte, N.C
Scientists identify ‘degrees of Kevin Bacon’ gene
  + stars: | 2024-05-02 | by ( Katie Hunt | ) edition.cnn.com   time to read: +6 min
Even humble fruit flies organize themselves into regularly spaced clusters, researchers have found. Within those social networks, certain individuals will often stand out as “gatekeepers,” playing an important role for cohesion and communication within that group. New research published Tuesday in the journal Nature Communications has identified a gene responsible for regulating the structure of social networks in fruit flies. The study opened up new opportunities for exploring the molecular evolution of social networks and collective behavior in other animals. FLPA/ShutterstockThe gene behind fruit fly social networksThe researchers investigated a number of gene candidates in fruit flies, a common lab organism used in the study of genetics.
Persons: , Kevin Bacon, Bacon, Joel Levine, Rebecca Rooke, ” Levine, Levine, , ” Allen J, Moore, wasn’t, ” Moore Organizations: CNN, Nature Communications, University of Toronto, University of Georgia’s Locations: Philadelphia, University of Toronto Mississauga
Robert B. Oxnam, an eminent China scholar who learned through psychotherapy that his years of erratic behavior could be explained by the torment of having multiple personalities, died on April 18 at his home in Greenport, N.Y., on the North Fork of Long Island. In the 1ate 1980s, Dr. Oxnam was president of the Asia Society, a television commentator and an accomplished sailor. In his 2005 book, “A Fractured Mind: My Life With Multiple Personality Disorder,” Dr. Oxnam recalled the session when Tommy first spoke to Dr. Smith. All that Dr. Oxnam could remember from the 50-minute session, he wrote, was telling the psychiatrist that he didn’t think the therapy was working for him. But Dr. Smith told him that he had been speaking to Tommy all that time.
Persons: Robert B, Vishakha Desai, Oxnam, Jeffery Smith, Bobby, Tommy, Smith Organizations: Asia Society Locations: China, Greenport, Long
“If we work with our physiology knowing that women are women and men are men, knowing that women are not small men, then imagine the (health) outcomes,” she said at a 2019 TED talk. Women of all ages should focus on strength training to help reduce risk of dementia, said exercise physiologist and nutrition scientist Dr. Stacy Sims (not shown). Dr. Stacy Sims said women should prioritize eating more protein to support building muscle, especially as bodies age. But if we have that lean mass from strength training, it really helps calm down that rate of change. Drinking something cold right after exercise helps bring that blood back centrally, reduces metabolites and starts the reparation process.
Persons: Joe Biden, , Stacy Sims, , MoMo, Sims, Darwin, that’s, Alzheimer’s, haven’t, It’s, , Melanie Radzicki McManus Organizations: CNN’s, CNN, TED, National Institutes of Health, Women’s, US National Institutes of Health Locations: Mount Maunganui , New Zealand
Sandra TorresTorres has a rare disorder called Laron syndrome that is caused by a genetic mutation. “This is how powerful this mutation seems to be.”What is Laron syndrome? Laron syndrome is a recessive gene, so only those who receive a copy from each parent will be affected. The condition leads to extreme obesity, a trigger for diabetes, heart disease, cancer and other diseases. While technically overweight at 100 pounds (45.4 kilograms), she was in good health, with no signs of diabetes or heart disease.
Persons: Paola Castro Torres, ” Torres, Torres, , ” Nathaly Paola Castro Torres, Sandra Torres Torres, , Valter Longo, Longo, Laron, Jaime Guevara, Aguirre, Guevara, ” Longo, ” Guevara, Andrew Freeman, Freeman, ” Hope, it’s Organizations: CNN, gerontology, University of Southern, of Endocrinology, Laron, Jewish Health Locations: Los Angeles, Quito, Ecuador, University of Southern California, Israel, Yemen, East, United States, Croatia, Ireland, Denver
Last year was called the year of Ozempic, though it was also a year of Ozempic backlash and Ozempic shortages, which could persist for years. Even so, we appear very far from a peak for GLP-1 drugs, like Ozempic and Wegovy, which are powered by a molecule called semaglutide, and Mounjaro, which uses its cousin tirzepatide. It seems possible to imagine a future in which almost everyone is taking some variety of GLP-1 drug, and with a pretty good reason to do so. Patients on Ozempic and Wegovy can lose 15 to 20 percent or more of their weight in a little over a year, and if they stay on the drugs, the weight tends to stay off. Semaglutide has been shown to eliminate or reduce the need for insulin among those with recent-onset Type 1 diabetes.
Persons: tirzepatide, Wegovy, we’ve, Semaglutide Locations: Alzheimer’s
Having a routine job with little mental stimulation during your 30s, 40s, 50s and 60s was linked to a 66% higher risk of mild cognitive impairment and a 37% greater risk of dementia after the age of 70, according to the study, when compared with having a job with high cognitive and interpersonal demands. Attending college, for example, reduced the impact of a repetitive job by about 60% but didn’t fully negate the risk. Routine jobs that were not classified as “cognitively protective” often involved repetitive manual and mental tasks, such as is typical of factory work and bookkeeping. “Most people in routine jobs in our sample included housekeepers, custodians, construction workers and mail carriers,” Edwin said. More cognitively demanding jobs were not based on routine tasks, even though repetition was required at times.
Persons: , Dr, Trine Edwin, Edwin said, Richard Isaacson, Isaacson, ” Edwin, Edwin, It’s, ” Isaacson Organizations: CNN, Oslo University Hospital, American Academy of Neurology, Locations: Norway, Florida
In 1817, James Parkinson expressed a hope about the disease that is named after him. He thought that at some point there would be a discovery and “the progress of the disease may be stopped.”Now, nearly 200 years since Parkinson expressed his hope, and after four decades of unsuccessful clinical trials, a group of French researchers reports the first glimmer of success — a modest slowing of the disease in a one-year study. And the drug they used? A so-called GLP-1 receptor agonist, similar to the wildly popular drugs Ozempic, for diabetes, and Wegovy, for obesity. As many as half a million Americans have been diagnosed with Parkinson’s disease, a degenerative brain illness second only to Alzheimer’s in prevalence.
Persons: James Parkinson, Parkinson
Betty Cole Dukert, who began her career in Washington as a secretary in the 1950s and later became the top producer of the weekly NBC News public affairs program “Meet the Press,” died on March 16 at her home in Bethesda, Md. Her late husband’s niece Barbara Dukert Smith said the cause was complications of Alzheimer’s disease. “She was the main point of contact on Capitol Hill for the show,” said Betsy Fischer Martin, who started on “Meet the Press” as an intern and became the program’s executive producer in 2002. “She worked the phones constantly. It wasn’t an era when you could send off an email to book someone.”
Persons: Betty Cole Dukert, , Barbara Dukert Smith, Dukert, Betsy Fischer Martin, Organizations: NBC News, Press, , NBC, Capitol Locations: Washington, Bethesda, Md
“Science postdocs perform the science,” Donna Ginther, an economist who studies the science labor market at the University of Kansas, told CNN. Biomedical companies take scientific contributions and, over time, aggregate them into a commercial product. Building on the discovery of mRNA in the 1960’s, the technology behind an mRNA vaccine for humans was in development for decades before the Covid-19 vaccine was first administered in 2020. By using that technology to develop their mRNA vaccines for Covid-19, pharmaceutical companies like Pfizer and Moderna made a windfall in profits. “That’s how they make money is through commercialization: they have a product, which they then patent and sell.”Why are scientists leaving academic labs?
Persons: postdocs, Donna Ginther, “ They’re, Michael Ciaglo, , , Nobel, Dr, Katalin Kariko, ” Ginther, they’re, Ginther Organizations: New, New York CNN —, National Institutes of Health, NIH, National Science Foundation, University of Kansas, CNN, , Pfizer, Moderna, Wired Magazine, NSF, World Health Organization Locations: New York, United States, Denver , Colorado, Europe, Alzheimer’s
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