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☆ G1 Therapeutics to scrap cancer drug trial, shares plunge
▼ + stars: | 2023-02-13 | by ( ) www.reuters.com time to read: +1 min

The drug, trilaciclib or Cosela, was unlikely to meet the main goals of extending overall survival or the time that a patient lives without the disease worsening, G1 Therapeutics said. Cosela is the company's lead therapy and the only drug being tested in clinical trials. However, the drug achieved its goal in the trial of the drug to reduce the occurrence of Neutropenia - an abnormally low count of a type of white blood cell - during induction and reduce its duration. The company is studying the drug in other indications such as breast and bladder cancer. The study was testing a combination of the drug administered along with chemotherapy and Roche's (ROG.S) therapy Avastin in patients with a type of colorectal cancer.

☆ 'Suite Life of Zack and Cody' star Brenda Song opened up about trying to make it in acting as a kid: 'We had no money'
▼ + stars: | 2023-02-12 | by ( Eboni Boykin-Patterson | ) www.businessinsider.com time to read: +5 min

Brenda Song famously played London Tipton on "The Suite Life of Zack and Cody." Song opened up about what life was like as a child actor back then, and how her family helped. While Song had a supportive immediate family as a child actor, she opened up in an interview with Glamour about some of the struggles she faced in pursuing her childhood dream. "I have a very different experience as a child actor," Song said, "My mom had me at 17 and my dad was a teacher and still in school. That year my mom got diagnosed with breast cancer, and I booked "The Suite Life of Zack and Cody" and got accepted to Harvard University, all within a few weeks."

☆ Stigma and poverty stymie cancer treatment as rates rise in Kenya
▼ + stars: | 2023-02-10 | by ( ) www.reuters.com time to read: +2 min

NAIROBI, Feb 10 (Reuters) - Like many people in Kenya, Sperenza Maina went into denial when she was first diagnosed with breast cancer, hiding it from her family for months and delaying important treatment. As in much of Africa, most cancer cases in Kenya are diagnosed at an advanced stage, when treatment options are limited and families make huge sacrifices by selling assets or borrowing money, according to a World Bank report. As the country gets wealthier, cancer diagnoses are on the rise; annual incidence increased by almost 30% between 2012 and 2018, data from the health ministry shows. Women in Kenya often fear seeking diagnosis for some of the most common and deadly cancers in Kenya such as cervical and breast cancer, said Bridget Nyabuto, a doctor at the Nairobi Radiotherapy and Cancer Centre. Having cancer is not a death sentence, you have to live to tell the story," she said.

☆ Biotech CEO famous for spending millions to reverse age accused of walking out on ex after her breast cancer diagnosis and manipulating her in the spirit of 'radical transparency"
▼ + stars: | 2023-02-10 | by ( Azmi Haroun | Lloyd Lee | ) www.businessinsider.com time to read: +6 min

A biotech CEO famous for trying to reverse his age was accused of walking out on a cancer-stricken partner. Ex-fiancée Taryn Southern alleged that Bryan Johnson emotionally and financially manipulated her. "Trickery, deceit, preying on Ms. Southern's physical and emotional weaknesses and financial dependence, and creating confusion and fear with his threats of legal action were major features of Johnson's scheme against Ms. Southern," Southern's attorneys wrote. "He aggressively pursued and propositioned Ms. Southern's own friends and acquaintances – while other women were paid prostitutes or girls from 'Sugar Daddy" apps,' Southern's attorneys said in the suit. "He became obsessed with his sexual conquests and relaying the details of his triumphs to Ms. Southern under the guise of 'radical transparency and honesty.'"

☆ Tyson Foods misses quarterly sales estimates
▼ + stars: | 2023-02-06 | by ( ) www.reuters.com time to read: +1 min

Feb 6 (Reuters) - Tyson Foods Inc (TSN.N) missed Wall Street estimates for quarterly revenue on Monday, pinched by falling beef prices and lower volumes in its pork segment. While soaring prices of beef, chicken and pork boosted sales at Tyson last year, the company reported an 8.5% drop in average sales price of beef in the reported quarter. The fall in beef prices dragged Tyson's sales at a time demand is already taking a hit from penny-pinched Americans reducing their spending on pricier meat cuts. The U.S. meatpacker's sales rose to $13.26 billion in the first quarter from $12.93 billion a year earlier. Analysts on average had expected sales of $13.52 billion, according to IBES data from Refinitiv.

☆ The art of the buffet: Cruise chef of two decades explains how ships feed thousands of passengers at sea
▼ + stars: | 2023-02-03 | by ( Hannah Towey | ) www.businessinsider.com time to read: +7 min

Marco Goetz has worked on some of the world's largest cruise ships as an executive chef. "On land, your daily routines are more organized — you know what is coming," Goetz told Insider. The art of the buffetGuests are served food in the Marketplace buffet onboard the cruise ship MSC Virtuosa. Throughout the cruise, buffet options are adjusted in accordance with guests' nationalities, Goetz told Insider. But, cruise ship workers receive living quarters (most chefs have their own cabin) and meals for free.

☆ Sanofi’s ailments are more than skin deep
▼ + stars: | 2023-02-03 | by ( ) www.reuters.com time to read: +2 min

LONDON, Feb 3 (Reuters Breakingviews) - Sanofi (SASY.PA) is battling multiple ailments. The $115 billion French pharma group on Friday forecast “low single digit” growth in earnings per share for 2023, disappointing analysts. Hence it’s more reliant on the star asthma and eczema drug Dupixent, which contributed nearly a fifth of Sanofi’s 43 billion euros of sales in 2022. Last August, $36 billion was wiped off Sanofi, GSK (GSK.L) and spinoff Haleon (HLN.L) shares on U.S. litigation fears. It currently trades on 10 times its forecast 2023 earnings, while Novartis (NOVN.S) trades on 13 times.

☆ I'm a plastic surgeon. More people are 'bundling' procedures — here's when it's a great idea and when it can get risky.
▼ + stars: | 2023-02-03 | by ( Fortesa Latifi | ) www.businessinsider.com time to read: +5 min

Dr. Robert Westreich is a plastic surgeon in New York who specializes in facial surgery. Westreich told Insider it seems like bundling surgeries escalated during the pandemic. In the last few years, I've noticed that patients are more interested in "bundling" plastic surgeries than ever before. For it to get risky, the surgery time would have to last longer than six to seven hours, and 90% of the time with plastic surgery, surgery doesn't last that long. For patients who are considering bundling plastic surgery procedures, I would advise taking the time to choose a doctor (or doctors) who fit your case and making sure you really understand the after-care instructions.

☆ Sanofi forecasts moderate profit growth on Dupixent demand
▼ + stars: | 2023-02-03 | by ( Ludwig Burger | ) www.reuters.com time to read: +3 min

Feb 3 (Reuters) - Sanofi (SASY.PA) on Friday forecast moderate earnings growth this year, saying higher demand for bestselling asthma and eczema drug Dupixent would be partly offset by competition for its multiple sclerosis pill Aubagio and product launch costs. Aubagio, with 2 billion euros in sales last year, will face competition from cheaper products over the next few months after losing patent protection, Sanofi said. The company reaffirmed its target to achieve sales of Dupixent, jointly developed with Regeneron (REGN.O), of 10 billion euros this year, up more than 20% from 8.29 billion euros in 2022. Sanofi reported a 20.7% rise in fourth-quarter business operating income, or adjusted earnings before interest and tax, to 2.72 billion euros ($2.96 billion), edging past an average analyst estimate of 2.69 billion euros posted on the company's website. Revenue from Dupixent surged 42% to 2.4 billion euros during the quarter ended Dec. 31, slightly above a consensus of 2.37 billion euros.

☆ Novartis says operating profit to grow again ahead of Sandoz spin-off
▼ + stars: | 2023-02-01 | by ( Ludwig Burger | ) www.reuters.com time to read: +2 min

Full-year core operating income was broadly flat at $16.7 billion, it said in a statement, coming in slightly below market expectations of $16.8 billion. Novartis shares were down 1.3% in early trade on Wednesday and have fallen about 11% since January 2020, underperforming most rivals. They were also disappointed by guidance for Sandoz's core operating income to decline by a "low double digit" percentage in 2023 due to cost inflation and investments to make it a stand-alone entity. MS drug Kesimpta, which requires fewer injections than standard therapies, is expected to become Novartis' second largest growth driver in 2023, after Entresto. Novartis shares lagReporting by Ludwig Burger; editing by Josephine Mason and Jason NeelyOur Standards: The Thomson Reuters Trust Principles.

☆ Women Have Been Misled About Menopause
▼ + stars: | 2023-02-01 | by ( Susan Dominus | ) www.nytimes.com time to read: +4 min

Until she stumbled on Alloy, she’d been relying on antibacterial creams to soothe the pain she felt. The space was clearly a no-judgment zone, a place where women could talk about how they personally felt about the risks and benefits of taking hormones. “My new OB-GYN and my cancer doc won’t put me on hormones,” the woman said. Faubion told me that in certain circumstances, higher-risk women who are fully informed of the risks but suffer terrible symptoms might reasonably make the decision to opt for hormones. Only once I took the hormones did I appreciate that my regular 2 a.m. wakings, too, were most likely a symptom of perimenopause.

☆ Novartis says operating profit to grow again ahead of Sandoz spin off
▼ + stars: | 2023-02-01 | by ( ) www.cnbc.com time to read: +3 min

Novartis on Wednesday predicted that core operating income would grow in a "mid single digit" percentage range in 2023 following stagnation last year, as the Swiss drugmaker prepares to spin off its Sandoz generics business. Full-year core operating income was broadly flat at $16.7 billion, it said in a statement, coming in slightly below market expectations of $16.8 billion. We're seeing health care systems stabilize a bit more, we're seeing China start to stabilize, and we see a second-half rebound in China. All of those are important tailwinds for a business like ours," he said during an interview in Basel, Switzerland. MS drug Kesimpta, requiring fewer injections than standard therapies, is expected to become Novartis' second largest growth driver in 2023, after Entresto.

☆ A Peloton instructor was diagnosed with breast cancer at age 35. Here's how common the disease is at every age.
▼ + stars: | 2023-01-31 | by ( Yeji Jesse Lee | ) www.businessinsider.com time to read: +2 min

A 35-year-old Peloton instructor recently said she had been diagnosed with breast cancer. Peloton instructor Leanne Hainsby, who is 35, announced in a recent Instagram post that she was diagnosed with breast cancer in August and has been undergoing treatments since then. The risk for getting breast cancer increases with age. The American Cancer Society recommends that women at average risk for breast cancer start getting screened at age 45, and considers screenings beginning at age 40. While treatments for breast cancer vary depending on the stage of the disease, they can include chemotherapy, surgery, and hormonal therapy.

☆ Amid high levels of contamination, Puerto Rico town's residents plead for action
▼ + stars: | 2023-01-30 | by ( Associated Press | ) www.nbcnews.com time to read: +8 min

SALINAS, Puerto Rico — Shuttered windows are a permanent fixture in Salinas, an industrial town on Puerto Rico’s southeast coast that is considered one of the U.S. territory’s most contaminated regions. Salinas also has one of the highest incidence rates of cancer in Puerto Rico, with 140 cases reported in 2019, the newest figures available from the island’s Central Registry of Cancer. Those measures have a limited effect, however, and residents continue frustrated that their complaints about contamination have been ignored for years. That has been hailed by many in Puerto Rico, which has one of the highest asthma rates in a U.S. jurisdiction and whose power generation system is 97% based on fossil fuels. Although she has been the target of protests organized by frustrated residents, she said she is pushing for corrective measures.

☆ I sell porn stars' breast implants, lingerie, bodily fluids, and other items — even their bath water. No request is off limits.
▼ + stars: | 2023-01-29 | by ( Jyoti Mann | ) www.businessinsider.com time to read: +5 min

Natasha Root set up a company to sell porn stars' items like breast implants, lingerie, and socks. Fans Utopia sells items from over 30 porn stars and OnlyFans creators, even underwear with urine. I created a company that sells items porn stars have used, everything from used breast implants and butt plugs to panties with urine, blood, or semen on them. The idea came from a dream I had in March 2021 where I was selling my friend's breast implants. In the beginning, I didn't have friends or anyone to introduce me to porn stars or creators, so I used Twitter and Instagram.

"Everybody has a different amount of fibroglandular tissue and a different pattern," Freer said, referring to dense breast tissue. In individual interviews as part of Gunn's survey, six out of 61 women said dense breasts contributed to breast cancer risk. There are two reasons dense breasts are linked to a higher risk of breast cancer. To lower one's risk of breast cancer overall, doctors recommend limiting alcohol intake, exercising regularly and maintaining a healthy diet. The Breast Cancer Surveillance Consortium offers an online tool to help people gauge their breast cancer risk based on multiple factors, including breast density.

☆ Tyler Posey is going to keep playing Scott McCall as long as 'Teen Wolf' fans will let him
▼ + stars: | 2023-01-28 | by ( Olivia Singh | ) www.businessinsider.com time to read: +8 min

Tyler Posey as Scott McCall on season one of "Teen Wolf." Tyler Posey as Scott, Vince Mattis as Eli, and Crystal Reed as Allison in "Teen Wolf: The Movie." "I hope there's more 'Teen Wolf,'" Posey reiterates. Tyler Posey as Scott McCall in "Teen Wolf: The Movie." "But also, 'Teen Wolf' has been known to bring every single person back from the dead, so it's never finite."

☆ 10 things about ancient Egypt that movies and TV got wrong, according to an expert
▼ + stars: | 2023-01-28 | by ( Marianne Guenot | Carter Thallon | ) www.businessinsider.com time to read: +11 min

Movies and television shape what people think about ancient Egypt. Here are 10 things that "Moon Knight", "The Mummy", and others got wrong and one they got right. When it comes to ancient Egypt, they can draw the portrait of pharaohs ruling Egypt with an iron fist, cruel torture, and wicked booby-trapped pyramids. "All of the sarcophagi that I've seen in Egypt were made of stone," said Browder, an author of several books on ancient Egypt. The curse that set Imhotep on his murderous path in "The Mummy" has no historical basisIn "The Mummy," Imhotep was mummified alive.

☆ Peloton instructor Leanne Hainsby, 35, said she was diagnosed with breast cancer after a doctor told her not to worry about a lump in her breast
▼ + stars: | 2023-01-27 | by ( ) www.businessinsider.com time to read: +2 min

Peloton instructor Leanne Hainsby said she was diagnosed with breast cancer at age 35. She wrote on Instagram that she noticed a lump in her breast, but a doctor initially said not to worry. "Chemo is no joke," Hainsby wrote. Family history of breast cancer is a major risk factor, but other factors like reproductive health and alcohol use can also play a role, according to the Mayo Clinic. Other symptoms of breast cancer include skin irritation, pain, or any other changes in the area that seem unusual, a breast surgeon previously told Insider.

☆ Exclusive: Inside the extramarital affair and cash-fueled double life of Charles McGonigal, the FBI spy-hunter indicted for allegedly taking Russian money
▼ + stars: | 2023-01-27 | by ( Mattathias Schwartz | ) www.businessinsider.com time to read: +15 min

She had dated federal law enforcement officials before. "Charlie McGonigal knew everybody in the national security and law enforcement world," Guerriero said, in an exclusive interview with Insider. One law enforcement source estimated that McGonigal stood to make roughly $300,000 to $350,000 a year, including annual bonuses. Former New York City Mayor Rudy Giuliani, whom she knew from law enforcement circles, let her stay in a guest bedroom. During her relationship with McGonigal, Guerriero says, they never talked about politics.

☆ Hawaii man imprisoned for 1991 murder and rape of tourist released after judge hears new evidence of innocence
▼ + stars: | 2023-01-25 | by ( The Associated Press | ) www.nbcnews.com time to read: +7 min

A court officer removes Albert Schweitzer's handcuffs at a hearing in Hilo, Hawaii, on Jan. 24, 2023. “Nerves, anxiety, scared.”The justice system is “flawed,” he said, calling himself one of many imprisoned for crimes they didn’t commit. Some intentional and some unintentional.”Ireland’s relatives couldn’t immediately be reached for comment on the petition and Schweitzer’s release. In 2019, Schweitzer’s attorneys and Hawaii County prosecutors entered into a “conviction integrity agreement” to reinvestigate the case. Despite the lack of evidence linking them to the killing, the two Schweitzers and Pauline were indicted in 1997.

☆ Plastics Export: How I Keep My Family, Baby Safe From Toxic Microplastics.
▼ + stars: | 2023-01-25 | by ( Adrienne Matei | ) www.businessinsider.com time to read: +12 min

Hardman does research on microplastics — tiny pieces of plastic debris that are broken down from larger plastic items. Microplastics are often too small to pick up or even notice, but they are everywhere: in the air, dust, and rain. Laura HardmanPlastic is a relatively new pollutant, so there's still a lot we don't know about it. In the lab, my team of researchers and I focus on the sources, effects, and fate of plastics in the ocean. The simple answer is we don't know what plastics might be doing to us, but I've started to get really concerned.

But to reach its ultimate destination - supermarket shelves - cultivated meat faces big obstacles, five executives told Reuters. California-based cultivated meat company GOOD Meat already has an application pending with the FDA, which has not been previously reported. Regulatory approval is just the first hurdle for making cultivated meat accessible to a broad swath of consumers, executives at UPSIDE, Mosa Meat, Believer Meats, and GOOD Meat told Reuters. But it will take hundreds of millions of dollars for GOOD Meat, for example, to build bioreactors of the size needed to make its meat at scale, Tetrick said. But cultivated meat companies have the advantage that they can claim their product is real meat, Tetrick said.

☆ Thinx to pay millions to settle class-action lawsuit alleging its period underwear contained potentially harmful chemicals
▼ + stars: | 2023-01-21 | by ( Jordan Hart | ) www.businessinsider.com time to read: +4 min

In a class-action lawsuit announced in November, plaintiffs accused Thinx of failing to tell customers their period underwear contained potentially harmful PFAS. The first report of Thinx underwear potentially containing the chemicals was in January 2020, from Sierra Club magazine columnist Jessian Choy. In her column, Choy said she mailed her Thinx underwear to a nuclear professor who discovered PFAS in the crotch of the item. An editor's note attached to Choy's story Friday suggested the class-action suit as a result of Choy's investigation into the toxicity of her own Thinx underwear. Ten years later, period underwear are still a small part of the menstrual care industry although more companies have come forward to compete with Thinx.

☆ Hormone therapy improves mental health for transgender youths, a new study finds
▼ + stars: | 2023-01-19 | by ( Jo Yurcaba | Jo Yurcaba Is A Reporter For Nbc Out. | ) www.nbcnews.com time to read: +8 min

Transgender youths reported more life satisfaction and fewer symptoms of depression and anxiety after receiving gender-affirming hormone therapy for two years, according to a new study. However, medical associations such as the American Medical Association and the American Academy of Pediatrics, among others, oppose efforts to restrict gender-affirming care for minors. In addition to the New England Journal of Medicine study, about half a dozen others have shown that access to puberty blockers and hormone therapy can improve mental health outcomes, including reducing suicidal ideation, among transgender youths. Three studies — two published in 2020 and another published in 2021 — found that earlier access to gender-affirming medical care is associated with better mental health. They also noted that improvement in mental health varied widely, and that some participants continued to report high levels of depression and anxiety and lower levels of positive emotions and life satisfaction.

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