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Boehringer to test obesity drug in three late-stage trials
  + stars: | 2023-08-17 | by ( ) www.reuters.com   time to read: +1 min
The logo of German pharmaceutical company Boehringer Ingelheim is seen at its building in Shanghai, China February 1, 2019. REUTERS/Stringer/File Photo Acquire Licensing RightsAug 17 (Reuters) - Germany's Boehringer Ingelheim said on Thursday it would conduct three late-stage studies for its obesity drug candidate after it showed up to 19% weight loss after 46 weeks in a mid-stage trial. The private company plans to start enrollments for the trial of the drug, survodutide, which it co-invented with Danish biotech company Zealand Pharma (ZELA.CO), before the end of the year. Boehringer and Zealand are among global drugmakers racing to grab a share of the potential $100 billion market for obesity treatments within a decade. Survodutide works by mimicing a gut hormone called glucagon-like peptide-1 (GLP-1), which suppresses appetite, as well as imitating another gut hormone called glucagon that helps break down fat.
Persons: Stringer, Boehringer Ingelheim, Boehringer, NASH, Leroy Leo, Sriraj Organizations: REUTERS, Zealand Pharma, Thomson Locations: Shanghai, China, Zealand, Bengaluru
In the latest Equity Talk, she shares how she's overcoming biases in the VC and biotech fields. Verge Genomics works with data derived from brains and spinal cords donated by people after they die. That's really been helpful because they don't necessarily see the same kind of questions. But I think part of that is just showing them that there can be a new way of doing things. I think that's an area where naivete can be a benefit, when you have big technological hurdles to overcome.
Persons: Alice Zhang, Zhang, it's, It's, That's, I've, we're, I'm, who's, There's, Alice, aren't, they're, that's unarguable, Organizations: Genomics, Morning, Verge Genomics, Eff, pharma, Tech
Investors should keep an eye on biotech company BeiGene as it scales up its global revenue streams, according to Jefferies. Analyst Kelly Shi initiated coverage of the stock with a buy rating and assigned a price target of $287, suggesting shares stand to gain 49.2% in the next 12 months. The stock has lost 12% so far this year but has had a more uplifting quarter with gains of about 8%. According to the analyst, BeiGene's product pipeline could expand beyond oncology, as it currently includes early autoimmune candidates. BeiGene's tislelizumab drug is another major growth driver for the company, Shi said, highlighting the drug's position as China's top-selling PD-1 drug with about 40% market share.
Persons: Kelly Shi, Shi, BeiGene, BGNE, Amgen, — CNBC's Michael Bloom Organizations: Jefferies, pharma, Novartis Locations: Cambridge , Massachusetts, Beijing, China, BeiGene
Pharma stocks are typically shunned by Wall St. when people feel confident about economy: Jim Cramer'Mad Money' host Jim Cramer talks the Pharma industry facing off against the federal government over IRA provisions.
Persons: Wall, Jim Cramer Organizations: Wall St, Pharma
Analysts at Morgan Stanley named companies that have quantified how much money they can make — or save — from using generative artificial intelligence (AI). While firms like Alphabet , Meta and Microsoft are on Morgan Stanley's list, non-tech companies are also financially benefiting from using generative AI, the bank said. Here's what some of the reporting companies said about how much they're making or saving by using AI or generative AI, according to Morgan Stanley's note. Alphabet said: "Our new generative AI offerings are expanding our total addressable market and winning new customers. We noted 47 quotes from management teams at 2Q23 relating to productivity gains or efficiency in employee training," Morgan Stanley said.
Persons: Morgan Stanley, Morgan, Edward Stanley, Morgan Stanley's, Meta, Intesa Sanpaolo, Comstock, Bruker Organizations: Microsoft, Energy, Health Care, OpenAI, Ceridian, Pharma, AstraZeneca Locations: Swiss
One piece of the puzzle that still confuses me is the price target. Using Eli Lilly as an example: Jim posted a new 12-month price target of $600 and the stock is around $528. The first thing to address: What exactly is a price target anyway? Eli Lilly (LLY) jumped over 18% over the past two weeks but is still far from its price target. Using Eli Lilly as an example: Jim posted a new 12-month price target of $600 and the stock is around $528.
Persons: Jim Cramer, Eli Lilly, Jim, Kathy, LLY, it's, , Jim Cramer's Organizations: Club, Jim Cramer's Charitable, CNBC
Get In on This Skin Disease Drug Before Big Pharma Does
  + stars: | 2023-08-15 | by ( David Wainer | ) www.wsj.com   time to read: 1 min
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Persons: Dow Jones
They said the GOP wants to slash earned benefits and hand out tax cuts for the wealthy. For instance, the Republican Study Committee released a report on spending priorities and reforms that would, among other measures, adjust the Social Security retirement age. "We will not now or ever support cutting or delaying retirement benefits for any senior in or near retirement," it said. "While the GOP tries to cut its funding, Democrats are committed to protecting Social Security for all Americans." "It's Medicare, Social Security, interest on the debt."
Persons: Biden, Andrew Bates, Bates, reconvenes, that's, California Sen, Alex Padilla, Kevin McCarthy, McCarthy, Sen, Ron Wyden Organizations: House, Republicans, GOP, Service, Privacy, White, Republican, Security, Labor, Health, Human Services, Education, Social Security, Big, Democratic, Social, Fox News, Senate Finance, AP News Locations: Wall, Silicon, California
Share Share Article via Facebook Share Article via Twitter Share Article via LinkedIn Share Article via EmailWhat pharma brands will be impacted by Medicare price negotiationsJared Holz, Mizuho healthcare strategist, joins 'The Exchange' to discuss Medicare drug price negotiations, the M&A impact of government intervention into drug pricing, and more.
Persons: Jared Holz Organizations: pharma Locations: Mizuho
Big Pharma and biotech companies often outsource clinical trials to external companies. Europe's early-stage clinical trials startups are flush with funds but they're struggling to grow. The fate — and market cap — of a biotech company often lies with a successful clinical trial. The COVID-19 pandemic also spotlighted another promising alternative to carry out these trials — startups. While the US touts around a dozen clinical trials unicorns valued at $1 billion or higher, per Dealroom estimates, Europe's startups are lagging behind.
Persons: BEN, Janssen, Christoph Ruedig, Maya Zlatanova, Europe hasn't, Matt Wilson, Wilson, Christoph Massner, it's, Ruedig Organizations: Big Pharma, pharma, Janssen Pharmaceuticals, Tempus, Venture, Albion VC, US, Earlybird Ventures Locations: Europe, New York, American
One such prediction came Monday from Morgan Stanley analysts who forecasted a 1.3% drop in calorie consumption in the U.S. by 2035. The shift in behavior is notable because it will affect a sizeable demographic group that represents a disproportionate share of food consumption, the analysts said. In fact, some patients taking these medicines say they have to sometimes force themselves to eat due to a lack of appetite. These types of patterns were seen in consumer research Morgan Stanley conducted in June and July among 300 patients taking these medicines. Keurig Dr Pepper, with its coffee business accounting for about 30% of corporate sales, offers some diversification from at-risk beverage categories, Morgan Stanley said.
Persons: you've, Morgan Stanley, Pamela Kaufman, Read, Campbell, Mondelez, Eli Lilly's Mounjaro, Morgan Stanley's, Morgan, John David Rainey, We've, we're, Rainey, Dara Mohsenian, Eric Serotta, Dr Pepper Organizations: Hostess Brands, Hershey, Nordisk's Ozempic, Centers for Disease Control, Food and Drug Administration, Novo Nordisk, Industry, Lawmakers, Walmart Locations: U.S, Cava
During another busy week of earnings and stock market swings, we picked our spots and made six trades, including calling up a Bullpen name. We also changed two Club price targets. Shortly after the opening bell, we trimmed some Caterpillar and booked some profits after the industrial giant's blowout earnings last week. Jim Cramer's Charitable Trust — the holdings we use for the Club — owns 315 shares of Caterpillar. As a subscriber to the CNBC Investing Club with Jim Cramer, you will receive a trade alert before Jim makes a trade.
Persons: Jim Cramer's, Club —, Stanley Black, Decker, Stanley, Wolfe, Eli Lilly, Lilly, Bob Iger's, Jeff Marks, Jim Cramer, Jim, Jim Cramer Rob Kim Organizations: Caterpillar, DuPont, Revenue, Club, Management, Coterra Energy, West Texas, Wolfe Research, Halliburton, HAL, GE Healthcare Technologies, Disney, The, GE Healthcare, pharma, Big Tech, CNBC Locations: Coterra
Opioids expose unhealthy bankruptcy addictions
  + stars: | 2023-08-11 | by ( Robert Cyran | ) www.reuters.com   time to read: +6 min
Between 2006 and 2014, it manufactured roughly 30 billion opioid pills. Its attempt to climb out of bankruptcy has been stalled multiple times, most recently on Thursday by the U.S. Supreme Court. Mallinckrodt agreed to a $260 million settlement last year and quarterly revenue from Acthar has tumbled 70% since 2019. If not, it will be up to elected officials to end such unhealthy bankruptcy addictions. As part of that settlement, Mallinckrodt agreed to pay $1.7 billion over eight years to settle opioid claims.
Persons: Johnson, Mark Trudeau, Sackler, Mallinckrodt, It’s, haven’t, Jeffrey Goldfarb, Sharon Lam Organizations: Reuters, Mallinckrodt Pharmaceuticals, Johnson, CVS Health, Purdue Pharma, U.S, Supreme, Department of Justice, Specialty Brands, Point, Purdue, Purdue Pharma’s, DOJ, Biden Administration, Thomson Locations: American, Delaware, Acthar
The excitement around new drugs that can help people shed weight quickly has created a banner week for certain health care ETFs. That would be its best stretch since the week ended June 24, 2022, when the fund gained 8.3%, according to FactSet. IHE 5D mountain The iShares fund focused on drugmakers is on track for its best week of the year. Zoetis , the third largest holding in the iShares fund, has rallied more than 6% this week after its second-quarter report. Meanwhile, the VanEck Pharmaceutical ETF (PPH) has gained more than 4% so far this week, which would also be its best week of the year.
Persons: Eli Lilly, Wegovy Organizations: U.S . Pharmaceuticals, Mounjaro, Novo Nordisk, VanEck Pharmaceutical Locations: U.S, Danish
The settlement involving Purdue, the maker of the prescription painkiller OxyContin, touches on one of the country’s largest public health crises. Experts say the decision may also have important consequences for other cases that use the bankruptcy system to settle claims of mass injuries. Here’s what you need to know about the court’s decision:Why did the Supreme Court decide to weigh in? It’s rare for the Supreme Court to agree to hear a bankruptcy court dispute, experts say, especially one dealing with a settlement agreement in a mass-injury case. Trustee Program, a watchdog office within the Justice Department, that petitioned the Supreme Court to review the deal.
Persons: Sackler Organizations: Supreme, Purdue Pharma, Purdue, U.S ., Justice Department Locations: U.S
Bank of America thinks Kura Oncology could be a winner in blood cancer treatment, believing the stock could nearly triple in value. The bank initiated research coverage of the clinical-stage biotech company with a buy rating and $31 per share price target. "Early clinical data has been favorable, where treatment with ziftomenib monotherapy produced robust responses in a heavily pretreated patient population where outcomes are often poor." Kura Oncology's stock price briefly rose as much as 6.5% in early Friday trading. KURA 1Y mountain Kura Oncology stock.
Persons: Jason Zemansky, ziftomenib monotherapy, Zemansky, Cash, BofA, — CNBC's Michael Bloom Organizations: of America, Bank of America's, Syndax Pharma, FactSet Locations: Kura
"We are confident in the legality of our nearly universally supported plan of reorganization, and optimistic that the Supreme Court will agree," the company added. Members of the Sackler family have denied wrongdoing but expressed regret that OxyContin "unexpectedly became part of an opioid crisis." They said in May that the bankruptcy settlement would provide "substantial resources for people and communities in need." In a court filing, the administration told the Supreme Court that Purdue's settlement is an abuse of bankruptcy protections meant for debtors in "financial distress," not people like the Sacklers. According to the administration, Sackler family members withdrew $11 billion from Purdue before agreeing to contribute $6 billion to its opioid settlement.
Persons: George Frey, Joe Biden's, Sackler, OxyContin, Biden, John Kruzel, Andrew Chung, Dietrich Knauth, Will Dunham Organizations: Purdue Pharma, REUTERS, WASHINGTON, U.S, Supreme, Purdue, . Trustee, The, Circuit, Thomson Locations: Provo , Utah, U.S, Stamford , Connecticut, Washington, New York
A pharmacist holds a bottle OxyContin made by Purdue Pharma at a pharmacy in Provo, Utah, U.S., May 9, 2019. At issue is whether U.S. bankruptcy law allows Purdue's restructuring to include legal protections for the Sackler family, who have not filed for personal bankruptcy. They said in May that the bankruptcy settlement would provide "substantial resources for people and communities in need." In a court filing, the administration told the Supreme Court that Purdue's settlement is an abuse of bankruptcy protections meant for debtors in "financial distress," not people like the Sacklers. According to the administration, Sackler family members withdrew $11 billion from Purdue before agreeing to contribute $6 billion to its opioid settlement.
Persons: George Frey, Joe Biden's, Sackler, OxyContin, Biden, John Kruzel, Andrew Chung, Dietrich Knauth, Will Dunham Organizations: Purdue Pharma, REUTERS, WASHINGTON, U.S, Supreme, Purdue, Circuit, U.S . Trustee, Thomson Locations: Provo , Utah, U.S, Stamford , Connecticut, Washington, New York
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Organizations: Wall Street
Novo Nordisk on Thursday said it will acquire Inversago Pharma, a privately held obesity drug maker, for up to $1.08 billion to broaden the Danish company's blockbuster weight loss portfolio. The deal's price depends on whether Inversago reaches certain development and sales goals, Novo Nordisk said in a release. Canada-based Inversago develops experimental therapies to treat people with obesity, diabetes and other conditions affecting the body's metabolism. Meanwhile, Novo Nordisk's Wegovy and Ozempic work by mimicking a hormone produced in the gut to suppress a person's appetite. Novo Nordisk intends to further investigate the potential of the oral drug for obesity and obesity-related complications.
Persons: Novo, Martin Holst Lange, Lars Fruergaard Jorgensen, availabilities Organizations: Novo Nordisk, Inversago Pharma, Novo, Novo Nordisk's Wegovy, Nordisk, Reuters Locations: Danish, Inversago, Canada, U.S
Though it is still unclear which 10 drugs Medicare will select, several pharmaceutical companies have already revealed in court filings that they expect four of their blockbuster medications to be targeted. Bristol-Myers Squibb and Johnson & Johnson , in separate filings, said their blood thinners Eliquis and Xarelto will be subject to the negotiations this year. The list price of Januvia has surged 275% since 2006, according to the AARP. Johnson & Johnson reported $2.47 billion in revenue from Xarelto. "More and more people face cost-sharing that is directly affected by drug price increases," Leigh Purvis, who analyzes health-care costs for AARP, told reporters on a call Thursday.
Persons: Daniel Acker, Merck, Johnson, Abbvie, Imbruvica, Jardiance, Boehringer Ingelheim, Amgen Symbicort, Pfizer Xtandi, Breo, Biden, Januvia, Eliquis, Xarelto, Leigh Purvis Organizations: Merck, Co, Inc, Bloomberg, Getty, Medicare, Services, Myers Squibb, Johnson, Pharmacy, AstraZeneca Ibrance, Pfizer, Astellas Pharma, GSK, AARP, Bristol Myers Squibb, Jama Network, Industry Locations: Bristol, U.S, Januvia, Xarelto
The Supreme Court agreed on Thursday to consider the government’s challenge of a bankruptcy settlement involving Purdue Pharma, putting on pause a deal that would have shielded members of the wealthy Sackler family from civil opioid lawsuits in exchange for payments of up to $6 billion to thousands of plaintiffs. In doing so, the court sided with the Justice Department, which had requested the court put the settlement plan on hold while it considered reviewing the agreement. The government has argued that the family behind Purdue Pharma, maker of the prescription painkiller OxyContin, should not be able to take advantage of legal protections meant for debtors in “financial distress.”The court’s order, which was unsigned, gave no reasons and included no public dissents, adds to the uncertainty around the plan to compensate states, local governments, tribes and individuals harmed by the opioid crisis while offering protection for the Sackler family. The order specified that the justices would hear arguments in the case in December. The court’s decision to take up the challenge to the bankruptcy agreement is the latest twist in the yearslong legal battle over compensation for victims of the prescription drug crisis.
Persons: Sackler Organizations: Purdue Pharma, Justice Department
(Prescription Addiction Intervention Now) and Truth Pharm staged a rally and die-in outside New York's Southern District Federal Court in White Plains. The Supreme Court on Thursday blocked for now a $6 billion bankruptcy settlement by Purdue Pharma that would protect its Sackler family owners from civil lawsuits related to the opioid crisis. The Supreme Court also said it will hear a challenge to the settlement by Purdue, the maker of the opioid OxyContin, by a U.S. Bankruptcy trustee. There were no dissents by any of the court's justices in the order granting the requested hold. The case will be argued in December at the high court.
Persons: Pharm Organizations: New York's Southern, Federal Court, Purdue Pharma, Purdue, U.S Locations: New York's, White Plains
We are buying 100 shares of GE Healthcare Technologies (GEHC) at roughly $73.76. Following the trade, Jim Cramer's Charitable Trust will own 850 shares of GEHC, increasing its weighting in the portfolio to 2.16% from 1.91%. The medical device group has been in a steady decline lately as the aversion to health-care stocks this year continues, and we are using this weakness to buy a little more of GE Healthcare. THE ABOVE INVESTING CLUB INFORMATION IS SUBJECT TO OUR TERMS AND CONDITIONS AND PRIVACY POLICY , TOGETHER WITH OUR DISCLAIMER . NO FIDUCIARY OBLIGATION OR DUTY EXISTS, OR IS CREATED, BY VIRTUE OF YOUR RECEIPT OF ANY INFORMATION PROVIDED IN CONNECTION WITH THE INVESTING CLUB.
Persons: Jim Cramer's, , Peter Arduini, Eli Lilly Eli Lilly, Lilly, Eli Lilly, Jim Cramer, Jim, Jim Cramer Rob Kim Organizations: GE Healthcare Technologies, GEHC, GE Healthcare, GE, Novo Nordisk, Jefferies, pharma, CNBC Locations: Lilly
Jim Cramer explains why he's letting this pharma stock run rather than taking profitsThis is one of those times when there's a stock in the portfolio that tests our discipline and conviction. It's understandable that some investors may want to trim this stock, but Jim thinks this pharma company will deliver the best-selling drug of all time and is sticking with it.
Persons: Jim Cramer, Jim
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