Tre Mann added 21 points off the bench.
Jaylen Brown scored 30 points, reserve Sam Hauser had 24 on six 3-pointers and Al Horford added 13 for Boston.
Anunoby added 27 points, 10 rebounds and three steals for the Raptors, who played without forward Pascal Siakam (groin).
Bennedict Mathruin scored 30 points, Tyrese Haliburton had 21 points and 11 assists for the Pacers, who had won four of their previous five games.
All five Hornets starters reached double figures in points, led by Terry Rozier with 18 in the team's sixth consecutive loss.