The Tokyo Stock Exchange (TSE), operated by Japan Exchange Group Inc. (JPX), in Tokyo, Japan, on Monday, Nov. 30, 2020.
The Nikkei 225 in Japan dropped 1% in early trade, while the Topix index fell 0.94%.
Shares in the Asia-Pacific opened lower Wednesday, following Wall Street's negative lead ahead of the Federal Reserve's expected rate hike .
"A sourer tone took hold over the past 24 hours, with equities lower and haven currencies, including the dollar, stronger," Taylor Nugent, economist at National Australia Bank, wrote in a Wednesday note.
The dollar index strengthened above the 110 level.