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Another key component was DNA from a living descendant of Samuel Washington. Samuel Washington, George Washington's younger brother, was buried in an unmarked grave at the cemetery at his Harewood estate (an interior view is pictured above) near Charles Town, West Virginia. Fortunately for the authors of the new study, “DNA analysis has come a long way since the early 2000s,” Cavagnino said. Further details came from 95,000 SNPs, an enormous volume of data targeting autosomal DNA (DNA that isn’t attached to sex chromosomes). “The search for Samuel Washington’s grave is no longer underway,” Marshall said.
Persons: George Washington’s, Samuel, Samuel Washington, , Charla Marshall, George, Courtney L, George Washington, Cavagnino, George Washington's, Harewood, Frances Benjamin Johnson, Samuel Washington’s, ” Cavagnino, Lucinda “ Lucy ” Payne, George Steptoe Washington Jr, Samuel Walter Washington, Dr, Lucy Payne, Connie J, Mulligan, , ” Mulligan, , that’s, — “, Augustine Washington, ” Marshall, Marshall, ” Mindy Weisberger Organizations: CNN, US Department of Defense DNA, West Virginia . Records, US Armed Forces DNA, Library, Zion Episcopal Church, Genomics, University of Florida, Scientific Locations: Washington, Harewood, Charles Town, West Virginia, Mount Vernon , Virginia, Zion
The rare find could help scientists further understand how changes in the human diet have led to the prevalence of cavities today. Uncovered during two excavations from 1993 and 1996, the teeth were among several human teeth and other remains found within a limestone cave in County Limerick in Ireland. One tooth had a surprising abundance of Streptococcus mutans (S. mutans), an oral bacteria that causes cavities. Researchers also believe the bacteria is not as commonly found within ancient teeth because the human diet included less refined sugar and fewer processed foods than are consumed today, Cassidy said. … ancient teeth can help us understand how the human oral microbiota (range of microorganisms) has evolved over time and the impact of these changes on human health in the past and today,” Humphrey said in an email.
Persons: Lara Cassidy, Cassidy, mutans, , , would’ve, Tannerella, mutans “, Louise Humphrey, ” Humphrey Organizations: CNN, Trinity College Dublin Locations: County Limerick, Ireland, France, London
NEW YORK (AP) — The nation's top public health agency is expanding a program that tests international travelers for COVID-19 and other infectious diseases. Those locations should provide more information about respiratory infections coming out of South America, Africa and Asia, particularly, CDC officials said. But they are given a COVID-19 home test kit to take with them, CDC officials say. That testing is for COVID-19, but CDC officials are evaluating the possibility of monitoring wastewater for other things, Walker said. The CDC program has a current budget of about $37 million.
Persons: , Allison Taylor Walker, Walker, Ginkgo Organizations: Disease Control, CDC, Health, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: COVID, Miami, South America, Africa, Asia, Chicago
CNN —President Joe Biden will issue an executive order on Wednesday aimed at curbing foreign governments’ ability to buy Americans’ sensitive personal information such as heath and geolocation data, according to senior US officials. The department will also issue regulations that require better protection of sensitive government information, including geolocation data on US military members, according to US officials. “Countries of concern, such as China and Russia, are buying Americans’ sensitive personal data from data brokers,” a separate senior administration official told reporters. In addition to health and location data, the executive order is expected to cover other sensitive information like genomic and financial data. Administration officials told reporters the new executive order would be applied narrowly so as not to hurt business transactions that do not pose a national security risk.
Persons: Joe Biden Organizations: CNN, Department, Justice Department, Social, Defense, Health, Human Services, Veteran Affairs Locations: China, Russia
U.S. President Joe Biden will issue an executive order Wednesday intended to safeguard the personal data of American citizens from countries deemed hostile. The executive order centers on the business of selling people's personal information, in which companies and so-called data brokers collect and trade data. The order focusses on specific, sensitive information like genomic data, biometric data, personal health data, geolocation data, financial data and other kinds of personally identifiable information. The executive order will direct the Department of Justice to issue several regulations intended to protect sensitive data. "American privacy concerns in the data broker industry are not new, and existing laws do not sufficiently protect Americans' data from misuse," the letter said.
Persons: Joe Biden, Kamala Harris, Mitch McConnell, Mike Johnson, Chuck Schumer, Hakeem Jeffries, Biden Organizations: White, Chinese Communist Party, Department of Justice, of Homeland Security, United States Telecommunications Services, U.S, Oracle, Trump, Biden Locations: Washington , DC, U.S, China
WASHINGTON (AP) — U.S. lawmakers are raising alarms about what they see as America’s failure to compete with China in biotechnology, warning of the risks to U.S. national security and commercial interests. Bills have been introduced in the House and Senate to bar “foreign adversary biotech companies of concern” from doing business with federally funded medical providers. Photos You Should See View All 33 ImagesCritics of the legislation warn that restrictions on Chinese companies would impede advances that could bring a greater good. “It’s not just a supply chain battle or a national security battle or an economic security battle; I would submit it’s a moral and ethical battle,” Gallagher said. He said any restrictive U.S. measures should be tailored to address military concerns and concerns about genomic data security.
Persons: walling, , Abigail Coplin, Rachel King, Mike Gallagher, Gallagher, “ It’s, ” Gallagher, “ we’re, Biden, Tom Bollyky, Bollyky, Ray Yip, Yip, , Anna Puglisi, Puglisi, ” Puglisi, BGI, WuXi AppTec, Dake Kang Organizations: WASHINGTON, — U.S, Biotechnology, Bills, Embassy, Biden, Vassar College, Biotechnology Innovation Organization, National Security Commission, Emerging Biotechnology, U.S . Senate, Chinese Communist Party, Wisconsin Republican, , Bloomberg, Council, Foreign Relations, U.S . Centers for Disease Control, Georgetown University’s Center for Security, Emerging, The Defense Department, Commerce Department, Associated Press Locations: China, U.S, , South China, Wisconsin, Boston, United States, WuXi, Beijing
Check out the companies making headlines in extended trading. Pinterest — Shares slid 6% in extended trading after the image-sharing company issued a weaker-than-expected forecast. Take-Two Interactive Software — Shares dropped almost 7% in extended trading after the video game publisher issued a disappointing forecast for the current quarter. Take-Two also slightly missed earnings estimates, with an adjusted 71 cents a share versus expected earnings of 72 cents a share per FactSet. Cloudflare – The cloud services provider jumped 18% in extended trading.
Persons: Pinterest, Expedia, Ariane Gorin, CleanSpark, Illumina, Cloudflare, Tanaya Macheel Organizations: Business, Revenue Locations: FactSet
DHR 1Y mountain Danaher 1 year Shares of Danaher rose as much as 5% to a 52-week high of $245.40 each. Core sales, not shown on the table, were down 22.5%. Core sales were down 4% year over year as strength from academic and life science research customers was more than offset by weakness from pharma and biopharma customers. Core sales fell about the same as strength in clinical diagnostics, driven by Beckman Coulter Diagnostics was more than offset by lower respiratory revenue at Cepheid. In this photo illustration, Danaher Corporation logo is seen displayed on a smartphone and PC screen.
Persons: we've, Danaher, Beckman Coulter, Jim Cramer's, Jim Cramer, Jim, Pavlo Gonchar Organizations: Revenue, LSEG, JPMorgan Healthcare, Sciences, Diagnostics, Biotechnology, Management, pharma, Beckman Coulter Diagnostics, CNBC, Getty Locations: Danaher, China, Biotechnology, North America, Europe, Asia, Pacific, Cepheid
BRUSSELS (AP) — Lawmakers on the European Parliament’s environment committee on Wednesday backed a proposal to relax rules on genetically modified plants produced using so-called new genomic techniques, prompting strong criticism from environmental groups. But lawmakers agreed Wednesday to create two different categories and two sets of rules for genetically modified plants produced using NGTs. Those considered equivalent to traditional crops would be exempt from GMO legislation, but other NGT plants would have to follow current requirements. The committee agreed that all NGT plants should remain prohibited in organic production. It aims to ensure that what is developed does not breach EU citizens’ rights to health and environmental protection.”
Persons: , Jessica Polfjard, Eva Corral, Organizations: — Lawmakers, European Union, Environment, Public Health, Food Safety, EU, Greenpeace Locations: BRUSSELS
In France, it was named the “Neapolitan disease” after the French army got infected during its invasion of Naples, Italy, in the first documented syphilis epidemic. A complex disease caused by a complex bacteriumWithout treatment, syphilis can cause physical disfigurement, blindness and mental impairment. Others believe T. pallidum bacteria always had a global distribution but perhaps grew in virulence after initially manifesting as a mild disease. Some bones had marks characteristic of infection with T. pallidum — the bacteria effectively eat away at bones, leaving concave lesions. “The modern tools available for extracting DNA from ancient samples, for enriching the treponemal DNA, and obtaining deep sequencing from samples has rapidly increased our understanding of the Treponema.”
Persons: Christopher Columbus, Treponema pallidum, , Brenda J, Baker, Jose Filippini It’s, Molly Zuckerman, wasn’t, ” Zuckerman, , it’s, Columbus, Europe ’, Sheila A, pallidum, Verena Schünemann, Schünemann, Mathew Beale, Beale, ” Lukehart Organizations: CNN, Research, Arizona State University, Bioarchaeology Laboratories, Mississippi State University, University of Washington, University of Zurich’s Institute of Evolutionary, Wellcome Sanger, Columbus Locations: France, Naples, Italy, Europe, Americas, Brazil, New, Laguna, Santa Catarina, Africa, Columbus, Finland, Estonia, Netherlands, Asia, Cambridge, England
These genetic variants may have subsequently proved beneficial to European populations in making the shift from hunting and gathering to farming. “DNA from hunter-gatherers is present at higher levels in Northeastern Europe, which means the region has an elevated genetic risk of developing Alzheimer’s disease,” Barrie said. Similarly, the ancient genetic information shed light on the evolutionary history of traits such as height and lactose tolerance. And for most traits, MS included, the genetic effects are the result of multiple genetic variants,” he said. “Ultimately, we can’t say that MS came from Bronze Age populations, but these populations’ movements and environments contribute to differences in MS risk today.”
Persons: , , Rasmus Nielsen, It’s, William Barrie, Astrid Iversen, ” Iversen, ε4, ” Barrie, Samira, Asgari, Tony Capra, Capra, wasn’t Organizations: CNN —, University of California, Danish National, University of Cambridge’s, University of Oxford, Icahn School of Medicine, Bakar Computational Health Sciences Institute Locations: Western Europe, Central Asia, Europe, Berkeley, Kazakhstan, Northeastern Europe, Mount Sinai, New York, Bakar, San Francisco
In the pharmaceutical industry, AI may one day accelerate new-drug development. In the foreseeable future, McClain expects the healthcare industry to use AI technology to design personalized medicines. Risks to considerWhile AI offers promise for the healthcare industry, there are also a variety of risks professionals using AI must consider and mitigate. Showalter said that a lack of "comprehensive regulations" can also make using AI technology in healthcare settings risky. With this in mind, he said, the medical industry must understand the "fundamentals of AI and its applications in healthcare."
Persons: , Sean McClain, McClain, Tim Showalter, Showalter, it's, Fred, haven't, Surya Josyula, Josyula Organizations: Experts, Service, Northwestern Medicine, Fred Hutchinson Cancer Center, UW Medicine, University of California, Fujitsu, Aichi Cancer, Fujitsu Laboratories of America Locations: University of California San Diego, Nagoya, Japan, China, United States
FactSet data shows that 70% of the 43 analysts covering Snowflake have buy or overweight ratings on the stock. Year-to-date shares in the biotechnology and life sciences equipment manufacturer are down nearly 4%, but Ghosh remains positive. Schneider Electric Elsewhere, French energy management company Schneider Electric is on the radar of Steven Glass, managing director and investment analyst at Pella Funds. "We're very bullish, although it's not as cheap as it used to be on Schneider Electric. Year-to-date, shares in Schneider Electric are up around 28%.
Persons: Karen Kharmandarian, Colette Kress, Warren Buffett, Rahul Ghosh, Rowe Price, Ghosh, Steven Glass, it's, Glass, Schneider Organizations: Big Tech, CNBC Pro, Nvidia, Thematics Asset Management, U.S, Robotics Fund, Berkshire Hathaway, BE Semiconductor Industries, BE Semiconductor, BE, Danaher Corp, Schneider, Pella Funds Locations: China, Snowflake, Danaher, Pella
Orchid, a startup that tests embryos for genetic diseases, has just raised $12 million. "The way that IVF and embryo screening works today is the amount of information available is really limited," Orchid CEO and cofounder Noor Siddiqui said. Genetic testing has been around for years, but it has been usually limited in the diseases it can identify, which include cystic fibrosis, Bloomberg reported. Orchid produces reports with two types of genetic testing: monogenic and polygenic. The cost of the test depends on the number of embryos that Orchid tests.
Persons: Noor Siddiqui, Siddiqui, Orchid, Dylan, Anne Wojcicki, Fidji Simo, Peter Kraft Organizations: Business, Bloomberg, Prometheus Fund, Starbloom Capital, One Ventures, Los Angeles Times Locations: San Francisco, Pebblebed
New COVID Variant Takes Hold in the United States
  + stars: | 2023-11-28 | by ( Nov. | At A.M. | ) www.usnews.com   time to read: +2 min
By Robin Foster HealthDay Reporter(HealthDay)TUESDAY, Nov. 28, 2023 (Healthday News) -- The prevalence of a highly mutated COVID variant has tripled in the past two weeks, new government data shows. Now, nearly 1 in 10 new COVID cases are fueled by the BA.2.86 variant, the U.S. Centers for Disease Control and Prevention reported Monday. Scientists first warned of the highly mutated variant back in August, but it has since spread in several regions of the United States. The CDC also noted that BA.2.86 variant poses a "low" public health risk. But the CDC data released Monday did show that emergency department visits linked to COVID-19 have begun to climb nationwide.
Persons: Robin Foster HealthDay, Jasmine Reed Organizations: U.S . Centers for Disease Control, EG, WHO, CDC, CBS News, JN Locations: New York, New Jersey, United States, U.S
CNN —The US Centers for Disease Control and Prevention is expanding its infectious disease surveillance program at four major US airports to more than 30 pathogens, including flu, RSV and other respiratory viruses. The program currently operates Covid-19 surveillance at seven major international airports in the United States. The traveler surveillance program was introduced in 2021 when the CDC began collecting nasal swab samples from anonymous international travelers arriving at participating airports who volunteer to get swabbed. The program has collected samples from travelers from more than 135 countries and has sequenced more than 14,000 samples for further analysis. The wastewater program, which was introduced in August 2022, collects wastewater from a single plane using a custom-made collection device.
Persons: Dr, Cindy Friedman, John F, , ” Friedman, Friedman, Ginkgo Bioworks, Matthew McKnight, ” McKnight, Sanjay Gupta, Deidre McPhillips Organizations: CNN, Centers for Disease Control, CDC’s, Health, Boston Logan International Airport, San Francisco International Airport, Dulles International, Washington , D.C, Kennedy International, CDC, Get CNN, CNN Health Locations: United States, Washington ,, New York, Ginkgo
[1/2] A sign hangs in front of the world headquarters of Vertex Pharmaceuticals in Boston, Massachusetts, U.S., October 23, 2019. REUTERS/Brian Snyder/File Photo Acquire Licensing RightsOct 31 (Reuters) - A panel of advisers to the U.S. health regulator said on Tuesday Vertex Pharmaceuticals (VRTX.O) and CRISPR Therapeutics (CRSP.BN) could assess potential safety risks of their sickle cell disease gene therapy after approval. If the therapy is approved, Vertex has proposed a 15-year follow up of patients to evaluate the safety outcomes of the therapy. Patients who were treated with the therapy were free from severe vaso-occlusive crisis for 12 months from the infusion of exa-cel. "It was made pretty clear that any theoretical off-target editing concerns do not outweigh the benefits of drug approval," said Salim Syed, analyst at Mizuho.
Persons: Brian Snyder, Scot Wolfe, Salim Syed, Sriparna Roy, Krishna Chandra Organizations: Vertex Pharmaceuticals, REUTERS, CRISPR Therapeutics, Staff, U.S . Food, Drug Administration, UMass Chan Medical, Analysts, FDA, Mizuho, Thomson Locations: Boston , Massachusetts, U.S, Bengaluru
Thirteen mouse mummies were found atop volcanoes in Chile and Argentina about 20,000 feet above sea level. The discovery has baffled scientists who did not think mammals could live at such high elevations. The species is known to live at high elevations, but baffled scientists at more than 20,000 feet. The scientists are now looking for signs of physiological adaptations that may allow these mice to survive at high elevations with low oxygen levels. Storz's team is also continuing to search the volcano tops for signs of mice, living or mummified.
Persons: , Jay Storz, University of Nebraska — Lincoln, Marcial Quiroga, Carmona, Storz, Mario Pérez Organizations: Service, University of Nebraska Locations: Chile, Argentina, University of Nebraska —
Tsai predicts that AI will one day help doctors analyze complicated genetic data — a hallmark of precision medicine. Together, AI imaging and genetic analysis may help doctors rapidly pinpoint a diagnosis and create a highly personalized treatment plan, thus improving a patient's care. AI and the potential for genetic analysisIn addition to medical imaging, AI could one day comb through large amounts of genetic information, a challenging task for researchers. A possible convergence in the clinicWang does not see combining AI imaging and AI genetic analysis at the doctor's office happening within the next couple of years. Chang and his colleagues are investigating how AI analysis of brain scans can predict genetic mutations in brain tumors.
Persons: James C, Tsai, Peter D, Chang, Zhenghe J, Wang Organizations: Healthcare, Morning, Center, Ophthalmic Artificial Intelligence, Human, Icahn School of Medicine, US Food and Drug Administration, Applied, Research, University of California, Case Western Reserve University Locations: Mount, Irvine
Scientists are setting out to collect genetic material from 500,000 people of African ancestry to create what they believe will be the world’s largest database of genomic information from the population. The initiative was launched Wednesday by Meharry Medical College in Nashville, Tennessee, as well as Regeneron Genetics Center, AstraZeneca, Novo Nordisk and Roche. Organizers said there’s a clear need for the project, pointing to research showing that less than 2% of genetic information being studied today comes from people of African ancestry. Each of the pharmaceutical companies involved intends to contribute $20 million toward the genetic and educational parts of the effort. ___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group.
Persons: Meharry, , Anil Shanker, Lyndon Mitnaul Organizations: Meharry Medical College, Genetics Center, AstraZeneca, Novo Nordisk, Roche, Genomics Institute, Organizers, Regeneron Genetics, University of Zambia, Project, Genetics, Corporate, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Nashville , Tennessee, Americas, Asia, Europe, Nashville, U.S, Africa, Meharry
BRUSSELS (AP) — The European Union on Thursday ordered U.S. biotech giant Illumina to undo its $7.1 billion purchase of cancer-screening company Grail because it closed the deal without approval of regulators in the 27-nation bloc. The EU already slapped a $475 million fine on Illumina over the summer for jumping the gun on the acquisition without its consent. Allowing the deal to stand would have undermined the credibility of EU regulators. The EU accused Illumina and Grail of knowingly and deliberately merging before getting clearance in what amounted to a vital infringement of the rules. Illumina must “restore the situation prevailing before” the acquisition, regulators said, and how Illumina divests itself of Grail also needs EU approval.
Persons: Didier Reynders, Illumina, , Grail Organizations: Union, Thursday, EU, Companies, European Commission, Illumina, Regulators, Federal Trade Commission Locations: BRUSSELS, EU, U.S, San Diego
EU to assess tech security risks and consider controls
  + stars: | 2023-10-03 | by ( ) www.reuters.com   time to read: +2 min
The European Commission said on Tuesday it had established a list of four technologies, as well a further six to look into later, as part of the European Economic Security Strategy it unveiled in June. The Commission stresses that it must first carry out a risk assessment with the EU's 27 members and consulting companies before determining any measures. "The risk assessment will be country agnostic, but we will take into account geopolitical factors to determine how severe those risks are," an EU official said. In advanced semiconductor technologies, areas of focus include microelectronics and chip-making equipment, in AI data analytics and object recognition, and for quantum cryptography, communications and sensing. The EU has previously carried out an assessment of the security of its 5G networks, which has led some EU countries to restrict use of equipment made by China's Huawei and ZTE.
Persons: China's, Philip Blenkinsop, Jan Harvey Organizations: European Union, European, European Economic Security, EU, China's Huawei, ZTE, Thomson Locations: BRUSSELS, China, EU, U.S, Japan, Britain, Australia
Then, there is the life sciences services segment, which provides comprehensive sample management programs, integrated cold chain solutions, informatics and sample-based laboratory services to advance scientific research and support drug development. Activist Commentary: Politan Capital Management was founded by Quentin Koffey. This is Politan's second 13D filing and third activist campaign, all of which have been in the health-care sector. One-third of the company is cash, and investors want to know how it plans to deploy that capital. Ken Squire is the founder and president of 13D Monitor, an institutional research service on shareholder activism, and the founder and portfolio manager of the 13D Activist Fund, a mutual fund that invests in a portfolio of activist 13D investments.
Persons: Quentin Koffey, Koffey, Shaw, Brooks, Azenta, Thomas H, , Politan, Ken Squire Organizations: Politan Capital Management, Investment Group, Elliott Associates, Lee Partners, B, Companies, 13D Locations: D.E
There are eight previously known species of pangolin — four found in Asia and four in Africa. Genomics can help protect threatened speciesThe scales’ form initially suggested they belonged to one of four species of pangolin found in Asia. But DNA analysis showed that their “genomic data provide robust and compelling evidence that it is a new pangolin species distinct from those previously recognized,” Hu said. An analysis of contraband pangolin scales revealed genetic markers not seen in known species, researchers said. “We also expect to find other pangolin species,” Hu said.
Persons: CNN —, , , Jing, Yan Hu, pangolin, ” Hu, Aryn Wilder, Wilder, Manis mysteria, Feng Yang One, ” Wilder, , Hu Organizations: CNN, State Key Laboratory for Conservation, Yunnan University, San Diego Zoo Wildlife Alliance Locations: Asia, Africa, Hong Kong, Yunnan
Data is trickling in on a new COVID-19 strain nicknamed “pirola,” giving researchers a wider picture of what the variant could mean for the U.S. and the world. Van Kerkhove said that the global COVID-19 variant picture is complex, and that while BA.2.86 is spreading, it is not currently outcompeting other strains. “It is quite a complex picture globally in terms of how these variants behave because different variants circulate in different countries at different times.”Will Vaccines Work on Pirola? Moderna and Pfizer have announced that early data indicates that their updated vaccines do produce an immune response against BA.2.86. "These results demonstrate that our updated COVID-19 vaccine generates a strong human immune response against the highly mutated BA.2.86 variant.
Persons: “ pirola, ” Mandy Cohen, Maria Van Kerkhove, ” Benjamin Murrell, Ashish Jha, pirola, Van Kerkhove, it’s, , , Stephen Hoge Organizations: U.S, CDC, Centers for Disease Control, World Health Organization, WHO, White, Moderna, Pfizer, EG Locations: United States, Denmark, Sweden, Portugal, Israel, Canada, South Africa
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