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Maker of Wegovy, Ozempic showers money on U.S. obesity doctors
  + stars: | 2023-12-01 | by ( ) www.reuters.com   time to read: +23 min
Novo spent at least $25.8 million over the past decade on U.S. medical professionals to promote its two obesity drugs, Wegovy and Saxenda, the analysis found. Jastreboff has also worked on clinical trials of obesity drugs for Eli Lilly, which markets a Wegovy competitor. Some doctors said Novo’s payments exemplify how the flood of industry money can dominate decision-making about care and coverage. Government pharmacy officer Solaru said her agency concluded that the new obesity drugs could be cost-effective by preventing other weight-related diseases and boosting workplace productivity. In January, the personnel office told its health plans they must cover at least one GLP-1 obesity drug for 8 million workers, retirees and family members.
Persons: Lee Kaplan, Kaplan, , gastroenterologist, He’s, Novo, Donna Ryan, Ryan, , ” Kaplan, ” Novo, Robert Lustig, “ I’m, Lustig, They’re, Ania, ” Jastreboff, Jastreboff, Eli Lilly, Lilly’s Zepbound, Lilly, ” Lilly, Novo’s, Ayana, Sanders, Arthur Kellermann, ” Kellermann, mouthpieces, ’ ”, “ I'm, Jamy Ard, Ard, Dele, ” Solaru, ” Ryan, Scott Kahan, Kahan, Solaru, Christine Gallagher, Wegovy, Rebekah Carl, Carl, Jen Wexler, gaunt, Wexler Organizations: Novo Nordisk, Dartmouth, Nutrition Institute, Massachusetts General Hospital, Harvard Medical School, Reuters, Cambridge, Obesity Society, U.S ., Management, Reuters . Pharmaceutical, , U.S, United, National Health Service, University of California, U.S . Food, Drug Administration, Doctors, Wegovy’s, BMI, Yale University’s Center, Weight Management, Wall Street, American Medical Association, Rutgers University’s School of Public Health, Affordable, . Pharmaceutical, Companies, Uniformed Services University of Health Sciences, Wake Forest University, Wake Forest Baptist Health Weight Management, Obesity, Pennington Biomedical Research, U.S . National Institutes of Health, Personnel Management, Coalition, STOP, George Washington University, Novo Locations: CAMBRIDGE, Massachusetts, Boston, U.S, Novo, Danish, United States, Louisiana, San Francisco, Wegovy, Pennington, Baton Rouge , Louisiana, Government, New Columbia , Pennsylvania, Florida
If the deal goes through, AbbVie would acquire ImmunoGen’s flagship cancer therapy Elahere. Photo: Brian L. Frank for The Wall Street JournalDrug company AbbVie has agreed to buy biotech ImmunoGen for $10.1 billion in a new bet on one of the most promising novel drug technologies for attacking cancer. ImmunoGen develops cancer drugs called antibody-drug conjugates, or ADCs, which work like guided missiles delivering a toxic agent directly to tumors. The technology is among the hottest areas in the pharmaceutical industry. Recent advancements have spread its use to common kinds of cancer such as breast, spawning other multibillion-dollar deals.
Persons: AbbVie, Brian L, Frank, ImmunoGen Organizations: The Wall Street Journal
Check out the companies making the biggest moves in premarket trading: Boeing — The aerospace stock added 1.5% following an upgrade to buy from hold by Deutsche Bank. PENN Entertainment — The gambling stock popped 4.4% on the back of a Bank of America upgrade to buy from neutral. The Food and Drug Administration won't be able to meet to make a decision by the target date of Dec. 16. Krispy Kreme — Shares of the doughnut chain slipped 1.8% following a downgrade by JPMorgan to neutral from overweight. Vale — U.S.-listed shares of the Brazil-based metal and mining company added 2.6% following an upgrade by Bank of America to buy from neutral.
Persons: Sam Altman, Cantor Fitzgerald, Bristol Myers, Krispy, Krispy Kreme, Goldman Sachs, Iovance, Morgan Stanley, Terri Kelly, Kelly, , Sarah Min, Alex Harring, Michael Bloom Organizations: Boeing, Deutsche Bank, Microsoft, PENN Entertainment, Bank of America, ESPN Bet, Myers, Drug Administration, Bristol, JPMorgan, Bros, Rentals, United Rentals Locations: Bristol, Vale — U.S, Brazil
Zoom Video Communications — The software stock added nearly 2% ahead of its third-quarter earnings due after market close. The Professional Fighters League announced on Monday that it completed its acquisition of mixed martial arts brand Bellator from Paramount. Penn Entertainment — The gambling stock jumped 7% on the heels of a Bank of America upgrade to buy from neutral. Boeing — The aerospace stock jumped 4% after Deutsche Bank upgraded the shares to a buy rating from hold. Chegg — Shares of the education technology company dropped 5% following a downgrade to underweight from equal weight by Morgan Stanley.
Persons: Wells, Sam Altman, Greg Brockman, Raymond James, Morgan Stanley, Krispy Kreme, Iovance, Goldman Sachs, Terri Kelly, Kelly, Peter Grom, , Alex Harring, Yun Li, Lisa Kailai Han, Sarah Min, Michelle Fox Organizations: Communications, FactSet, Paramount, Professional Fighters League, Bellator, Penn Entertainment, Bank of America, ESPN Bet, Spectrum Brands, Microsoft —, Microsoft, Nvidia, Boeing, Deutsche Bank, JPMorgan, Caterpillar —, HSBC, United Rentals — United Rentals, Bristol Myers, Energizer Holdings, UBS, RBC Capital Markets Locations: FactSet
CNBC's Jim Cramer on Tuesday gave his take on earnings as the season draws to a close, saying that sectors as a whole managed to perform fairly well. "When you look at all the groups, this was not a disappointing earnings season at all," he said. He argued that Alphabet also reported positive results, he said, adding the stock may have "roared" if management had better explained issues with the company's cloud business. He also said that companies in the utilities sector reported positive figures, but were hurt primarily because of the bond market. "Aside from Whirlpool and drug company Pfizer, I've been very impressed with pretty much every company that's reported so far," Cramer said.
Persons: CNBC's Jim Cramer, Cramer, industrials, DR, Toll, I've Organizations: Microsoft, Apple, Intel, Whirlpool, Pfizer Locations: Pulte, DR Horton
Amazon is beefing up its mainstay Prime subscription program with a new benefit that gives members access to discounted One Medical memberships. Prime members can add up to five additional memberships on the same plan at a rate of $6 per person, Amazon said. Amazon is integrating One Medical into its Prime membership service after acquiring the primary health-care provider in July 2022 for roughly $3.9 billion. The tech giant has steadily added a buffet of benefits to its Prime membership program over the years as a way to lure more subscribers. Launched in 2005, Amazon Prime gives members access to free two-day shipping, as well as access to exclusive movies and TV shows, among other perks.
Persons: Neil Lindsay Organizations: Amazon Health, Amazon Prime, Amazon Locations: U.S, Haven
A 0.25 mg injection pen of Novo Nordisk's weight-loss drug Wegovy is shown in this photo illustration in Oslo, Norway, September 1, 2023. "Supply of Wegovy is the most important thing for specialist healthcare investors covering Novo right now," said Barclays analyst Emily Field. Some analysts said a firm date would ease concerns that Novo's supply constraints could allow rival Eli Lilly (LLY.N) to get ahead, when it launches its Mounjaro weight-loss drug. Eli Lilly, the world's most valuable drug company ahead of Novo, has said it expects U.S. approval for the drug, currently licensed for diabetes, to be used for weight loss by the end of the year. Novo is spending billions to increase Wegovy output and hiring more contract manufacturers to fill the pens.
Persons: Victoria Klesty, Wegovy, Novo, Emily Field, Eli Lilly, Markus Manns, Manns, Catalent, Jefferies, Jacob Gronholt, Pedersen, Maggie Fick, Josephine Mason, Jane Merriman Organizations: REUTERS, Novo Nordisk, Wegovy, Barclays, U.S . Food, Drug Administration, Union Investment, Thomson Locations: Oslo, Norway, Victoria, COPENHAGEN, United States, Danish, Germany, Novo, U.S, Brussels, London
Such forecasts have prompted a sell-off in a wide range of companies from makers of bariatric surgery devices to companies whose products address the health issues created by excess weight, from diabetes to sleep apnea. "The market is in a shoot-first, ask-questions-later mood when it comes to weight-loss drugs," said Nicholas Anderson, manager of the Thornburg International Growth Fund, which holds shares of Novo Nordisk. By contrast, the iShares U.S. Medical Devices exchange-traded fund has lost more than 22% in the last three months. Injectable weight-loss drugs, known as GLP-1 receptor agonists, are considered highly effective but are also expensive, costing more than $1,300 per month. "Overall, we'll see an increased interest in bariatric surgery, but that will get delayed in the short term."
Persons: Doctor Thomas Horbach, Wegovy, Nicholas Anderson, Eli Lilly, Kenneth Stein, Margaret Kaczor Andrew, William Blair, Michael Farrell, Jeff Jonas, Johnson, Myriam Curet, Ann Hynes, Hynes, David Gaffen, Manas, Michael Erman, Caroline Humer, Sonali Paul Organizations: Novo Nordisk, Healthcare, Growth Fund, Medical Devices, Boston, Gabelli Funds, Johnson, Reuters, Mizuho Securities, Manas Mishra, Thomson Locations: Germany, Munich, Danish, U.S, Boston, GLP, New York, Bengaluru
Ozempic Maker Novo Nordisk Has a Weight Problem
  + stars: | 2023-10-23 | by ( Stephen Wilmot | ) www.wsj.com   time to read: 1 min
Ozempic packets at a Novo Nordisk facility. When the company’s shares become more than 10% of Danish fund managers’ holdings, they are forced to sell. Photo: Carsten Snejbjerg/Bloomberg NewsThe company behind diabetes and obesity phenomena Ozempic and Wegovy is overweight. Novo Nordisk became Europe’s most valuable company last month, overtaking luxury goods maker LVMH, which itself took the title from food giant Nestlé in 2021. This might be a reason why the shares trade at a discount to those of its closest peer, U.S.-listed Eli Lilly .
Persons: Carsten Snejbjerg, Eli Lilly Organizations: Novo Nordisk, Bloomberg Locations: Novo, Danish
Merck’s cancer rush may spawn lower returns
  + stars: | 2023-10-20 | by ( ) www.reuters.com   time to read: +2 min
The American drug company said on Thursday it signed a giant deal with Daiichi Sankyo (4568.T) for the rights to sell three potential drugs outside Japan. Merck will pay $4 billion upfront, up to another $1.5 billion over the next two years, and as much as $16.5 billion if the drugs pass certain sales milestones. Merck’s Keytruda accounts for about 40% of the company’s revenue, and that cancer drug might face cut-price competition before the end of the decade. The potential is giant, as these targeted therapies might eventually account for a quarter of the current oncology market. With over 100 of these drugs in clinical trials, the stampede might lead to lower-than-expected returns.
Persons: Jeff Zelevansky, Robert Cyran, Jean, Pierre Mustier, Atos, Jennifer Saba, Aditya Sriwatsav Organizations: Merck & Co, REUTERS, Reuters, Merck, Pfizer, X, News Corp, Thomson Locations: Linden , New Jersey, American, Japan
CNBC's Jim Cramer said it's important to understand that a trade is not the same as an investment. "Hopefully, you'll turn out to be right about the catalyst and you'll rack up a nice gain. When making an investment, Cramer said investors should have a thesis about how the stock will perform well over an extended period of time. However, he stressed that it's important to continue to research an investment to make sure the thesis holds up. Some of it's deceptively simple, like the distinction between a trade and an investment," Cramer said.
Persons: CNBC's Jim Cramer, Cramer
Spotify — Shares of the music streaming service company fell 2.5% after Redburn Atlantic downgraded the streaming giant to neutral from buy. Tesla — The automaker's stock fell 2.3% in Monday trading upon news that the company's year-over-year sales declined 10.9% in China last month, according to data from the China Passenger Car Association. Oil stocks — Energy stocks soared following the escalation of the Israel-Hamas conflict over the weekend. Airline stocks — On a broader level, airline names were down after several major airlines suspended service to Israel following this weekend's attacks. United Airlines slid 5.3%, while Delta Air Lines and American Airlines shed 4.5% and 5.3%, respectively.
Persons: Elizabeth, Saket Kalia, Bristol Myers, Tesla, Baird, — Datadog, Hess, Northrop Grumman, Yun Li, Tanaya Macheel, Sarah Min, Jesse Pound Organizations: General Dynamics Corp, Spotify, Atlantic, Amazon, Barclays, Therapeutics, Bristol, Bristol Myers Squibb, China Passenger Car Association, Motorola Solutions, Motorola, Bank of America, — Energy, Halliburton, CF Industries, Defense, L3Harris Technologies, General Dynamics, Airline, United Airlines, Delta Air Lines, American Airlines Locations: NASSCO, Norfolk , Virginia, China, Israel, Palestine
CNN —For the first time, adults 60 and older are eligible to receive a vaccine against the respiratory syncytial virus, or RSV. Since this is the first time an RSV vaccine has been made widely available, some older people may be wondering why it might be needed. Is RSV a major problem in adults, especially older adults? Tragically, around 10,000 to 13,000 older adults annually die from this infection. I also do not recommend that people who have decided to get the RSV vaccine to wait.
Persons: Abrysvo, Leana Wen, , Wen Organizations: CNN, Food and Drug Administration, GlaxoSmithKline, Pfizer, US Centers for Disease Control, CNN Wellness, George Washington University Milken Institute School of Public Health, CDC, FDA Locations: United States, It’s
The commodities market is a "much more constructive place to invest" right now — and "integrated" names in the energy sector in particular are "extremely attractive," according to one portfolio manager. For now, Dunn said, he is "certainly concerned about and paying attention to the U.S. onshore shale era," when evaluating what equities to invest in. Integrated energy companies typically engage in the exploration, production, refinement, and distribution of oil and gas. "It's a U.S. company, but they have a lot of assets outside the U.S. and they have been investing outside the U.S.," he said. 'Uncover interesting equities' While the ongoing pullback in the U.S. stock market presents concerns on what stocks to invest in, Dunn said it can help "uncover very interesting equities."
Persons: Aaron Dunn, CNBC's, Dunn, they're, TotalEnergies, Stocks Organizations: Morgan Stanley Investment Management, ExxonMobil, Chevron, BP, ConocoPhillips, Constellation Brands, BJ's Wholesale Locations: U.S, British, Netherlands, Qatar, Australia
In an uncertain market environment, Morgan Stanley thinks investors can regain confidence with some large-cap defensive stocks. All are members of the top 1000 by market cap universe, have outperformed on a year-to-date basis, and are classified as a growth stock based on Morgan Stanley's proprietary factor classification model. "In our view, the best way to express that in a portfolio is to hold a barbell of defensive growth (select growth stories and more traditional defensive sectors like Healthcare and Consumer Staples) with late-cycle cyclicals (Industrials and Energy)." Here are some names from Morgan Stanley's playbook: McDonald's is a sure defensive play, according to the firm. Still, Morgan Stanley analysts view the burger chain as a growth stock that is set to outperform in the coming months.
Persons: Morgan Stanley, Morgan, Michelle Weaver, Consumer Staples, Morgan Stanley's, FactSet Organizations: Healthcare, Consumer, Energy, Costco, Apple, Analysts, Accenture, Ross Stores, Marriott Locations: California
Drug company Danco Laboratories on Friday asked the Supreme Court to review the case challenging the legality of the abortion pill mifepristone. Danco, which distributes the abortion pill, wants the Supreme Court to reverse the lower court ruling. Danco's request for the Supreme Court to take up the case comes nearly 15 months after the court's conservative majority overturned Roe v. Wade, the landmark 1973 decision that protected abortion as a constitutional right. Four justices have to agree to take up the abortion pill case. The U.S. Department of Justice is also expected to ask the high court to review the case.
Persons: Roe, Wade Organizations: Danco Laboratories, U.S ., Appeals, Fifth Circuit, U.S . Department of Justice
For decades, drugmakers have argued that patents are critical to bringing new drugs to the market. But in 2004, when a promising H.I.V. treatment emerged, Gilead Sciences decided to slow-walk its release to maximize profit on the company’s existing patents. Rebecca Robbins, who covers the pharmaceutical industry for The Times, discusses one man’s case and how patents can create perverse incentives to delay new and better drugs.
Persons: drugmakers, Rebecca Robbins Organizations: Gilead Sciences, The Times
Amir Dan Rubin, CEO of primary care provider One Medical, which Amazon acquired about a year ago, is leaving the company later this year. Twitch CEO Emmett Shear resigned from Amazon in March, and Whole Foods CEO John Mackey retired last year. Amazon has looked to shore up its presence in health care through the One Medical and PillPack deals, as well as by developing services in-house. Last August, the company shuttered its Amazon Care telehealth service amid broader cost-cutting efforts. Haven, a joint venture intended to disrupt health care, disbanded in 202.
Persons: Amir Dan Rubin, Neil Lindsay, Rubin, Trent Green, Trent, PillPack, TJ Parker, Elliot Cohen, Twitch, Emmett Shear, John Mackey, It's Organizations: Amazon, Amazon Health Services, CNBC, Washington Post, Federal Trade Commission, Whole Foods Locations: Haven
These four are responsible for 46% of the 17% gain in the S & P 500 year to date. In 2003, the largest stocks – General Electric , Microsoft, Pfizer and Exxon Mobil – represented merely 4.4% of the total index market value. By 2013, the share commanded by giants Apple, Exxon, Microsoft and GE rose to 8.9% of the S & P 500. That's still below their 21% market value share, but it helps explain what investors are paying for: exceptional free cash flow and sustainable margins. The S & P 500 will struggle without participation from its biggest components.
Persons: That's, Price, Karen Firestone Organizations: Apple, Microsoft, Nvidia, Meta, Delta Air Lines, Micron Technology, Electric, Pfizer, Exxon Mobil, Exxon, GE, U.S, Union, Asset Management
So if people are less likely to be hospitalized or die from a Covid-19 infection now, has the danger passed? Through genetic bad luck, some people may just be at higher risk of serious reactions to Covid-19 infections, and they probably wouldn’t know it. Researchers defined it as any new or continuing symptoms more than 90 days after a Covid-19 infection. Based on his experience treating long Covid patients, Griffin said that the percentage reported in the Australian paper seems high. Earlier in the pandemic, pediatric infectious disease specialists were on the lookout for a rare complication of Covid-19 infection in kids called multisystem inflammatory syndrome in children, or MIS-C.MIS-C starts two to six weeks after a Covid-19 infection.
Persons: CNN —, we’ve, aren’t, Good, , Megan Ranney, Covid, ” Ranney, that’s, Evusheld, haven’t, you’ve, they’re, They’re, Mandy Cohen, It’s, , Jesse Bloom, Daniel Griffin, it’s ‘, Griffin, , Peter Chin, Chin, Hong, Nathaniel Hendrix, Hendrix, it’s, hasn’t, she’s, Kristin Englund, shouldn’t, Dr, Sanjay Gupta, “ It’s, Ellie Murray, ” Murray Organizations: CNN, US Centers for Disease Control, Yale School of Public Health, Covid, National Institutes of Health, FDA, US Department of Health, Human Services, CDC, Fred Hutchinson Cancer Center, HHS, Columbia University, University of California, Census Bureau, Nature Medicine, American Board of Family Medicine, Nature, Veterans Affairs, Cleveland Clinic, CNN Health, Boston University School of Public Health Locations: South Africa, Botswana, United States, China, Seattle, Israel, Denmark, United Kingdom, Portugal, US, Switzerland, Thailand, Australia, San Francisco, Ohio
CVS Health is partnering with drugmaker Sandoz to produce a near identical version of the blockbuster arthritis treatment Humira that will sell for 80% below the price of the brand-named drug. The move is part of the company's new venture focused on securing, and in some cases co-producing, biosimilar drugs, which are the equivalent of generic versions of complex gene or protein-based therapies known as biologics. CVS is already one of the leading players when it comes to sourcing generic drugs through Red Oak, its joint venture with Cardinal Health . Abbvie reported more than $4 billion in Humira sales in its most recent quarter, which was slightly better than expected. Correction: CVS Health subsidiary Cordavis will partner with Sandoz on biosimilar drugs.
Persons: drugmaker Sandoz, We've, it'll, Prem Shah, drugmaker, Amgen's Amjevita, Murdo Gordon, Abbvie, Cuban's, John Ransom, Raymond James, Ransom, Sandoz Organizations: CVS Health, CVS, Cardinal Health, Novartis Pharmaceuticals, Sandoz, Novartis, FDA, Blue, Drug Company, Amazon Pharmacy Locations: U.S, Red, California
Analysts at Bank of America screened for "triple momentum" stocks based on their momentum in three areas: earnings, price and positive news. Price momentum concerns market sentiment, while news momentum refers to media coverage and corporate news releases. In health care, the top-performing "triple momentum" stocks are drug company Novo Nordisk , medical equipment firm Boston Scientific and robotics manufacturer Intuitive Surgical . For software, it picked Workday and Oracle as among the names with the "most positive" momentum across the three measures. "We screen for Triple Momentum stocks with above-average Earnings Momentum, above-average Price Momentum, top quintile by News Momentum, and above-average one-month change in News Momentum," BofA's analysts said.
Persons: BofA, Vinci, Safran, Berkshire Hathaway, — CNBC's Michael Bloom Organizations: Bank of America, Triple, Novo Nordisk, Boston Scientific, Netflix, Semiconductor, ON Semiconductor, AMD, Lam Research, Oracle, Triple Momentum, News Momentum Locations: industrials, BofA
CVS Health logo is seen displayed in this illustration taken, May 3, 2022. The regional health insurance provider will still retain CVS Caremark for managing specialty drugs, which are costly medications used to treat complex conditions like cancer and rheumatoid arthritis. Other analysts highlighted difficulties in shifting to a different model than the one offered by companies like CVS - which provide other services including home drug delivery and reimburse pharmacies for patients' prescriptions. Amazon Pharmacy will provide at-home delivery of prescription drugs as well as upfront pricing, while Mark Cuban Cost Plus Drug Company will provide access to generic drugs, Blue Shield said. Blue Shield of California's other partners include privately held Abarca for processing claims related to prescription drugs, while smaller PBM Prime Therapeutics will work to negotiate savings with drugmakers.
Persons: Dado Ruvic, Cigna, UnitedHealth, Mark, Elizabeth Anderson, J.P, Morgan, Lisa Gill, Gill, Blue, Manas Mishra, Mariam Sunny, Bhanvi, Shweta Agarwal, Pooja Desai, Krishna Chandra Eluri, Frances Kerry Organizations: CVS, REUTERS, Amazon, Cigna, UnitedHealth, Evercore ISI, Mark Cuban, Plus, Thomson Locations: Bengaluru
CVS Health logo is seen displayed in this illustration taken, May 3, 2022. Blue Shield, whose health plans cover 4.8 million members, said it will now work with five different companies, including Mark Cuban's drug company, to provide "convenient, transparent access to medications while lowering costs." Privately held Abarca will pay prescription drug claims, while Prime Therapeutics will work with Blue Shield to negotiate savings with drugmakers, the company said. Blue Shield will also work with CVS Caremark for specialty pharmacy services. The loss of the Blue Shield pharmacy benefit management contract is another blow to Caremark, which is also set to lose the contract to manage Centene's (CNC.N) $40 billion annual pharmacy needs from next year.
Persons: Dado Ruvic, UnitedHealth, Mark Cuban's, Paul Markovich, Mark, Manas Mishra, Mariam Sunny, Bhanvi, Shweta Agarwal, Pooja Desai Organizations: CVS, REUTERS, Blue, Cigna, UnitedHealth, Pharmacy, Wall Street, Mark Cuban, Plus, Thomson Locations: Blue, Bengaluru
Check out the companies making the biggest moves in premarket trading:Walmart — Shares added as much as 1% after the big-box retailer raised its full-year forecast and reported an earnings and revenue beat. Adobe — The software company added about 2% after Bank of America upgraded shares to buy from neutral. Hawaiian Electric — The utility company that oversees Maui Electric sank nearly 18% in premarket trading, continuing its slide over concerns of its potential liability in Maui's wildfires. On Wednesday, the Wall Street Journal reported Hawaiian Electric is in talks with firms that specialize in restructuring. VinFast Auto — Shares of the electric vehicle start-up fell nearly 5% in premarket trading as VinFast's stock searches for its level after debuting earlier this week.
Persons: Adobe, Cuban's, Wolfspeed, , Alex Harring, Jesse Pound, Michael Bloom Organizations: Walmart, Refinitv . Revenue, Cisco Systems, postmarket, Refinitiv, Revenue, Adobe, Bank of America, Maui Electric, Wall Street Journal, CVS, California, Drug Company, Amazon Pharmacy, BAE Systems Locations: Williston , Vermont, California
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