The region's benchmark Stoxx 600 index closed 0.6% lower, with sectors mixed as trading came to a close.
Household goods fell 2.5% as industrials dropped 1.3%, while oil and gas stocks gained 0.9%.
The euro zone Composite Purchasing Managers' Index for May showed solid growth that continued to be driven by services, with manufacturing hit by weak demand and a fall in selling prices.
"Eurozone GDP is likely to have grown in the second quarter thanks to the healthy state of the services sector.
However, the manufacturing sector is a powerful drag on the momentum of the economy as a whole," said Cyrus de la Rubia, chief economist at Hamburg Commercial Bank.
Persons:
Cyrus de la Rubia
Organizations:
Hamburg Commercial Bank
Locations:
Hamburg, France