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United Airlines , Delta Airlines – United gained 4% following a Morgan Stanley upgrade to overweight from equal weight on the notion that 2023 could be a "goldilocks" year for the airline. Silvergate Capital — Shares dropped more than 5% after Morgan Stanley downgraded the crypto bank to underweight from equal weight, saying there is more revenue pressure following the FTX fallout. Signature Bank — The stock declined more than 7% after Morgan Stanley downgraded it to equal weight from overweight. Morgan Stanley expects funding costs to jump "significantly" over the next several quarters as Signature works to retain deposits from customers. Many Chinese stocks pared earlier gains, however, as the broader market sold off amid fears of aggressive monetary tightening.
The news marks a second setback for GSK's oncology portfolio this week, after the company on Monday revealed its blood cancer drug Blenrep failed to outperform an older therapy in a key study, calling into question Blenrep's existing U.S. approval. Zejula belongs to a family of drugs called PARP inhibitors - which include AstraZeneca (AZN.L) and Merck's (MRK.N) Lynparza and Clovis Oncology's (CLVS.O) Rubraca. In September, GSK withdrew the use of Zejula in certain ovarian cancer patients who had previously undergone three or more chemotherapy regimens. For GSK, Zejula's use in the first-line setting - as a therapy designed to keep cancer at bay in ovarian cancer patients who have partially or fully benefited from platinum-based chemotherapy, remains a priority. Zejula - which GSK acquired through its $5.1 billion acquisition of U.S. cancer specialist Tesaro in 2018 - generated a total of 120 million pounds ($141.4 million) last quarter.
Cancer drugmaker Clovis flags possible bankruptcy
  + stars: | 2022-11-09 | by ( ) www.reuters.com   time to read: +1 min
Nov 9 (Reuters) - U.S. drugmaker Clovis Oncology (CLVS.O) said on Wednesday it was likely to file for bankruptcy "in the very near term", as the company struggles to sell its cancer drug Rubraca. Sales of Rubraca, Clovis's only approved drug, have been hit in recent years by intensifying competition from rival ovarian cancer treatments, and partly by lower cancer diagnoses during the COVID-related lockdowns. Colorado-based Clovis also highlighted future regulatory uncertainty around Rubraca, as health regulators have increasingly focused on data that shows cancer treatments help extend the survival in patients. "It appears increasingly unlikely that additional funding will be available on acceptable terms or at all outside of a Chapter 11 bankruptcy process," Clovis said in a filing. Shares of Clovis, which had a market capitalization of $141.59 million as of Tuesday's closing, slumped 71.9% to 28 cents on Wednesday.
HOBBS, New Mexico, Nov 7 (Reuters) - A New Mexico town near the Texas border on Monday unanimously passed an ordinance designed to ban abortions, despite the procedure being legal in the state. The so-called "sanctuary city for the unborn" ordinance blocks abortion clinics from operating and its passage by the Hobbs city commission marks a first for a town in a state controlled by the Democratic Party, according to anti-abortion advocates. The all-male Hobbs city commission voted 7-0 to approve the ordinance after hearing from several speakers on both sides of the issue. Another New Mexico city, Clovis, last week indefinitely postponed a similar ordinance, with city commissioners there saying they felt it was too rushed. Reporting by Brad Brooks in Hobbs, New Mexico; Editing by Donna Bryson and Edwina GibbsOur Standards: The Thomson Reuters Trust Principles.
Rep. Teresa Leger Fernández is running against Republican Alexis Martinez Johnson in New Mexico's 3rd Congressional District. Democratic incumbent Rep. Teresa Leger Fernández faces off against Republican Alexis Martinez Johnson in New Mexico's 3rd Congressional District. New Mexico's 3rd Congressional District candidatesLeger Fernández, first elected in 2020, is seeking a second term in Congress. Martinez Johnson, Leger Fernández's challenger, is an environmental engineer who's worked with energy companies on the eastern side of the state. Voting history for New Mexico's 3rd Congressional DistrictNew Mexico's 3rd Congressional District covers large swaths of southeast New Mexico.
New Mexico town delays banning abortion
  + stars: | 2022-11-04 | by ( Brad Brooks | ) www.reuters.com   time to read: +3 min
Clovis does not have an abortion clinic, but could be a place that could serve people from Republican-controlled Texas, to the east. On Monday, the city commission of the nearby town of Hobbs is expected to take up a similar measure. Mitchell participated in the city commission meeting by phone. What it's doing is it's putting women — women and girls' lives at risk." Laura Wight, a Clovis resident helping lead Eastern New Mexico Rising, a progressive group opposed to ordinance, welcomed the delay.
A woman and child attend an anti-abortion rally outside of the Hobbs City Commission Chamber in Hobbs, New Mexico, U.S., October 17, 2022. The New Mexican abortion provider within closest reach for most Texas women is currently in Albuquerque - about a four-hour drive from Clovis and five hours from Hobbs. Voters in Lubbock, Texas, which is near the New Mexico border, outlawed abortion in 2021. In New Mexico, Dickson worked with conservative lawyer Jonathan Mitchell, who was the architect of Texas’ 2021 “heartbeat” abortion law. Read more:U.S. abortion clinic moves up the street to escape one state’s banEXPLAINER-How abortion became a divisive issue in U.S. politicsHow Texas’ abortion ban hurts Big Oil’s effort to transform its workforceWIDER IMAGE-With U.S. abortion access in jeopardy, this doctor travels to fill a void
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