First Republic's demise was the third regional bank failure since early March, when Silicon Valley Bank and Signature Bank folded within days of each other.
There is cautious optimism on Wall Street that First Republic will be the last failure of this period.
However, reports from other regional banks weren't nearly as dire, with many reporting that deposits had stabilized and were growing again.
However, the failure of First Republic could cause some more turbulence, at least in the short-term, for both deposits and bank stocks.
"We don't believe that regional banks are completely out of the woods," Wolfe Research chief investment strategist Chris Senyek said in a note to clients on Monday.