The Seahawks have won three of their last four while the Giants are on a four-game win streak.
The Colts beat their division rivals 34-27 thanks to a last-gasp touchdown from quarterback Matt Ryan to rookie Alec Pierce.
Just last week, Giants quarterback Daniel Jones earned NFC Player of the Week honors for his performance against the Jaguars.
The Jaguars played in London just last year, when quarterback Trevor Lawrence became the first rookie quarterback to win a regular season game in London.
Jaguars quarterback Trevor Lawrence is coming off a turnover-free Week 7 against the Giants.