The central bank stated in a note that Serra's departure follows the end of his term on Feb. 28.
The day after Serra's departure, the director of Economic Policy, Diogo Guillen, began temporarily accumulating his function, a common practice at the central bank until substitutions are made.
Supervision director Paulo Souza, whose term also expired at the end of February, remains in his current position.
Under a 2021 law granting formal autonomy to the central bank, Governor Roberto Campos Neto will remain in office until December 2024.
Lula, who has criticized Campos Neto and the central bank for keeping interest rates high to combat inflation, will eventually replace all nine members of the bank's board, which decides monetary policy.