As Iranian authorities marked the anniversary this week of the seizure of the U.S. embassy in Tehran by radical students, President Joe Biden backed the protesters, saying: "We're gonna free Iran.
In Syria, mass demonstrations against Iran's ally President Bashar al-Assad were confronted with force and the country spiralled into conflict which continues 11 years on.
By contrast, Iranian cities were now "safe and sound", Raisi said, promising retribution for the unrest the country had seen.
At least 14,170 people have been arrested, including 392 students, in protests in 136 cities and towns, and 134 universities, it said.
The crisis has dragged Iran's currency to new historic lows.