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☆ Obesity drugs take brakes off Big Pharma’s growth
▼ + stars: | 2023-08-08 | by ( Robert Cyran | ) www.reuters.com time to read: +4 min

That’s what Eli Lilly (LLY.N) did in the second quarter, thanks to demand for its diabetes and weight loss drug Mounjaro. While doctors are currently free to prescribe Mounjaro for obesity, insurers and governments typically won’t pay for what some still insist is a vanity treatment. Even so a regulatory green light, and clear evidence that these drugs have tangible health benefits, will help loosen purse strings. The brakes are off these firms’ growth, and investors are counting on them remaining so. Mounjaro, the company’s diabetes drug, brought in revenue of $980 million, compared to $16 million a year ago.

Persons: Eli Lilly, LLY.N, Lilly, That’s, David Ricks, Mounjaro, Peter Thal Larsen, Sharon Lam Organizations: Reuters, Novo Nordisk, U.S . Food, Drug Administration, Merck, Investors, Thomson Locations: Danish, U.S, Novo

☆ As few as 4,000 steps a day can reduce your risk of death, but more is better
▼ + stars: | 2023-08-08 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +5 min

CNN —Walking a minimum of 4,000 steps a day significantly reduces your risk of an early death, while taking 2,337 steps a day will reduce your risk of death specifically from cardiovascular disease but “more is better,” according to a new meta-analysis of studies. Anything below 5,000 steps a day is considered a “sedentary lifestyle,” according to the study. While approximately 4,000 steps a day was associated with a “significant” reduction in the risk of an early death, the biggest impact on risk occurred when people walked more than 7,000 steps a day, with the most benefit occurring at about 20,000 steps, the study found. Start early and keep it upAdults 60 and older who walked between 6,000 and 10,000 steps a day saw a 42% reduction in risk of early death, while people under 60 who walked between 7,000 and 13,000 steps a day had a 49% reduction in risk, he said. The difference is likely explained by the formula, “the earlier, the better,” Banach said.

Persons: Maciej Banach, David Katz, ”, Katz, “, Banach, Dr Ibadete Bytyçi, ” Banach, Andrew Freeman, Freeman, ‘, ‘ Don’t, ’ Organizations: CNN, European Society of Cardiology, Johns Hopkins University School of Medicine, True Health Initiative, European, Preventive Cardiology, University Clinical, Jewish Health, CNN’s Locations: Baltimore , Maryland, Australia, Japan, Norway, Spain, United Kingdom, United States, Kosovo, Pristina, Denver , Colorado

☆ Novo Nordisk shares pop after key trial data shows Wegovy cuts risk of heart attack or stroke by 20%
▼ + stars: | 2023-08-08 | by ( Sam Meredith | ) www.cnbc.com time to read: +2 min

Packages of the weight-loss drug Wegovy from the pharmaceutical company Novo Nordisk lie on the sales counter in a Danish pharmacy. Shares of Danish drugmaker Novo Nordisk soared on Tuesday, after late-stage trial data showed that its obesity drug Wegovy reduced the risk of major cardiovascular events such as heart attacks or strokes by 20%, compared with a placebo. Shares of Novo Nordisk rose nearly 16% during mid-morning deals, before paring gains. Martin Holst Lange, executive vice president for development at Novo Nordisk, said that the results showed that the company's obesity drug "has the potential to change how obesity is regarded and treated." "Therefore, we are very excited about the results from SELECT showing that semaglutide 2.4 mg reduces the risk of cardiovascular events."

Persons: Martin Holst Lange, Holst Lange Organizations: Novo Nordisk, Nordisk, Investors, Reuters Locations: Danish, semaglutide

☆ Weight Loss Drug Cuts Risk of Heart Problems, Maker Says
▼ + stars: | 2023-08-08 | by ( Benjamin Mueller | More About Benjamin Mueller | ) www.nytimes.com time to read: +1 min

A new obesity drug, Wegovy, slashed the risk of serious heart problems by 20 percent in a large trial, the drug’s maker said on Tuesday, a finding that could put pressure on insurers to cover the in-demand treatment. The trial — the first to demonstrate that one of the new class of obesity drugs could also shore up patients’ heart health — reinforced the scientific consensus that obesity brings with it medical risks like heart attacks and strokes. And it bolstered the idea that those obesity drugs can deliver long-term health benefits in addition to helping patients lose weight. The drug’s maker, Novo Nordisk, reported only its top-line findings from the trial on Tuesday and not details about how Wegovy affected the risk of individual cardiovascular complications or patients’ weight. The data has not yet been published in a peer-reviewed journal.

Organizations: Novo Nordisk

☆ Promise around Eli Lilly's expected obesity drug, great earnings adds some $60 billion in market cap
▼ + stars: | 2023-08-08 | by ( Kevin Stankiewicz | In Kevinstankiewicz | ) www.cnbc.com time to read: +9 min

(When excluding one-time divestment contributions and last year's Covid antibody revenue, Lilly's sales rose 22% on an annual basis.) Eli Lilly shares soared more than 16% to a new all-time high during Tuesday's session. LLY YTD mountain Eli Lilly's stock performance so far in 2023. Eli Lilly now expects adjusted earnings per share between $9.70 and $9.90, up significantly from the old guidance between $8.65 and $8.85. For its part, Eli Lilly is also studying Mounjaro's impact on other health outcomes including cardiovascular events.

Persons: Eli Lilly, Mounjaro, —, Jim Cramer's, Jim, Lilly's, Cheplapharm —, Lilly, Anat Ashkenazi, Ashkenazi, Eli Lilly's, Lilly Diabetes, Michael Mason, Mason, Verzenio, Trulicity, we've, David Ricks, Jim Cramer, Cristina Arias Organizations: Novo Nordisk, U.S, Amphastar Pharmaceuticals, Management, CNBC, Company, Pharmaceutical Locations: Indianapolis, North Carolina, U.S, Trulicity, Danish, Novo, Alcobendas, Madrid, Spain

☆ Morgan Stanley sees Eli Lilly shares rallying on data showing heart benefit of Novo's obesity drug
▼ + stars: | 2023-08-08 | by ( Yun Li | ) www.cnbc.com time to read: +1 min

Danish drugmaker Novo Nordisk 's promising data on its obesity drug Wegovy should benefit Eli Lilly 's pipeline and its stock, according to Morgan Stanley. Shares of Novo Nordisk soared 15% in early trading Tuesday after late-stage trial data showed that Wegovy reduced the risk of major cardiovascular events, such as heart attacks or strokes, by 20%, compared with a placebo. "This is above our expectations and our prior analysis," Morgan Stanley analyst Terence Flynn said. Flynn has an overweight rating on Eli Lilly and a $560 12-month price target, which would translate into a 23% gain from Monday's close of $454.08. Eli Lilly raised its full-year guidance Tuesday as second-quarter profit jumped 85% from the same period a year ago on strong sales resulting from its drug pipeline.

Persons: Eli Lilly, Morgan Stanley, Terence Flynn, Eli Lilly's, Flynn, — CNBC's Michael Bloom Organizations: Nordisk, Novo Nordisk Locations: Indianapolis

☆ Most children in South Asia are exposed to extreme high temperatures, UNICEF says
▼ + stars: | 2023-08-07 | by ( Rhea Mogul | ) edition.cnn.com time to read: +4 min

CNN —Nearly half a billion children in South Asia are exposed to extreme high temperatures as life-threatening heat waves caused by the climate crisis become stronger and more frequent, according to the United Nations’ children’s agency. The analysis showed 76% of children in South Asia were exposed to extreme high temperature compared to 32% globally, UNICEF said. Not only is there high potential for record extreme heat, the impacts are compounded by dire social and economic problems. At the same time, extreme weather has had a deadly impact in other parts of the region. In its report, UNICEF warned that ultimately children, adolescents and women are among those who pay the highest price for extreme weather events.

Persons: ”, Sanjay Wijesekera, Sudipta Das, Shahid Saeed Mirza, “ Young, ” Wijesekera Organizations: CNN, United Nations ’, UNICEF, South, Mashal, Getty, stillbirths Locations: South Asia, Afghanistan, India, Pakistan, Sindh, Farah Province, Xinhua, New Delhi, Kolkata, Multan, AFP

☆ How the heat wave is hurting your productivity at work
▼ + stars: | 2023-08-02 | by ( Noah Sheidlower | ) www.businessinsider.com time to read: +6 min

There are no federal regulations that protect workers in extreme heat, contributing to losses in productivity. "There's of course the worst case, the risk of death, but there is the risk of injury with the rise in temperature and reduced work hours. How much heat impacts productivityPlenty of studies show that extreme heat can crush economic activity across a variety of sectors. Long-term exposure to extreme heat, the authors write, causes inflammation and cardiovascular pressure. Workers in high-exposure industries worked about an hour less when the temperature was above 85 degrees Fahrenheit compared to the 76-80 degrees Fahrenheit range.

Persons: Algernon Austin, Biometeorology, Austin Organizations: Service, Bureau of Labor Statistics, Center for Economic, Policy Research, Economics, Workers, International Locations: Wall, Silicon, New Orleans, Nashville, California

☆ Just one drink a day can raise blood pressure, study says
▼ + stars: | 2023-07-31 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +8 min

CNN —As little as one alcoholic drink a day increased systolic blood pressure — the top number in a blood pressure reading — even in men and women with no existing hypertension, a new study found. The negative impact of alcohol on systolic blood pressure continued to rise over the years, the study found, even in men and women who drank little each day. Blood pressure and cardiovascular healthBlood pressure is measured in units of millimeters of mercury (abbreviated as mmHg), and written as two numbers, one above the other. No amount of alcohol is good for blood pressure, study says. “However, this review found relatively low levels of alcohol impacted blood pressure,” said Freeman, who was not involved with the research.

Persons: ”, Marco Vinceti, Paul Whelton, Vinceti, Andrew Freeman, Freeman, you’re, ” Whelton, we’re, “, ” Vinceti, ” Tulane’s Whelton, Whelton, ” Freeman Organizations: CNN, University of Modena, Reggio Emilia, Tulane University’s School of Public Health, Tropical Medicine, Hypertension, American Heart Association, AHA, Boston University’s School of Public Health, Jewish Health, World Health Organization, WHO, “ Locations: Italy, New Orleans, Denver, Japan, South Korea, United States

The team is pumping between 4,000 and 5,000 barrels of oil every hour, and has so far transferred more than 120,000 barrels to the replacement vessel carrying the offloaded oil, Gressly said. A potential spill from this vessel would be enough to make it the fifth largest oil spill from a tanker in history, a UN website said. The Red Sea is a vital strategic waterway for global trade. Video Ad Feedback Oil being removed from tanker near Yemen in Red Sea 02:29 - Source: CNNAfter The Safer is emptied, it must then be cleaned to ensure no oil residue is left, Gressly said. The Red Sea fisheries in Yemen could be “almost completely wiped out,” Rehkopf added.

Persons: CNN —, –, Yemen David Gressly, SMIT, Gressly, Bab, ” Gressly, “, ” David Rehkopf, ” Rehkopf, that’s, ”, Ahmed Nagi, ” Nagi, Nagi Organizations: CNN, United, Endeavor, UN, Yemen’s, HSA, FSO, Exxon, US Energy Information Administration, Systems, Stanford University School of Medicine, Stanford University, Group Locations: Yemen, United Nations, Suez, Red, Alaska, Africa, Asia, Persian, Saudi, Stanford University School of Medicine . Yemen, Saudi Arabia, Eritrea, Brussels, Yemeni, Hodeidah

☆ Olive oil may lower risk of death from dementia
▼ + stars: | 2023-07-27 | by ( Kristen Rogers | ) edition.cnn.com time to read: +5 min

Whether olive oil is linked with risk of dementia-related death had never been studied until now, according to the authors. Over a follow-up period of 28 years, regardless of diet quality, eating more than half a tablespoon of olive oil per day was associated with a 28% lower risk of dying from dementia, compared with participants who never or rarely consumed olive oil. Additionally, replacing a daily teaspoon of mayonnaise or margarine with the same amount of olive oil was correlated with an 8% to 14% lower risk of dementia-related death, the authors found. “It is also possible that olive oil has an indirect effect on brain health by benefiting cardiovascular health,” she added. Besides cooking with olive oil, you can also use it to make salad dressings or vinaigrettes, mayonnaise, pesto or bread dip.

Persons: “, ”, Anne, Julie Tessier, David Curtis, Duane Mellor, Olive, Tessier, ” Curtis, Curtis, it’s, Mellor Organizations: CNN, Nutrition, American Society for Nutrition, Harvard, of Public Health, Nurses, Health, UCL, Institute, University College London, Aston Medical School, Aston University in Locations: Boston, Chan, North America, Aston University in England, Olive

☆ Blood pressure best lowered by 2 exercises, study finds
▼ + stars: | 2023-07-27 | by ( Kristen Rogers | ) edition.cnn.com time to read: +7 min

CNN —When it comes to lowering blood pressure, studies have typically shown that aerobic or cardio exercises are best. Exercises that engage muscles without movement — such as wall squats and planks — may be best for lowering blood pressure, according to a large study published Tuesday in the British Journal of Sports Medicine. “Overall, isometric exercise training is the most effective mode in reducing both systolic and diastolic blood pressure,” said study coauthor Dr. Jamie O’Driscoll in a news release. Systolic blood pressure measures the maximum pressure in the arteries as the heart contracts and relaxes, while diastolic blood pressure denotes what the arterial pressure is when the heart rests between beats, according to the US Centers for Disease Control and Prevention. The authors defined healthy resting blood pressure as a reading below 130 over 85 millimeters of mercury — a measurement of pressure known as mmHg — pre-high blood pressure as ranging from 130/85 mmHg to 139/89 mmHG, and high blood pressure as 140/90 mmHG or greater.

Persons: ”, Jamie O’Driscoll, Joanne Whitmore, Whitmore wasn’t, Jim Pate, wasn’t, Whitmore, ” Pate Organizations: CNN, British, of Sports Medicine, Mayo Clinic, Canterbury Christ Church University’s School of Psychology, Sciences, US Centers for Disease Control, British Heart Foundation, World Health Organization, Marylebone Health Group, Arthritis Foundation, “, CNN’s Locations: Canterbury, England, London

☆ Morgan Stanley sees profound shift in diabetes treatment boosting opportunity for weight-loss drugs
▼ + stars: | 2023-07-25 | by ( Christina Cheddar Berk | ) www.cnbc.com time to read: +6 min

Morgan Stanley analysts said they are seeing a profound shift in the way diabetes is being treated, with doctors intensifying the focus on weight management, which is accelerating the uptake of GLP-1 medications. Meanwhile, Eli Lilly has been approved to sell Mounjaro, or tirzepatide, as a Type 2 diabetes treatment. Both GLP-1 medications have attracted a lot of attention for their ability to lower blood sugar, curb food cravings and help patients with weight loss. Morgan Stanley said GLP-1 medicines now make up nearly 30% of all new diabetes prescriptions in the U.S. About 22% of all diabetes prescriptions are for this class of drug. The analysts now anticipate the market for GLP-1 medications will reach $77 billion in 2030, up from a prior forecast of $54 billion.

Persons: Morgan Stanley, Lilly GLP, Eli Lilly, Lilly, GLP, Morgan, Wells, Mohit Bansal, Bansal, he's, — CNBC's Michael Bloom Organizations: Novo Nordisk, Food and Drug Administration, U.S, GLP Locations: U.S, Wells Fargo

☆ Here are the only 4 global stocks to raise dividends by more than 10% for the past 15 years
▼ + stars: | 2023-07-25 | by ( Ganesh Rao | ) www.cnbc.com time to read: +3 min

Among the stocks screened by CNBC Pro, the 98-year-old firm offered the highest dividend yield at 3.3%. Dividend yield is calculated as the dividend per share divided by the share price. The dividend yield can go up if the share price drops, and conversely, the yield can drop if the share price goes up. The stock has risen 340% in price returns, which strips out dividend payments, over the past 15 years. If the stock price also appreciates, the total return for the investor (capital gains plus dividends) would be even higher.

Persons: Japan — Organizations: CNBC Pro, Atrion Corporation, Kerry Group Locations: Brussels, Africa, Japan

Two other cough syrups made in India killed 19 children in Uzbekistan around December, according to the Uzbekistan government. India's overall pharma exports in the April-June quarter rose 5% to $6.58 billion. COUNTRY VISITSPharmexcil delegations have visited countries including Nigeria, Egypt and Russia in recent months to allay any concerns about Indian drugs, he said. Apart from Gambia, no other country has asked for additional tests for Indian drugs since the deaths, he said. Manufacturing a drug in Europe or the United States costs more than 30% than in India, giving India a big advantage, he said.

Persons: syrups, Udaya Bhaskar, Bhaskar, drugmakers, Krishna N, Alison Williams Organizations: Reuters, World Health Organization, WHO, pharma, Pharmaceuticals Export, of India, India's pharma, Marion Biotech, Thomson Locations: DELHI, Gambia, India, Uzbekistan, United States, China, U.S, Nigeria, Egypt, Russia, South Africa, Brazil, Europe

☆ A 72-year-old woman in Phoenix got her power cut over a $51 bill when it was 107 degrees — and she died. Her memory is behind efforts to stop future deaths.
▼ + stars: | 2023-07-25 | by ( Associated Press | ) www.businessinsider.com time to read: +4 min

Stephanie Pullman, 72, died after her power was shut off over a $51 late bill. Pullman's death in 2018 led to changes in how power companies deal with overdue bills in the summer. A recent heatwave in Arizona has the governor asking power companies to put policies in writing. The medical examiner's office said Pullman died from "environmental heat exposure " combined with cardiovascular disease after the shutoff. Electric utilities can choose to pause disconnections from June 1 through October 15 or pause them on days forecasted to be above 95 degrees Fahrenheit or below 32 degrees Fahrenheit.

Persons: Stephanie Pullman, Stacey Champion, Pullman, Patrick T, Fallon, Katie Hobbs Organizations: Service, Arizona Public Service, Getty, Arizona Corporation Commission, APS, Tucson Electric Power, ACC, National Weather Service, Gov Locations: Arizona, Wall, Silicon, sweltering Arizona, Phoenix, Mohave, Santa Cruz, Maricopa County, shutoffs

☆ Plant-based and cow’s milk are not nutritionally equal, study says
▼ + stars: | 2023-07-25 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +8 min

CNN —The plant-based milk market is exploding, offering beverages made from seeds, nuts, legumes, grains and blends of those ingredients, often marketed as ready replacements for the traditional choice of cow’s milk. The study analyzed nutrition labels and ingredients for 233 plant-based milk products from 23 different manufacturers and found only 28 of the beverages had as much or more protein, vitamin D and calcium as cow’s milk. “Most of the plant milk products fall between the level of 1% and skim milk in terms of saturated fat,” Johnson said. “As a person who studies the microbiome, however, I wouldn’t recommend plant-based milk products for fiber yet. “About a third of the plant-based milk products have sugar or added sugar in quantities that’s more similar to a flavored milk like a strawberry or chocolate milk,” Johnson said.

Persons: ”, Abigail Johnson, “ I’m, Johnson, Christopher Gardner, Gardner, ” Gardner, Walter Willett, Harvard T.H, Willett, milks, ” Johnson, ” Willett, “, ” That’s Organizations: CNN, Nutrition, American Society for Nutrition, University of Minnesota School of Public Health Nutrition Coordinating, Stanford Prevention Research, Stanford Diabetes Research Center, Harvard, of Public Health, Harvard Medical School, University of Minnesota Locations: Boston, Minneapolis, California, Chan

☆ Adults with depression are at a greater risk of developing dementia, study shows
▼ + stars: | 2023-07-24 | by ( Madeline Holcombe | ) edition.cnn.com time to read: +4 min

A diagnosis of depression in adulthood could more than double your risk of developing dementia in older age, according to a new study. But the latest study shows a connection between dementia risk and depression diagnoses in early and mid-life as well. “Our results therefore provide strong evidence that depression is not only an early symptom of dementia, but also that depression increases dementia risk,” she said. “For example, there may be shared common risk factors for depression and dementia that occur earlier in the lifecourse, depression may increase dementia risk through alterations in levels of key neurotransmitters, or depression may lead to changes in health behaviors that in turn increase risk for dementia,” she added in an email. Regardless of dementia risk, treating depression should be a priority, Elser agreed.

Persons: Holly Elser, Natalie Marchant, Marchant, Elser, ”, ” Elser, ” Marchant Organizations: CNN, University of Pennsylvania, University College London

☆ Jay Shetty: 'Every day we are assaulted by negativity'—the No. 1 tactic he uses to maintain a positive mindset
▼ + stars: | 2023-07-22 | by ( Ashton Jackson | ) www.cnbc.com time to read: +3 min

That's according to Jay Shetty, a former monk turned life coach and New York Times bestselling author. In his self-help book, "Think Like a Monk," Shetty explains that negative thoughts practically surround us. "Every day we are assaulted by negativity," Shetty writes. Negative thoughts are more prevalent than we may think. On average, a person has 11 negative thoughts every day, including "I'm not good enough" or "I'm not good looking," according to a January poll of over 2,000 people from StudyFinds.

Persons: —, Jay Shetty, Shetty, absolves, Barack Obama, Hasan Minhaj, Obama Organizations: New York Times, Mayo Clinic

☆ Heat Affects Older People More. Here’s How to Stay Safe.
▼ + stars: | 2023-07-20 | by ( Dana G. Smith | More About Dana G. Smith | ) www.nytimes.com time to read: +1 min

How heat affects an aging bodyThe human body has two main mechanisms to cool itself: sweating and increasing blood flow to the skin. In older adults, those processes are compromised — they sweat less and they have poor circulation compared with younger adults. A diseased heart isn’t able to pump as much blood, further reducing blood flow to the skin. And if the nerves become affected in people with severe diabetes, the body might not receive the message that it needs to start sweating. In hot conditions, that can cause them to become dehydrated faster, which is “hugely detrimental for temperature control,” Dr. Crandall said.

Persons: ”, Craig Crandall, Glen Kenny, “, Dr, Crandall Organizations: University of Texas Southwestern Medical Center, University of Ottawa

☆ Weekend-only workouts may also be protecting your heart health
▼ + stars: | 2023-07-18 | by ( Madeline Holcombe | ) edition.cnn.com time to read: +6 min

A cohort of more than 100,000 people used accelerometers to capture their movement over the course of a week, the study said. Adults need at least 150 minutes of moderate-intensity physical activity per week, according to the Physical Activity Guidelines for Americans. “Even for me, if I have a crazy something or other going on, I might concentrate more on a weekend,” Freeman said. One study from 2021 found that as little as 11 minutes a day can increase your life span. On the days you miss a workout, Freeman encourages making sure to make up the time later in the week to get the 150 minutes.

Persons: —, ”, Shaan Khurshid, ” Khurshid, Andrew Freeman, Freeman, ” Freeman, Khurshid, Oleg Breslavtsev, “, Dana Santas Organizations: CNN’s, CNN, JAMA, Massachusetts General Hospital, Harvard Medical School, Jewish Health, Denver's National Jewish Health Locations: Massachusetts, Boston, Denver

☆ Hearing aids may reduce your risk of dementia by half, study says
▼ + stars: | 2023-07-18 | by ( Madeline Holcombe | ) edition.cnn.com time to read: +6 min

CNN —For people facing a greater threat of cognitive decline, getting hearing aids could cut your risk in half, according to a new study. Over the past decade, research has established that hearing loss is one of the biggest risk factors for developing dementia, but it wasn’t clear whether intervening with hearing aids would reduce the risk, he added. In the total group, hearing aids did not appear to reduce cognitive decline, the study said. Why hearing loss may increase dementia riskEveryone’s hearing declines with age, Lin said. In those cases, lower cost over-the-counter hearing aids — available without a prescription — may be a good option.

Persons: ”, Frank Lin, Lin, Thomas Holland, Holland, couldn’t, that’s, ” Lin, “, Benjamin Tan, Dean’s, Tan, ” Holland Organizations: CNN, US Centers for Disease Control, Johns Hopkins University School of Medicine, Bloomberg School of Public Health, Rush Institute for Health Aging, Loo Lin, of Medicine, National University of Singapore Locations: United States

REUTERS/Remo CasilliLONDON, July 18 (Reuters) - The world is baking under extreme heat - with Asia, Europe and the United States all dealing with scorching temperatures. LESS OBVIOUS RISKSAir pollution also poses a health risk, with serious potential effects from wildfire smoke including inflammation and tissue damage. Dr Vikki Thompson, Climate Scientist, Royal Netherlands Meteorological Institute, said extreme heat often contributes to poorer mental health, as well as a rise in car crashes and drownings. Location matters, too; people are at higher risk in places where they are not used to such heat, including parts of Europe. It is also important to check on the vulnerable, including older and isolated people, they said.

Persons: Remo Casilli, Liz Stephens, Dr Vikki Thompson, Modi Mwatsama, Heatstroke, Jennifer Rigby, Kate Turton, Catherine Evans Organizations: REUTERS, Remo Casilli LONDON, WHO, heatwaves, Britain's University of Reading, Royal Netherlands Meteorological Institute, Wellcome, Public, Thomson Locations: Italy, Rome, Asia, Europe, United States, London

Overall, an FDA spokesperson says that “trial participants should reflect the population that is likely to use the product if FDA-approved. Across a group of 10 novel cancer therapies approved by the FDA in 2022, data shows the share of Black participants in key clinical trials ranged from zero to 8%. “Access to clinical trials at the sites where patients are living is an important factor to changing the landscape,” Perez says. “There’s been some novel ways to recruit patients, like using the church and using barbershops to recruit Black patients,” Cho says. Haddad says a number of Mayo patients were receiving experimental therapies through clinical trials when the pandemic began.

Persons: ”, Leslie Cho, Robert, Suzanne Tomsich, it’s, Edith Perez, Bolt Biotherapeutics, ” Perez, Eli Lilly, “, Lilly “, they’ll, Craig Lipset, ” Lipset, ” Cho, “ There’s, Dr, Tufia Haddad, Haddad, Mayo, Jennifer Dahne, Larry Hawk, Hawk Organizations: Women’s Cardiovascular, Cleveland Clinic, of Cardiovascular Medicine, U.S . Food, Drug Administration, FDA, “, Health, Committee, Cancer, Janssen Pharmaceuticals, Centers for Disease Control, Research Alliance, Mayo Clinic Comprehensive Cancer Center, Care, Mayo’s Center for Digital Health, College of Medicine, Medical University of South, of Psychology, University, Buffalo, SUNY, JAMA Locations: U.S, Chicago, Dallas, Los Angeles, Philadelphia, Los Angeles County, Alaska, “, Medical University of South Carolina

☆ What investors need to know about weight loss medicines and suicide risk
▼ + stars: | 2023-07-16 | by ( Christina Cheddar Berk | ) www.cnbc.com time to read: +7 min

Investors would be forgiven if talk of a potential suicide risk associated with a new class of diabetes and weight loss drugs led to skittishness last week. Prior attempts to treat overweight or obese patients with medications were often plagued with side effects and drug recalls. The first is that most obesity drugs, including GLP-1s, are "centrally acting," which means they work on a patient's brain. The second is that prior obesity drugs have been withdrawn because of high rates of psychiatric disorders, he said, citing Sanofi's Acomplia as one of the more recent examples. This was not the case for the GLP-1 medications.

Persons: skittishness, Eli Lilly's Trulicity, Lilly's, Wolfe, Tim Anderson, Anderson, Sanofi's Acomplia, Eli Lilly, Wolfe's Anderson, Colin Bristow, Lilly, LLY's, Peter Verdult, Wegovy, Verdult, Bristow, Emmanuel Papadakis, Papadakis, — CNBC's Michael Bloom Organizations: Nordisk's Ozempic, Wall Street, European Medicines Agency, EMA, Wolfe Research, FDA, UBS, Citi, Novo Nordisk, Deutsche Bank, Prevention Locations: United States, U.S

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