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Across the United States, cases of respiratory syncytial virus, or RSV, and influenza are increasing. Influenza activity continues to increase in the US – the number of flu illnesses, hospitalizations and deaths so far this season nearly doubled in the past week. RSV cases are also increasing nationally, although there are regional differences in the circulation of these viruses, Romero said. In the South and Mountain West, RSV cases appear to have peaked in October. There are signs that RSV cases are slowing in the southern region of the US, but test positivity rates and cases continue to rise in other regions, especially the Midwest.
Respiratory syncytial virus results in 58,000 hospitalizations annually of children under five years, and 100 to 500 deaths each year. An experimental vaccine from Pfizer Inc. significantly reduced the risk of infants developing severe cases of a respiratory virus that kills hundreds of children each year, according to the company. Among mothers who received the vaccine for the respiratory syncytial virus, their infants had an 81.8% lower risk of developing severe lower respiratory tract infections requiring medical attention within three months of birth than infants whose mothers received a placebo, Pfizer said Tuesday.
An experimental RSV vaccine for pregnant women from Pfizer is effective at protecting newborns against severe illness for at least six months, the company said in a press release Tuesday. The vaccine was also about 70% effective against severe infections through the first six months of life. Pfizer said in a statement that it is currently not conducting an RSV vaccine trial in infants. Pfizer's RSV vaccine could be "a major step forward so that we can attack this last really bad communicable disease of the neonatal period," Schaffner said. Aside from pregnant women, Pfizer is testing its vaccine in older adults, who are also at risk for severe RSV infections.
Respiratory syncytial virus results in 58,000 hospitalizations annually of children under five years, and 100 to 500 deaths each year. An experimental vaccine from Pfizer Inc. significantly reduced the risk of infants developing severe cases of a respiratory virus that kills hundreds of children each year, according to the company. Among mothers who received the vaccine for the respiratory syncytial virus, their infants had an 81.8% lower risk of developing severe lower respiratory tract infections requiring medical attention within three months of birth than infants whose mothers received a placebo, Pfizer said Tuesday.
New RSV vaccines may soon put an end to rough seasons
  + stars: | 2022-10-31 | by ( Brenda Goodman | ) edition.cnn.com   time to read: +15 min
The monoclonal antibody, Synagis, is given monthly during RSV season to protect preemies and other high-risk babies. In the failed RSV vaccine trial, the chemical the researchers used to deactivate the virus denatured its proteins – essentially flattening them. Four companies have RSV vaccines for adults in the final phases of human trials: Pfizer and GSK are testing vaccines for pregnant women as well as seniors. Janssen, Pfizer and GSK each appear effective at preventing infections in adults for the first RSV season after the vaccine. The vaccines for pregnant women are meant to get newborns through their first RSV season.
Flu Hospitalizations Hit Decade-Plus High for October
  + stars: | 2022-10-28 | by ( Brianna Abbott | ) www.wsj.com   time to read: 1 min
A flu vaccination in Chicago recently. There have been at least 880,000 cases of flu this season. The U.S. flu season is off to a fast and early start, with hospitalization rates the highest for this time of year in more than a decade, federal data showed. Centers for Disease Control and Prevention estimates showed Friday that there have been at least 880,000 cases of flu this season, some 6,900 hospitalizations and 360 deaths, including one pediatric death. The data is through the week ending Oct. 22.
There are early signs that this year's flu shot appears to work well at keeping people out of the hospital. A report on Chile's flu season, released Thursday by the CDC, found the vaccine was 49% protective against flu-related hospitalizations. That might seem low, but from 2015 to 2020, flu shot effectiveness in the U.S. ranged from 29% to 48%. It's unclear whether this year's flu shots in the U.S. will be as effective as was found during Chile's flu season. Only about half of the population gets an annual flu shot, typically.
CNN —The Omicron BA.5 subvariant is no longer the dominant cause of Covid-19 infections in the United States, according to estimates released Friday by the US Centers for Disease Control and Prevention. The gaggle of new variants have been gaining ground against BA.5, which has dominated Covid-19 infections in the United States since July. Together, they now account for more than 1 in 4 new Covid-19 infections nationwide, according to CDC data. BQ.1.1 is now causing about 1 in 5 new Covid-19 infections in the Northeast, where cases and hospitalizations are rising. But that strain is causing just 3% of new Covid-19 infections in the Pacific Northwest.
CNN —Flu season has ramped up early in the United States, and flu hospitalizations are worse than usual for this time of year, according to data published Friday by the US Centers for Disease Control and Prevention. It’s been more than a decade – since the H1N1 swine flu pandemic – since flu hospitalization rates have been this high at this point in the season. “We’re in a bit of a race with the virus,” he said, with the flu season starting at least a month earlier than usual. “The flu season will be with us for at least a few more months. And the flu season is ramping up amid the surge of RSV that is filling pediatric hospitals and an ongoing Covid-19 pandemic.
That there is no RSV vaccine for kids is not for lack of interest, experts say. But a trial gone wrong many years ago and a tricky target protein have made developing an RSV vaccine difficult. Researchers’ attempts to develop an RSV vaccine go back decades, according to Dr. Ofer Levy, the director of the Precision Vaccines Program at Boston Children's Hospital. In August, Pfizer announced that its experimental RSV vaccine was nearly 86% effective in preventing severe illness in adults ages 60 and older. GSK, however, said it abandoned its efforts last year to develop a pediatric RSV vaccine, because trials suggested it wasn't effective.
REUTERS/Carlo Allegri/File PhotoOct 26 (Reuters) - U.S. doctors are warning that a surge in cases of respiratory syncytial virus (RSV) is coinciding with an increase in COVID transmission and an earlier-than-normal flu season, raising the specter of a "tripledemic" of respiratory illness this winter. In particular, RSV infections among young children are reportedly filling some U.S. hospitals to capacity. Older children and most adults typically experience mild, cold-like symptoms. In the meantime, it is important "for everyone to get up to date on their COVID and flu vaccines," Varma said. Part of the increase in RSV cases is due to the relaxation of COVID-precautions, such as masking and social distancing, which reduced rates of both RSV and flu during the pandemic, Varma said.
That “immunity gap” from the last few years is probably behind the “unprecedented” early surge in RSV infections this year, scientists say – and it has thrown other seasonal respiratory viruses out of whack around the world. Across the US, the number of flu cases has also been increasing a little earlier than usual. A handful of schools have seen large absences, and medical offices say they are seeing more people sick with other respiratory viruses at times that don’t fit the usual patterns. Like Covid-19, RSV and the flu spread through droplets released into the air when people cough or sneeze. The pandemic behaviors created an “immunity gap” or “immunity debt” that makes more people in the US vulnerable to diseases like RSV.
Similar immune responsesThe studies have important limitations, and they aren’t the final word on the updated boosters. In Barouch’s study, antibody concentrations were 15 times higher after the original boosters, rising from 184 to 2,829. They were 17 times higher after the updated shots, jumping from 211 to 3,693. After waiting the recommended three months since his last Covid-19 infection, President Joe Biden got an updated booster Tuesday and urged eligible Americans to do the same. Worobey says that when the strains are combined as they are in the updated boosters, they actually end up competing.
Ed Fischbach, on his farm in Spink County, S.D., said no to the carbon pipeline on his land. But some energy experts say safety is an issue with carbon capture pipelines — carbon dioxide doesn’t like to stay put, and the fear is that a pipeline could rupture and leak. Asked about the Mississippi leak, Hill of Summit Carbon Solutions characterized the event as tragic but anomalous. Braun says she is afraid the Summit pipeline will disturb sacred land around Whitestone Hill. Both Braun and Locke say they are happy to be forging new ties with farmers and ranchers in opposition to the Summit project.
Oct 25 (Reuters) - Daily global COVID-19 infections are projected to rise slowly to about 18.7 million by February from the current 16.7 million aveage daily cases, driven by the northern hemisphere's winter months, the University of Washington said in an analysis. The increase in cases is not expected to cause a surge in deaths, the University of Washington's Institute for Health Metrics and Evaluation (IHME) said. It forecast that global daily deaths would average 2,748 people on Feb. 1, compared with around 1,660 currently. IHME estimates that daily infections in the United States will increase by a third to more than a million, driven by students back in schools and cold weather-related indoor gatherings. A rapid increase in hospital admissions in Germany – the highest since the COVID outbreak in 2020 - remains an area of concern, it said.
Oct 25 (Reuters) - Daily global COVID-19 infections are projected to rise slowly to about 18.7 million by February from the current 16.7 million aveage daily cases, driven by the northern hemisphere's winter months, the University of Washington said in an analysis. The increase in cases is not expected to cause a surge in deaths, the University of Washington's Institute for Health Metrics and Evaluation (IHME) said. It forecast that global daily deaths would average 2,748 people on Feb. 1, compared with around 1,660 currently. A surge in Germany has peaked already, it said in its report on Oct. 24. A rapid increase in hospital admissions in Germany – the highest since the COVID outbreak in 2020 - remains an area of concern, it said.
An unseasonal early surge of respiratory viruses among babies and toddlers has caught doctors off guard and worried about the coming months. "There is no one virus that's causing pediatric respiratory viruses this fall," said Dr. Deanna Behrens, a pediatric critical care physician at Advocate Children's Hospital in suburban Chicago. CDCWhile RSV is inundating many children's hospitals, the number of pediatric flu cases is also increasing. But the fact that kids are testing positive for multiple respiratory viruses at once can blur the signs of any one virus. In addition to RSV, Combs expects the number of pediatric flu illnesses to double in the coming weeks.
Experts say: prepare for more COVID infections this winter. But "among the new variants, XBB has the most significant immune evasion properties," market forecasters at Morgan Stanley said Thursday in a memo. Experts say we should expect many more infections this fall and winter, including infections in vaccinated, boosted Americans. But there are some simple things you can do to prepare to battle XBB and other evasive COVID variants on the horizon. Both have a slight growth advantage over BA.5, which is the dominant version of COVID right now in the US.
Oct 21 (Reuters) - HCA Healthcare Inc (HCA.N) on Friday reported lower-than-expected third-quarter revenue as hospital admissions related to COVID-19 dropped, dragging its shares nearly 5% lower in premarket trade. The decline in COVID-related admissions, which had peaked due to the Delta variant-led wave last year, led to a 1.5% drop in overall same facility admissions, and a 3.5% fall in same facility revenue per equivalent admission. Total revenue fell 2% to $14.97 billion, falling short of analysts' estimates of $15 billion, as per Refinitiv IBES data. Register now for FREE unlimited access to Reuters.com RegisterA similar trend was also seen at rival Tenet Healthcare Corp (THC.N), which also saw a decline in same-hospital admissions and revenue. Excluding one-off items, HCA reported earnings of $3.93 per share, above estimates of $3.88 per share.
COVID variants BQ.1, BQ 1.1 make up 16.6% of U.S. cases - CDC
  + stars: | 2022-10-21 | by ( ) www.reuters.com   time to read: +2 min
The variants have spread quickly in the country in the last few weeks, particularly in New York. The CDC said on Friday that BQ.1 last week was estimated to make up 5.8% of circulating variants, while BQ.1.1 had made up 3.6% of all variants. New variants are monitored closely by regulators and vaccine manufacturers in case they start to evade protection offered by current shots. The World Health Organization this week said BQ.1.1 is circulating in at least 29 countries. The BA.5 variant is estimated to made up 62.2% of cases for the week of Oct 22, down from 70.2% in the week of Oct 15.
As soon as they saw her vitals, the staff at UH Rainbow Babies & Children’s Hospital in Cleveland knew they had to admit Raegan, her mom said. “I’m glad I didn’t wait.”There’s now an “unprecedented” rise in RSV cases among children in the US, some doctors tell CNN. In Texas, where RSV cases usually spike in December or January, the emergency department at Cook Children’s in Fort Worth and its urgent cares are seeing a significant number of RSV cases. Nearly half the ICU is filled with RSV cases, hospital spokesperson Kim Brown said; between October 2 and 8, there were 210 RSV cases at Cook Children’s; a week later, there were 288. RSV symptoms RSV is a common virus, but it can cause serious illness, especially in younger infants and older adults.
Chickenpox vaccines have virtually wiped out severe complications and deaths in American children from the highly contagious virus, a new report finds. Chickenpox —which is caused by the varicella-zoster virus, a type of herpes virus — was considered just a normal part of growing up until the vaccine became available in 1995. The chickenpox vaccine implementation is “a tremendous achievement,” said the study’s lead author, Dr. Mona Marin, a medical epidemiologist at the CDC’s National Center for Immunization and Respiratory Disease. An estimated 90.3% of children have been vaccinated against chickenpox by age 2, according to the CDC. The CDC recommends two doses of chickenpox vaccine for children, teens and adults who have never had the disease.
During the pandemic, states and insurers overnight did what years of advocacy for telemedicine had failed to accomplish. During the pandemic, states and insurers overnight did what years of advocacy for telemedicine had failed to accomplish. It also increases patients’ access to critical information because they can see their own charts and ask questions at any time. Telemedicine access in rural areas is particularly urgent given how many hospitals in these places are shuttering their doors. Whatever the reasoning, navigating the politics and funding streams of our complicated health care system oftentimes takes years to create lasting, positive change.
Last year, many on Wall Street were estimating the number of COVID-19 shots would be in line with the annual flu vaccine, which is the vaccine market leader with more than 160 million shots per year in the United States and 600 million shots globally. A recent poll by Kaiser Family Foundation found that two-thirds of American adults do not plan on getting a COVID vaccine soon. He added that instances of COVID infections in those who have been vaccinated has left many to question the effectiveness of the vaccine. The companies could make up for some of the weaker demand with price increases. That would mean annual revenue of $3 billion to $5 billion over the long-term for a company like Moderna, he added.
CNN —A flurry of new Covid-19 variants appears to be gaining traction globally, raising fears of a winter surge. As the US moves into the fall, Covid-19 cases are dropping. But virus experts fear that the downward trend may soon reverse itself, thanks to this gaggle of new variants. Lumped together, the variants accounted for almost 1 in 3 new Covid-19 infections nationwide last week, according to the latest estimates from the US Centers for Disease Control and Prevention. The updated bivalent booster vaccines and antiviral drugs like Paxlovid are expected to continue to be protective against severe outcomes from Covid-19 infections caused by the new variants.
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