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Pens for the diabetes drug Ozempic sit on a production line at Danish drugmaker Novo Nordisk's site in Hillerod, Denmark, September 26, 2023. "Based on currently available clinical data and scientific evidence, Fresenius Medical Care assesses the overall effect of GLP-1 analog use on its own patient flow model as neutral," it said in a statement to Reuters. Novo said on Wednesday that the Ozempic trial was stopped ahead of schedule because independent supervisors had ruled the drug's positive effect on chronic kidney disease had become clear enough. In its statement, Fresenius Medical said that the early termination of the study, known as FLOW, does not allow for clear conclusions. Earlier on Thursday, rival DaVita (DVA.N) said that Novo's FLOW trial would only have a limited impact on overall dialysis patient numbers.
Persons: Tom Little, DaVita, Novo, Fresenius, Ludwig Burger, Jane Merriman, Kirsten Donovan Organizations: REUTERS, Rights, Novo Nordisk's, Reuters, Thomson Locations: Hillerod, Denmark
The eye-popping predictions for weight loss drug sales hinge on insurance companies agreeing to provide coverage of the pricey treatments, and momentum seems to be building on that front. The drugs include Novo Nordisk's semaglutide, which is sold as Ozempic for diabetes management and as Wegovy for weight loss. Unlike earlier generations of weight loss medicines, their side effects have been largely mild and included diarrhea, constipation and nausea. Higher hospital labor costs as well as GLP-1 medications are contributing to the biggest jump in health insurance costs since 2012, Lutz said. But those numbers will grow, especially as ongoing research continues to make the case for benefits beyond blood sugar control and weight loss.
Persons: Allen Lutz, Lutz, Lutz's, Savanta, Accolade, Eli Lilly, Mercer, Willis Towers Watson, Peter Verdult, Verdult, — CNBC's Michael Bloom Organizations: Bank of America, Accolade, Novo Nordisk's semaglutide, Food, Drug Administration, Citi, Nordisk, Centers for Disease Control Locations: U.S
Obesity revolution gorges on dialysis maker
  + stars: | 2023-10-11 | by ( Aimee Donnellan | ) www.reuters.com   time to read: +3 min
REUTERS/Megan Jelinger Acquire Licensing RightsLONDON, Oct 11 (Reuters Breakingviews) - Kidney dialysis kit-makers look set to be the latest victim of the obesity drug boom. On Wednesday, shares in Germany-listed Fresenius Medical Care (FMEG.DE) fell 20% after a medical trial showed a Novo Nordisk (NOVOb.CO) drug can reduce the risk of kidney failure. Diabetes and obesity drugs are showing their fringe benefits. In a recent drug trial, Wegovy, an obesity remedy made by Denmark’s Novo Nordisk, reduced the incidence of serious cardiovascular events like strokes and heart attacks by 20% in overweight patients. The collapse in Fresenius Medical Care’s share price looks appropriate.
Persons: Dawn, Megan Jelinger, Michael Sen, Danish drugmaker, Neil Unmack, Oliver Taslic Organizations: REUTERS, Reuters, Novo Nordisk, Denmark’s Novo Nordisk, Fresenius, Thomson Locations: Findlay , Ohio, U.S, Germany, Fresenius, Vamed, Danish
Lindsay Bira swears by freediving — lengthy stints of underwater diving while holding your breath — as a stress reduction method. When you're stressed at work, practicing a "breath hold" freediving exercise at your desk can help, Bira said on Wednesday at the 2023 NeuroLeadership Institute Summit in New York. It only takes 60 seconds. "You are, physiologically, totally capable" of holding your breath longer than 60 seconds, but your brain starts to send distress signals before you reach the milestone, she added. When you take a second — or 60 seconds — to breath-hold and reframe your thinking in those moments, you're doing something called "reappraisal," Bira said.
Persons: Lindsay Bira, freediving, Bira Organizations: The University of Texas Health Science Center, San, Harvard Medical School, Boston University School of Medicine, UT Health San, National Library of Medicine, CNBC Locations: San Antonio, New York, UT Health San Antonio
Here are Wednesday's biggest calls on Wall Street on Wednesday: Goldman Sachs upgrades Shoals to buy from neutral Goldman Sachs said the solar company is very attractive. Morgan Stanley upgrades Cava to overweight from neutral Morgan Stanley said it's gaining confidence in the restaurant chain. JPMorgan upgrades CSX to overweight from neutral JPMorgan said rail concerns have already played out. JPMorgan upgrades Iris Energy to overweight from neutral JPMorgan said the bitcoin mining company is "best-in-class." JPMorgan initiates CleanSpark as overweight JPMorgan said the bitcoin miner offers "relative value."
Persons: Goldman Sachs, Wells, Wells Fargo, TD Cowen, Cowen, Stephens, Raymond James, it's bullish, Morgan Stanley, Cava, it's, UBS downgrades Morgan Stanley, Oppenheimer, Needham, Robinhood, MAUs, Truist, Piper Sandler, JPMorgan, Mizuho, SoFi, SOFI, Leerink, Apple Organizations: Netflix, JPMorgan, CSX, Nvidia, Iris Energy, Energy, UBS, Boeing, Oppenheimer downgrades Texas, Texas, Qs, Logistics, Amazon, Arista Networks, Barclays, Ball Corporation, Apple, Walmart, Deutsche Bank, Cboe Locations: CAVA, OW, U.S, China, ANET, SoFi
Pens for the diabetes drug Ozempic sit on a production line to be packaged at Danish drugmaker Novo Nordisk's site in Hillerod, Denmark, September 26, 2023. Novo said the trial would be halted almost a year early based on a recommendation from the independent data monitoring board overseeing the study. Independent monitors can recommend stopping a trial early if there is clear evidence that a drug was going to succeed or fail based on interim analyses. Semaglutide is also the active ingredient in Novo Nordisk's powerful weight-loss drug Wegovy. Novo's success has also created an economic boom for Denmark, according to Danish economists, analysts, and executives at the Novo Nordisk Foundation.
Persons: Tom Little, Novo, Danish drugmaker, Wegovy, Emily Field, Patrick Wingrove, Sriparna Roy, Bill Berkrot Organizations: REUTERS, Novo Nordisk, Barclays, Novo Nordisk Foundation, Thomson Locations: Hillerod, Denmark, Danish, New York, Bengaluru
Share Share Article via Facebook Share Article via Twitter Share Article via LinkedIn Share Article via EmailHow soaring demand for Ozempic and Wegovy have led to Novo Nordisk's meteoric riseNovo Nordisk has experienced astounding growth in the past few years with its new diabetes and obesity care drugs, Ozempic and Wegovy. Besides what they've done to transform the company's financials, the drugs also boast the potential to help solve the obesity crisis along with aiding in the treatment of cardiovascular diseases. Analysts say the drugs could be worth up to $300 billion annually in the near future.
Organizations: Novo Nordisk
Los Angeles CNN —Charles “Chuck” Feeney, a retail entrepreneur and investor who amassed a multibillion-dollar fortune and then gave it all away, has died. He died peacefully in San Francisco on Monday, the Atlantic Philanthropies, Feeney’s foundation, said on its website. Feeney made much of his fortune after co-founding Duty Free Shoppers, a chain of duty-free airport stores specializing in luxury goods, in 1960 with an undergraduate classmate from Cornell University. In total, the Atlantic Philanthropies made grants totaling $8 billion across five continents — much of it anonymously, the foundation said. He gave nearly $1 billion to Cornell through his foundation since 1982, according to an obituary on Cornell’s website.
Persons: Los Angeles CNN — Charles “ Chuck ” Feeney, Feeney, , ” Feeney, frugally, Cornell’s, , Bill, Melinda Gates, Warren Buffett, Organizations: Los Angeles CNN, Free Shoppers, Cornell University, DFS, Cornell Locations: San Francisco, Vietnam, Ireland, Elizabeth , New Jersey
Four scientists told Insider his plan is bad for technical, scientific, and ethical reasons. Yes, experts agree we might want to settle other worlds, but Mars might not be our best bet, at least not now, four scientists told Insider. SpaceX's first priority is "establishing a cargo route to Mars," Musk told the Washington Post in 2016. From Mars, Musk told the IAC, people could go to the asteroid belts, the moons of Jupiter and Saturn, and the Kuiper belt. AdvertisementAdvertisementEssentially, terraforming Mars would involve melting its polar ice caps, which would release CO2 reserves.
Persons: Elon Musk, , Ray Bradbury's, Arnold Schwarzenegger, Christopher Edwards, He's, Musk, Refugio Ruiz Musk's, they'd, he's, Edwards, PATRICK T, FALLON, there's, Bruce Jakosky, Jakosky, Andrew Coates, Coates, Mars, terraformed, Alexander Gerst, Rachael Seidler, Refugio Ruiz, Seidler, Jeff Bezos, Buzz Aldrin, Chris McKay, " Edwards, that's Organizations: Service, Northern Arizona University, SpaceX, Mars SpaceX, International Astronautical, Washington Post, IAC, Elon Musk, NASA, Getty, Mars, ESA, University College London's, Science, University of Florida, AP, JPL, Caltech, SETI, Center for Strategic, International Studies, NASA's Ames Research Center Locations: Texas, Mars
Two Books on Being All By Ourselves
  + stars: | 2023-10-01 | by ( Andrew Stark | ) www.wsj.com   time to read: 1 min
Photo: Fine Art/Getty ImagesEarlier this year the U.S. surgeon general, Vivek Murthy, issued a report on “loneliness and isolation” in America. Loneliness, Dr. Murthy explained, is a mental phenomenon. Isolation, by contrast, is a physical experience, arising when we are prevented, as during the pandemic, from being in the actual presence of family and friends. Either form of solitude, physical or mental, can increase the risk of everything from cardiovascular disease to diabetes to depression. And, Dr. Murthy says, we are facing an epidemic.
Persons: Brandy ’, Édouard Manet, Vivek Murthy, Murthy Locations: U.S, America
Certain lifestyle factors can lower your chances of developing dementia, from physical activity to brain-stimulating exercises and even the foods you incorporate in your diet. This may sound very similar to popular diets like the Mediterranean diet and the DASH diet, and researchers thought so, too. 1 best diet for 2023The MIND diet definedThe MIND diet is the Mediterranean-DASH Intervention for Neurodegenerative Delay Diet, which was coined in a 2015 study led by nutritional epidemiologist Martha Clare Morris. Researchers discovered that people who adhered to the Mediterranean and DASH diets had better levels of cognitive functioning compared to people who didn't follow those diets. These are the foods that are included in the MIND diet, as listed in The Nutrition Source: Whole grainsVegetables, especially green, leafy onesNutsBeansBerriesPoultryFishOlive oil The MIND diet also encourages you to limit your consumption of these foods: Pastries and sweetsRed meatCheeseFried foodsButter/Margarine'We have to be more holistic'
Persons: Hussein Yassine, Yassine, Martha Clare Morris Organizations: Keck School of Medicine, University of Southern, CNBC, New York Times, Harvard, Chan's, Public Locations: University of Southern California
Here's a look at the top four and bottom four Club stocks in the third quarter as Wall Street gears up for the first trading day of the fourth quarter on Monday. The winners LLY mountain 2023-06-30 Eli Lilly's stock performance in the third quarter. CAT mountain 2023-06-30 Caterpillar's stock performance in the third quarter. F mountain 2023-06-30 Ford Motor's stock performance since the end of the second quarter. In the first few weeks of the quarter, shares of the medical equipment giant actually edged higher, but its fortunes would turn significantly.
Persons: , Eli Lilly, Eli Lilly's, Lilly, Wegovy —, Microsoft's, Locker, Mary, Jim Cramer, Dillon, Estee Lauder, we're, Fabrizio Freda, Stellantis, Ford, Jim, we've, there's, Foot Locker, GE Healthcare's, Jim Cramer's, Frederick Florin Organizations: Federal Reserve, Dow Jones, Nasdaq, Dow, Novo Nordisk, Investors, Caterpillar, Natural Resources, West Texas, Google, Microsoft, FL, Ford, United Auto Workers, UAW, General Motors, Detroit, GM, GE, GE Healthcare, CNBC, AFP, Getty Locations: U.S, WTI, Asia, Illinois, Estee Lauder, GOOGL, Fegersheim, France
If that sounds like you and you’re looking for a way to improve your health, consider giving “cozy cardio” a try. Before these cozy cardio workouts, Zuckerbrow followed a workout plan, filled with loud music, to lose 100 pounds. The first TikTok video she posted of her new exercise routine garnered 400,000 views, and cozy cardio was born. Adults should be getting 150 minutes of moderate-intensity physical activity each week, according to the Physical Activity Guidelines for Americans, published by the US Department of Health and Human Services. Cozy for lifeZuckerbrow’s fitness and stamina continue to increase, and trips to the gym have replaced some of her cozy cardio workouts.
Persons: Zuckerbrow, Hope Zuckerbrow, , ” Zuckerbrow, , David Sabgir, Nick Occhipinti, ” Occhipinti, martin, Occhipinti, Sabgir, ” Sabgir, Cozy, Melanie Radzicki McManus Organizations: CNN, Rutgers University, US Department of Health, Human Services, CNN’s, Physicians Locations: Paradise , Texas, Columbus , Ohio, Newark , New Jersey
Welcome to the hot flashes and other symptoms of approaching menopause — an experience experts say about 75% of women will share if they live long enough. Intense hot flashes could indicate an increased risk of Alzheimer's and heart disease in the future, new research found. The women were also fitted with sweat monitors to record their hot flashes on one of those nights. Frequent moderate to severe hot flashes can often last seven to 10 years, on average, and less frequent or severe hot flashes can last even longer, according to experts. “A lot of people actually underreport their hot flashes, saying they’re not having many when they really are,” Faubion said.
Persons: Peter Dazeley, , Stephanie Faubion, Faubion, Rebecca Thurston, , Thurston, ” Faubion, they’ve, Thurston’s, they’re, Mary Carson Organizations: CNN, Bank, Getty, Mayo, Specialty Clinic, , University of Pittsburgh’s Pitt Public Health, University of Pittsburgh Locations: Philadelphia, Jacksonville , Florida
(AP) — Kim Mulkey, the coach of defending national champion LSU, is publicizing that she had two stents put in a major artery this summer as she tries to promote screening for life-threatening arterial blockages. Mulkey had stents put in by catheter in late June and has fully resumed coaching activities, overseeing the first practice for the 2023-24 season, which was open to fans. “It’s not going to slow me down," Mulkey told The Advocate of Baton Rouge. "A lot of my issues were hereditary.”Last season's national title was Mulkey's fourth as a head coach — the first three coming at Baylor, where she coached from 2000 to 2021. Her record at LSU in two seasons combined is 50-8, with NCAA Tournament appearances both years.
Persons: — Kim Mulkey, “ It’s, Mulkey, , Angel Reese, Hailey Van Lith Organizations: LSU, of Fame, Tigers, Baylor, Cardinals, AP, womens Locations: BATON ROUGE, La, Baton Rouge, Louisville
How Much Coffee Is Too Much Coffee?
  + stars: | 2023-09-26 | by ( Alice Callahan | ) www.nytimes.com   time to read: 1 min
Q: I routinely drink three or four cups of coffee per day, but often wonder if this is too much. Coffee can be many things: a morning ritual, a cultural tradition, a productivity hack and even a health drink. Studies suggest, for instance, that coffee drinkers live longer and have lower risks of Type 2 diabetes, Parkinson’s disease, cardiovascular conditions and some cancers. “Overall, coffee does more good than bad,” said Rob van Dam, a professor of exercise and nutrition sciences at the Milken Institute School of Public Health at George Washington University. But between your breakfast brew, lunchtime latte and afternoon espresso, is it possible to have too much?
Persons: , Rob van Organizations: Milken Institute School of Public Health, George Washington University
BRUSSELS, Sept 26 (Reuters) - Edwards Lifesciences (EW.N) was raided by EU antitrust regulators at one of its facilities in an EU country a week ago, two people with direct knowledge of the matter told Reuters on Tuesday. Edwards Lifesciences' shares dipped after the Reuters story, falling 2.5% in pre-market trade. Edwards Lifesciences, which says it is a global leader in making medical products for structural heart disease, did not respond to repeated emailed requests for comment. Companies found guilty of violating EU antitrust rules face fines as much as 10% of their global turnover. According to analysts, Edwards Lifesciences competes with Abbot Laboratories (ABT.N), Medtronic (MDT.N), Zimmer Biomet (ZBH.N) and Boston Scientific Corp (BSX.N), among others.
Persons: Edwards, Edwards Lifesciences, Zimmer Biomet, Foo Yun Chee, Kirsten Donovan, Louise Heavens Organizations: Reuters, European, EU, Abbot Laboratories, Boston Scientific Corp, Thomson Locations: BRUSSELS, EU
The hormonal changes alter acidity levels of the vagina, Dr. Streicher said, which can lead to recurrent urinary tract infections among menopausal women, creating discomfort in the area whether or not they are having sex. And some common health conditions among older people, like diabetes or cardiovascular disease, can also dry out the vagina, she added. Dr. Streicher recommends warming the lubricant because “cold is a vasoconstrictor, which will make you have even less natural lubrication, whereas heat is a vasodilator and will help the muscles relax,” she said. Vaginal moisturizers: These creams and gels can be found over the counter. Estrogen creams: Studies have repeatedly found that this prescription option is highly effective at reducing pain, including in the vestibule area.
Persons: Streicher, , I’m, , Goetsch
In search of connection, young people are spending on gym memberships, social clubs, and art classes. Most said they spend more on social activities than pre-pandemic. All but three said they're spending more money now than they were before the pandemic on social activities such as art classes and gym memberships to make friends. The software engineer said he's increased his investment in social activities after struggling to make friends at work. Other Gen Zers told Insider they made connections through free gallery events, volunteering, and joining book clubs.
Persons: Zers, Lynette Ban, she's, Ban, Vivek Murthy, Richard Weissbourd, Weissbourd, Murthy, Rachael, Matt Schulz, William Cabell, Cabell, he's, Cabell isn't, Kazerouni, Kelly Lohr, , Barley Vogel, there's, Rebecca Schweiger, Schweiger, Noureen Shallwani, Shallwani, Gen Zers, Zers don't, Lillian Lema, Bumble BFF, Lillian Lema Lema, BFF, She's, Margaux Duvall, Duvall, Alexandra York Organizations: Service, Soho House, Harvard Graduate School of Education, IRL, SEC, Studio Arts Dallas, Studio, The, Facebook Locations: Wall, Silicon, New York, Austin, Italy, Richmond , Virginia, Soho, Soho House's New York, Philadelphia, Maine, Portland , Maine, Ohio, Denver, nsheidlower@insider.com
Two more members of the FDNY died this September from 9/11-related illnesses, shortly after the 22nd anniversary of the World Trade Center attacks, according to a statement on social media from the fire department. Hilda Vannata, an emergency medical technician for the fire department, died on September 20 from cancer, says the department. Hilda Vannata, an emergency medical technician for the fire department, died on September 20 from cancer, the department said. According to the fire department, 11,000 firefighters suffer from World Trade Center-related diseases, including 3,500 who have cancer. Retired firefighter Robert Fulco, who responded to the September 11 terror attacks, died Saturday morning from pulmonary fibrosis.
Persons: Hilda Vannata, Vannata, Robert Fulco, , Laura Kavanagh, Kavanagh Organizations: CNN, New, New York City Fire Department, FDNY, World Trade, Lincoln Hospital, World Trade Center Health Registry, World Trade Center Locations: New York City, Puerto Rico
Gertjan van der Geer, a senior investment manager at the firm, describes megatrends as large social, economic, political, environmental, or technological transformations that significantly impact the economy, society, cultures, or businesses. Additionally, five criteria must be met before Pictet creates a thematic fund, van der Geer said. When it comes down to picking the right basket of stocks, van der Geer noted that a company's fundamentals are key. And there are a few things that we are looking for in these companies," van der Geer said. And one of the key ways to improve our CO2 footprint globally is to reduce the unnecessary pollution," van der Geer said.
Persons: they're, Gertjan van der Geer, Pictet, van der Geer, It's, Van der Geer Organizations: Microsoft, Apple, Pictet, Management, Premium Brands, Security, Health, Schneider, Clean Energy, Nordisk, Asml, Roper Technologies, Kla Corp, Republic Services Locations: megatrends
A few compounds picked by AI are now in development, but those bets will take years to play out. Reuters interviews with more than a dozen pharmaceutical company executives, drug regulators, public health experts and AI firms show, however, that the technology is playing a sizeable and growing role in human drug trials. The U.S. Food and Drug Administration (FDA) said it had received about 300 applications that incorporate AI or machine learning in drug development from 2016 through 2022. Without AI, Bayer said it would have spent millions more, and taken up to nine months longer to recruit volunteers. Finding real-world patients by mining electronic patient data can be done manually, but using AI speeds up the process dramatically.
Persons: Dado Ruvic, Jeffrey Morgan, Amgen, Badhri Srinivasan, Sameer Pujari, drugmaker Bayer, Bayer, Blythe Adamson, Roche, Richard Pazdur, Gen Li, John Concato, Natalie Grover, Martin Coulter, Julie Steenhuysen, Josephine Mason, David Clarke Organizations: Pharmaceutical Research, REUTERS, Pharmaceutical, Bayer, Novartis, Deloitte, U.S . Food, Drug Administration, Reuters, World Health, Flatiron Health, FDA, European Medicines Agency, FDA's Oncology, Excellence, Medical, FDA's Center, Drug, Research, Thomson Locations: U.S, Johannesburg, Texas, Finland, United States, London, Chicago
AdvertisementAdvertisementWhen numbers take overThe 10,000-step benchmark has generally been the baseline goal for smartphone apps and fitness trackers. When the Fitbit tracker launched in 2009, 45 years after Yamasa's gadget cemented the 10,000-steps ideal in the public consciousness, it kick-started a boom in fitness wearables and spawned a frenzy for health data. This flood of easily accessible health data has certainly had some positive effects. Many fitness-tracking products also incorporate social-sharing features, which can give us a better perspective on how our exercise habits stack up against our friends', providing a little healthy competition as motivation. Many health- and fitness-tracking apps and wearables issue notifications throughout the day to urge their users toward their movement goals.
Persons: I've, Amanda Paluch, , Paluch, John Toner, Toner, Cathleen Kronemer, Louis, she's, Kronemer, there's, I'm, Kelli María Korducki Organizations: Apple, US Department of Health, Human Services, University of Massachusetts Amherst, University of Hull, Health, Washington University School of Medicine, Locations: East Asia, St, New York City
How to Change Your Mind-Set About Aging
  + stars: | 2023-09-20 | by ( Holly Burns | ) www.nytimes.com   time to read: +1 min
From the crotchety neighbor to the clueless Luddite, negative stereotypes of aging are everywhere. To change your negative age beliefs, you first need to become more aware of them, Dr. Levy said. “People can strengthen their positive age beliefs at any age,” Dr. Levy said. In one 2014 study, 100 adults — with an average age of 81 — who were exposed to positive images of aging showed both improved perceptions of aging and improved physical function. Find aging role models.
Persons: Becca Levy, Levy, ” Dr, you’re, , Regina Koepp Organizations: Yale
CNN —Eating greater amounts of ultraprocessed food and drinks, especially if those items are artificially sweetened, may be linked to the development of depression, according to a new study. Ultraprocessed foods include hot dogs, sausages, French fries, sodas, store-bought cookies, cakes, candies, ice cream and many foods containing artificial sweeteners. For one, there is a known link between ultraprocessed foods and chronic inflammation, Chan said. For example, studies have linked ultraprocessed foods colorectal cancer in men and heart disease and early death in both men and women. In addition, the study is observational, which means that researchers can only find an association between the onset of depression and the intake of ultraprocessed foods.
Persons: ” Gunter Kuhnle, , Andrew T Chan, Daniel K, Harvard T.H, Chan, Kuhnle, ” Marion Nestle, Paulette Goddard, ” Chan, David Katz, ” Katz, ” It’s, Katz, It’s, Paul Keedwell, Keith Frayn, Frayn, ” Frayn Organizations: CNN, University of Reading, Harvard Medical School, Harvard, of Public Health, Massachusetts General Hospital, New York University, ” Association, JAMA, Nurses, True Health Initiative, Royal College of Psychiatrists, BMI, University of Oxford Locations: Chan, Boston, Massachusetts, McDonald’s
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