Genesis is owned by Stamford, Connecticut-based venture capital company Digital Currency Group.
The contagion concerns stem from Genesis' prominence in crypto, its links to troubled firms and broader reach into the financial world.
"It's a signal of worse outcomes" for the crypto market, particularly since Genesis also deals with brokers, family offices and money managers.
Last year, Genesis extended $130.6 billion in crypto loans and traded $116.5 billion in assets, according to its website.
Crypto.com, an exchange, and Tether, which operates the world's largest stablecoin, on said Wednesday they had no exposure to Genesis.