The 21-year-old Sinner was outclassed, falling flat on the big occasion and allowing Djokovic, 14 years his senior, to turn the screw at key moments in the contest.
He let break points slip through his fingers, including two set points in the third, while Djokovic was clinical as usual, applying constant pressure on the Italian's serve and pouncing on opportunities when they arose.
Sinner then spurned another chance to break in the fifth game, leaving Djokovic to cruise through the rest of the opener.
Djokovic won only six points on the Sinner serve in the first set, but that was all he needed, celebrating with a clenched fist as he strolled back to his chair.
The Serbian set up three further break points in the third game of the second set, with Sinner saving the first two before sending a forehand long to fall behind again.
Persons:
Novak Djokovic, Djokovic, Roger Federer's, Carlos Alcaraz, Russian Daniil Medvedev, Margaret Court's, Sinner, Sinner's, Richard Haigh, penalising Djokovic, scuffed, Toby Davis, Ken Ferris
Organizations:
Djokovic, Serbian, Wimbledon, Thomson
Locations:
Serbian, Russian