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Roche said Thursday that its Wegovy rival weight loss drugs will be part of a suite of medicines aimed at combatting the effects of obesity. CEO Thomas Schinecker welcomed positive early stage trial results from the firm's two weight loss drug candidates as showing "best in disease potential." "We do believe we have two next generation GLP-1/GIPs that have a best in disease potential," he said of the obesity drugs. GLP-1s, or glucagon-like peptide 1 agonists, are a group of drugs used to treat diabetes and obesity. They form the basis of weight loss drugs such as Novo Nordisk's Wegovy and Eli Lilly's Zepbound.
Persons: Roche, Thomas Schinecker, Schinecker, CNBC's, Nordisk's Wegovy, Eli Lilly's Zepbound Organizations: Nordisk's
He follows the Longevity Diet, created by his colleague and L-Nutra cofounder Valter Longo, a professor of gerontology and director of the USC Longevity Institute. It's mainly a plant-based diet but includes fish a few times a week, plus lots of complex carbohydrates, and healthy fats from nuts, Antoun said. Eat nuts every dayNuts are a good source of plant-based protein, complex carbs, and healthy fats, Antoun said. In a 2023 study published in JAMA Network Open, 22 pairs of twins were randomly assigned either a healthy vegan diet or a healthy omnivorous diet for eight weeks. Have dinner early and breakfast lateAnother part of Longo's Longevity Diet, and the central tenant of L-Nutra's business model, is intermittent fasting.
Persons: , Joseph Antoun, Antoun, Valter Longo, biohacking bros Organizations: Service, Business, gerontology, USC Longevity Institute, American College of Cardiology, Mayo Clinic, JAMA
It will mean fundamentally reevaluating our conception of free will and human agency — and reckoning with our tortured relationship with shame. Many health plans have refused to cover GLP-1s for weight loss , citing limited approval from the Food and Drug Administration. I don't know when I first became overweight, but I remember the moment I was taught to be ashamed of it. They can stop the vicious feedback loop where our food choices and weight drive the shame that drives our food choices and weight. But no matter how heavy that burden was, one thing made it easier to bear: I wasn't weighed down by my shame.
Persons: I'd, They're, , dieters, I've, Wayne LaPierre, David Vades Joseph, Mounjaro, , you'd, would've, Kit Kat, they've, untangling, Stephen Spielberg's Organizations: National Rifle Association, NRA, Food and Drug Administration, New York City Marathon, Harvard Law School, GLP, BI Locations: York, Greenwich Village, darting, GLP
Losing weight is hard. Here are 5 things to keep in mind
  + stars: | 2024-01-26 | by ( Andrea Kane | ) edition.cnn.com   time to read: +7 min
We delve into a slew of topics, including new weight loss drugs and how to talk to kids about weight. (CNN) — If you think it’s hard to lose weight and keep it off, you are not alone — and you are also 100% correct. “We evolved not to lose weight intentionally,” paleoanthropologist Daniel Lieberman told CNN Chief Medical Correspondent Dr. Sanjay Gupta recently on the podcast Chasing Life. It’s because we evolved not to lose weight intentionally. “So when people diet, they almost always struggle to overcome ancient, fundamental adaptations to prevent their bodies from losing weight,” he added.
Persons: Sanjay Gupta, it’s, ” paleoanthropologist Daniel Lieberman, Lieberman, , ” Lieberman Organizations: CNN, Harvard University
How could she, the queen of WeightWatchers and doyenne of dieting, be abandoning the equation of diet + exercise = slim? Taking weight-loss drugs, rejecting diet culture or choosing to diet are all valid health decisions. Just look at the tragic history of diet drugs. When considered in this context, semaglutide isn’t the weight loss panacea it may appear to be. Oprah and the millions of other Americans on prescription semaglutide and similar medications should be respected — or at least not ridiculed — for ignoring the insults and choosing what’s right for them, drug or no drug, diet or no diet.
Persons: Adrienne Bitar, , Oprah Winfrey, WeightWatchers, Oprah, couldn’t, Cancer, dieters, , gaunt, Jimmy Kimmel, Atkins “, John Harvey Kellogg, Kellogg, dieter, Organizations: , Studies, Cornell University, CNN, , Federal Food
U.S. crude declined Thursday, erasing early gains, as traders grew more convinced that OPEC+, a group composed of OPEC plus its oil-producing allies, will not deliver on promised output cuts. Riyadh agreed to extend its voluntary production cut of 1 million barrels per day, a source in the Energy Ministry told the Saudi Press Agency. Iraq is cutting by 223,000 bpd, the United Arab Emirates 163,000 bpd, Kuwait 135,000 bpd, Kazakhstan 82,000 bpd, Algeria 51,000 bpd and Oman 42,000 bpd. OPEC+ has a major problem when it comes to cohesion and compliance on output cuts, said John Kilduff of Again Capital. "They have their hands full and to me it's not going to prove to be a winning strategy for them," he said of the output cuts.
Persons: Brent, Alexander Novak, Phil Flynn, Flynn, John Kilduff, Kilduff, CNBC's, it's Organizations: West Texas Intermediate, Energy Ministry, Saudi Press Agency, United Arab Emirates, Traders, Price Futures, U.S, OPEC, CNBC PRO Locations: OPEC, Saudi Arabia, Riyadh, Iraq, Kuwait, Kazakhstan, Algeria, Oman, Russia, Asia, China
A new version of the popular diabetes treatment Mounjaro can be sold as a weight-loss drug, U.S. regulators announced Wednesday. The U.S. Food and Drug Administration approved Eli Lilly's drug, named Zepbound. Zepbound is the latest diabetes drug approved for chronic weight management, joining Novo Nordisk's Wegovy, a high-dose version of its diabetes treatment Ozempic. Those with diabetes, who have a harder time losing weight, cut about 12%, or nearly 27 pounds (12 kilograms), the FDA said. Approved for weight loss in 2021, Wegovy helped people lose about 15% of their weight or 34 pounds (15 kilograms), according to study results.
Persons: Eli Lilly's, dieters, Zepbound, Wegovy, Fatima Cody Stanford, tirzepatide, pare, , Katherine Saunders, Eli Lilly, Mounjaro, Kelly Burns, Burns Organizations: U.S . Food, Drug Administration, Novo Nordisk's Wegovy, FDA, Massachusetts General Hospital, New York's Weill Cornell Medicine, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: U.S, Zepbound, Wegovy, Massachusetts, Boston, St . Petersburg , Florida
By comparison, a group of people who also dieted and exercised, but then received dummy shots, lost weight initially but then regained some, researchers reported Sunday in the journal Nature Medicine. Participants in both groups lost about 7% of their body weight, or almost 17 pounds (8 kilograms), during the diet-and-exercise phase. Those who received the drug went on to lose an additional 18.4% of initial body weight, or about 44 pounds (20 kilograms) more, on average. Nearly 29% of those taking the drug lost at least a quarter of their body weight, compared with just over 1% of those taking placebo. Side effects including nausea, diarrhea and constipation were reported more frequently in people taking the drug than those taking the placebo.
Persons: Mounjaro, , Thomas Wadden, Eli Lilly, it's, Caroline Apovian, wasn't, tirzepatide, , Lilly Organizations: Nature, University, Pennsylvania, Brigham, Women's, Novo Nordisk, U.S . Food, Drug Administration, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: U.S,
Jell-O GirlEarly Jell-O advertising depicted women as inept, needing the help of a simple recipe like Jell-O. Jell-O released flavors such as seasoned tomato, celery, mixed vegetable and Italian salad, and Jell-O salads were a colorful way to use leftovers in side dishes. In 1955, the company introduced the slogan “A Jell-O salad makes the meal.”“The Jell-O salad really hits the American sensibility and palate perfectly. Constance Bannister Corp/Getty ImagesBut as more Americans traveled and global cuisines entered the mainstream, the simplicity of Jell-O salads became a downside. “Upscale becomes the new mainstream and Jell-O salads moves into a niche,” Shapiro said.
President Rumpelstiltskin
  + stars: | 2022-10-22 | by ( The Editorial Board | ) www.wsj.com   time to read: 1 min
The White House doesn’t have much good economic news to report these days, so sometimes it pretends that the straw it’s selling is really gold. That was the case Friday when President Biden and his economic advisers claimed that a $1.4 trillion budget deficit for fiscal 2022 was a great fiscal and economic success. “Today my administration announced that this year the deficit fell by $1.4 trillion—the largest one-year drop in American history—$1.4 trillion decline in the deficit,” President Biden said in remarks at the White House. Readers who are dieters will appreciate his logic: Gain 100 pounds, but then lose 50 and you can qualify to be a contestant on “The Biggest Loser.”
Noom is a weight-loss app that uses a psychology-based approach to change your eating habits. One writer tried Noom for eight months to shed some pounds and prevent pandemic weight gain. In my latest attempt to lose weight, I turned to the Noom app. Lisa Rabasca RoepeI imagine that this is a powerful exercise for someone who has more than 10 pounds to lose. In fact, I've noticed that the people who have the most weight to lose have the most success with Noom.
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