Auction house Villa Grisebach in Berlin estimates that 'Self-portrait in yellow-pink' will attract bids of up to 30 million euros.
The self-portrait, painted in 1943, is a rarely seen masterpiece, Micaela Kapitzky, director and partner at Villa Grisebach, told Reuters.
"The opportunity to buy a Beckmann self-portrait of this quality will not come up again.
After the Nazis branded his paintings "degenerate art", Beckmann and his wife, Mathilde, known as "Quappi", fled Germany in 1937.
Markus Krause, director and partner at Villa Grisebach, expressed excitement at the auction, which he is to conduct.