Compher had a goal and three assists, and Nathan MacKinnon posted a goal and two helpers for Colorado.
Valeri Nichushkin, Logan O'Connor and Artturi Lehkonen also scored, Samuel Girard had two assists and Alexandar Georgiev turned away 35 shots.
Leon Draisaitl and Tyson Barrie each had a goal, Cody Ceci had two assists and Jack Campbell made 37 saves.
Ridly Greig scored his first NHL goal, Claude Giroux had two assists and Mads Sogaard made 30 saves.
Wild 4, Predators 3Ryan Hartman scored with 21 seconds remaining, and Minnesota defeated Nashville after surrendering a two-goal, third-period lead.