There have been at least 8.7 million illnesses, 78,000 hospitalizations, and 4,500 deaths from flu so far this season, according to CDC estimates.
She said flu season started earlier and "hospitalizations for flu continue to be the highest we have seen at this time of year in a decade."
People also likely have weakened defenses after not being exposed to flu and RSV while working or schooling from home during the COVID-19 pandemic.
About 12% fewer pregnant women have been vaccinated so far this season compared to last season, and about 5% fewer children, Walensky said.
COVID-19 cases have risen following the Thanksgiving holiday and COVID-related hospitalizations have also increased about 15% to 20% over the last week, Walensky said.