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The U.S. on Saturday reported its first case of a more aggressive strain of mpox: an individual in California who had recently traveled from Eastern Africa. It is classified into two distinct groups: the more aggressive strain, clade I, and a somewhat milder strain, clade II. In the current outbreak, clade I has been spreading largely through contact with infected animals and transmission within households, according to disease experts. But a version of the strain, clade Ib, has also spread through sexual contact among female sex workers and men who have sex with men in Congo. That’s compared to a 0.2% global fatality rate for the 2022 outbreak.

Persons: “, Marc Siegel Organizations: California Department of Public Health, Centers for Disease Control, CDC, World Health Organization, Democratic, George Washington School of Medicine, Health Sciences, of Health, Human Service, Health Locations: California, Eastern Africa, San Mateo County, U.S, Africa, Central Africa, East Africa, Democratic Republic of Congo, Sweden, Thailand, Germany, India, United Kingdom, Congo

☆ Riley Strain update: Missouri college student’s death ruled accidental drowning and alcohol poisoning, police say
▼ + stars: | 2024-06-18 | by ( Rebekah Riess | Christina Zdanowicz | ) edition.cnn.com time to read: +2 min

CNN —Riley Strain, a Missouri college student who went missing after leaving a downtown Nashville bar and whose body was later found in a river, died of accidental drowning and alcohol poisoning, the medical examiner’s office said Tuesday. Strain’s body was found in the Cumberland River in West Nashville on the morning of March 22, several miles from where he had gone missing. The autopsy report said Strain’s blood alcohol level was 0.228, which is almost three times the legal driving limit. CNN obtained a copy of the autopsy report from CNN affiliate WTVF and has reached out to the Strain family’s attorney for comment. Correction: A previous version of this story cited the wrong CNN affiliate for the copy of the autopsy report.

Persons: CNN — Riley Strain, Strain, Riley Strain’s, Strain’s Organizations: CNN, of Missouri, The Metropolitan Nashville Police Department, Police, Gay, WTVF Locations: Missouri, Nashville, Cumberland, West Nashville

Data is trickling in on a new COVID-19 strain nicknamed “pirola,” giving researchers a wider picture of what the variant could mean for the U.S. and the world. Van Kerkhove said that the global COVID-19 variant picture is complex, and that while BA.2.86 is spreading, it is not currently outcompeting other strains. “It is quite a complex picture globally in terms of how these variants behave because different variants circulate in different countries at different times.”Will Vaccines Work on Pirola? Moderna and Pfizer have announced that early data indicates that their updated vaccines do produce an immune response against BA.2.86. "These results demonstrate that our updated COVID-19 vaccine generates a strong human immune response against the highly mutated BA.2.86 variant.

Persons: “ pirola, ” Mandy Cohen, Maria Van Kerkhove, ” Benjamin Murrell, Ashish Jha, pirola, Van Kerkhove, it’s, ”, “, Stephen Hoge Organizations: U.S, CDC, Centers for Disease Control, World Health Organization, WHO, White, Moderna, Pfizer, EG Locations: United States, Denmark, Sweden, Portugal, Israel, Canada, South Africa

☆ 'Pinocchio' review: A reimagined story is beautiful but comes with too many strings attached
▼ + stars: | 2022-12-09 | by ( Brian Lowry | ) edition.cnn.com time to read: +3 min

CNN —The mere title “Guillermo del Toro’s Pinocchio” announces that this stop-motion animated movie reflects the keen eye and visual style of the directing auteur, with a healthy dose of revisionism and reimagining baked into that. Yet despite its beauty, several of those narrative touches don’t fully work, leaving behind a movie that’s aesthetically lovely but narratively uneven. Perhaps foremost, del Toro makes the ill-advised decision to incorporate songs into the story, although he keeps interrupting them, which might speak to a certain lack of conviction about that particular aspect. It’s around that point where del Toro (who shares directing credit with animator Mark Gustafson) appears determined to connect this “Pinocchio” to larger and more ambitious themes. “Guillermo del Toro’s Pinocchio” premieres December 9 on Netflix.

☆ Fact Check-Boston University hybrid COVID virus kills 80% of mice, not people
▼ + stars: | 2022-10-25 | by ( Reuters Fact Check | ) www.reuters.com time to read: +6 min

The authors then infected different sets of transgenic mice designed to be susceptible to SARS-CoV-2 with one of the three strains: Omicron, the ancestral virus, or the Omi-S hybrid virus (here). In the study, 100% of mice infected with the ancestral virus strain died, while 80% of those infected with Omi-S died, and none of the mice infected with Omicron died. Others shared the claim that the Omi-S had an “80% kill rate,” without specifying whether this referred to mice or humans. The ancestral virus (the viruses as they were when introduced in Europe and the US) in this mouse model kills 100% of the animals. Early in the pandemic, the fatality rate of the ancestral virus for people in a multicountry European analysis was estimated at about 4% (here).

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