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Among participants who experienced excessive daytime sleepiness and a lack of enthusiasm, 35.5% developed motoric cognitive risk syndrome compared with 6.7% of people without those problems, according to the study published Wednesday in the journal Neurology. “Establishing the relationship between sleep dysfunction and MCR risk is important because early intervention may offer the best hope for preventing dementia,” the authors said. Over a follow-up period of roughly three years on average, 36 participants developed motoric cognitive risk syndrome. But when the authors considered the seven sleep components separately, only daytime dysfunction was associated with 3.3 times higher risk of MCR. Spires-Jones pointed out that for the potential link between daytime dysfunction and MCR, reverse causation is also possible.
Persons: , Dr, Victoire Leroy, Leroy, Richard Isaacson, Richardson wasn’t, Tara Spires, Jones, wasn’t, Isaacson, ” Leroy, , neurotoxins, Lewy, you’re, Organizations: CNN, Tours University Hospital, New, Central Control, Mobility, Centre, Discovery Brain Sciences, University of Edinburgh Locations: France, Westchester County, Pittsburgh, Florida, Scotland, MCR
“What’s scary and embarrassing is that I can see people come to help me, but I’m unable to respond.”Horsnell has narcolepsy, a sleep disorder that makes it hard to stay awake for long periods. In fact, it’s estimated that only 25% of people who have narcolepsy are diagnosed and receive treatment, according to the Narcolepsy Network. “But the terrifying thing was, I’m lying in a puddle of my sweat and I’m hearing everybody whisper, ‘Is he OK? Horsnell’s experience with narcolepsy hallucinations, however, is quite different. As a trained speaker for Project Sleep’s Rising Voices of Narcolepsy leadership program, he visited the White House in 2023 to raise awareness about narcolepsy and sleep disorders.
Persons: Matthew Horsnell, , Horsnell, , ” Horsnell, Jennifer Mundt, Mundt, ” Mundt, “ There’s, aren’t, orexin, Heather Lill, it’s Organizations: CNN, Northwestern University’s Feinberg School of Medicine, Narcolepsy, cataplexy, , Narcolepsy Network, Scientists, US Food and Drug Administration, Society, Behavioral Sleep, Sleep Research Society, American Academy of Cardiovascular Sleep, White House Locations: Chicago, United States
CNN —Already multitool smart devices, Apple Watches added another buzzworthy feature last month: an app to detect sleep apnea. The sleep apnea notification is available on the latest Series 10 Apple Watches and some older models after a software update. In order to detect sleep apnea, the watch measures breathing disturbances during sleep over 30 days. But the US Food and Drug Administration approved marketing of the sleep apnea feature on Apple Watches in mid-September. The Apple Watch has a few of these capabilities, but the company did not factor them into the sleep apnea feature.
Persons: It’s, , Robson Capasso, ” Capasso, Erring, Apple, Jing Wang, Wang, ” Wang, Eric Topol, , ” Topol, Capasso, Dr, Sanjay Gupta, they’re Organizations: CNN, Apple, Stanford University School of Medicine, Food and Drug Administration, Apple Watch, Scripps, Research, Get CNN, CNN Health Locations: Sinai
Centessa Pharmaceuticals could be at the forefront of a leading narcolepsy treatment that can send its shares soaring, according to Morgan Stanley. One of the company's drugs is ORX750 for the treatment of sleep-wake disorders, including narcolepsy type 1 and 2, or NT1 and NT2. Additionally, Centessa is developing ORX142 for the treatment of excessive daytime sleepiness, or EDS, in certain neurological, neurodegenerative and psychiatric disorders. The drug is designed to increase wakefulness, reduce cataplexy and potentially be a novel treatment for narcolepsy type 1. Given the firm's view of ORX750 as a now de-risked mechanism for treating narcolepsy, Hung modeled a higher peak market share for the treatment in NT1 by 2036.
Persons: Morgan Stanley, Jeffrey Hung, narcolepsy, Hung Organizations: Pharmaceuticals, IH, EDS Locations: NT1, NT2
“Given that sleep is highly visible as a risk factor, non-stigmatizing, and highly treatable … we suggest study of sleep as a risk factor and critical intervention target for youth suicide,” said senior study author Dr. Rebecca Bernert, a suicidologist and founder of the Stanford Suicide Prevention Research Laboratory in California, via email. Suicide is a leading cause of death among children ages 10 to 14, a group that also has high rates of sleep disturbance, according to the study. And sleep disturbances “have emerged as an evidence-based risk factor for suicidal behaviors” among adults, regardless of whether a person has depressive symptoms, the authors said. At that time, guardians answered questionnaires about their child’s sleep health, which included factors such as problems with falling or staying asleep, waking up, excessive sleepiness, sleep-disorder breathing, excessive sweating during sleep, and behaviors that occur when someone partially awakes from deep sleep. Supporting your child’s healthAt all ages, your kids need good nighttime habits that support healthy sleep, Willard said.
Persons: ideation, , Rebecca Bernert, Christopher Willard, wasn’t, ” Willard, Rebecca Berry, University’s, Berry wasn’t, Bernert, ” Bernert, Berry, Sleep, Willard, ” Berry, Organizations: Lifeline, CNN, JAMA, Stanford, Prevention Research, Harvard Medical School, University’s Grossman School of Medicine, Stanford University School of Medicine Locations: California, United States, Massachusetts, Boston, New
Eli Lilly presented the new data from the trials at the American Diabetes Association's 84th Scientific Sessions in Orlando, Florida, on Friday. An estimated 80 million patients in the U.S. experience the disease, Eli Lilly said in a press release. Disease resolution for OSA is defined as a patient having fewer than five AHI events per hour, according to Eli Lilly. Eli Lilly on Friday reiterated that Zepbound met the main goal of the trial, which was reducing AHI events. Eli Lilly previously announced that the FDA granted Zepbound "fast track designation" for patients with moderate-to-severe OSA and obesity.
Persons: Eli Lilly, Zepbound, Patrik Jonsson, Jonsson, Leonard Glass, , Eli Lilly's Organizations: Food and Drug Administration, Diabetes, CNBC, OSA, FDA Locations: Orlando , Florida, U.S
CNN —The US Food and Drug Administration is warning consumers and retailers to not “eat, sell or serve” any of Diamond Shruumz-brand’s microdosing chocolate bars after people across four states were left hospitalized. Eight people reported falling ill after eating Diamond Shruumz’s chocolates, the FDA said in an advisory. People who consumed the chocolate bars reported experiencing symptoms that include “seizures, central nervous system depression (loss of consciousness, confusion, sleepiness), agitation, abnormal heart rates, hyper and hypotension, nausea and vomiting,” said the FDA. CNN has reached out to Diamond Shruumz for comment but has not heard back by the time of publishing. If you or someone you know becomes ill after consuming Diamond Shruumz’s chocolate bars, the FDA recommends speaking to a health care provider and/or contacting the Poison Help Line at 1-800-222-1222.
Persons: Diamond, , Dr, Sanjay Gupta, Diamond Shruumz Organizations: CNN, Food and Drug Administration, FDA, People, CNN Health, US Centers for Disease Control, Centers Locations: Arizona, Indiana, Nevada, Pennsylvania
It's time for investors to buy the dip on Jazz Pharmaceuticals , according to Goldman Sachs. The investment bank initiated coverage of the pharmaceuticals stock with a buy rating, setting a 12-month price target of $169. Jazz Pharmaceuticals has slipped 15% this year. Indeed, investors have grown concerned over Jazz's potential loss of exclusivity and rising competition regarding oxybates, which reduces daytime sleepiness. An additional catalyst comes in the form of Vision 2025, Jazz's strategic initiative launched in January 2022 to target $5 billion in revenue from 2025.
Persons: Goldman Sachs, Andrea Tan, Tan Organizations: Jazz Pharmaceuticals
Stayed up all night? Here’s how to feel better
  + stars: | 2024-04-19 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +5 min
CNN —It was a dream come true for millions of Taylor Swift fans, after the superstar released her latest album, “The Tortured Poets Department,” at midnight on Friday. “The strongest reset for the circadian system is bright light,” said Dr. Phyllis Zee, director of the Center for Circadian and Sleep Medicine at Northwestern University Feinberg School of Medicine in Chicago. “Research shows that movement can boost circulation and increase alertness, helping you shake off that sleepiness faster,” Daddy Dasgupta said. “It could limit your ability to sleep well that night,” said sleep specialist Kristen Knutson, an associate professor of neurology and preventive medicine at Northwestern University’s Feinberg School of Medicine. And of course, listening to Taylor Swift counts as long as you turn it off before bed!”CNN’s Madeline Holcombe, Kristen Rogers and Ashley Strickland contributed Taylor Swift lyrics to this article.
Persons: Taylor Swift, , Phyllis Zee, , Mina Dasgupta, Raj Dasgupta, Daddy Dasgupta, Taylor, ” Mina, ” Dasgupta, Cynthia Ackrill, Swift, it’s, Kristen Knutson, Dasgupta, Knutson, Madeline Holcombe, Kristen Rogers, Ashley Strickland Organizations: CNN, Poets Department, , Maserati, Center, Northwestern University Feinberg School of Medicine, “ Research, American Institute of, Northwestern University’s Feinberg School of Medicine Locations: Chicago, Huntington Heath, Pasadena , California
An injection pen of Zepbound, Eli Lilly’s weight loss drug, is displayed in New York City, U.S., December 11, 2023. Eli Lilly on Wednesday said its highly popular weight loss drug Zepbound showed the potential to treat patients with the most common sleep-related breathing disorder in two late-stage clinical trials. Zepbound was more effective than a placebo at reducing the severity of obstructive sleep apnea, or OSA, in patients with obesity after a year, according to preliminary data from both trials. Eli Lilly previously announced that the FDA granted Zepbound "fast track designation" for patients with moderate-to-severe OSA and obesity. Zepbound has slipped into shortages since receiving approval in the U.S. for weight management in November.
Persons: Eli Lilly’s, Eli Lilly, Zepbound, Dr, Jeff Emmick, Eli Lilly's Organizations: U.S . Food, Drug Administration, FDA, OSA Locations: New York City, U.S
But too much of supplements, including fish oil and vitamin D, can be harmful. A toxicologist shared the side effects of overdoing some of the most popular supplements. AdvertisementChilcott shared the long-term risks of taking too much of some of the most popular supplements. You're unlikely to get symptoms from taking too much vitamin D if you're taking less than 250 mcg a day, according to the ODS. Of all the supplements Chilcott spoke about, he said this was the one that's the most potentially risky, but only at very high doses.
Persons: , Rob Chilcott, Chilcott, it's Organizations: Service, University of Hertfordshire, FDA, Cleveland Clinic, BI, US Food and Drug Administration
CNN —An implant for obstructive sleep apnea — a serious sleep malady in which breathing stops for 10 seconds to two minutes many times an hour each night — works best in people who are overweight but not severely obese, a new study found. “There’s a huge unmet need of patients that are suffering with obstructive sleep apnea and not able to tolerate CPAP,” Landsness said. nicolesy/iStockphoto/Getty ImagesAbout a third of patients have difficulty using a CPAP and may ultimately abandon the device, Landsness said. Obstructive sleep apnea is also connected to type 2 diabetes, asthma, obesity, kidney disease, chronic obstructive pulmonary disease, thyroid disease and mental illnesses such as depression and anxiety. “As an alternative treatment for sleep apnea, this hypoglossal nerve stimulation surgery could revolutionize some people’s lives,” he said.
Persons: Eric Landsness, St . Louis, ” Landsness, , Kristen Knutson, , Landsness, CPAP, Brandon Peters, Mathews, ” Peters, Raj Dasgupta, Dasgupta, “ I’ve Organizations: CNN, Washington University School of Medicine, Medicare, BMI, Northwestern University’s Feinberg School of Medicine, Virginia Mason Medical Center, Food and Drug Administration, Huntington Health, Mayo Clinic, telltale Locations: St ., Chicago, Seattle, Pasadena , California
Feeling older than you are? It could be how you sleep
  + stars: | 2024-03-26 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +5 min
CNN —Not getting enough sleep may cause you to feel five to 10 years older than you really are, according to two new studies. A lack of energy and motivation can certainly contribute to feeling older while limiting a person’s ability to remain physically and socially active, both of which contribute to feeling young, Balter said. For every night of poor sleep during that time, people reported feeling about a quarter of a year older than their chronological age. “These findings support that sleep, a vital biological phenomenon, might hold the key to feeling young,” Balter and her colleagues wrote in the study. “If you suspect that your sleep deprivation is due to a sleep disorder such as insomnia or sleep apnea, it’s crucial to seek evaluation and treatment from a healthcare professional,” he said.
Persons: CNN —, , ” Leonie Balter, Balter, , Chang, Ho Yun, ” Yun, It’s, ” Balter, Sleepiness, chronotype, Yun Organizations: CNN, Stockholm University, Royal Society, Seoul National University, Getty Locations: Sweden, Seongnam, South Korea
One of the most helpful things to do might be to get some exercise, according to a new study. “It gives us an idea of something that maybe we don’t always think about for treatment of insomnia,” Paruthi said. Regular exercise was associated with significantly better sleep, the study showed. There are plenty of reasons why physical activity may help in getting a good night’s rest. Physical activity helps regulate the body’s internal clock and promotes deeper, more restorative sleep,” Björnsdóttir said.
Persons: , Erla, sleepiness, David Neubauer, ” Björnsdóttir, Shalini Paruthi, ” Paruthi, Neubauer, Paruthi Organizations: CNN’s, CNN, Reykjavik University, Johns Hopkins University School of Medicine, Saint Louis University School of Medicine, American Academy of Sleep
Waking up several times throughout the night is a natural occurrence often due to sleep architecture, which are the stages of sleep that one cycles through every night. When people naturally wake up in the night, they are more likely to remember it happening during the second half of the night. That’s when people typically have longer REM stage, light sleep, while the first half of the night has longer stages of deep sleep instead. The most important thing to do when waking up in the middle of the night is to resist looking at the clock, Peters-Mathews said. It’s also important to ensure the awakenings are not happening from something external, such as disturbances from your sleep partner, Peters-Mathews said.
Persons: Brandon Peters, Mathews, ” Peters, , , Michelle Drerup, Drerup, that’s, ” Drerup, It’s, Peters, Cathy Goldstein, Goldstein, we’re, ” Goldstein, — Goldstein, it’s Organizations: CNN, Virginia Mason Franciscan Health, Sleep, Cleveland Clinic, University of Michigan Health, University of Michigan Sleep Disorders Locations: Virginia, Seattle, Ann Arbor
How to adapt your sleep to Daylight Saving Time
  + stars: | 2024-03-09 | by ( Katia Hetter | ) edition.cnn.com   time to read: +6 min
CNN —I know I’m supposed to gradually go to bed and get up earlier over the course of a week or two before Daylight Saving Time hits. CNN: Daylight Saving Time starts Sunday at 2 a.m. Dasgupta: If you find yourself grappling with significant daytime sleepiness in the days after switching to daylight saving time, a short nap before 2 p.m. may be beneficial. Although there are many components of healthy sleep hygiene, some of my favorite tips following the transition to Daylight Saving Time are:1. Remember, with all the focus on your kid’s sleep, don’t forget to take care of yourself, too.
Persons: CNN —, Raj Dasgupta, haven’t, Dasgupta, you’ve, It’s, — Aiden, Mina, Sadie Organizations: CNN, Huntington Heath Locations: Huntington,
When Yaneth Flores first moved to Albany, in upstate New York, in 2008, she needed some time to get used to the sleepiness of a small city. She had been working at a fish market near Boston, where she lived after fleeing violence and a bleak economy in El Salvador. She met her husband in Albany and eventually settled into life there. But ever since the start of the pandemic, she has not been not herself. Ms. Flores managed child care duties from home for their young daughter, who was born premature and developed asthma.
Persons: Yaneth Flores, Flores, , Locations: Albany, New York, Boston, El Salvador
Lyew identifies as a highly sensitive person or HSP, a term popularized by psychology researcher Elaine Aron. AdvertisementImi Lo , a mental health consultant who works with highly sensitive clients, said that more awareness of HSPs is important. You may have some sensory sensitivitiesHSPs "can be quite physically sensitive," Lo said, whether they're bothered by uncomfortable clothing, strong smells, or loud noises. Being put on the spot can also cause a highly sensitive person's mind to go blank. "If you know that you are highly sensitive, then you can actually do things to manage your sensitivity, and even use it as a strength," she said.
Persons: , Sylina Lyew, Elaine Aron, Lyew, you've, Lo, they're, HSPs, Aron Organizations: Service
The lack of sunlight from shorter winter days can bring on depressive symptoms, and social isolation is common among people with seasonal affective disorder. BenAkiba/E+/Getty ImagesTaking care of your health is key to dealing with seasonal affective disorder. Here’s what experts say you can do to manage seasonal affective disorder. Social isolation is common among people with seasonal affective disorder, and isolating may contribute to depressive symptoms. Antidepressants are another option that Manu recommended for people with severe seasonal affective disorder.
Persons: Joseph Takahashi, , Jason Tucciarone, ” Tucciarone, Tucciarone, Thomas Kilkenny, Kilkenny, Lucian Manu, Manu, Jocelyn Solis, Moreira Organizations: CNN, University of Texas Southwestern Medical Center, Stanford University School of Medicine, Northwell Health, Kilkenny, , Stony Brook Medicine Locations: New York, Tucciarone, Stony
CNN —If TikTok and Reddit influencers are to be believed, the plant-based compound called berberine can be a replacement for such popular diabetes and weight loss drugs as Ozempic and Wegovy. Is berberine’s weight loss effect meaningful? Berberine may enhance the body’s natural production of GLP-1, or glucagon-like peptide 1, a gastrointestinal hormone that’s used in Ozempic and other new weight loss drugs. However, in terms of its weight loss benefits, they are modest at best,” he said. “Metformin lowers blood sugar, and berberine lowers blood sugar,” Levitt said.
Persons: Berberine, , , Caroline Apovian, Justin Ryder, Ryder, Joshua Levitt, Ashurbanipal, ” Levitt, Gaston Ernesto Gonzalez Avila, Levitt Organizations: CNN, US Food and Drug Administration, Harvard Medical School, Center, Weight Management, Wellness, Brigham, Women’s Hospital, Northwestern University’s Feinberg School of Medicine, BMI, National Library of Medicine, FDA, American Chemical Society Locations: Boston, Chicago, Ayurveda, Hamden , Connecticut
What is sleep apnea and how is it treated?
  + stars: | 2023-06-28 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +5 min
The condition is called “obstructive” sleep apnea because unlike central sleep apnea — in which the brain occasionally skips telling the body to breathe — obstructive sleep apnea is due to a blockage of the airways by weak, heavy or relaxed soft tissues. Muscle tone weakens with age, including in the soft palate and neck, making sleep apnea common among people older than 50, experts say. Biden’s getting treatmentIf left untreated, obstructive sleep apnea raises the risk of hypertension, heart disease, type 2 diabetes, depression and even an early death, according to the American Academy of Sleep Medicine. Deep sleep is considered one of the best markers of sleep quality, because a person must typically have relatively uninterrupted sleep to achieve it. Anyone with symptoms of sleep apnea need to be evaluated by a sleep specialist.
Persons: Joe Biden Organizations: CNN, American Academy of Sleep, Mayo Clinic, US Centers for Disease Control, Prevention
Stroke risk is typically higher in older adults with more health problems, the study noted. After controlling for other factors that contribute to stroke risk, researchers found people with five to eight symptoms of insomnia had a 51% increased risk of stroke compared with people who did not have insomnia, according to a statement on the study published Wednesday in the journal Neurology. In comparison, people who had one to four symptoms had a 16% increased risk of stroke compared with people with no symptoms of insomnia, the study found. Getting more than nine hours of sleep on average was linked with a twofold increase in stroke risk. However, taking a planned nap of less than an hour was not associated with an increased stroke risk, the study said.
Persons: , epidemiologist Wendemi, snored, Napping, Phyllis Zee, ” Zee, Andrew Freeman Organizations: CNN, Mayo Clinic, Virginia Commonwealth University, US Centers for Disease Control, Center, Northwestern University’s Feinberg School of Medicine, Jewish Health Locations: Richmond, Chicago, Denver
Red light therapy: How it affects sleep
  + stars: | 2023-06-01 | by ( Kristen Rogers | ) edition.cnn.com   time to read: +7 min
CNN —Red light therapy has been found to be helpful for skin health, wound healing, hair growth among people with alopecia and pain management. “That’s why when we talk about blue light or red light, we’re not talking about a red-colored light bulb. A 2019 study led by Figueiro looked into whether delivering red light to closed eyes during sleep — using a red light mask — and to open eyes upon waking — via red light goggles — reduced sleep inertia among 30 adults. In other words, it might be that any benefits come from replacing the light you’re exposed to before sleep with red light, rather than adding the latter during sleep. The bottom line is that when it comes to sleep, “what’s better than red light is no light,” Dasgupta said.
Persons: , Raj Dasgupta, , ” Dasgupta, , Dasgupta, Joshua Tal, Mariana Figueiro, Figueiro, who’s, ” Figueiro Organizations: CNN, US Centers for Disease Control, University of Southern California’s Keck School of Medicine, Mount Sinai, Health Research Center, Icahn School of Medicine Locations: China, New York City, Mount Sinai
However, people who snore heavily or who have sleep apnea can experience hundreds of mini-arousals per night — even though they don’t realize it. The study group underwent brain scans, memory tests that were repeated at about 21 months, and an overnight sleep study done at their homes. Severe sleep apnea was associated with worrisome changes in the brains of middle-aged and older adults, a July 2018 study found. “We surmise that hypoxia may also have a deleterious effect on the volume of the regions of the medial temporal lobe. Studies such as these reinforce the need to be assessed by a sleep specialist and treated for sleep apnea.
Persons: , Géraldine Rauchs, ” Rauchs, , Rudy Tanzi, ” Tanzi, Tanzi, Rauchs Organizations: CNN, National Institute of Health, Medical Research, Harvard Medical School, Massachusetts General Hospital Locations: Caen, France, Boston, Massachusetts
When we've been awake for a long time, our sleep drive kicks in and tells us we need to sleep. During REM sleep, the cortex – responsible for cognition and emotion-processing – is activated in some regions and deactivated in others. After cycling through non-REM and REM sleep around 4 to 5 times, the basal forebrain and other structures receive signals to start exiting sleep. WHEN SLEEP GOES WRONGIn the U.S. alone, 50 to 70 million people experience some type of chronic sleep disorder, according to the American Academy of Sleep Medicine (AASM). In the United States, a list of board-certified sleep medicine physicians and accredited sleep disorders centers is available from the American Academy of Sleep Medicine.
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