This helped push the Dow Jones Transport Average index (.DJT) down 3.6%, for its biggest one-day drop since September.
The Nasdaq Composite (.IXIC) dropped 238.05 points, or 1.98%, to 11,799.16 in its biggest one-day percentage decline since March 9.
The KBW Regional Banking index (.KRX) dropped 3.9% as First Republic (FRC.N) shares fell 49%, hitting a record low.
General Motors Co (GM.N) shares fell 4% after it cautioned that 2022 price gains will not last as the year goes on, even as it lifted full-year profit and cash flow forecasts.
On U.S. exchanges 10.78 billion shares traded compared with the 10.32 billion average for the last 20 sessions.