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Amazon Prime Video's "The Legend of Vox Machina" is one of the many shows using animation from independent studio Titmouse Animation. Amazon StudiosThere's a powerhouse in the entertainment industry that remains unknown to many casual cartoon viewers — it's called Titmouse Animation. Titmouse worked on Disney's "Star Wars Galaxy of Adventures," a series of animated shorts set in the Star Wars universe. "When we were looking at animation studios, Chris [Prynoski] made it really clear that Titmouse wanted to get into prime-time-style adult animation and that their No. Netflix's "Big Mouth" was produced through Titmouse's animation studio.
Persons: it's, haven't, you've, Chris Prynoski, doesn't, Titmouse, Prynoski, we've, Chris, Shannon Prynoski, Daria, Beavis, Ben Kalina, they've, Kalina, Andrew Goldberg Organizations: Amazon, Amazon Studios, Netflix, Paramount, Hollywood, Disney, Universal, MTV, Cartoon Network, MTV Animation, Wars Galaxy, Star Wars, Warner Bros
The off-duty Alaska Airlines pilot accused of trying to shut down the engines of an airborne plane last year spoke on the incident for the first time. The plane, Flight 2059 operated by Alaska Airlines subsidiary Horizon Air, was traveling from Everett, Washington, to San Francisco and was diverted to Portland. "I did something unfathomable to me, something I have to take responsibility for and I regret," he said. "There was a feeling of being trapped, like am I trapped in this airplane?" Emerson was initially charged with more than 80 counts of attempted murder, but those charges where reduced to reckless endangerment.
Persons: ABC's, Joseph Emerson, Emerson, GMA's Gio Benitez, Noah Horst, , Joe Organizations: Alaska Airlines, Horizon Locations: Everett , Washington, San Francisco, Portland
The drug company Lykos Therapeutics had spent much of this year expecting to vault to meteoric heights. It had sent an application to the Food and Drug Administration seeking approval to use MDMA to treat post-traumatic stress disorder. It was the capstone to months of increasingly loud concerns being voiced over the quality of Lykos’s clinical trials. Lykos has spent years conducting clinical trials testing whether MDMA-assisted psychotherapy could alleviate the symptoms of PTSD. Its most recent drug trial showed that more than 86 percent of people treated had a measurable reduction in symptom severity.
Persons: , Lykos Organizations: Lykos Therapeutics, Food and Drug Administration, Lykos, Merck
The initial application from Lykos presented positive data from two late-stage clinical trials that used MDMA in combination with talk therapy to treat PTSD. The advisers said it was also difficult to parse how much the accompanying talk therapy — an area that the FDA does not regulate — contributed to outcomes. Advocates for the treatment, including some veterans groups, said they were “incredibly disappointed” by the FDA decision. Dozens of clinical trials involving psychedelics are in various stages, and additional scrutiny can help strengthen the findings and build confidence. Psychopharmacology did not allow the study authors to publish a correction with data that excluded findings from one study site, said Allison Feduccia, an author in all three retracted studies.
Persons: Lykos, , ” Martin Steele, Brett Waters, , Rachel Yehuda, , , Michael Bogenschutz, Yehuda, It’s, Lori Bruce, Psychopharmacology, caressed, “ it’s, Amy Emerson, ” Lykos, Allison Feduccia, Dr, Sanjay Gupta, Brian Barnett, ” Bruce, Nadia Kounang Organizations: CNN, Food and Drug Administration, Lykos Therapeutics, FDA, Veteran Mental Health Leadership Coalition, Hope, Center, Psychedelic Psychotherapy, Mount, Icahn, of Medicine, NYU Langone Center, Psychedelic Medicine, Oxford, NUS, Neuroethics, Interdisciplinary Center, Bioethics, Yale University, , Multidisciplinary Association for Psychedelic Studies, Health Canada, Institutional, Board, CNN Health, Cleveland Clinic Locations: Canada,
The journal Psychopharmacology has retracted three papers about MDMA-assisted therapy based on what the publication said was unethical conduct at one of the study sites where the research took place. Several of the papers’ authors are affiliated with Lykos Therapeutics, the drug company whose application for MDMA-assisted therapy to treat post-traumatic stress disorder was rejected last week by the Food and Drug Administration. The company said the research in the retracted papers was not part of its application to the F.D.A. has asked Lykos to conduct an additional clinical trial of its MDMA-assisted therapy, which would have been the first psychedelic medicine to win approval by federal regulators. Lykos has said it would appeal the decision.
Persons: Lykos Organizations: Lykos Therapeutics, Food and Drug Administration
Tracey Tee founded Moms on Mushrooms, a platform where moms can discuss, both online and in person, their interest and experiences with microdosing psilocybin mushrooms. "Some girlfriends invited me to a camping trip that summer [in 2020] to just camp out with some moms," Tee says. She lives in Colorado where psilocybin mushrooms are legal to grow, use and share. So, Tee sought out an alternative solution for managing her mental health as she began to wean herself off the SSRI: microdosing psilocybin mushrooms. Moms on Mushrooms is the platform Tee created for moms to discuss their interest and experiences with psilocybin mushrooms.
Persons: Tracey Tee, Tee, that's, wean, Tee wasn't, Microdosing, microdosing, Louis, Joshua Siegel, Siegel Organizations: Lancet, Facebook, CNBC, Washington University School of Medicine, Washington University, NYU Langone Health, Center, Psychedelic Medicine, Psychedelic Locations: Colorado, St
If approved, it would have been the first new treatment for PTSD in more than two decades. Lykos Therapeutics had asked the FDA to approve the drug as part of a treatment regimen, given alongside talk therapy. Lykos Therapeutics had asked the FDA to approve the drug as part of a treatment regimen, given alongside talk therapy. Lykos added that the agency expressed concerns similar to those raised during the advisory committee meeting in June. Davis Institute for Psychedelics and Neurotherapeutics, said he doesn’t think the FDA decision will hinder the development of psychedelics for mental health disorders, including PTSD.
Persons: , , Holly Fernandez Lynch, Lykos, Amy Emerson, Sarah Silbiger, David Olson, Olson, ” Olson, Brian Barnett, ” Barnett, Joe Biden, Biden, Robert Califf, ” Lynch, psychedelics, David Rind Organizations: Drug Administration, Therapeutics, FDA, Lykos Therapeutics, University of Pennsylvania, Davis Institute for Psychedelics, Cleveland Clinic, Clinical Locations: U.S, White Oak, Md, Ohio
The Food and Drug Administration on Friday declined to approve MDMA-assisted therapy for the treatment of post-traumatic stress disorder, dealing a serious blow to the nascent field of psychedelic medicine and dashing the hopes of many Americans who are desperate for new treatments. An additional clinical trial could add years, and millions of dollars, to the approval process. If approved, MDMA would have become the first psychedelic compound to be regulated by federal health authorities. “This is an earthquake for those in the field who thought F.D.A. approval would be a cinch,” said Michael Pollan, the best-selling author and co-founder of the UC Berkeley Center for the Science of Psychedelics.
Persons: F.D.A, , Michael Pollan Organizations: Drug Administration, Lykos Therapeutics, UC Berkeley Center, Psychedelics
You can opt-out at any time by visiting our Preferences page or by clicking "unsubscribe" at the bottom of the email. Congress created the Shuttered Venue Operators Grant in 2021 to help theaters and indie music venues stay in business during the pandemic lockdowns. A 2023 Business Insider investigation found that dozens of wealthy musicians used ineffective oversight and loopholes in the law to line their pockets. But once the law was passed, Strickland said he focused on helping as many people get money as possible. According to an email, he ended up telling NKSFB to pull the application, figuring he was being fed "BS" by a consultant.
Persons: Post Malone, Chris Brown, Nickelback, Lil Wayne, didn't, , Paul Anka —, David Hickok, Hickok, Bessy Wong, Mickey Segal, Anka, Segal, NKSFB, Kyle Leunissen, Suicideboys, Michael Strickland, Lites, Strickland, Paul Anka Organizations: Service, Small Business Administration, Business, Post, SBA, BI, Billboard Locations: Angeles, American, NKSFB
There could be risks involved with using psychedelics, and research is still being done to evaluate therapeutic uses. Barry, now my husband, was the person who introduced me to LSD almost 50 years ago when I was 23. Barry and I use psychedelics on average two or three times a year. For example, not long ago, we thought we'd take acid while camping in southern Oregon, but I got poison oak. They really are the key to the success of our long-lasting marriage.
Persons: Barry, Barry scribbled, Louisa, Sarah Louisa, Michael Pollan, Psychedelics, I've, , it's Organizations: Service, Business Locations: Manning, British, Oregon
Read previewAdministered ketamine is being used in concert with therapy to treat Ukrainian veterans who experience post-traumatic stress disorder from fighting on the battlefield. AdvertisementA study published earlier this year focused on the treatment of depression among veterans using ketamine taken through an IV. The doses provided at least partial relief to many of the test subjects and after six weeks of ketamine infusions, depression scores dropped significantly. "Soldiers, for them, it's natural to consider themselves like a strong man," Matrenitsky said, explaining that the effects of the ketamine therapy allow individuals to overcome defensive barriers over their emotions. In partnership with Heal Ukraine Trauma, Matrenitsky along with other healthcare professionals have teamed up to form the Ketamine-Assisted Psychotherapy initiative in hopes of educating Ukrainian therapists on Ketamine-Assisted Therapy.
Persons: , Elaine Klein, Julia Rendleman, Dr, Vladislav Matrenitsky, Yulia Brockdorf, Wolfgang Schwan, Matrenitsky, Bandura, Paula Reynal, Klein Organizations: Service, Business, Heal, Washington, Center, Psychotherapy, 24th Brigade, Getty, Strategic, International Studies Locations: American, Ukraine, US, Kyiv, Anadolu, That's, Washington
This is a healthy brain on psilocybin
  + stars: | 2024-07-17 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +8 min
It wasn’t until his brain morphed into a computer, however, that he knew for sure he was on a psychedelic trip. “We found that psilocybin desynchronizes the brain,” said co-senior author Ginger Nichols of the study published Wednesday in the journal Nature. “When psilocybin is on board, the brain is disconnecting from its typical pathways and reconnecting to different parts of the brain,” said Nichols, an associate professor of psychiatry at Washington University School of Medicine in St. Louis. “Science doesn’t fully understand the brain yet, but I felt as if I suddenly knew exactly how the brain works. Sara Moser/Washington University School of MedicineA window for changeScans showed that in the days after the psilocybin trip, most brain networks returned to normal.
Persons: Dr, Nico Dosenbach wasn’t, he’d, it’s, , Dosenbach, St . Louis, , ” Dosenbach, Ginger Nichols, Nichols, ” Nichols, psychotherapists, Petros Petridis, ” Petridis, Sara Moser Organizations: CNN, Washington University School of Medicine, US Food and Drug Administration, NYU Langone Center, Psychedelic Medicine, Washington University School of Locations: , St ., Oregon, New York City, reconnection
This Is Literally Your Brain on Drugs
  + stars: | 2024-07-17 | by ( Andrew Jacobs | ) www.nytimes.com   time to read: +1 min
The image, as it happens, comes from dozens of brain scans produced by researchers at Washington University School of Medicine in St. Louis who gave psilocybin, the compound in “magic mushrooms,” to participants in a study before sending them into a functional M.R.I. The kaleidoscopic whirl of colors they recorded is essentially a heat map of brain changes, with the red, orange and yellow hues reflecting a significant departure from normal activity patterns. The blues and greens reflect normal brain activity that occurs in the so-called functional networks, the neural communication pathways that connect different regions of the brain. The scans, published Wednesday in the journal Nature, offer a rare glimpse into the wild neural storm associated with mind-altering drugs. “Psilocybin, in contrast to any other drug we’ve tested, has this massive effect on the whole brain that was pretty unexpected,” said Dr. Nico Dosenbach, a professor of neurology at Washington University and a senior author of the study.
Persons: Louis, , Nico Dosenbach Organizations: Washington University School of Medicine, Washington University Locations: St
"It layers on, these losses, these injuries, the ungrieved pain," Brockdorf told Business Insider. Ukrainian soldiers walk past a volunteer bus burning after a Russian drone hit it near Bakhmut. Ukrainian soldiers firing mortars from trench positions. Pierre Crom/Getty ImagesSome of Ukraine's soldiers have been serving on the front lines for long stretches as Ukraine grapples with manpower shortages. AdvertisementAnd, indeed, that damage can be lasting, which is why Brockdorf says it's important to be there for Ukrainian soldiers.
Persons: , Yulia Brockdorf, Brockdorf, she's, DAWN, Shandyba Mykyta, Vladislav Matrenitsky, Matrenitsky, Pierre Crom, Mark Hertling, Ryan Pickrell Organizations: Service, Business, Mountain Assault, AP, Center, Psychotherapy, Ukrainian, Washington Post, US Army, CNN Locations: Ukraine, Russian, Bakhmut, Ukrainian, Europe, Kyiv
Meinert started going to food therapists at five years old, but it wasn't until she tried psilocybin — the psychedelic property in "magic" mushrooms — that she felt her symptoms fade. A lifelong struggle with foodDanielle Meinert eating Mexican food with ingredients that she used to find scary. Still, Meinert felt progress was agonizingly slow and involved "force-feeding" herself foods that scared her. An eating disorder treatment in 'magic' mushrooms? Unlocking motivation to do hard thingsDanielle Meinert happily eating a range of foods after her psilocybin session.
Persons: , Danielle Meinert, Meinert, ARFID, Michael Pollan's, Johns Hopkins, Natalie Gukasyan, Gukasyan, nervosa, I'd, you've Organizations: Service, Business, Columbia University Irving Medical Center
The Wide, Wide World of Judy Chicago
  + stars: | 2024-07-03 | by ( Emily Labarge | ) www.nytimes.com   time to read: +1 min
Like all women and all art, Judy Chicago contains multitudes. Across venues in Britain and France, six decades of Chicago’s distinctly feminist oeuvre show a remarkable range. Minimalist sculptures; psychedelic spray-painted car hoods; landscapes billowing with bright plumes of smoke; and paintings of swirling, hallucinatory flowers fill the galleries with Chicago’s hallmark bright colors and undulating line. Many works incorporate personal texts in tidy, looping cursive about gendered rejection, shame, longing and anger. These works foreground the female nude, its life-giving properties and implicit connection to the natural world.
Persons: Judy Chicago, Locations: Britain, France
CNN —The US Food and Drug Administration is warning consumers and retailers to not “eat, sell or serve” any of Diamond Shruumz-brand’s microdosing chocolate bars after people across four states were left hospitalized. Eight people reported falling ill after eating Diamond Shruumz’s chocolates, the FDA said in an advisory. People who consumed the chocolate bars reported experiencing symptoms that include “seizures, central nervous system depression (loss of consciousness, confusion, sleepiness), agitation, abnormal heart rates, hyper and hypotension, nausea and vomiting,” said the FDA. CNN has reached out to Diamond Shruumz for comment but has not heard back by the time of publishing. If you or someone you know becomes ill after consuming Diamond Shruumz’s chocolate bars, the FDA recommends speaking to a health care provider and/or contacting the Poison Help Line at 1-800-222-1222.
Persons: Diamond, , Dr, Sanjay Gupta, Diamond Shruumz Organizations: CNN, Food and Drug Administration, FDA, People, CNN Health, US Centers for Disease Control, Centers Locations: Arizona, Indiana, Nevada, Pennsylvania
At least eight people in four states have fallen ill after eating Diamond Shruumz-brand Microdosing Chocolate Bars, including several who had seizures or lost consciousness and needed to be placed on ventilators. Diamond Shruumz has marketed the chocolates as “trippy little squares” and calls the chocolate a “microdose,” referring to a term for a small amount of a psychedelic. But the company has said the bars do not contain psychedelic substances, including psilocybin, the hallucinogenic drug found in so-called magic mushrooms. Instead, Diamond Shruumz says its products have “nootropic and functional mushrooms,” like Lion’s Mane, Reishi and Chaga mushrooms. The Food and Drug Administration and Centers for Disease Control and Prevention are working with poison control centers and state health agencies to investigate the cause of the illnesses.
Persons: Diamond, Diamond Shruumz Organizations: Drug Administration, Centers for Disease Control
The FDA is investigating Diamond Shruumz-brand microdosing chocolate bars. Eight people fell ill after consuming the product, the agency said. Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . AdvertisementEight people in four states fell ill after consuming Diamond Shruumz-brand microdosing chocolate bars, the FDA said on Friday.
Persons: Diamond, , Microdosing, It's, they've Organizations: FDA, Service, Business Locations: Silicon Valley
F.D.A. Panel Weighs MDMA Therapy and Its Risks
  + stars: | 2024-06-04 | by ( Andrew Jacobs | ) www.nytimes.com   time to read: +1 min
The Food and Drug Administration is weighing whether to approve the use of MDMA, also known as Ecstasy, for treatment of post-traumatic stress disorder. An independent advisory panel of experts will review studies on Tuesday and is expected to vote on whether the treatment would be effective and whether its benefits outweigh the risks. The panel will hear from Lykos Therapeutics, which has submitted evidence from clinical trials in an effort to obtain agency approval to sell the drug legally to treat people with a combination of MDMA and talk therapy. Methylenedioxymethamphetamine (MDMA) is a synthetic psychoactive drug first developed by Merck in 1912. After being resynthesized in the mid-1970s by Alexander Shulgin, a psychedelic chemist in the Bay Area, MDMA gained popularity among therapists.
Persons: Alexander Shulgin Organizations: Drug Administration, Lykos Therapeutics, Merck Locations: Bay
The Food and Drug Administration on Friday raised concerns about the health effects of MDMA as a treatment for post-traumatic stress disorder, citing flaws in a company’s studies that could pose major obstacles to approval of a treatment anticipated to help people struggling with the condition. The agency said that bias had seeped into the studies because participants and therapists were readily able to figure out who got MDMA versus a placebo. It also flagged “significant increases” in blood pressure and pulse rates that could “trigger cardiovascular events.”The staff analysis was conducted for an independent advisory panel that will meet Tuesday to consider an application by Lykos Therapeutics for the use of MDMA-assisted therapy. The agency’s concerns highlight the unique and complex issues facing regulators as they weigh the therapeutic value of an illegal drug commonly known as Ecstasy that has long been associated with all-night raves and cuddle puddles. Approval would mark a seismic change in the nation’s tortuous relationship with psychedelic compounds, most of which the Drug Enforcement Administration classifies as illegal substances that have “no currently accepted medical use and a high potential for abuse.”
Persons: Organizations: Drug Administration, Lykos Therapeutics, Drug
The use of weed to replace alcohol is a growing trend in the United States. “We know that moderate alcohol consumption has health risks, and risk increases as alcohol consumption increases,” Boyd said in an email. “Cannabis smoke contains toxins, carcinogens, and particulate matter that have been linked to cancer, lung damage, and cardiovascular disease,” Cohen said in an email. Research on edibles, such as baked goods, candies and beverages, and other methods of using cannabis is in its infancy. “In and of itself, it’s not good that more people are using cannabis,” Grinspoon said.
Persons: CNN —, , , , “ I’ve, Carol Boyd, ” Boyd, Weed, Peter Grinspoon, ” “, ” Grinspoon, Beth Cohen, ” Cohen, I’m, Boyd, ” Robert Page II, Grinspoon, ideation, it’s Organizations: CNN, National Survey, Center, Drugs, University of Michigan, US Centers for Disease Control, Massachusetts General Hospital, Marijuana, University of California, University of Colorado Skaggs School of Pharmacy, Pharmaceutical Sciences, Drug, Food and Drug Administration, National Poison Center, FDA, Lifeline Locations: United States, Washington, Ann Arbor, Boston, San Francisco, Aurora, Georgia
Here are the biggest calls on Wall Street on Wednesday: Bernstein reiterates Nvidia as outperform Bernstein said it's sticking with its outperform rating on the stock. " Argus upgrades Berkshire Hathaway to buy from hold Argus said it's getting bullish on shares of Warren Buffett's multinational conglomerate. UBS reiterates First Solar as buy UBS raised its price target on First Solar to $350 per share from $270. Bank of America reiterates Apple as buy Bank of America said it's bullish on top pick Apple and its entry into iPhones with AI. Bank of America reiterates Dell as buy Bank of America raised its price target on Dell to $180 per share from $130.
Persons: Bernstein, Berkshire Hathaway, Argus, it's, Fluence, LBRT, Jefferies, TD Cowen, Medpace, Cowen, Morgan Stanley, JPMorgan, Wells, Baird, MM120, Truist, Dell, Jack Hartung, Cindy Olsen Organizations: Nvidia, Argus, Warren, UBS, Citi, Liberty Energy, United Airlines, Airlines, American Airlines, " Bank of America, Apple, Bank of America, Netflix, Disney, RBC, Eldorado, Eldorado Gold, BTC, Citi downgrades Bank, JPMorgan, Mind, of America, Norwegian Cruise Line Holdings, Dell, Field Locations: Berkshire, U.S, OFS, United, El Paso, Parks, F4Q, CAVA, Chicago
Ms. Shanahan, 38, a onetime Silicon Valley lawyer, has never held public office and has scant name recognition. But she was selected after Mr. Rodgers and Mr. Ventura fell through as vice-presidential candidates and Mr. Kennedy’s campaign needed money to fund its efforts to get onto state ballots, three people familiar with the events said. And money was something that Ms. Shanahan could provide in abundance. During their five-year marriage, Ms. Shanahan partied with Silicon Valley’s elite and used recreational drugs including cocaine, ketamine and psychedelic mushrooms, according to eight people and documents reviewed by The New York Times. Ms. Shanahan and Mr. Brin separated after she had a sexual encounter with Elon Musk in 2021, three of the people said.
Persons: Robert F, Kennedy Jr, Aaron Rodgers, Jesse Ventura, Kennedy, Nicole Shanahan, Ms, Shanahan, Rodgers, Ventura, Sergey Brin, Brin, Elon Musk Organizations: Google, The New York Times Locations: Minnesota
The police in Los Angeles are working with the Drug Enforcement Administration to investigate the source of the ketamine that caused the death of the actor Matthew Perry in October, the authorities said on Tuesday. The inquiry began after investigators determined that ketamine, an anesthetic with psychedelic properties, was the cause of Mr. Perry’s death, Capt. Scot Williams of the Los Angeles Police Department said in a brief interview. Captain Williams said investigators would seek to discover whether the ketamine was obtained legally. TMZ reported earlier that the authorities were still looking into the source of the ketamine.
Persons: Matthew Perry, Perry’s, Scot Williams, Perry, superstardom, Chandler Bing, , Captain Williams Organizations: Drug, Administration, Los Angeles Police Department, TMZ Locations: Los Angeles, Los Angeles County
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