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A Mammoth First: 52,000-Year-Old DNA, in 3-D
  + stars: | 2024-07-11 | by ( Siobhan Roberts | ) www.nytimes.com   time to read: +1 min
They probed the sample with an innovative experimental technique that revealed the three-dimensional architecture of the mammoth’s genome. Hendrik Poinar, an evolutionary geneticist at McMaster University in Canada, was “floored” — the technique had successfully captured the original geometry of long stretches of DNA, a feat never before accomplished with an ancient DNA sample. “It’s absolutely beautiful,” said Dr. Poinar, who reviewed the paper for the journal. An organism’s full genome resides in cell nuclei, in long, unfragmented DNA strands called chromosomes. “To have the actual architectural structure of the genome, which suggests gene expression patterns, that’s a whole other level,” Dr. Poinar said.
Persons: , Hendrik Poinar, , Poinar Organizations: McMaster University Locations: Houston, Copenhagen, Barcelona, Siberia, Canada
CNN —A piece of woolly mammoth skin excavated from the Siberian permafrost has been found to contain fossil chromosomes in a first-of-its-kind discovery, according to a new study. The new study revealed that fossils of ancient chromosomes survive in this skin sample. But the DNA from elephants was also needed to assemble the mammoth genome. The researchers hope to use the findings to assemble the woolly mammoth genome completely. “This structural information provides insights into functions of the woolly mammoth genome that were invisible using previous genomic methods,” Heintzman said in an email.
Persons: , Erez Lieberman Aiden, Lieberman Aiden, Olga Dudchenko, Dudchenko, Elena Kizilova, Kevin Campbell, ” Campbell, ” Dudchenko, ” Aiden, , Cynthia Pérez Estrada, ” Pérez Estrada, there’s, Adam Fotos “, Marcela Sandoval, Velasco, Pérez Estrada, Peter Heintzman, ” Heintzman, Dmitry Filatov, ” Filatov, ” Hendrik Poinar, Poinar Organizations: CNN, Baylor College of Medicine, Center, Theoretical, Rice University, of Cytology, University of Manitoba, Stockholm University, Houston Astros, Center for Genome Architecture, Baylor, Rice’s, University of Copenhagen, University of Oxford, McMaster University Locations: Belaya Gora, Siberia, Canada, Stockholm, Denmark, , Sweden, paleogenomics, United Kingdom, Ontario
The Black Death which ravaged Europe 670 years ago may still be harming humans today a study found. A scientist holds up a tooth from human remains buried in the 1300s. The Black Death, one of the greater killers in human history, was the perfect model to look at, Lee said. In just five years between 1346 and 1350, the Black Death, a pandemic caused by the bacteria Yersinia Pestis, killed tens to hundreds of millions of people, many before they were old enough to have children. Human remains being excavated from the plague pit in East Smithfield.
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