Blinken told reporters that he had sent a letter to every member of the Senate urging swift confirmation of dozens of nominees for State Department positions.
The nominations are being held back by Republican Senator Rand Paul while he seeks information from the administration on the origins of COVID-19.
The department said it currently has 62 nominees outstanding with the Senate, including 38 ambassadorial nominees.
Separately, nominations for more than 250 positions in the U.S. military are also being delayed by a single Republican - Senator Tommy Tuberville.
Most nominations are approved by Senate committees, and eventually reviewed by the full Senate, which is controlled by Biden's fellow Democrats.
Persons:
Antony Blinken, Joe Biden's, Blinken, Rand Paul, Paul, Tommy Tuberville, Tuberville, Patricia Zengerle, Simon Lewis, Rosalba O'Brien
Organizations:
State Department, Republican, Senate, Defense Department, Thomson
Locations:
U.S