Scientists have diagnosed Down syndrome from DNA in the ancient bones of seven infants, one as old as 5,500 years.
Their method, published in the journal Nature Communications, may help researchers learn more about how prehistoric societies treated people with Down syndrome and other rare conditions.
Down syndrome, which occurs in 1 in 700 babies today, is caused by an extra copy of chromosome 21.
The extra chromosome makes extra proteins, which can cause a host of changes, including heart defects and learning disabilities.
But Down syndrome — also known as trisomy 21 — is a remarkably variable disease.
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Nature Communications