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Deload weeks mostly involve toning down the intensity of your workouts. These symptoms occur gradually — meaning overtraining syndrome only becomes apparent when you are in its throes. It’s hard to say how common overtraining syndrome is because the symptoms are so vague. Deload weeks differ from rest days in that rest days generally incorporate no exercise (or only extremely light exercise) once or twice a week. Deload weeks will not only benefit your performance but also your health.
Persons: , you’ve, Daniel Brayson, Brayson Organizations: CNN, UK’s University of Westminster, British Heart Foundation, Muscular Dystrophy, Physiological Society
Hinton isn’t the first Nobel laureate to warn about the risks of the technology that he helped pioneer. Irene Joliot-Curie and Frederic Joliot shared the Nobel Prize for chemistry in 1935. AFP/Getty Images1945: Antibiotic resistanceSir Alexander Fleming shared the 1945 Nobel Prize in medicine with Ernst Chain and Sir Edward Florey for the discovery of penicillin and its application in curing bacterial infections. “I, for one, would not shrink from that challenge.”Jennifer Doudna won the Nobel Prize in chemistry in 2020 for her work on a new method of gene editing. Nobel Prize Outreach/Brittany Hosea-Small/Handout/Reuters2020: Gene editingFour years ago, Jennifer Doudna and Emmanuelle Charpentier shared the Nobel Prize in chemistry for the development of a method for genome editing called CRISPR-Cas9.
Persons: Geoffrey Hinton, , ” Hinton, John Hopfield “, Hinton, Hinton isn’t, Irene Joliot, Curie, Frederic Joliot, Marie, Pierre Curie, Joliot, , Sir Alexander Fleming, Ernst Chain, Sir Edward Florey, Fleming, underdose, Jeffrey Gerber, ” Gerber, ” Paul Berg, Tobbe, Paul Berg, Berg, Joanna Rose, it’s, Jesse Gelsinger, ” Jennifer Doudna, Brittany Hosea, Gene, Jennifer Doudna, Emmanuelle Charpentier, ” Doudna, “ We’ve, ” CNN’s Christian Edwards, Katie Hunt Organizations: CNN, Google, University of Toronto, Princeton University, Hulton, Getty, Children’s Hospital of Philadelphia, World Health Organization, Nobel, Innovative Genomics Institute Locations: AFP, , Stockholm
Analyst Corinne Johnson initiated coverage of the biopharmaceutical stock focused on unique diseases at a buy rating. "Our positive view of the company is based on what we view as multi-blockbuster, first-to-market commercial opportunities ... coupled with the scalable nature of the company's antibody oligonucleotide conjugate platform," Johnson wrote to clients. The first is del-brax, a drug designed to fight facioscapulohumeral muscular dystrophy, or FSHD — which has estimated peak sales of $2.7 billion. The other is del-desiran, a therapy to treat myotonic dystrophy type 1, or DM1 — with a predicted peak sale figure of $4 billion. Shares have soared more than 380% in 2024, reversing course after dropping more than 59% last year.
Persons: Goldman Sachs, Corinne Johnson, Johnson, what's Organizations: Avidity Biosciences, LSEG Locations: Monday's
For people with non-standard speech, it can happen in nearly every interaction with this kind of technology — Israeli company Voiceitt aims to change that. By using personalized voice models, its AI-powered speech recognition system helps people with speech impairments, caused by conditions like cerebral palsy, Parkinson’s, Down Syndrome or stroke, communicate more effectively with both people and digital devices. For Voiceitt co-founder Sara Smolley, facilitating speech recognition for non-standard speech patterns is a personal mission. “By the time I was born, she had lost most of her motor capabilities, and her speech was impacted.”Voiceitt was launched as an app in 2021 and operated as a simple vocal translator, converting non-standard speech to audio. Voiceitt has developed integrations with WebEx and ChatGPT, along with a Google Chrome extension, which convert non-standard speech to captions shown on the screen.
Persons: CNN — You’ve, Sara Smolley, , , Voiceitt, Smolley, ” Smolley, Colin Hughes, Hughes, ” Hughes, it’s anonymized Organizations: CNN, Microsoft, University of Illinois ’ Beckman Institute, Advanced Science, Technology, Apple, Union
Stocks with smaller market capitalizations are set to reap the benefits from the start of the Federal Reserve's latest rate-cutting campaign. Sarepta's total debt is more than one-and-a-half times bigger than its total equity. Civitas' total debt recently stood at about 79% of total equity. Chart's total debt currently eclipses its total equity by 1.4 times. "GTLS's core portfolio is comprised of natural gas, energy transition and renewables applications, where our outlook remains constructive," wrote analyst Devin McDermott.
Persons: Russell, Gavin Clark, Gartner, Clark, Zach Parham, Parham, Morgan Stanley, Devin McDermott Organizations: Dow Jones Industrial, Nasdaq, CNBC, Sarepta Therapeutics, ISI, Civitas Resources, Wednesday, JPMorgan, Civitas, Industries Locations: U.S, Cambridge, Sarepta, Friday's
Gypsy Rose Blanchard and her boyfriend will soon be the proud parents of a baby girl. TODAY.com has reached out to Blanchard, Urker, and Anderson for comment but did not hear back at the time of publication. In her video, titled “I’m Pregnant, My Journey So Far,” Gypsy Rose Blanchard revealed she was 11 weeks pregnant and was due in January 2025. Dee Dee Blanchard, Gypsy Rose Blanchard’s mother, “was convinced Gypsy suffered from a wide range of health issues,” according to Ozarks First. Gypsy Rose Blanchard detailed how she was forced to use both a wheelchair and an oxygen tank although she required neither, according to the Springfield News-Leader.
Persons: Rose Blanchard, Blanchard, Ken Urker, ” Blanchard, Urker, ” Blanchard teed, , It’s, “ Ken, We’re, Ryan Anderson, , TODAY.com, Anderson, Clauddine “ Dee Dee ” Blanchard, . Blanchard, anyone’s, ” “, Dee Dee Blanchard, Gypsy Rose, Gypsy, Gypsy Rose Blanchard, Nicholas Godejohn, Godejohn, “ I’m, I’m, she’s, Ken, Poor Ken, “ He’s, He’s, Rod, Kristy’s, Kristy, ovulating Organizations: Springfield News, Potosi Correctional Center, The Springfield News, People Locations: Louisiana, Urker, Potosi
So I thought, ‘Let me see if I can go to the Athens Olympics. An unexpected opportunityOmaira got to watch the final dress rehearsal of the opening ceremony of the Athens 2004 Olympic Games on August 13, 2004. And then Omaira was off to work at the shooting center, where the Games’ shooting events were held. But while Omaira was cultivating a pretty heady crush, Dimitris didn’t really have time to engage with his potential feelings. Omaira GillThis year marks 20 years since Omaira and Dimitris crossed paths at the Athens Olympics.
Persons: CNN — Omaira Gill, ” Omaira, ‘ I’m, , , Omaira, ’ ”, … ’, , , Omaira didn’t, “ I’d, David Gray MD, she’d, ’ Omaira Gill, Dimitris Athanasiou, Dimitris, , they’re, ” Dimitris, ” Dimitris ’, hadn’t, Dimitris who’d, he’d, Dimtiris, Dimitris didn’t, Dimitris quizzed, “ Will, She’d, I’m, … ’ ”, couldn’t, didn’t, “ You’ve, Dimitris ’, that’s, we’d, Omaira Gill, Paulo Coelho, “ Omaira, ” Here's Dimitris, Omaira Gill Omaira, Hermes, Dimitiris, Hector, Orion, they’ll, “ Hermes, We’re, Dimitris – Organizations: CNN, Olympic, CNN Travel, Athens, , ‘ Volunteers, Uni, Reuters, Olympics, Olympic Games, Paralympic, MSN, Omaira, , Athens Olympics, Stade de France, Disneyland Locations: Athens, Greece, Birmingham, United Kingdom, London, inbox, Omaira, Pakistan, India, Paris, Disneyland Paris, Europe
Gypsy Rose Blanchard is pregnant
  + stars: | 2024-07-09 | by ( Lisa Respers France | ) edition.cnn.com   time to read: +2 min
CNN —Gypsy Rose Blanchard, who served eight and a half years for helping to kill her abusive mother, announced Tuesday that she is set to become a mother herself. Blanchard shared the news on social media that and her ex-fiancé, Ken Urker, are expecting their first child. “It’s not about anything other than the tiny little life that’s inside you that you are now in charge of protecting.”“And that little tiny life is a baby, a little tiny human that’s yours,” she added as she got emotional. Gypsy Rose Blanchard pleaded guilty to second-degree murder in 2016. Soon after their breakup, Blanchard married Louisiana teacher Ryan Anderson in a prison wedding ceremony in July 2022 before parting ways in March.
Persons: Rose Blanchard, Blanchard, Ken Urker, , , ” Blachard, it’s, “ It’s, ” Blanchard, Dee Dee Blanchard, Nicholas Godejohn, Urker, Ryan Anderson, CNN’s Elizabeth Wagmeister, Harmeet Kaur Organizations: CNN, Prosecutors Locations: Springfield , Missouri, Louisiana
Editor’s Note: Luis “Vance” Taylor is the chief of the Office of Access and Functional Needs at the California Governor’s Office of Emergency Services. And for some individuals with access and functional needs, it was a nightmare. Unfortunately, nobody from the emergency management team had told the accessible transportation provider that they were part of the plan. Yet virtually all disasters have one critical commonality: They disproportionately impact individuals with access and functional needs, such as people with disabilities and older adults. Inclusive emergency management is an achievable mission.
Persons: Luis “ Vance ” Taylor, Taylor, CNN — I’ll, I’ve, there’s, Vance Taylor, Elijah Nouvelage, arth, I’m, you’re, Bill de Blasio, Jonathan Lamberton, Andy Katz, There’s, Allen J, we’re Organizations: California Governor’s, Emergency Services, CNN, Operations Center, Governor's, Emergency, Centers for Disease Control, New, Emergency Management, Pacific Press, California State Operations Center, Los Angeles Times, Getty, Twitter, Facebook Locations: California, Oroville, United States, Sierra Nevada, Sacramento, Oroville , California, New York City, , California
This report is from today's CNBC Daily Open, our international markets newsletter. CNBC Daily Open brings investors up to speed on everything they need to know, no matter where they are. The tech-centric Nasdaq Composite remained flat, while the Dow Jones Industrial Average had its best week since May, rising 1.45%. The yield on the 10-year Treasury ticked higher and U.S. oil prices rose 2.9% for the week. [PRO] Comeback stocksThe S&P 500 has soared to record levels, fueled by the AI boom, but not all stocks are riding the wave.
Persons: JPMorgan Chase, Goldman Sachs, Tesla, Elon Musk, Musk, Tim Lugo, William Blair's Organizations: CNBC, Nvidia, Microsoft, Apple, Nasdaq, Dow Jones, Citigroup, JPMorgan, Bank of America, Apple Intelligence, Union, Therapeutics, FDA, Organization for Rare Disorders, Nike, Starbucks Locations: U.S
In this videoShare Share Article via Facebook Share Article via Twitter Share Article via LinkedIn Share Article via EmailSarepta CEO on what's next after expanded muscular dystrophy drug approvalDouglas Ingram, Sarepta CEO, joins 'Fast Money' to talk FDA approval of Elevidys and its impact on the company's stock.
Persons: what's, Douglas Ingram
Hertz Global — Shares rose more than 10% after the car rental giant upsized a bond offering to $1 billion . Asana — The stock popped 10.5% after the software firm announced a share buyback plan that would cost $150 million. Nvidia — The chipmaker dropped another 1% following a 3.5% decline in the previous session. Gilead Sciences — Shares of the pharmaceutical company popped around 2%, adding to an 8.5% rally from the previous session. Palo Alto Networks — Shares rose 2.4% after D.A.
Persons: Gilead, LendingTree, Davidson, D.A, Boyd Gaming, Boyd, , Alex Harring, Yun Li, Lisa Kailai Han, Hakyung Kim, Michelle Fox Organizations: Therapeutics, U.S . Food, Drug Administration, FDA, Hertz, Nvidia, Gilead Sciences, Bloomberg, Palo Alto, D.A, Penn Entertainment, Boyd, Reuters, Boeing Locations: U.S, Gilead, Palo, cybersecurity, Thursday's
The decline comes after the AI chipmaker on Tuesday briefly topped Microsoft as the most valuable public company. Nike — The athletic clothing maker moved 1% higher following an upgrade at Oppenheimer to outperform from market perform. Asana — Shares popped more than 3% after the software firm announced a $150 million share buyback plan. Gilead Sciences — The pharmaceutical stock rose more than 2.6%, building on a rally of 8.5% from the previous session. Delta Air Lines — The stock rose 0.7% following news Thursday that the airliner announced a quarterly dividend of 15 cents a share, a 50% increase from previous levels.
Persons: Oppenheimer, Gilead, LendingTree, Bernstein, Toni Sacconaghi, — CNBC's Brian Evans, Michelle Fox, Jesse Pound, Sarah Min Organizations: Nvidia, Microsoft, Sarepta Therapeutics, U.S . Food, Drug Administration, Nike, Gilead Sciences, Bloomberg, Apple —, Air Lines Locations: U.S, Gilead
“We saw that with the mRNA (messenger RNA) vaccines that it can be a good messenger,” says Cech. The Catalyst by Thomas R. Cech W W NortonYou mentioned in “The Catalyst” that research on RNA has been around since the ‘50s. What is something that most people get wrong about mRNA vaccines, such as the Covid-19 ones? Thomas R. Cech in a lab in 1984, five years before he won the Nobel Prize in Chemistry. How does this apply to DNA, RNA, mRNA and CRISPR?
Persons: you’re, , Thomas R, Cech, ” Cech, Sidney Altman, he’s, Norton, It’s, Thomas R . Cech, Organizations: CNN, Pfizer, DNA, University of Colorado, Denver Post, Rotary Clubs, Lions Locations: Moderna, University of Colorado , Boulder, Boulder , Colorado, China, Cambridge , Massachusetts, United States, Germany
Wells Fargo reiterates Nvidia as overweight Wells increased its price target on Nvidia to $1,150 per share from $970. Jefferies upgrades Boston Beer to buy from hold Jefferies said in its upgrade of the beverage company that it sees "multiple expansion." Bank of America reiterates Apple as buy Bank of America said it's sticking with its buy rating on shares of Apple. JPMorgan upgrades Planet Fitness to overweight from neutral JPMorgan said in its has increased confidence in Planet Fitness' growth. JPMorgan upgrades Vtex to overweight from neutral JPMorgan said it sees an attractive entry point for the software-as-a-service company.
Persons: Tesla, Goldman Sachs, Goldman, it's, Wells, ests, Jefferies, Beer, Roth, Morgan Stanley, GXO's, Baird, Oppenheimer, Edwards Organizations: Barclays, Oncology, Fulcrum Therapeutics, ISI, Nvidia, Jefferies, Boston Beer, GXO Logistics, Bank of America, Apple, HSBC, Citi, Weatherford, Energy, JPMorgan, LT, Fortrea Holdings, Edison International, RBC, North, Deutsche Bank, Amazon, Deutsche, Western Digital, Seagate Locations: China, North America
CNN —The mix of local residents visiting the Enfield Food Shelf in Connecticut has changed a lot in the last few years. It now seems that one unexpected expense tips people’s finances.”Between 300 and 400 households visit the Enfield Food Shelf in Connecticut each week. Khamphay Khen shops at the Enfield Food Shelf to help feed his family of six. The Enfield Food Shelf serves between 300 and 400 households a week. “Even though there are a lot of jobs available, and the unemployment rate is low, we’re seeing food insecurity increasing,” said East.
Persons: Kathleen Souvigney, Souvigney, , , Jason Jakubowski, Khamphay, he’s, Khen, Honda, it’s, Enfield, Chloe East Organizations: CNN, Enfield Food, Survey, Connecticut Foodshare, Enfield Food Shelf, Urban Institute, The Hamilton, Brookings Institution Locations: Connecticut, Enfield, America
Avidity Biosciences stock has more room to run thanks to the company's pipeline of multiple treatments for rare muscle disorders, according to Bank of America. Avidity has a therapeutic platform — antibody oligonucleotide conjugates — that was well-received at the time it went public in 2020, Meacham said. But shares were hurt by a clinical hold on Avidity's leading program for treating an uncommon muscle disorder, DM1. The program, tested in the Marina trial, recently saw long-term data that has "helped lift that key overhang on the stock," Meacham said. Those catalysts are tied to two other drugs in the muscle disorder space that are expected to report data this year, according to Meacham.
Persons: Geoff Meacham, Meacham Organizations: Biosciences, Bank of America Locations: San Diego, Thursday's
JPMorgan upgrades Williams-Sonoma to neutral from underweight JPMorgan said in its upgrade of the stock that the home furnishings category is stabilizing. "We are downgrading shares of EXPE to Mkt Perform from OP with a target price of $145 vs. $165 previously." JPMorgan upgrades Joby to neutral from underweight JPMorgan said its bear thesis has largely played out for the aviation company. Guggenheim reiterates Target as buy Guggenheim said investors should buy the dip in shares of Target . Morgan Stanley downgrades Estee Lauder to equal weight from overweight Morgan Stanley said it sees a slower recovery for shares of Estee Lauder .
Persons: Stifel, Wells, Truist, OLLI, Guggenheim, Tim Cook, William Blair, Amgen, Jefferies, We've, Ari sta, it's, Morgan Stanley downgrades Estee Lauder, Morgan Stanley, Estee Lauder, TD Cowen, Parsons, Bernstein, Oppenheimer, CFRA, Berkshire Hathaway Organizations: RBC, FTAI Aviation, Pacific, Union Pacific, JPMorgan, Williams, WSM, BMO, Bank of America, Apple, Kiniksa Pharmaceuticals, JOBY, Guggenheim, Target, Citi, MCW, Arista, PSN, Avidity, ~$ Locations: Sonoma, EXPE, GEICO
The Food and Drug Administration on Friday approved Pfizer 's treatment for a rare genetic bleeding disorder, making it the company's first-ever gene therapy to win clearance in the U.S. The agency greenlit the drug, which will be marketed as Beqvez, for adults with moderate to severe hemophilia B who meet certain requirements. Without that protein, called factor IX, patients with hemophilia B bruise easily and bleed more frequently and for longer periods of time. The gene therapy will compete with Australia-based CSL Behring's Hemgenix, a similar treatment that won FDA approval for hemophilia B in 2022. The company is also developing a gene therapy for Duchenne muscular dystrophy, a genetic disorder that causes muscles to weaken gradually.
Persons: IX, hemophilia, Adam Cuker, Cuker Organizations: Drug Administration, Pfizer, U.S, Penn's, Spark Therapeutics, hemophilia Locations: U.S, Australia
Global mergers and acquisition activity will soar this year, and several names could benefit from the comeback, according to Morgan Stanley. The firm expects global M & A volume activity to rise by 50% this year compared to 2023. "We believe that a cyclical and structural rebound in M & A is coming," Morgan Stanley said in a note titled "Stocks with Elevated Likelihood of Receiving an Offer," which was released Monday. Morgan Stanley pointed out that 2021 to 2023 could have seen a drop of activity worth between $4 trillion and $11 trillion. Morgan Stanley said it has no information about M & A activity involving the companies.
Persons: Morgan Stanley, Morgan, Stephen Ju, Morgan Stanley's Organizations: Health, Sarepta Therapeutics, Tenet Healthcare, Analysts, BMO Capital Markets, UBS, Hertz Global Holdings Locations: Europe
To the Editor:Re “Why Can’t More Children Get the Treatment That Saved My Son’s Life?,” by Elizabeth Currid-Halkett (Opinion guest essay, Feb. 24):Our three children, ages 5 and 7, battle a rare, relentless and ultimately fatal disease called cystinosis. We recently found hope in the initial phase of a gene therapy clinical trial that was shown to be safe and yielded very promising results — a therapy that could one day save our children’s lives. Our biggest fear is that it will not be accessible to them or others in desperate need. We applaud Dr. Marks’s wisdom and perspective. reviewers’ initial rejection is a cautionary tale of how patient access to lifesaving therapies could be impeded by a narrow interpretation of efficacy.
Persons: Elizabeth Currid, Currid, Peter Marks, Organizations: Biologics
On Jan. 8, 2020, as I was parking my car, I got a long-awaited phone call from one of my son’s doctors. She informed me that our 7-month-old son, Eliot, had Duchenne muscular dystrophy, a fatal neuromuscular disease. I can see my neighbor walking up her steps with groceries, a leaf falling, oblivious to the devastation below. It is caused by a genetic mutation on the X chromosome, thus the disease almost exclusively affects boys (one in 3,300). lose muscle mass and thus the ability to do basic things like run and walk.
Persons: Eliot, Joan Didion, D.M.D, Jerry Mendell Organizations: Nationwide Children’s Hospital, D.M.D Locations: Columbus , Ohio
CNBC's Jim Cramer on Thursday encouraged investors to look beyond the Magnificent Seven, saying there's money to be made in other companies. Cramer named several stocks that have seen percentage gains of 10% or higher since Tuesday's close. Trucking company XPO caught Cramer's eye as its stock was able to soar thanks to a better-than-expected quarter. Cramer also named infrastructure company Advanced Drainage Systems , saying there's so much activity in the sector it's not hard to make money there. Some stocks are seeing gains thanks to innovative new tech, he added, pointing to the recent climb of Regenxbio .
Persons: CNBC's Jim Cramer, Cramer, XPO, we've Organizations: Trucking, Nvidia, Broadcom, Drainage Systems
The Russell 1000 , which tracks the top 1,000 largest companies — large- and mid-cap names — is up about 3% in 2024. With this in mind, CNBC Pro screened for the stocks making a comeback in 2024. However, the consensus price target is just 4.6% from its current levels — putting into question whether there's more room for upside. Just 35.7% of analysts are bullish on the shares, and the average price target implies shares can grow just 4.3%. Sarepta Therapeutics has soared 27.4% this year — and it could jump 20.1% more according to its consensus price target, per LSEG.
Persons: Russell, they're, Merck's, Sarepta Organizations: CNBC Pro, Pharmaceutical, Merck, Verizon, Barclays, VZ, LSEG, Novo Nordisk, Sarepta Therapeutics Locations: Novo
At Sundance, a reckoning with our digital selves
  + stars: | 2024-01-29 | by ( Thomas Page | ) edition.cnn.com   time to read: +11 min
Harper that premiered at this month’s Sundance Film Festival, rapper Kemba enters an electronics store. Sundance is a broad church, but one throughline this year was a reckoning with our digital selves. Courtesy of Sundance InstituteIn the game Steen could be whatever he wanted to be, do whatever he wanted to do. The Sundance Film Festival concluded on January 28. Documentary Competition)“Sujo” (World Cinema Dramatic Competition)“A New Kind of Wilderness” (World Cinema Documentary Competition)Audience Favorite Awards“Daughters” (U.S.
Persons: J.M, Harper, Kemba, , headspace Harper, Deus, J.M . Harper, Jazmin Jones, Olivia McKayla Ross, Mavis Beacon, Mandela, she’s, Jones, McKayla Ross Gen, we’re, Siri, knotty, L’espérance, feelgood, Thelma, Squibb, Beacon, Yeleen Cohen, , Kristin Stewart, Sam, Andy Zuchero, Stewart, Steven Yeun, Déja, Liam, “ Sebastian ”, Mikko Mäkelä, Ruaridh, Mollica, David Nellist, Sebastian, James Watson, “ Ibelin, Benjamin Ree, Mats Steen, Steen, Steen’s, Ibelin . Ibelin, he’d, Ree, Ibelin, Steen's avater Ibelin, It’s, ’ “, Steen –, Sujo, Dìdi ”, Ibelin ”, Kneecap Organizations: CNN, Sundance, Motorola, Sundance Institute, Americans, Iam, AIs, Netflix, Sundance Film Locations: , Haiti, , New York, Norwegian
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