I'm happy to get the win and hope you guys enjoyed it," said Tiafoe.
"I love playing on grass and I have high hopes here for Wimbledon," added Tiafoe, who warmed up by winning the Stuttgart grasscourt title.
"I'm a really relaxed guy but I do like finishing a tennis match.
The 10th seed, who reached the fourth round last year, meets Swiss qualifier Dominic Stricker or Australian Alexei Popyrin in the next round.
The world number nine, along with Tiafoe, is now looking to become the first American men's Grand Slam champion since Andy Roddick won the U.S. Open in 2003.
Persons:
Frances Tiafoe, China's Yibing Wu, Hannah Mckay LONDON, Wu Yibing, Tiafoe, Pete Sampras, it's, you've, Wu, Dominic Stricker, Alexei Popyrin, Taylor Fritz, Mikael Ymer, Yannick Hanfmann, Fritz up, Andy Roddick, Shrivathsa Sridhar, Ed Osmond
Organizations:
Lawn Tennis, Croquet Club, Wimbledon, Stuttgart, Swiss, U.S, Thomson
Locations:
London, Britain, Bengaluru