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Taking a high dose of ADHD drugs is linked to more than five times greater risk of developing psychosis or mania, according to a new study published Thursday in the American Journal of Psychiatry. The research is among the first to find a relationship between escalating doses of the drugs — amphetamines, in particular — and a greater likelihood of psychotic symptoms. The drugs include Adderall, Vyvanse and generic amphetamines, such as dextroamphetamine. The medium dosage — 20 mg to 40 mg of Adderall, 50 mg to 100 mg of Vyvanse or 15 mg to 30 mg of dextroamphetamine — was linked to a 3.5 times higher risk. There was no increased risk of psychosis with another ADHD drug, Ritalin, which isn’t an amphetamine.

Persons: it’s, ”, Jacob Ballon, hadn’t, Will Cronenwett, ” Cronenwett, Vyvanse, Takeda, Lauren Moran, Brigham, “, ” Moran, Moran, Cronenwett, ” Ballon, they’re Organizations: American, of Psychiatry, Stanford Medicine, Northwestern Medicine, Psychiatry, NBC News, Takeda Pharmaceuticals, . Food, Drug Administration, FDA, Pharmaceuticals, McLean Hospital, Mass Locations: United States, U.S, Boston

Long Covid continues to evade a clear diagnostic test, researchers reported in a study published Monday in the Annals of Internal Medicine. They found no differences between those with long Covid and those without the condition. Different symptoms were assigned different scores, and a long Covid diagnosis was met if the score reached a level of 12. There was no time cutoff for symptoms and a positive Covid test was not required for diagnosis. Dr. Nisha Viswanathan, the director of the long Covid clinic at UCLA Health, was not surprised with the results based on her experience working with long Covid patients for three years.

Persons: Long Covid, Kristine Erlandson, “, we’ve, ” Erlandson, Marc Sala, ” Sala, —, Nisha Viswanathan, ” Viswanathan Organizations: Internal Medicine, National Institute of Health’s, University of Colorado Anschutz Medical, Johns Hopkins University School of Medicine, Northwestern Medicine, UCLA Health, Yale School of Medicine

The U.S. is in what may end up being its biggest summer wave of Covid, with no end yet in sight. This year’s summer wave also began earlier than last year’s, Jha said. “Besides that, there’s not much that we can sort of put our finger on to say this is what’s driving this summer surge," Pekosz said. Jha said that what happens this winter is impossible to predict but that there could be a silver lining to a large summer wave. “A big summer wave tends to lead to a little bit of a smaller winter wave and vice versa, just because there’s a little bit more immunity in the population,” he said.

Persons: ”, Ashish Jha, “ It’s, ” It's, There's, Maria Van Kerkhove, Van Kerkhove, Rosem Morton, Jha, Andrew Pekosz, “, there’s, Pekosz, Michael Phillips, epidemiologist, ” Phillips Organizations: Brown University School of Public Health, White, Covid, World Health Organization, Centers for Disease Control, The Washington, Getty, Food and Drug Administration, CDC, Johns Hopkins Bloomberg School of Public Health, didn't, NYU Langone Health Locations: U.S, Europe, Washington, Western U.S, Texas, California, Florida, North Carolina, Covid, New York City

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