But oil and mining guilds say their industries are needed to shore up Ecuador's battered economy and that bans would expose the areas to illegal mining and deforestation.
Outgoing President Guillermo Lasso, who moved ahead elections after lawmakers attempted to oust him, has failed to raise oil production or attract more mining investment as violence and social problems have worsened.
A "yes" vote in both referendums could complicate finances for his successor.
State oil company Petroecuador says a "yes" on the Yasuni referendum would cost the country $13.8 billion in income over the next two decades.
But residents say mining will threaten high altitude wetlands, water and animals like the spectacled bear.
Persons:
Read, Ecuadoreans, Guillermo Lasso, Santiago Pérez, Ramon Correa, Correa, Rafael Correa, Pedro Bermeo, Bermeo, Petroecuador, Australia's SolGold, Maria Eulalia Silva, Morelia Fuentes, Alexandra Valencia, Tito Correa, Karen Toro, Julia Symmes Cobb, Marguerita Choy
Organizations:
ITT, Environmental, Reuters, Voters, of Mining, Mining, Thomson
Locations:
Orellana, Orellana province, Ecuador, QUITO, Quito, Choco, North America, State, Pastaza